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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF707 Gene

protein-coding   GIFtS: 48
GCID: GC08P144766

zinc finger protein 707

  Search for ZNF707
in our new
 Human Malady Compendium 
Biological research products
for ZNF707
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 7071 2

External Ids:    HGNC: 278151   Entrez Gene: 2860752   Ensembl: ENSG000001811357   UniProtKB: Q96C283   

Export aliases for ZNF707 gene to outside databases

Previous GC identifers: GC08P144825 GC08P144838 GC08P140019


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN707_HUMAN, Q96C28
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF707 gene promoter:
         AREB6   Ik-2   HTF   Pax-6   Sox9   ZID   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF707 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF707

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF707


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

ZNF707 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF707 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P144766:  view genomic region     (about GC identifiers)

Start:
144,766,622 bp from pter      End:
144,796,068 bp from pter
Size:
29,447 bases      Orientation:
plus strand

1 alternative location:
Chr8+,PATCHES 144,752,987-144,763,920     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN707_HUMAN, Q96C28 (See protein sequence)
Recommended Name: Zinc finger protein 707  
Size: 371 amino acids; 43088 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=AAH14894.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAF83121.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K317 B3KNY1 D3DWK7

Explore the universe of human proteins at neXtProt for ZNF707: NX_Q96C28

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96C28

  • ZNF707 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001094068.1  NP_001094069.1  NP_776192.2  

    ENSEMBL proteins: 
     ENSP00000434791   ENSP00000437134   ENSP00000434322   ENSP00000435251   ENSP00000434503  
     ENSP00000436362   ENSP00000435679   ENSP00000434215   ENSP00000393748   ENSP00000351482  
     ENSP00000436634   ENSP00000436250   ENSP00000436394   ENSP00000435906   ENSP00000436212  
     ENSP00000409029   ENSP00000413215  
    Reactome Protein details: Q96C28
    Human Recombinant Protein Products: 
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    Novus Biologicals ZNF707 Protein
    Novus Biologicals ZNF707 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF707

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--


    ZNF707 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZNF707


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF707 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96C28

    ProtoNet protein and cluster: Q96C28

    1 Blocks protein family: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN707_HUMAN, Q96C28
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 7 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN707_HUMAN, Q96C28
    Function: May be involved in transcriptional regulation

    miRNA
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    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF707

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF707

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    ZNF707 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF707
        Generic Transcription Pathway
    Gene Expression



    ZNF707 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF707

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF707 (Q96C282, 3 ENSP000003514824) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997502, 3, ENSP000002303214MINT-67200 I2D: score=4 STRING: ENSP00000230321
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    ZNF707 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF707
    Search CenterWatch for drugs/clinical trials and news about ZNF707 / ZN707 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF707 gene (3 alternative transcripts): 
    NM_001100598.1  NM_001100599.1  NM_173831.3  

    Unigene Cluster for ZNF707:

    Zinc finger protein 707
    Hs.521922  [show with all ESTs]
    Unigene Representative Sequence: AK055198
    18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000532003 ENST00000525185 ENST00000534303 ENST00000533031 ENST00000525619
    ENST00000528456 ENST00000529833 ENST00000530574 ENST00000531985 ENST00000527293
    ENST00000533254 ENST00000442058 ENST00000525538 ENST00000358656(uc010mfh.3)
    ENST00000532571 ENST00000534589 ENST00000531811 ENST00000532486(uc003yzh.4)


    miRNA
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    OriGene 3'-UTR Clone (see all 3): ZNF707
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    Inhib. RNA
    Products:
         
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    OriGene shRNA RFP: ZNF707
    OriGene siRNA: ZNF707
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF707
    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF707

    Additional cDNA sequence: 

    AK001126.1 AK055198.1 AK055263.1 AK095138.1 AK290432.1 AK300926.1 BC014894.1 

    14 DOTS entries:

    DT.100754170  DT.406663  DT.100754172  DT.97837966  DT.100754169  DT.100754171  DT.121489273  DT.121489277 
    DT.121489267  DT.121489290  DT.100699773  DT.121489282  DT.121489285  DT.91932967 

    24/31 AceView cDNA sequences (see all 31):

    R19069 AA741278 AK095138 BX355262 CB145342 BM796285 AI299135 BM553072 
    AK055263 AK055198 CA489396 BC014894 AU120593 BX349356 AK001126 CB132949 
    NM_173831 BG035016 BX106732 AU146619 BE502736 BM905287 BE885629 BG149371 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF707 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10a · 10b · 10c · 10d · 10e ^
    SP1:                          -     -           -                                               -           -     -     -     -     -           -     -     -   
    SP2:                          -     -     -     -           -     -                             -           -     -     -     -     -           -     -     -   
    SP3:                          -     -     -     -     -     -     -     -     -                 -                 -     -     -     -           -     -     -   
    SP4:                          -     -     -     -     -     -     -     -     -                 -           -     -     -     -     -           -     -     -   
    SP5:                          -     -     -     -     -     -     -                             -           -     -     -     -     -                           

    ExUns: 11a · 11b · 11c · 11d · 11e · 11f
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for ZNF707

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF707 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACCTGGAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF707 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF707

    SOURCE GeneReport for Unigene cluster: Hs.521922
        SABiosciences Custom PCR Arrays for ZNF707
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF707

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF707 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp7071 , 5 zinc finger protein 7071, 5 74.43(n)1
    68.66(a)1
      15 (35.17 cM)5
    690201  NM_001081065.11  NP_001074534.11 
     759691235 
    chicken
    (Gallus gallus)
    Aves --
    --
    (see all 9)
    --
    33(a)
    33(a)
    (see all 9)
    many ↔ many
    many ↔ many
    (see all 9)
    Un(44416808-44418962)
    Un(22692321-22695358)


    ENSEMBL Gene Tree for ZNF707 (if available)
    TreeFam Gene Tree for ZNF707 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF707 gene
    ZFP922  ZNF32  ZNF222  
    18/419 SIMAP similar genes for ZNF707 using alignment to 9 protein entries:     ZN707_HUMAN (see all proteins) (see all similar genes):
    ZNF283    ZNF721    ZNF619    ZNF655    ZNF761    ZNF554
    ZNF559    ZNF124    ZNF577    ZFP90    ZNF33B    ZNF471
    ZNF519    ZNF19    ZNF879    ZNF844    ZNF78L1    kr-znf3

    ZNF707 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/289 NCBI SNPs in ZNF707 are shown (see all 289    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs48750351,2
    C,F,A,H,--144764638(+) ACTGAA/TCTTTT 3 -- us2k1 trp314Minor allele frequency- T:0.12NS EA NA WA CSA 553
    rs1380792241,2
    --144764759(+) CCTGAC/TTCTAG 3 -- us2k10--------
    rs48750361,2
    C,F,A,H,--144764763(+) ACTCTG/AGCATA 3 -- us2k117Minor allele frequency- A:0.09NS NA WA CSA EA 1149
    rs713186171,2
    C--144764809(-) GTCTC-/AAAAAA 3 -- us2k12Minor allele frequency- A:0.00NA CSA 4
    rs1873061151,2
    --144764832(+) TGAGAC/TGGAGT 3 -- us2k10--------
    rs1436119701,2
    --144764849(+) CTGTCA/GCCCAG 3 -- us2k10--------
    rs1917075111,2
    --144764871(+) GTGGCA/GCGATC 3 -- us2k10--------
    rs1835872181,2
    --144764872(+) TGGCGC/TGATCT 3 -- us2k10--------
    rs1126983371,2
    C,--144764955(+) CAGGCG/ACCCGC 3 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1864304121,2
    --144764970(+) ATGCCC/TGGCTA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF707 (144766622 - 144796068 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZNF707: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF707
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF707

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF707 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF707)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Shifted Transversal Design smart-pooling for high cov erage interactome mapping. (PubMed id 19447967)1 Xin X....Thierry-Mieg N. (2009)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
    8. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    9. Human ORFeome version 1.1: a platform for reverse proteomics. (PubMed id 15489335)1 Rual J.F....Vidal M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 286075 HGNC: 27815 AceView: LOC286075 Ensembl:ENSG00000181135 euGenes: HUgn286075
    ECgene: ZNF707 H-InvDB: ZNF707

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF707 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF707 gene:
    Search GeneIP for patents involving ZNF707

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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