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ZNF709 Gene

protein-coding   GIFtS: 48
GCID: GC19M012571

Zinc Finger Protein 709

  Search for ZNF709
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 7091 2

External Ids:    HGNC: 206291   Entrez Gene: 1630512   Ensembl: ENSG000002428527   UniProtKB: Q8N9723   
ORGUL members:         

Export aliases for ZNF709 gene to outside databases

Previous GC identifers: GC19M012434 GC19M012145


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF709 Gene:
ZNF709 (zinc finger protein 709) is a protein-coding gene. An important paralog of this gene is ZNF669.

UniProtKB/Swiss-Prot: ZN709_HUMAN, Q8N972
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF709 gene promoter:
         SRF   NF-1   NF-1/L   AML1a   SRF (504 AA)   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   C/EBPalpha   PPAR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF709 promoter sequence
   Search Chromatin IP Primers for ZNF709

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF709


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF709 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF709 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M012571:  view genomic region     (about GC identifiers)

Start:
12,571,998 bp from pter      End:
12,624,668 bp from pter
Size:
52,671 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN709_HUMAN, Q8N972 (See protein sequence)
Recommended Name: Zinc finger protein 709  
Size: 641 amino acids; 74652 Da
Secondary accessions: A8K4E6

Explore the universe of human proteins at neXtProt for ZNF709: NX_Q8N972

Explore proteomics data for ZNF709 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF709 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689814.1  
    ENSEMBL proteins: 
     ENSP00000380840   ENSP00000398085  
    Reactome Protein details: Q8N972

    ZNF709 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N972

    ProtoNet protein and cluster: Q8N972

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN709_HUMAN, Q8N972
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 19 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF709 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN709_HUMAN, Q8N972
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF709 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF709:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF709
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    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ZNF709:
    hsa-miR-188-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF709

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF709

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF709


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN709_HUMAN, Q8N972: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF709 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF709 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF709
        Generic Transcription Pathway



    ZNF709 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF709
    Interactions:

        Search GeneGlobe Interaction Network for ZNF709

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF709 (Q8N9723 ENSP000003808404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARF6P623303, ENSP000002983164I2D: score=1 STRING: ENSP00000298316
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF709 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF709 (ZN709)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF709 gene (2 alternative transcripts): 
    NM_001145647.1  NM_152601.3  

    Unigene Cluster for ZNF709:

    Zinc finger protein 709
    Hs.631623  [show with all ESTs]
    Unigene Representative Sequence: NM_152601
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397732(uc002mtv.4 uc002mtw.4 uc002mtx.4) ENST00000455490
    ENST00000493776
    miRNA
    Products:
         
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    1 qRT-PCR Assays for microRNA that regulate ZNF709:
    hsa-miR-188-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF709
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF709
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    GenScript: all cDNA clones in your preferred vector: ZNF709 (NM_152601)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ZNF709
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF709
      QuantiFast Probe-based Assays in human, mouse, rat ZNF709

    Additional mRNA sequence: 

    AK290911.1 BC038531.1 BC136746.1 BC136751.1 

    7 DOTS entries:

    DT.95138204  DT.95218815  DT.303133  DT.91842705  DT.97768516  DT.97780540  DT.99933058 

    Selected AceView cDNA sequences (see all 26):

    BC038531 W01677 AW243490 AI800025 BG115649 N93104 BC036481 BE856068 
    BX954970 BX098390 AI668686 AA829697 BQ027911 BI548573 BQ956044 NM_152601 
    AL157423 AK095600 W24407 AA079177 AA373865 AA079178 AV732939 AW979179 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF709 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTATGTTTT
    ZNF709 Expression
    About this image

    ZNF709 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF709 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631623
        Custom PCR Arrays for ZNF709
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF709

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF709 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp8725 zinc finger protein 872   --   9 (8.57 cM) 22188168 


    ENSEMBL Gene Tree for ZNF709 (if available)
    TreeFam Gene Tree for ZNF709 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF709 gene
    ZNF6692  ZNF5642  ZNF4902  ZNF4412  ZNF625-ZNF202  ZNF8782  ENSG000002671792  ZNF142  
    ENSG000002697552  ENSG000001968262  ZNF7002  ZNF692  ZNF4402  ZNF4432  ZNF670-ZNF6952  ZNF442  
    ZNF4392  ZNF8232  ENSG000001884742  ZNF4912  ZNF5552  ENSG000002688702  ZNF6252  ZNF7992  
    ZNF202  ZNF7882  ZNF1012  ZNF7912  ZNF4422  ZNF4332  ZNF572  ZNF6272  
    ZNF5632  ENSG000002573552  ZNF1362  ZNF5562  ZNF7632  ENSG000002687442  ZNF8442  ZNF772  
    Selected SIMAP similar genes for ZNF709 using alignment to 2 protein entries:     ZN709_HUMAN (see all proteins) (see all similar genes):
    LOC101928664    ZNF625-ZNF20    HZF36    ZNF625    ZNF226    ZNF833P
    ZNF791    DKFZp666M039    ZNF14    ZNF232    ZNF136    ZNF664
    ZNF556    ZNF627    ZNF239    ZNF852    ZSCAN21    ZNF823

    ZNF709 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for ZNF709
    PGOHUM00000262870 PGOHUM00000259304 PGOHUM00000234276 PGOHUM00000245876 PGOHUM00000235445


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF709 (see all 469)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs340020051,2
    C--12168911(+) ATGGA-/TTTCTGA 1 -- us2k12Minor allele frequency- TT:0.25NA 4
    rs129729301,2
    C,F--12571767(+) GGGAAC/TTGAAC 1 -- int17Minor allele frequency- T:0.38NA WA CSA 13
    rs799668811,2
    C,F--12571917(+) TGTATG/ACCTAT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1838951001,2
    C--12571922(+) ACCTAG/TGTAAT 1 -- int10--------
    rs1884302551,2
    --12572287(+) CAGTGA/CAGTGG 1 -- ut310--------
    rs48041941,2
    C,F,A,H--12572300(+) AAGCAA/GACACC 1 -- ut3129Minor allele frequency- G:0.35NA NS EA WA CSA 2499
    rs1815795291,2
    C--12572315(+) TAGTTA/CTTTTT 1 -- ut310--------
    rs1856905611,2
    --12572429(+) CAACCG/TAGAGA 1 -- ut310--------
    rs568362841,2
    C,F--12572561(+) AAGACA/C/TATTTG 2 -- ut311WA 118
    rs1411721861,2
    --12572690(+) AGCCTA/GGCCAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF709 (12571998 - 12624668 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF709:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911075CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF709
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF709

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    ZNF709 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF709

    Export disorders for ZNF709 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF709 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF709)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    4. Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4. (PubMed id 16737952)1 Fang Z....Yao X. (amp 2006)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 163051 HGNC: 20629 AceView: FLJ38281 Ensembl:ENSG00000242852 euGenes: HUgn163051
    ECgene: ZNF709 H-InvDB: ZNF709

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF709 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF709 gene:
    Search GeneIP for patents involving ZNF709

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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