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Aliases for ZNF708 Gene

Aliases for ZNF708 Gene

  • Zinc Finger Protein 708 2 3 5
  • Zinc Finger Protein 15-Like 1 (KOX 8) 2 3
  • ZNF15L1 3 4
  • ZNF15 3 4
  • KOX8 3 4
  • Zinc Finger Protein 708 (KOX8) 2
  • Zinc Finger Protein 15-Like 1 4
  • Zinc Finger Protein KOX8 4
  • Zinc Finger Protein 15 4

External Ids for ZNF708 Gene

Previous HGNC Symbols for ZNF708 Gene

  • ZNF15
  • ZNF15L1

Previous GeneCards Identifiers for ZNF708 Gene

  • GC07U901540
  • GC19M021266
  • GC19M021473
  • GC19M020964
  • GC19M021222
  • GC19M021346
  • GC19M021462

Summaries for ZNF708 Gene

GeneCards Summary for ZNF708 Gene

ZNF708 (Zinc Finger Protein 708) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF724.

UniProtKB/Swiss-Prot for ZNF708 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF708 Gene

Genomics for ZNF708 Gene

Regulatory Elements for ZNF708 Gene

Enhancers for ZNF708 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F021322 1.4 FANTOM5 Ensembl ENCODE 31.3 +6.8 6766 1.1 ATF1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A GLI4 DMAP1 ZNF2 ZNF48 ZNF708 LOC105372321 ZNF429 ZNF493 BNIP3P25 GC19P021323
GH19F021314 1.2 FANTOM5 Ensembl ENCODE 24.2 +14.5 14472 1.3 JUND CUX1 ZNF708 ZNF429 ENSG00000213976 ZNF493 ZNF100 ZNF430 BNIP3P25 GC19M021717
GH19F021328 0.9 ENCODE 24.1 +0.3 270 2.0 HDGF ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 ELK1 ZNF143 LOC105372321 ZNF708 ZNF100 RPL7AP10 ZNF66 BNIP3P26 ZNF431 LOC641367 ENSG00000213976 GC19P021323
GH19F021358 1.1 ENCODE 23.7 -29.8 -29755 1.7 CTCF TBP PKNOX1 SAP130 TAF1 WRNIP1 IRF3 SIN3A ZBTB40 RFX5 LOC105372321 ZNF708 ZNF738 LOC100422298
GH19F021461 0.8 ENCODE 21 -133.8 -133760 2.7 TBP PKNOX1 SMAD5 GTF2B ZBTB40 POLR2A PBX2 MLLT1 ZFX CREM ENSG00000268555 ZNF708 LOC105372321 BNIP3P26 GC19P021412
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF708 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF708 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000345027 539 1801 HDGF ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF263 ZNF202

Transcription factor binding sites by QIAGEN in the ZNF708 gene promoter:

Genomic Location for ZNF708 Gene

Chromosome:
19
Start:
21,291,160 bp from pter
End:
21,329,439 bp from pter
Size:
38,280 bases
Orientation:
Minus strand

Genomic View for ZNF708 Gene

Genes around ZNF708 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF708 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF708 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF708 Gene

Proteins for ZNF708 Gene

  • Protein details for ZNF708 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17019-ZN708_HUMAN
    Recommended name:
    Zinc finger protein 708
    Protein Accession:
    P17019
    Secondary Accessions:
    • Q6ZMR0

    Protein attributes for ZNF708 Gene

    Size:
    499 amino acids
    Molecular mass:
    57357 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18665.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ZNF708 Gene

Post-translational modifications for ZNF708 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF708 Gene

Domains & Families for ZNF708 Gene

Gene Families for ZNF708 Gene

Protein Domains for ZNF708 Gene

Suggested Antigen Peptide Sequences for ZNF708 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17019

UniProtKB/Swiss-Prot:

ZN708_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF708: view

Function for ZNF708 Gene

Molecular function for ZNF708 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF708 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF708: view
genes like me logo Genes that share phenotypes with ZNF708: view

Animal Model Products

miRNA for ZNF708 Gene

miRTarBase miRNAs that target ZNF708

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF708 Gene

Localization for ZNF708 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF708 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF708 Gene COMPARTMENTS Subcellular localization image for ZNF708 gene
Compartment Confidence
nucleus 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZNF708 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF708: view

Pathways & Interactions for ZNF708 Gene

SuperPathways for ZNF708 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF708: view

Pathways by source for ZNF708 Gene

2 Reactome pathways for ZNF708 Gene

Interacting Proteins for ZNF708 Gene

Gene Ontology (GO) - Biological Process for ZNF708 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF708: view

No data available for SIGNOR curated interactions for ZNF708 Gene

Transcripts for ZNF708 Gene

mRNA/cDNA for ZNF708 Gene

(7) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF708 Gene

Zinc finger protein 708:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF708 Gene

No ASD Table

Relevant External Links for ZNF708 Gene

GeneLoc Exon Structure for
ZNF708
ECgene alternative splicing isoforms for
ZNF708

Expression for ZNF708 Gene

mRNA expression in normal human tissues for ZNF708 Gene

Protein differential expression in normal tissues from HIPED for ZNF708 Gene

This gene is overexpressed in Placenta (62.2) and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF708 Gene



Protein tissue co-expression partners for ZNF708 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF708 Gene:

ZNF708

SOURCE GeneReport for Unigene cluster for ZNF708 Gene:

Hs.466296
genes like me logo Genes that share expression patterns with ZNF708: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF708 Gene

Orthologs for ZNF708 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF708 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF708 34 35
  • 98.64 (n)
mouse
(Mus musculus)
Mammalia Zfp493 35
  • 61 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 57 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 50 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 56 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
Species where no ortholog for ZNF708 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF708 Gene

ENSEMBL:
Gene Tree for ZNF708 (if available)
TreeFam:
Gene Tree for ZNF708 (if available)

Paralogs for ZNF708 Gene

(545) SIMAP similar genes for ZNF708 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ZNF708: view

Variants for ZNF708 Gene

Sequence variations from dbSNP and Humsavar for ZNF708 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10404076 -- 21,319,008(+) tacta(C/G)tcata intron-variant
rs10415892 -- 21,303,015(+) ggtca(A/C)agtgg intron-variant
rs10426878 -- 21,300,903(+) gatcc(A/C)cctgc intron-variant
rs10658051 -- 21,300,546(+) ACAAG(-/CAAA)CAAAC intron-variant
rs11085441 -- 21,290,935(+) CCTAC(A/G)GAAAC intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF708 Gene

Variant ID Type Subtype PubMed ID
esv2665276 CNV deletion 23128226
esv2718325 CNV deletion 23290073
esv2718327 CNV deletion 23290073
esv2751783 CNV loss 17911159
esv2762027 CNV loss 21179565
esv3643921 CNV loss 21293372
esv3893179 CNV loss 25118596
esv4924 OTHER complex 18987735
nsv1061327 CNV gain 25217958
nsv1116311 CNV deletion 24896259
nsv1140249 OTHER inversion 24896259
nsv1151573 OTHER inversion 26484159
nsv458377 CNV gain 19166990
nsv578809 CNV gain 21841781
nsv578950 CNV loss 21841781
nsv963023 CNV duplication 23825009

Variation tolerance for ZNF708 Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.99; 60.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF708 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF708

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF708 Gene

Disorders for ZNF708 Gene

Relevant External Links for ZNF708

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF708

No disorders were found for ZNF708 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF708 Gene

Publications for ZNF708 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (PMID: 2014798) Huebner K. … Thiesen H.J. (Am. J. Hum. Genet. 1991) 2 3 64
  3. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen H.-J. (New Biol. 1990) 3 4 64
  4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for ZNF708 Gene

Sources for ZNF708 Gene

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