ZNF708 Gene
protein-coding GIFtS: 43
GCID: GC19M021473
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zinc finger protein 708(Previous names: zinc finger protein 15-like 1 (KOX 8), zinc finger protein...)
(Previous symbols: ZNF15, ZNF15L1)
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Aliases
for ZNF708 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 7081 2 | | Zinc Finger Protein 152 3 | | KOX81 2 3 | | Zinc Finger Protein KOX82 3 | | ZNF151 2 3 | | Zinc Finger Protein 708 (KOX8)1 | | ZNF15L11 2 3 | | Zinc Finger Protein 15-Like 13 | | Zinc Finger Protein 15-Like 1 (KOX 8)1 2 | | |
Export aliases for ZNF708 gene to outside databasesPrevious GC identifers: GC07U901540 GC19M021266 GC19M020964 |
Summaries
for ZNF708 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN708_HUMAN, P17019Function: May be involved in transcriptional regulation
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Genomic Views
for ZNF708 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF708 gene promoter:
GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF708
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF708 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p12 Ensembl cytogenetic band: 19p12 HGNC cytogenetic band: 19p12ZNF708 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M021473: view genomic region
(about GC identifiers)
Start:
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21,473,963 bp from pter |
End:
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21,512,212 bp from pter |
Size:
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38,250 bases |
Orientation:
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minus strand |
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Proteins
for ZNF708 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN708_HUMAN, P17019 (See
protein sequence)Recommended Name: Zinc finger protein 708 Size: 563 amino acids; 64779 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q6ZMR0Explore the universe of human proteins at neXtProt for ZNF708: NX_P17019
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P17019
ZNF708 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_067092.2
ENSEMBL proteins: ENSP00000349401 Reactome Protein details: P17019
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF708 for ontologies About GeneDecksing
ZNF708 Antibody Products:
Assay Products for ZNF708: |
Protein
Domains /
Families
for ZNF708 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF708 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P17019ProtoNet protein and cluster: P17019 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN708_HUMAN, P17019Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 15 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF708 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN708_HUMAN, P17019Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF708 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF708
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: ZNF708 (NM_021269) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF708 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF708 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF708 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF708 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF708
ZNF708 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF708
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF708 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF708 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF708
Search CenterWatch for drugs/clinical trials and news about ZNF708 / ZN708
|
Transcripts
for ZNF708 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF708 gene: NM_021269.2 Unigene Cluster for ZNF708: Zinc finger protein 708 Hs.466296 [show with all ESTs]Unigene Representative Sequence: AK1315271 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000356929(uc002npq.1 uc002npr.1 uc010ecs.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF708 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF708
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF708 (NM_021269) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF708 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF708 |
Additional cDNA sequence: AK128184.1 AK131527.1 AK311130.1 BC039403.1 BX647526.1 X52339.1 X59845.1 4 DOTS entries: DT.99961357 DT.95073830 DT.40122199 DT.92431200
GeneLoc Exon Structure
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Expression
for ZNF708 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF708 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF708 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF708
SOURCE GeneReport for Unigene cluster: Hs.466296
SABiosciences Custom PCR Arrays for ZNF708
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF708
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF708 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF708 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF708 |
Orthologs
for ZNF708 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF708 gene from 1/4 species (see all 4) About this table
ENSEMBL Gene Tree for ZNF708 (if available)
TreeFam Gene Tree for ZNF708 (if available) |
Paralogs
for ZNF708 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF708 gene
- ZNF852 ZNF4932 ZNF4862 ZNF1002 ZNF922 ZNF7322 ZNF1382 ZNF6752
- ZNF5062 ZNF2732 ZNF66P2 ZNF6952 ZNF6262 ZNF6802 ZNF2532 ZNF4792
- ZNF932 ZNF4922 ZNF6822 ZNF6762 ZNF1412 ZNF6812 ZNF6792 ZNF2572
- ZNF2542 ZNF7372 ZNF724P2 ZNF982 ZNF849P2 ZNF7162 ZNF7142 ZNF4292
- ZNF4302 ZNF7302 ZNF6782 ZNF1172 ZNF1072 ZNF4312 ZNF902
18/509 SIMAP similar genes for ZNF708 using alignment to 4 protein entries: ZN708_HUMAN (see all proteins)
(see all similar genes):MGC12518 ZFS-4 ZNF738 ZNF273 ZNF66 ZFS-6
ZNF818P ZNF85 ZNF506 ZNF724P ZNF78L1 ZNF254
DKFZp762K012 ZFS-1 ZNF429 ZNF737 smap-7 ZNF66P
ZNF708 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF708 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF708 (21473963 - 21512212 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF708
1 CNV: 9303 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF708 |
|
Disorders
/ Diseases
for ZNF708 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF708 for disorders About GeneDecksing
5  diseases for ZNF708: About MalaCardsbeckwith-wiedemann syndrome alagille syndrome thyroid adenoma adenoma
thyroiditis
1 disease from the University of Copenhagen DISEASES database for ZNF708:Alagille syndrome Export disorders for ZNF708 gene to outside databases
|
Publications
for ZNF708 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF708 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF708) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Twenty-seven nonoverlapping zinc finger cDNAs from hu man T cells map to nine different chromosomes with apparent clustering. (PubMed id 2014798)1, 3 Huebner K....Thiesen H.J. (1991)
- Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (1990)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- A universal strategy for proteomic studies of SUMO an d other ubiquitin-like modifiers. (PubMed id 15576338)1 Rosas-Acosta G....Wilson V.G. (2005)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Chromosomal localization of two KOX zinc finger genes on chromosome bands 7q21-q22. (PubMed id 7486829)1 Rousseau-Merck M.F....Thiesen H.J. (1995)
- Conserved KRAB protein domain identified upstream fro m the zinc finger region of Kox 8. (PubMed id 1861988)1 Thiesen H.J....Martial J.A. (1991)
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External Searches for ZNF708 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ZNF708 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF708 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF708 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF708 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ZNF708 gene:
Search GeneIP for patents involving ZNF708
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF708 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF708 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF708 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF708 | | | OriGene Protein Over-expression Lysate for ZNF708 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF708 | | OriGene 3'-UTR Clone for ZNF708 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF708 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF708 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF708 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF708 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF708 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF708 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF708 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF708 |
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 | | | ZNF708 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for ZNF708 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF708 |
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