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Aliases for ZNF71 Gene

Aliases for ZNF71 Gene

  • Zinc Finger Protein 71 2 3 4 5
  • EZFIT 3 4
  • Endothelial Zinc Finger Protein Induced By Tumor Necrosis Factor Alpha 3
  • Kruppel-Related Zinc Finger Protein 3
  • Zinc Finger Protein 71 (Cos26) 2

External Ids for ZNF71 Gene

Previous GeneCards Identifiers for ZNF71 Gene

  • GC22U990056
  • GC19P057560
  • GC19P061593
  • GC19P061617
  • GC19P061608
  • GC19P061798
  • GC19P057108
  • GC19P053416

Summaries for ZNF71 Gene

GeneCards Summary for ZNF71 Gene

ZNF71 (Zinc Finger Protein 71) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZFP2.

UniProtKB/Swiss-Prot for ZNF71 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF71 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF71 Gene

Genomics for ZNF71 Gene

Regulatory Elements for ZNF71 Gene

Enhancers for ZNF71 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F056139 0.4 ENCODE 13.3 -452.9 -452942 5.2 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF71 ZFP28 ZNF580 ZNF471 ISOC2 ENSG00000279794 ZNF444
GH19F056594 0.9 ENCODE 11.6 +0.2 177 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A YBX1 FEZF1 GLI4 ZNF48 ETS1 ZNF773 ZNF550 U2AF2 ZNF543 ZNF264 ZNF17 ENSG00000267523 ZNF549 ENSG00000267096 ZFP28
GH19F057171 0.5 Ensembl ENCODE 11 +577.1 577137 2.0 ZNF48 ZNF2 ZNF366 ZNF548 SP3 CEBPB ZFP69B ZNF585B ZNF341 GLIS1 LOC100132009 ZNF17 ZNF134 ZNF773 ZNF417 ZNF805 ZNF606 ZNF549 AURKC ZNF256
GH19F056403 0.2 ENCODE 10.9 -191.1 -191115 2.0 ATF1 CREB3L1 ZNF133 ARID4B SIN3A GLI4 DMAP1 ZNF48 YY1 GTF3C2 ZNF543 ZNF582-AS1 ZNF805 LOC100506374 ZNF264 ZNF581 U2AF2 ENSG00000267523 ZNF628 ZNF548
GH19F056392 0.4 ENCODE 10.9 -201.8 -201808 1.5 ATF1 ARNT CREB3L1 ZNF133 SIN3A ZNF48 BRCA1 ZNF2 ETS1 YY1 ZNF543 ZNF582-AS1 ZNF805 LOC100506374 ZNF264 ZNF581 U2AF2 ENSG00000267523 ZNF628 ZNF548
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF71 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF71 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045592 336 2000 HDGF PKNOX1 ZNF133 ARID4B SIN3A YBX1 FEZF1 GLI4 ZNF48 ETS1

Genomic Location for ZNF71 Gene

Chromosome:
19
Start:
56,595,264 bp from pter
End:
56,626,481 bp from pter
Size:
31,218 bases
Orientation:
Plus strand

Genomic View for ZNF71 Gene

Genes around ZNF71 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF71 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF71 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF71 Gene

Proteins for ZNF71 Gene

  • Protein details for ZNF71 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQZ8-ZNF71_HUMAN
    Recommended name:
    Endothelial zinc finger protein induced by tumor necrosis factor alpha
    Protein Accession:
    Q9NQZ8
    Secondary Accessions:
    • Q15919
    • Q9UC09
    • Q9UQD3

    Protein attributes for ZNF71 Gene

    Size:
    489 amino acids
    Molecular mass:
    54498 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD23608.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF71 Gene

Post-translational modifications for ZNF71 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF71 Gene

No data available for DME Specific Peptides for ZNF71 Gene

Domains & Families for ZNF71 Gene

Gene Families for ZNF71 Gene

Protein Domains for ZNF71 Gene

Suggested Antigen Peptide Sequences for ZNF71 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQZ8

UniProtKB/Swiss-Prot:

ZNF71_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF71: view

Function for ZNF71 Gene

Molecular function for ZNF71 Gene

GENATLAS Biochemistry:
zinc finger protein 71 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
UniProtKB/Swiss-Prot Induction:
By TNF.

Gene Ontology (GO) - Molecular Function for ZNF71 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF71: view
genes like me logo Genes that share phenotypes with ZNF71: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF71 Gene

Localization for ZNF71 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF71 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF71 Gene COMPARTMENTS Subcellular localization image for ZNF71 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF71 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF71: view

Pathways & Interactions for ZNF71 Gene

SuperPathways for ZNF71 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF71: view

Pathways by source for ZNF71 Gene

2 Reactome pathways for ZNF71 Gene

Interacting Proteins for ZNF71 Gene

Gene Ontology (GO) - Biological Process for ZNF71 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF71: view

No data available for SIGNOR curated interactions for ZNF71 Gene

Drugs & Compounds for ZNF71 Gene

(1) Drugs for ZNF71 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF71: view

Transcripts for ZNF71 Gene

Unigene Clusters for ZNF71 Gene

Zinc finger protein 71:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF71 Gene

No ASD Table

Relevant External Links for ZNF71 Gene

GeneLoc Exon Structure for
ZNF71
ECgene alternative splicing isoforms for
ZNF71

Expression for ZNF71 Gene

mRNA expression in normal human tissues for ZNF71 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF71 Gene:

ZNF71

SOURCE GeneReport for Unigene cluster for ZNF71 Gene:

Hs.301431

mRNA Expression by UniProt/SwissProt for ZNF71 Gene:

Q9NQZ8-ZNF71_HUMAN
Tissue specificity: Highly expressed in placenta, followed by brain, testis, pancreas, heart, small intestine, muscle, uterus, prostate and peripheral blood leukocytes. Not detected in liver, lung, colon, stomach, salivary and thyroid gland.
genes like me logo Genes that share expression patterns with ZNF71: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ZNF71 Gene

Orthologs for ZNF71 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF71 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF71 34 35
  • 99.59 (n)
cow
(Bos Taurus)
Mammalia ZNF71 34
  • 83.09 (n)
-- 35
  • 53 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia ZNF71 34 35
  • 79.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZNF71 34
  • 62.39 (n)
-- 35
  • 48 (a)
OneToMany
Species where no ortholog for ZNF71 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF71 Gene

ENSEMBL:
Gene Tree for ZNF71 (if available)
TreeFam:
Gene Tree for ZNF71 (if available)

Paralogs for ZNF71 Gene

(474) SIMAP similar genes for ZNF71 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF71 Gene

genes like me logo Genes that share paralogs with ZNF71: view

Variants for ZNF71 Gene

Sequence variations from dbSNP and Humsavar for ZNF71 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1024785 -- 56,614,399(+) TTGGG(A/T)CAGCT intron-variant
rs1024786 -- 56,614,473(+) CCTTT(A/G)GAAAT intron-variant
rs1035115 -- 56,597,415(+) ATAAC(C/T)TCTAC intron-variant, utr-variant-5-prime
rs1035116 -- 56,620,068(+) TGTGA(C/T)GTAGC intron-variant
rs10404342 -- 56,620,870(+) CACGA(A/C)TGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF71 Gene

Variant ID Type Subtype PubMed ID
dgv1823n106 CNV deletion 24896259
dgv231e215 CNV deletion 23714750
esv2719039 CNV deletion 23290073
esv2719041 CNV deletion 23290073
esv8168 CNV loss 19470904
nsv1055357 CNV gain 25217958
nsv1071951 CNV deletion 25765185
nsv580388 CNV loss 21841781
nsv956595 CNV deletion 24416366

Variation tolerance for ZNF71 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.22; 62.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF71 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF71

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF71 Gene

Disorders for ZNF71 Gene

Relevant External Links for ZNF71

Genetic Association Database (GAD)
ZNF71
Human Genome Epidemiology (HuGE) Navigator
ZNF71
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF71

No disorders were found for ZNF71 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF71 Gene

Publications for ZNF71 Gene

  1. A novel zinc finger protein mRNA in human umbilical vein endothelial cells is profoundly induced by tumor necrosis factor alpha. (PMID: 11426589) Mataki C. … Kodama T. (J. Atheroscler. Thromb. 2000) 3 4 22 64
  2. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). (PMID: 1639391) Aubry M. … Rouleau G.A. (Genomics 1992) 2 3 4 64
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 46 64
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ZNF71 Gene

Sources for ZNF71 Gene

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