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Aliases for ZNF706 Gene

Aliases for ZNF706 Gene

  • Zinc Finger Protein 706 2 3 5
  • PNAS-106 3
  • PNAS-113 3
  • HSPC038 3

External Ids for ZNF706 Gene

Previous GeneCards Identifiers for ZNF706 Gene

  • GC08M102280
  • GC08M097407
  • GC08M102190

Summaries for ZNF706 Gene

GeneCards Summary for ZNF706 Gene

ZNF706 (Zinc Finger Protein 706) is a Protein Coding gene. Among its related pathways are Gene Expression.

UniProtKB/Swiss-Prot for ZNF706 Gene

  • Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF706 Gene

Genomics for ZNF706 Gene

Regulatory Elements for ZNF706 Gene

Enhancers for ZNF706 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F101172 0.5 Ensembl 17 +33.5 33493 1.4 SMARCA4 POLR2A SPI1 ZNF706 ENSG00000261087 GC08M101180
GH08F101136 1.3 FANTOM5 Ensembl ENCODE 16.5 +67.6 67593 4.8 PKNOX1 SIN3A CBX5 ZNF143 FOS ZNF263 ZHX2 REST ZNF592 KAT8 ZNF706 LOC100419977 YWHAZ PABPC1 ENSG00000253737 RN7SKP249
GH08F101171 0.5 ENCODE 11.2 +35.1 35106 0.2 JUND ZNF706 ENSG00000261087 GC08M101180
GH08F101180 0.9 ENCODE 11.2 +25.1 25105 1.3 RFX1 JUN BHLHE40 SIN3A JUND ATF3 HMBOX1 FOSL2 FOS MAFK ZNF706 LOC100419977 GC08M101180 ENSG00000261087
GH08F101148 0.8 FANTOM5 Ensembl ENCODE 11.1 +56.0 56034 2.7 HDGF ATF1 ARNT CREB3L1 GATA2 GTF2B NCOA1 REST SREBF1 MEF2D PABPC1 ZNF706 LOC100419977 LOC105375676 ENSG00000261087
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF706 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF706 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001397844 893 4601 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF207

Genomic Location for ZNF706 Gene

Chromosome:
8
Start:
101,177,878 bp from pter
End:
101,206,193 bp from pter
Size:
28,316 bases
Orientation:
Minus strand

Genomic View for ZNF706 Gene

Genes around ZNF706 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF706 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF706 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF706 Gene

Proteins for ZNF706 Gene

  • Protein details for ZNF706 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5V0-ZN706_HUMAN
    Recommended name:
    Zinc finger protein 706
    Protein Accession:
    Q9Y5V0
    Secondary Accessions:
    • A8K362

    Protein attributes for ZNF706 Gene

    Size:
    76 amino acids
    Molecular mass:
    8498 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF706 Gene

Post-translational modifications for ZNF706 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF706 Gene

Domains & Families for ZNF706 Gene

Protein Domains for ZNF706 Gene

Suggested Antigen Peptide Sequences for ZNF706 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5V0

UniProtKB/Swiss-Prot:

ZN706_HUMAN :
  • Contains 1 C2H2-type zinc finger.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with ZNF706: view

No data available for Gene Families for ZNF706 Gene

Function for ZNF706 Gene

Molecular function for ZNF706 Gene

UniProtKB/Swiss-Prot Function:
Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4.

Gene Ontology (GO) - Molecular Function for ZNF706 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF706: view
genes like me logo Genes that share phenotypes with ZNF706: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF706 Gene

Localization for ZNF706 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF706 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF706 Gene COMPARTMENTS Subcellular localization image for ZNF706 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF706 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with ZNF706: view

Pathways & Interactions for ZNF706 Gene

SuperPathways for ZNF706 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF706: view

Pathways by source for ZNF706 Gene

2 Reactome pathways for ZNF706 Gene

Gene Ontology (GO) - Biological Process for ZNF706 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0045892 negative regulation of transcription, DNA-templated ISS --
GO:1902455 negative regulation of stem cell population maintenance ISS --
genes like me logo Genes that share ontologies with ZNF706: view

No data available for SIGNOR curated interactions for ZNF706 Gene

Transcripts for ZNF706 Gene

Unigene Clusters for ZNF706 Gene

Zinc finger protein 706:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF706 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2: -
SP3:

Relevant External Links for ZNF706 Gene

GeneLoc Exon Structure for
ZNF706
ECgene alternative splicing isoforms for
ZNF706

Expression for ZNF706 Gene

mRNA expression in normal human tissues for ZNF706 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF706 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.6), Blymphocyte (12.3), and Islet of Langerhans (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF706 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF706 Gene:

ZNF706

SOURCE GeneReport for Unigene cluster for ZNF706 Gene:

Hs.374485
genes like me logo Genes that share expression patterns with ZNF706: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF706 Gene

Orthologs for ZNF706 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF706 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF706 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia MGC133632 35
  • 100 (a)
OneToOne
ZNF706 34
  • 99.12 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF706 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF706 34 35
  • 97.37 (n)
mouse
(Mus musculus)
Mammalia Zfp706 34 16 35
  • 97.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF706 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF706 34 35
  • 90.35 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF706 35
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf706 34
  • 81.14 (n)
Str.186 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.13706 34
zebrafish
(Danio rerio)
Actinopterygii znf706 34 35
  • 76.75 (n)
Dr.7909 34
fruit fly
(Drosophila melanogaster)
Insecta CG18081 34 35
  • 67.12 (n)
CG15715 35
  • 65 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005603 34
  • 64.86 (n)
worm
(Caenorhabditis elegans)
Secernentea C01F6.9 35
  • 70 (a)
OneToMany
K10B3.1 34 35
  • 64.04 (n)
Species where no ortholog for ZNF706 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF706 Gene

ENSEMBL:
Gene Tree for ZNF706 (if available)
TreeFam:
Gene Tree for ZNF706 (if available)

Paralogs for ZNF706 Gene

No data available for Paralogs for ZNF706 Gene

Variants for ZNF706 Gene

Sequence variations from dbSNP and Humsavar for ZNF706 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10086418 -- 101,203,400(+) GATTT(A/G)TATCA intron-variant
rs10089286 -- 101,203,790(+) AGACT(A/T)AGCTT intron-variant
rs10104478 -- 101,203,895(+) ACCTA(C/T)TCCCA intron-variant
rs1108839 -- 101,203,851(+) TTTTT(A/T)AAAGT intron-variant
rs112026153 -- 101,202,580(+) GGCAA(A/G)GCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF706 Gene

Variant ID Type Subtype PubMed ID
nsv1077062 CNV deletion 25765185
nsv831410 CNV gain 17160897

Variation tolerance for ZNF706 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF706 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF706

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF706 Gene

Disorders for ZNF706 Gene

Relevant External Links for ZNF706

Genetic Association Database (GAD)
ZNF706
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF706

No disorders were found for ZNF706 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF706 Gene

Publications for ZNF706 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  2. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay J.L. … van den Oord E.J. (Neuropsychopharmacology 2011) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64

Products for ZNF706 Gene

Sources for ZNF706 Gene

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