Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF706 Gene

Aliases for ZNF706 Gene

  • Zinc Finger Protein 706 2 3 5
  • PNAS-106 3
  • PNAS-113 3
  • HSPC038 3

External Ids for ZNF706 Gene

Previous GeneCards Identifiers for ZNF706 Gene

  • GC08M102280
  • GC08M097407
  • GC08M102190

Summaries for ZNF706 Gene

GeneCards Summary for ZNF706 Gene

ZNF706 (Zinc Finger Protein 706) is a Protein Coding gene. Among its related pathways are Gene Expression.

UniProtKB/Swiss-Prot for ZNF706 Gene

  • Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4.

Additional gene information for ZNF706 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF706 Gene

Genomics for ZNF706 Gene

GeneHancer (GH) Regulatory Elements for ZNF706 Gene

Promoters and enhancers for ZNF706 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I101202 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.8 810 5.2 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A ZNF706 GC08P101206 RNF19A LOC100419977 PABPC1 GC08M101180
GH08I101136 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 16.5 +67.6 67592 4 PKNOX1 CLOCK SIN3A ZBTB7B IRF4 POLR2B ZNF766 ZNF143 FOS ZNF263 ENSG00000253737 RN7SKP249 GC08P101138 ZNF706 RNF19A LOC100419977 YWHAZ PABPC1 LOC105375675
GH08I101148 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +56.0 56034 2.7 HDGF SMAD1 ATF1 ARNT TCF12 ZNF766 ARID2 ATF7 GTF2B NCOA1 LOC105375676 PABPC1 ZNF706 LOC100419977 ENSG00000261087
GH08I101157 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.2 +47.3 47311 3 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT NEUROD1 SIN3A ZBTB7B ZNF766 LOC100419977 ZNF706 YWHAZ PABPC1 LOC105375676 ENSG00000261087
GH08I101153 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.2 +50.8 50787 3.6 HDGF PKNOX1 ARNT ZNF766 E2F8 ZNF143 FOS SP3 NFYC REST RNF19A ZNF706 LOC100419977 LOC105375676 ENSG00000261087
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF706 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF706 gene promoter:

Genomic Locations for ZNF706 Gene

Genomic Locations for ZNF706 Gene
chr8:101,177,878-101,206,193
(GRCh38/hg38)
Size:
28,316 bases
Orientation:
Minus strand
chr8:102,190,106-102,218,421
(GRCh37/hg19)

Genomic View for ZNF706 Gene

Genes around ZNF706 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF706 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF706 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF706 Gene

Proteins for ZNF706 Gene

  • Protein details for ZNF706 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5V0-ZN706_HUMAN
    Recommended name:
    Zinc finger protein 706
    Protein Accession:
    Q9Y5V0
    Secondary Accessions:
    • A8K362

    Protein attributes for ZNF706 Gene

    Size:
    76 amino acids
    Molecular mass:
    8498 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF706 Gene

Post-translational modifications for ZNF706 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF706 Gene

Domains & Families for ZNF706 Gene

Gene Families for ZNF706 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF706 Gene

Suggested Antigen Peptide Sequences for ZNF706 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF706: view

No data available for UniProtKB/Swiss-Prot for ZNF706 Gene

Function for ZNF706 Gene

Molecular function for ZNF706 Gene

UniProtKB/Swiss-Prot Function:
Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4.

Phenotypes From GWAS Catalog for ZNF706 Gene

Gene Ontology (GO) - Molecular Function for ZNF706 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF706: view
genes like me logo Genes that share phenotypes with ZNF706: view

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF706 Gene

Localization for ZNF706 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF706 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF706 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF706 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with ZNF706: view

Pathways & Interactions for ZNF706 Gene

SuperPathways for ZNF706 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF706: view

Pathways by source for ZNF706 Gene

2 Reactome pathways for ZNF706 Gene

Gene Ontology (GO) - Biological Process for ZNF706 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0045892 negative regulation of transcription, DNA-templated ISS --
GO:1902455 negative regulation of stem cell population maintenance ISS --
genes like me logo Genes that share ontologies with ZNF706: view

No data available for SIGNOR curated interactions for ZNF706 Gene

Drugs & Compounds for ZNF706 Gene

No Compound Related Data Available

Transcripts for ZNF706 Gene

Unigene Clusters for ZNF706 Gene

Zinc finger protein 706:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF706 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2: -
SP3:

Relevant External Links for ZNF706 Gene

GeneLoc Exon Structure for
ZNF706
ECgene alternative splicing isoforms for
ZNF706

Expression for ZNF706 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF706 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF706 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.6), Blymphocyte (12.3), and Islet of Langerhans (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF706 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF706 Gene:

ZNF706

SOURCE GeneReport for Unigene cluster for ZNF706 Gene:

Hs.374485

Evidence on tissue expression from TISSUES for ZNF706 Gene

  • Nervous system(4.7)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with ZNF706: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF706 Gene

Orthologs for ZNF706 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF706 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF706 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia MGC133632 34
  • 100 (a)
OneToOne
ZNF706 33
  • 99.12 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF706 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF706 33 34
  • 97.37 (n)
mouse
(Mus musculus)
Mammalia Zfp706 33 16 34
  • 97.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF706 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF706 33 34
  • 90.35 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF706 34
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf706 33
  • 81.14 (n)
Str.186 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13706 33
zebrafish
(Danio rerio)
Actinopterygii znf706 33 34
  • 76.75 (n)
Dr.7909 33
fruit fly
(Drosophila melanogaster)
Insecta CG18081 33 34
  • 67.12 (n)
CG15715 34
  • 65 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005603 33
  • 64.86 (n)
worm
(Caenorhabditis elegans)
Secernentea C01F6.9 34
  • 70 (a)
OneToMany
K10B3.1 33 34
  • 64.04 (n)
Species where no ortholog for ZNF706 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF706 Gene

ENSEMBL:
Gene Tree for ZNF706 (if available)
TreeFam:
Gene Tree for ZNF706 (if available)

Paralogs for ZNF706 Gene

No data available for Paralogs for ZNF706 Gene

Variants for ZNF706 Gene

Sequence variations from dbSNP and Humsavar for ZNF706 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000151254 -- 101,197,130(-) A/G 3_prime_UTR_variant
rs1000661161 -- 101,206,165(-) C/T upstream_transcript_variant
rs1000941955 -- 101,201,811(-) A/G intron_variant
rs1001103202 -- 101,200,187(-) A/G intron_variant
rs1001488223 -- 101,203,022(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF706 Gene

Variant ID Type Subtype PubMed ID
nsv1077062 CNV deletion 25765185
nsv831410 CNV gain 17160897

Variation tolerance for ZNF706 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF706 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF706

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF706 Gene

Disorders for ZNF706 Gene

Additional Disease Information for ZNF706

No disorders were found for ZNF706 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF706 Gene

Publications for ZNF706 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  2. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay JL … van den Oord EJ (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF706 Gene

Sources for ZNF706 Gene

Content
Loading form....