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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF706 Gene

protein-coding   GIFtS: 49
GCID: GC08M102190

Zinc Finger Protein 706

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 7061 2
PNAS-1062
PNAS-1132

External Ids:    HGNC: 249921   Entrez Gene: 511232   Ensembl: ENSG000001209637   UniProtKB: Q9Y5V03   

Export aliases for ZNF706 gene to outside databases

Previous GC identifers: GC08M102280 GC08M097407


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF706 Gene: 
ZNF706 (zinc finger protein 706) is a protein-coding gene. Diseases associated with ZNF706 include schizophrenia, and among its related super-pathways are Gene Expression. GO annotations related to this gene include zinc ion binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF706 gene promoter:
         FOXO3a   FOXO3   FOXJ2   ZID   Pax-4a   FOXO3b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF706 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF706

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF706


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.3   Ensembl cytogenetic band:  8q22.3   HGNC cytogenetic band: 8q22.3

ZNF706 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF706 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M102190:  view genomic region     (about GC identifiers)

Start:
102,190,106 bp from pter      End:
102,218,421 bp from pter
Size:
28,316 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN706_HUMAN, Q9Y5V0 (See protein sequence)
Recommended Name: Zinc finger protein 706  
Size: 76 amino acids; 8498 Da
Secondary accessions: A8K362

Explore the universe of human proteins at neXtProt for ZNF706: NX_Q9Y5V0

Explore proteomics data for ZNF706 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y5V0

  • ZNF706 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF706 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001035975.1  NP_001254637.1  NP_001254638.1  NP_057180.1  

    ENSEMBL proteins: 
     ENSP00000427761   ENSP00000431059   ENSP00000311768   ENSP00000429645   ENSP00000428227  
     ENSP00000427803   ENSP00000430823   ENSP00000428985   ENSP00000430165   ENSP00000428696  
     ENSP00000430845   ENSP00000429260   ENSP00000430090  
    Reactome Protein details: Q9Y5V0
    Human Recombinant Protein Products for ZNF706: 
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    Novus Biologicals ZNF706 Lysates
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    Cloud-Clone Corp. ELISAs for ZNF706 
    Cloud-Clone Corp. CLIAs for ZNF706


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR007513 Uncharacterised_SERF
     IPR015880 Znf_C2H2-like
     IPR026939 Zinc_finger_706

    Graphical View of Domain Structure for InterPro Entry Q9Y5V0

    ProtoNet protein and cluster: Q9Y5V0

    UniProtKB/Swiss-Prot: ZN706_HUMAN, Q9Y5V0
    Similarity: Contains 1 C2H2-type zinc finger


    ZNF706 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    ZNF706 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF706 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidZNF706 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF706 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF706
        Generic Transcription Pathway
    Gene Expression



    ZNF706 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF706

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for ZNF706 (Q9Y5V03 ENSP000003117684) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAC3P607633I2D: score=1 
    GLOD4ENSP000003013294STRING: ENSP00000301329
    TREHENSP000002640294STRING: ENSP00000264029
    SNRPGENSP000002723484STRING: ENSP00000272348
    WDR82ENSP000002964904STRING: ENSP00000296490
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF706 (ZN706)

    Search CenterWatch for drugs/clinical trials and news about ZNF706 / ZN706

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF706 gene (4 alternative transcripts): 
    NM_001042510.1  NM_001267708.1  NM_001267709.1  NM_016096.3  

    Unigene Cluster for ZNF706:

    Zinc finger protein 706
    Hs.374485  [show with all ESTs]
    Unigene Representative Sequence: NM_001267708
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520984 ENST00000518071 ENST00000311212(uc003yka.3 uc003ykb.3)
    ENST00000519744 ENST00000520498 ENST00000517844 ENST00000519103 ENST00000520347
    ENST00000519882 ENST00000521272 ENST00000518336 ENST00000523146 ENST00000519916
    ENST00000523922 ENST00000520454
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF706
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF706 (see all 57):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-548k hsa-miR-30d hsa-miR-223 hsa-miR-124 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidZNF706 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ZNF706
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF706
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF706
    Sirion Biotech Customized lentivirus for stable overexpression of ZNF706 
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    Primer
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    Additional mRNA sequence: 

    AF125099.1 AF275802.1 AF275809.1 AK129859.1 AK290477.1 BC015925.1 BC068524.1 

    19 DOTS entries:

    DT.91987058  DT.448346  DT.95177681  DT.100037906  DT.91646352  DT.91751429  DT.100795093  DT.95177683 
    DT.121485951  DT.91751423  DT.100037904  DT.100736092  DT.100795096  DT.40215756  DT.91696954  DT.91744107 
    DT.100795095  DT.91751425  DT.91848003 

    24/321 AceView cDNA sequences (see all 321):

    AI091132 AI635237 BI712441 AA305255 CB178336 AA970862 AA156665 AI279571 
    BQ437810 CD678663 BU737311 BC015925 BG034955 BI963040 AI286284 AI139325 
    N39264 BM689956 AK129859 AA055283 AI423797 BQ949752 CA431354 AA402938 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF706    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
    SP1:                              
    SP2:        -                     
    SP3:                              


    ECgene alternative splicing isoforms for ZNF706

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF706 expression in normal human tissues (normalized intensities)      ZNF706 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAAGACAAT
    ZNF706 Expression
    About this image


    ZNF706 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass

     -- (Gastrointestinal Tract)
             pharynx   

    See ZNF706 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF706

    SOURCE GeneReport for Unigene cluster: Hs.374485
        SABiosciences Custom PCR Arrays for ZNF706
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF706

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF706 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp7061 , 5 zinc finger protein 7061, 5 97.37(n)1
    100(a)1
      15 (14.59 cM)5
    680361  NM_026521.41  NP_080797.11 
     369970315 
    chicken
    (Gallus gallus)
    Aves ZNF7061 zinc finger protein 706 90.35(n)
    98.68(a)
      768824  NM_001097531.1  NP_001091000.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF7066
    Uncharacterized protein
    100(a)
    1 ↔ 1
    4(14440731-14445970)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.137062 Xenopus laevis transcribed sequence with moderate similarity more 81.27(n)    BJ615823.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.79092 Danio rerio clone RK123A2A07 HSPC038 protein (LOC51123) more 80.34(n)    AY398376.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG180816
    CG157156
    --
    65(a)
    65(a)
    many → 1
    many → 1
    3L(15826895-15828488)
    3L(15828855-15830582)
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_C01F6.91 Protein C01F6.9 64.81(n)
    70.83(a)
      177731  NM_069182.2  NP_501583.1 


    ENSEMBL Gene Tree for ZNF706 (if available)
    TreeFam Gene Tree for ZNF706 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/197 SNPs in ZNF706 are shown (see all 197)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114396361,2
    C--102211679(+) AAAAA-/ATCCAA 3 -- int10--------
    rs786911761,2
    C--102211711(+) AGTGA-/ATAACT 3 -- int10--------
    rs1913252121,2
    --102486471(+) CATGGA/GTTTTC 1 -- int10--------
    rs1837142681,2
    --102486495(+) TAATGC/TTGATA 1 -- int10--------
    rs1873073401,2
    --102486511(+) TATCTC/TATGCT 1 -- int10--------
    rs70181791,2
    C,F,A,H--102486516(+) TATGCT/CGCATC 1 -- int124Minor allele frequency- C:0.49NS EA NA WA CSA 2484
    rs1928990551,2
    --102486562(+) TAGTAC/TCTTTA 1 -- int10--------
    rs1853462971,2
    C--102486692(+) CTTTCA/CAACAA 1 -- int10--------
    rs1996280681,2
    C--102486737(+) ACAAG-/TTTTTT 1 -- int10--------
    rs1900478311,2
    --102486836(+) ACCAAA/CCTATA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF706 (102190106 - 102218421 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF706:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831410CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZNF706:    About MalaCards
    schizophrenia    

    1 disease from the University of Copenhagen DISEASES database for ZNF706:
    Laryngeal squamous cell carcinoma

    ZNF706 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF706

    Export disorders for ZNF706 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF706 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF706)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    2. Genome-wide pharmacogenomic study of neurocognition a s an indicator of antipsychotic treatment response in schizophrenia. (PubMed id 21107309)1, 4 McClay J.L....van den Oord E.J. (2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. The molecular and functional interaction between ICln and HSPC038 proteins modulates the regulation of cell volume. (PubMed id 21917931)1 Dossena S....Paulmichl M. (2011)
    9. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51123 HGNC: 24992 AceView: LOC51123 Ensembl:ENSG00000120963 euGenes: HUgn51123
    ECgene: ZNF706 H-InvDB: ZNF706

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF706 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF706 gene:
    Search GeneIP for patents involving ZNF706

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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