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Aliases for ZNF71 Gene

Aliases for ZNF71 Gene

  • Zinc Finger Protein 71 2 3 4 5
  • EZFIT 3 4
  • Kruppel-Related Zinc Finger Protein 3
  • Zinc Finger Protein 71 (Cos26) 2

External Ids for ZNF71 Gene

Previous GeneCards Identifiers for ZNF71 Gene

  • GC22U990056
  • GC19P057560
  • GC19P061593
  • GC19P061617
  • GC19P061608
  • GC19P061798
  • GC19P057108
  • GC19P053416

Summaries for ZNF71 Gene

GeneCards Summary for ZNF71 Gene

ZNF71 (Zinc Finger Protein 71) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF70.

UniProtKB/Swiss-Prot for ZNF71 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF71 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF71 Gene

Genomics for ZNF71 Gene

Regulatory Elements for ZNF71 Gene

Promoters for ZNF71 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF71 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF71 Gene

Chromosome:
19
Start:
56,595,264 bp from pter
End:
56,626,481 bp from pter
Size:
31,218 bases
Orientation:
Plus strand

Genomic View for ZNF71 Gene

Genes around ZNF71 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF71 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF71 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF71 Gene

Proteins for ZNF71 Gene

  • Protein details for ZNF71 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQZ8-ZNF71_HUMAN
    Recommended name:
    Endothelial zinc finger protein induced by tumor necrosis factor alpha
    Protein Accession:
    Q9NQZ8
    Secondary Accessions:
    • Q15919
    • Q9UC09
    • Q9UQD3

    Protein attributes for ZNF71 Gene

    Size:
    489 amino acids
    Molecular mass:
    54498 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD23608.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF71 Gene

Proteomics data for ZNF71 Gene at MOPED

Post-translational modifications for ZNF71 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF71 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZNF71 Gene

Domains & Families for ZNF71 Gene

Gene Families for ZNF71 Gene

Protein Domains for ZNF71 Gene

Suggested Antigen Peptide Sequences for ZNF71 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQZ8

UniProtKB/Swiss-Prot:

ZNF71_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 13 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 13 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF71: view

Function for ZNF71 Gene

Molecular function for ZNF71 Gene

GENATLAS Biochemistry:
zinc finger protein 71 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
UniProtKB/Swiss-Prot Induction:
By TNF.
genes like me logo Genes that share phenotypes with ZNF71: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF71 Gene

Localization for ZNF71 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF71 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF71 Gene COMPARTMENTS Subcellular localization image for ZNF71 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF71 Gene

Pathways & Interactions for ZNF71 Gene

SuperPathways for ZNF71 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF71: view

Pathways by source for ZNF71 Gene

2 Reactome pathways for ZNF71 Gene

Gene Ontology (GO) - Biological Process for ZNF71 Gene

None

No data available for SIGNOR curated interactions for ZNF71 Gene

Drugs & Compounds for ZNF71 Gene

(1) Drugs for ZNF71 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF71: view

Transcripts for ZNF71 Gene

mRNA/cDNA for ZNF71 Gene

Unigene Clusters for ZNF71 Gene

Zinc finger protein 71:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF71 Gene

No ASD Table

Relevant External Links for ZNF71 Gene

GeneLoc Exon Structure for
ZNF71
ECgene alternative splicing isoforms for
ZNF71

Expression for ZNF71 Gene

mRNA expression in normal human tissues for ZNF71 Gene

SOURCE GeneReport for Unigene cluster for ZNF71 Gene Hs.301431

mRNA Expression by UniProt/SwissProt for ZNF71 Gene

Q9NQZ8-ZNF71_HUMAN
Tissue specificity: Highly expressed in placenta, followed by brain, testis, pancreas, heart, small intestine, muscle, uterus, prostate and peripheral blood leukocytes. Not detected in liver, lung, colon, stomach, salivary and thyroid gland.
genes like me logo Genes that share expression patterns with ZNF71: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ZNF71 Gene

Orthologs for ZNF71 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF71 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF71 35
  • 83.09 (n)
  • 82.27 (a)
-- 36
  • 53 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia ZNF71 35
  • 79.91 (n)
  • 82.72 (a)
ZNF71 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF71 35
  • 99.59 (n)
  • 99.18 (a)
ZNF71 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 55 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZNF71 35
  • 62.39 (n)
  • 51.9 (a)
-- 36
  • 48 (a)
OneToMany
Species with no ortholog for ZNF71:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF71 Gene

ENSEMBL:
Gene Tree for ZNF71 (if available)
TreeFam:
Gene Tree for ZNF71 (if available)

Paralogs for ZNF71 Gene

(474) SIMAP similar genes for ZNF71 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF71: view

Variants for ZNF71 Gene

Sequence variations from dbSNP and Humsavar for ZNF71 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2072501 - 56,621,600(+) CACCC(A/G)TAAGG reference, missense
rs10405299 - 56,621,366(+) CCACG(A/G)GGAAT reference, missense
rs35392779 - 56,621,649(+) GCCCC(C/T)CATGC reference, missense
rs887954 -- 56,608,988(+) tgtta(C/T)ggttg intron-variant
rs887955 -- 56,609,001(+) caaag(A/G)cttgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF71 Gene

Variant ID Type Subtype PubMed ID
nsv912518 CNV Gain 21882294
esv2719039 CNV Deletion 23290073
esv8168 CNV Loss 19470904
esv2719041 CNV Deletion 23290073
nsv912520 CNV Loss 21882294
nsv912521 CNV Gain 21882294

Variation tolerance for ZNF71 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.22; 62.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF71 Gene

HapMap Linkage Disequilibrium report
ZNF71

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF71 Gene

Disorders for ZNF71 Gene

Relevant External Links for ZNF71

Genetic Association Database (GAD)
ZNF71
Human Genome Epidemiology (HuGE) Navigator
ZNF71
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF71

No disorders were found for ZNF71 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF71 Gene

Publications for ZNF71 Gene

  1. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). (PMID: 1639391) Aubry M. … Rouleau G.A. (Genomics 1992) 2 3 4 67
  2. A novel zinc finger protein mRNA in human umbilical vein endothelial cells is profoundly induced by tumor necrosis factor alpha. (PMID: 11426589) Mataki C. … Kodama T. (J. Atheroscler. Thromb. 2000) 3 23
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  5. A genome-wide association study of total serum and mite-specific IgEs in asthma patients. (PMID: 23967269) Kim J.H. … Shin H.D. (PLoS ONE 2013) 3

Products for ZNF71 Gene

Sources for ZNF71 Gene

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