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Aliases for ZNF708 Gene

Aliases for ZNF708 Gene

  • Zinc Finger Protein 708 2 3 5
  • Zinc Finger Protein 15-Like 1 (KOX 8) 2 3
  • ZNF15L1 3 4
  • ZNF15 3 4
  • KOX8 3 4
  • Zinc Finger Protein 708 (KOX8) 2
  • Zinc Finger Protein 15-Like 1 4
  • Zinc Finger Protein KOX8 4
  • Zinc Finger Protein 15 4

External Ids for ZNF708 Gene

Previous HGNC Symbols for ZNF708 Gene

  • ZNF15
  • ZNF15L1

Previous GeneCards Identifiers for ZNF708 Gene

  • GC07U901540
  • GC19M021266
  • GC19M021473
  • GC19M020964
  • GC19M021222

Summaries for ZNF708 Gene

GeneCards Summary for ZNF708 Gene

ZNF708 (Zinc Finger Protein 708) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF718.

UniProtKB/Swiss-Prot for ZNF708 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF708 Gene

Genomics for ZNF708 Gene

Regulatory Elements for ZNF708 Gene

Promoters for ZNF708 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF708 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF708 gene promoter:

Genomic Location for ZNF708 Gene

21,221,500 bp from pter
21,329,439 bp from pter
107,940 bases
Minus strand

Genomic View for ZNF708 Gene

Genes around ZNF708 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF708 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF708 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF708 Gene

Proteins for ZNF708 Gene

  • Protein details for ZNF708 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 708
    Protein Accession:
    Secondary Accessions:
    • Q6ZMR0

    Protein attributes for ZNF708 Gene

    499 amino acids
    Molecular mass:
    57357 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD18665.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZNF708 Gene

Proteomics data for ZNF708 Gene at MOPED

Post-translational modifications for ZNF708 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF708 Gene

No data available for DME Specific Peptides for ZNF708 Gene

Domains & Families for ZNF708 Gene

Gene Families for ZNF708 Gene

Protein Domains for ZNF708 Gene

Suggested Antigen Peptide Sequences for ZNF708 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF708: view

Function for ZNF708 Gene

Molecular function for ZNF708 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF708: view

Animal Model Products

CRISPR Products

miRNA for ZNF708 Gene

miRTarBase miRNAs that target ZNF708

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF708 Gene

Localization for ZNF708 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF708 Gene

Subcellular locations from

Jensen Localization Image for ZNF708 Gene COMPARTMENTS Subcellular localization image for ZNF708 gene
Compartment Confidence
nucleus 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZNF708 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with ZNF708: view

Pathways & Interactions for ZNF708 Gene

SuperPathways for ZNF708 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF708: view

Pathways by source for ZNF708 Gene

2 Reactome pathways for ZNF708 Gene

Interacting Proteins for ZNF708 Gene

Gene Ontology (GO) - Biological Process for ZNF708 Gene


No data available for SIGNOR curated interactions for ZNF708 Gene

Drugs & Compounds for ZNF708 Gene

No Compound Related Data Available

Transcripts for ZNF708 Gene

mRNA/cDNA for ZNF708 Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF708 Gene

Zinc finger protein 708:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF708 Gene

No ASD Table

Relevant External Links for ZNF708 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF708 Gene

mRNA expression in normal human tissues for ZNF708 Gene

Protein differential expression in normal tissues from HIPED for ZNF708 Gene

This gene is overexpressed in Placenta (62.2) and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF708 Gene

SOURCE GeneReport for Unigene cluster for ZNF708 Gene Hs.466296

genes like me logo Genes that share expression patterns with ZNF708: view

Protein tissue co-expression partners for ZNF708 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF708 Gene

Orthologs for ZNF708 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF708 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF708 35
  • 98.64 (n)
  • 98.58 (a)
ZNF708 36
  • 99 (a)
(Bos Taurus)
Mammalia -- 36
  • 57 (a)
(Canis familiaris)
Mammalia -- 36
  • 40 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
-- 36
  • 50 (a)
(Mus musculus)
Mammalia Zfp493 36
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
-- 36
  • 38 (a)
-- 36
  • 47 (a)
-- 36
  • 41 (a)
-- 36
  • 36 (a)
-- 36
  • 36 (a)
-- 36
  • 35 (a)
-- 36
  • 31 (a)
Species with no ortholog for ZNF708:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF708 Gene

Gene Tree for ZNF708 (if available)
Gene Tree for ZNF708 (if available)

Paralogs for ZNF708 Gene

(545) SIMAP similar genes for ZNF708 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF708: view

Variants for ZNF708 Gene

Sequence variations from dbSNP and Humsavar for ZNF708 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs547516 - 21,309,260(+) TGGCT(A/G)CCATC reference, missense
rs1781873 - 21,294,629(+) ACTTT(C/T)ACAGC reference, missense
rs1781872 - 21,294,601(+) CTCCT(G/T)TGTGC reference, missense
rs504280 - 21,294,577(+) CACAC(C/T)GGTTA reference, missense
rs598959 -- 21,292,618(-) AGAGG(A/G)TTGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF708 Gene

Variant ID Type Subtype PubMed ID
nsv458377 CNV Gain 19166990
esv2665276 CNV Deletion 23128226
esv4924 CNV Complex 18987735
esv2718325 CNV Deletion 23290073
dgv3806n71 CNV Loss 21882294
dgv3807n71 CNV Loss 21882294
nsv911420 CNV Loss 21882294
esv2718327 CNV Deletion 23290073
esv2751783 CNV Loss 17911159

Variation tolerance for ZNF708 Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.99; 60.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF708 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF708 Gene

Disorders for ZNF708 Gene

Relevant External Links for ZNF708

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF708 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF708 Gene

Publications for ZNF708 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (PMID: 2014798) Huebner K. … Thiesen H.J. (Am. J. Hum. Genet. 1991) 2 3
  3. Chromosomal localization of two KOX zinc finger genes on chromosome bands 7q21-q22. (PMID: 7486829) Rousseau-Merck M.F. … Thiesen H.J. (Ann. Genet. 1995) 3
  4. Conserved KRAB protein domain identified upstream from the zinc finger region of Kox 8. (PMID: 1861988) Thiesen H.J. … Martial J.A. (Nucleic Acids Res. 1991) 3
  5. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3

Products for ZNF708 Gene

Sources for ZNF708 Gene

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