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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF71 Gene

protein-coding   GIFtS: 55
GCID: GC19P057108

Zinc Finger Protein 71

(Previous name: zinc finger protein 71 (Cos26))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 711 2 3
EZFIT2 3
Zinc Finger Protein 71 (Cos26)1
Endothelial Zinc Finger Protein Induced By Tumor Necrosis Factor Alpha2
Kruppel-Related Zinc Finger Protein2

External Ids:    HGNC: 131411   Entrez Gene: 584912   Ensembl: ENSG000001979517   OMIM: 1945455   UniProtKB: Q9NQZ83   

Export aliases for ZNF71 gene to outside databases

Previous GC identifers: GC22U990056 GC19P057560 GC19P061593 GC19P061617 GC19P061608 GC19P061798 GC19P053416


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF71 Gene: 
ZNF71 (zinc finger protein 71) is a protein-coding gene. Diseases associated with ZNF71 include osteonecrosis, and choriocarcinoma, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF436.

UniProtKB/Swiss-Prot: ZNF71_HUMAN, Q9NQZ8
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF71 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF71 gene promoter:
         GR   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF71 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF71

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF71


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.4

ZNF71 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF71 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P057108:  view genomic region     (about GC identifiers)

Start:
57,106,632 bp from pter      End:
57,137,849 bp from pter
Size:
31,218 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZNF71_HUMAN, Q9NQZ8 (See protein sequence)
Recommended Name: Endothelial zinc finger protein induced by tumor necrosis factor alpha  
Size: 489 amino acids; 54498 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAD23608.1; Type=Erroneous initiation;
Secondary accessions: Q15919 Q9UC09 Q9UQD3

Explore the universe of human proteins at neXtProt for ZNF71: NX_Q9NQZ8

Explore proteomics data for ZNF71 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NQZ8

  • ZNF71 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF71 Protein Expression
    REFSEQ proteins: NP_067039.1  
    ENSEMBL proteins: 
     ENSP00000471138   ENSP00000328245  
    Reactome Protein details: Q9NQZ8
    Human Recombinant Protein Products for ZNF71: 
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    Cloud-Clone Corp. Proteins for ZNF71 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--

    ZNF71 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9NQZ8

    ProtoNet protein and cluster: Q9NQZ8

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: ZNF71_HUMAN, Q9NQZ8
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 13 C2H2-type zinc fingers


    ZNF71 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF71_HUMAN, Q9NQZ8
    Function: May be involved in transcriptional regulation
    Induction: By TNF

         Genatlas biochemistry entry for ZNF71:
    zinc finger protein 71 (C2H2 type,Kruppel-like)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF71 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF71 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF71
        Generic Transcription Pathway
    Gene Expression



    ZNF71 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF71

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/9 Interacting proteins for ZNF71 (Q9NQZ82, 3 ENSP000003282454) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253825 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253825 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253825 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253825 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253825 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--

    ZNF71 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ZNF71 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF71

    1 Novoseek inferred chemical compound relationship for ZNF71 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 61.8 10 11426589 (2), 14727140 (1), 7865130 (1), 1381359 (1) (see all 8)

    Search CenterWatch for drugs/clinical trials and news about ZNF71

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF71 gene: 
    NM_021216.4  

    Unigene Cluster for ZNF71:

    Zinc finger protein 71
    Hs.301431  [show with all ESTs]
    Unigene Representative Sequence: NM_021216
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000599599 ENST00000328070(uc002qnm.4) ENST00000594944
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF71

    Additional mRNA sequence: 

    AF269249.1 AK057019.1 BC014280.2 

    2 DOTS entries:

    DT.445454  DT.40302564 

    24/78 AceView cDNA sequences (see all 78):

    AA970681 BF528411 BQ071941 BQ430414 NM_021216 BM453638 BM673945 AI969460 
    AL527747 AF269249 CR601440 AL137486 BC014280 AA903897 BF966463 W55974 
    BP339763 N51178 AA147829 CA416578 BU688804 BU160530 BE540015 AI597978 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF71 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF71 Expression
    About this image


    See ZNF71 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF71

    SOURCE GeneReport for Unigene cluster: Hs.301431

    UniProtKB/Swiss-Prot: ZNF71_HUMAN, Q9NQZ8
    Tissue specificity: Highly expressed in placenta, followed by brain, testis, pancreas, heart, small intestine,
    muscle, uterus, prostate and peripheral blood leukocytes. Not detected in liver, lung, colon, stomach, salivary
    and thyroid gland

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF71 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ZNF2321 zinc finger protein 232 61.99(n)
    51.75(a)
      425244  XM_003643802.1  XP_003643850.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    ZNF106
    (see all 7)
    Uncharacterized protein
    (see all 7)
    59(a)
    58(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    GL343312.1(8265-9200)
    GL344392.1(35306-36196)
    zebrafish
    (Danio rerio)
    Actinopterygii CR792418.16
    BX842593.26
    (see all 11)
    Uncharacterized protein
    (see all 11)
    47(a)
    47(a)
    (see all 11)
    many ↔ many
    many ↔ many
    (see all 11)
    4(33542000-33543552)
    5(54699992-54700939)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG122996
    --
    18(a)
    1 → many
    2L(10737345-10740762)
            Species with no ortholog for ZNF71

    ENSEMBL Gene Tree for ZNF71 (if available)
    TreeFam Gene Tree for ZNF71 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF71 gene
    ZNF4362  ZNF1802  ZNF3222  ZNF5722  ZFP22  ZNF6972  ZKSCAN72  ZNF6782  
    ZNF7742  ZNF102  ZFP372  ZSCAN22  ZNF3292  ZNF8522  ZNF5442  ZFP32  
    ZNF6062  ZNF8352  ZNF5022  
    18/474 SIMAP similar genes for ZNF71 using alignment to 2 protein entries:     ZNF71_HUMAN (see all proteins) (see all similar genes):
    ZFP2    ZNF146    ZNF852    ZNF436    DKFZp666C237    ZKSCAN8
    ZNF211    ZNF589    ZNF879    DKFZp547L155    DKFZp666M039    ZNF
    ZNF16    ZNF256    ZNF347    ZNF484    ZNF502    ZNF558

    ZNF71 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/763 SNPs in ZNF71 are shown (see all 763)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs739344751,2
    C,F--57104683(+) TTGTAT/AATATG 1 -- us2k13Minor allele frequency- A:0.10WA CSA 122
    rs1901792661,2
    --57104801(+) TCTGTC/GTCTTG 1 -- us2k10--------
    rs1486081181,2
    --57104866(+) GAAATA/TACCTA 1 -- us2k10--------
    rs1420837351,2
    --57104895(+) GTATGA/GTTTCT 1 -- us2k10--------
    rs1165172101,2
    C,F--57105016(+) TTGTGG/ACCACT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1479562731,2
    C--57105083(+) CTCAGC/TCAGGC 1 -- us2k10--------
    rs1817500101,2
    --57105106(+) CCTTTC/TCTCTT 1 -- us2k10--------
    rs1873575361,2
    --57105263(+) AGATAC/TAGGGA 1 -- us2k10--------
    rs1159629981,2
    F--57105366(+) CAAGCA/GGAGGA 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs104390831,2
    C,F,H--57105454(+) tttccC/Ttatca 1 -- us2k17Minor allele frequency- T:0.08NS EA CSA WA NA 652

    HapMap Linkage Disequilibrium report for ZNF71 (57106632 - 57137849 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZNF71:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2719039CNV Deletion23290073
    esv2719041CNV Deletion23290073
    nsv912520CNV Loss21882294
    esv8168CNV Loss19470904
    nsv912521CNV Gain21882294
    nsv912518CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 194545    OMIM disorders: --

    5 diseases for ZNF71:    About MalaCards
    osteonecrosis    choriocarcinoma    endotheliitis    thyroiditis
    prostatitis


    ZNF71 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for ZNF71 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 4.77 1 1381359 (1)
    tumors 0 1 1381359 (1)

    Genetic Association Database (GAD): ZNF71
    Human Genome Epidemiology (HuGE) Navigator: ZNF71 (2 documents)

    Export disorders for ZNF71 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF71 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with ZNF71)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). (PubMed id 1639391)1, 2, 3 Aubry M.... Rouleau G.A. (1992)
    2. A novel zinc finger protein mRNA in human umbilical vein endothelial cells is profoundly induced by tumor necrosis factor alpha. (PubMed id 11426589)1, 2, 9 Mataki C.... Kodama T. (2000)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    6. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PubMed id 1505991)1, 2 Lichter P....Ward D.C. (1992)
    7. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    8. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    9. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58491 HGNC: 13141 AceView: ZNF71 Ensembl:ENSG00000197951 euGenes: HUgn58491
    ECgene: ZNF71 H-InvDB: ZNF71

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF71 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF71 gene:
    Search GeneIP for patents involving ZNF71

    GeneCards and IP:
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