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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF708 Gene

protein-coding   GIFtS: 44
GCID: GC19M021473

Zinc Finger Protein 708

(Previous names: zinc finger protein 15-like 1 (KOX 8), zinc finger protein...)
(Previous symbols: ZNF15, ZNF15L1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 7081 2     Zinc Finger Protein KOX82 3
ZNF151 2 3     KOX82 3
ZNF15L11 2 3     Zinc Finger Protein 708 (KOX8)1
Zinc Finger Protein 15-Like 1 (KOX 8)1 2     Zinc Finger Protein 15-Like 13
Zinc Finger Protein 152 3     

External Ids:    HGNC: 129451   Entrez Gene: 75622   Ensembl: ENSG000001821417   UniProtKB: P170193   

Export aliases for ZNF708 gene to outside databases

Previous GC identifers: GC07U901540 GC19M021266 GC19M020964


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF708 Gene: 
ZNF708 (zinc finger protein 708) is a protein-coding gene. Diseases associated with ZNF708 include alagille syndrome, and thyroid adenoma, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot: ZN708_HUMAN, P17019
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF708 gene promoter:
         GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF708 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF708

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF708


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF708 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF708 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M021473:  view genomic region     (about GC identifiers)

Start:
21,473,962 bp from pter      End:
21,512,227 bp from pter
Size:
38,266 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN708_HUMAN, P17019 (See protein sequence)
Recommended Name: Zinc finger protein 708  
Size: 499 amino acids; 57357 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAD18665.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q6ZMR0

Explore the universe of human proteins at neXtProt for ZNF708: NX_P17019

Explore proteomics data for ZNF708 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17019

  • ZNF708 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF708 Protein Expression
    REFSEQ proteins: NP_067092.2  
    ENSEMBL proteins: 
     ENSP00000349401   ENSP00000472827   ENSP00000469961   ENSP00000471855  
    Reactome Protein details: P17019
    Human Recombinant Protein Products for ZNF708: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF708 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17019

    ProtoNet protein and cluster: P17019

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZN708_HUMAN, P17019
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 15 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF708 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN708_HUMAN, P17019
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF708 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF708 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF708
        Generic Transcription Pathway
    Gene Expression



    ZNF708 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF708

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF708 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF708 (ZN708)

    Search CenterWatch for drugs/clinical trials and news about ZNF708 / ZN708

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF708 gene: 
    NM_021269.2  

    Unigene Cluster for ZNF708:

    Zinc finger protein 708
    Hs.466296  [show with all ESTs]
    Unigene Representative Sequence: AK131527
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356929(uc002npq.1 uc002npr.1 uc010ecs.1) ENST00000598046
    ENST00000601295 ENST00000602023
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF708
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF708
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF708
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF708

    Additional mRNA sequence: 

    AK128184.1 AK131527.1 AK311130.1 BC039403.1 BX647526.1 X52339.1 X59845.1 

    4 DOTS entries:

    DT.99961357  DT.95073830  DT.40122199  DT.92431200 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF708 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF708 Expression
    About this image


    See ZNF708 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF708

    SOURCE GeneReport for Unigene cluster: Hs.466296
        SABiosciences Custom PCR Arrays for ZNF708
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF708

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF708 gene from 2/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp7085
    Zfp721
    zinc finger protein 7085
    zinc finger protein 721
    73.88(n)1
    63.61(a)1
      13 (34.54 cM)5
    2387221  NM_001081680.11  NP_001075149.11 
     670694005 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    29(a)
    1 → many
    GL343733.1(125230-159240)


    ENSEMBL Gene Tree for ZNF708 (if available)
    TreeFam Gene Tree for ZNF708 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF708 gene
    ZNF852  ZNF4862  ZNF1952  ZNF7272  ZNF922  ZNF1002  ZNF7322  ZNF6752  
    ZNF1382  ZNF5062  ZNF662  ZNF2732  ZNF6952  ZNF6262  ZNF6802  ZNF4792  
    ZNF2532  ZNF6822  ZNF4922  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF6792  
    ZNF2572  ZNF2672  ZNF2542  ZNF7372  ZNF982  ZNF7142  ZNF5192  ZNF7162  
    ZNF4302  ZNF7302  ZNF1172  ZNF4312  ZNF902  ZNF7262  ZNF7282  
    18/515 SIMAP similar genes for ZNF708 using alignment to 4 protein entries:     ZN708_HUMAN (see all proteins) (see all similar genes):
    MGC12518    ZNF738    ZNF273    ZNF818P    ZNF724P    DKFZp762K012
    ZFS-1    ZNF429    smap-7    ZNF208    DKFZp686M04222    ZNF492
    ZNF431    ZNF92    ZNF254    ZNF66    HZF30    ZNF100

    ZNF708 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/898 SNPs in ZNF708 are shown (see all 898)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882168531,2
    --21449383(+) CTCCAG/TCCTGG 1 -- us2k10--------
    rs1155755581,2
    C,F--21449470(+) TAACCA/GTAGGT 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs6172581,2
    C,A,H--21473476(-) GAGGGT/GCTCGA 1 -- ds50013Minor allele frequency- G:0.00NA WA 6
    rs1865586601,2
    --21473512(+) TCTACC/TAAAAA 1 -- ds50010--------
    rs6171861,2
    C,F--21473528(-) CAGCTT/AATTTT 1 -- ds50013Minor allele frequency- A:0.50NA 6
    rs5719371,2
    C,A,H--21473574(+) AGGACG/ACTGAG 1 -- ds50018Minor allele frequency- A:0.07NA WA CSA 15
    rs358070281,2
    C--21473675(+) AAAAA-/ATTAAA 1 -- ds50010--------
    rs110854411,2
    C,F,A,H--21473737(+) CCTACA/GGAAAC 1 -- ds500120Minor allele frequency- G:0.40NS EA NA WA CSA 1932
    rs1910227881,2
    --21473781(+) ACTGGC/TAAAGG 1 -- ds50010--------
    rs1826909531,2
    --21473901(+) CTTCAC/TTGAAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ZNF708 (21473962 - 21512227 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ZNF708:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2665276CNV Deletion23128226
    esv2718325CNV Deletion23290073
    esv2718327CNV Deletion23290073
    dgv3806n71CNV Loss21882294
    nsv911420CNV Loss21882294
    esv2751783CNV Loss17911159
    dgv3807n71CNV Loss21882294
    nsv458377CNV Gain19166990
    esv4924CNV Complex18987735

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for ZNF708:    About MalaCards
    alagille syndrome    thyroid adenoma    beckwith-wiedemann syndrome    adenoma
    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for ZNF708:
    Alagille syndrome

    ZNF708 for disorders           About GeneDecksing


    Export disorders for ZNF708 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF708 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF708)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Twenty-seven nonoverlapping zinc finger cDNAs from hu man T cells map to nine different chromosomes with apparent clustering. (PubMed id 2014798)1, 3 Huebner K....Thiesen H.J. (1991)
    3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. A universal strategy for proteomic studies of SUMO an d other ubiquitin-like modifiers. (PubMed id 15576338)1 Rosas-Acosta G....Wilson V.G. (2005)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    7. Chromosomal localization of two KOX zinc finger genes on chromosome bands 7q21-q22. (PubMed id 7486829)1 Rousseau-Merck M.F....Thiesen H.J. (1995)
    8. Conserved KRAB protein domain identified upstream fro m the zinc finger region of Kox 8. (PubMed id 1861988)1 Thiesen H.J....Martial J.A. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7562 HGNC: 12945 Ensembl:ENSG00000182141 euGenes: HUgn7562 ECgene: ZNF708
    H-InvDB: ZNF708

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF708 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF708 gene:
    Search GeneIP for patents involving ZNF708

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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