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Aliases for ZNF706 Gene

Aliases for ZNF706 Gene

  • Zinc Finger Protein 706 2 3 5
  • PNAS-106 3
  • PNAS-113 3
  • HSPC038 3

External Ids for ZNF706 Gene

Previous GeneCards Identifiers for ZNF706 Gene

  • GC08M102280
  • GC08M097407
  • GC08M102190

Summaries for ZNF706 Gene

GeneCards Summary for ZNF706 Gene

ZNF706 (Zinc Finger Protein 706) is a Protein Coding gene. Among its related pathways are Gene Expression.

UniProtKB/Swiss-Prot for ZNF706 Gene

  • Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF706 Gene

Genomics for ZNF706 Gene

Regulatory Elements for ZNF706 Gene

Promoters for ZNF706 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF706 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF706 Gene

Chromosome:
8
Start:
101,177,878 bp from pter
End:
101,206,193 bp from pter
Size:
28,316 bases
Orientation:
Minus strand

Genomic View for ZNF706 Gene

Genes around ZNF706 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF706 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF706 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF706 Gene

Proteins for ZNF706 Gene

  • Protein details for ZNF706 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5V0-ZN706_HUMAN
    Recommended name:
    Zinc finger protein 706
    Protein Accession:
    Q9Y5V0
    Secondary Accessions:
    • A8K362

    Protein attributes for ZNF706 Gene

    Size:
    76 amino acids
    Molecular mass:
    8498 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF706 Gene

Proteomics data for ZNF706 Gene at MOPED

Post-translational modifications for ZNF706 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF706 Gene

Domains & Families for ZNF706 Gene

Protein Domains for ZNF706 Gene

Suggested Antigen Peptide Sequences for ZNF706 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y5V0

UniProtKB/Swiss-Prot:

ZN706_HUMAN :
  • Contains 1 C2H2-type zinc finger.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with ZNF706: view

No data available for Gene Families for ZNF706 Gene

Function for ZNF706 Gene

Molecular function for ZNF706 Gene

UniProtKB/Swiss-Prot Function:
Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4.

Phenotypes for ZNF706 Gene

genes like me logo Genes that share phenotypes with ZNF706: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF706 Gene

Localization for ZNF706 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF706 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF706 Gene COMPARTMENTS Subcellular localization image for ZNF706 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF706 Gene

Pathways & Interactions for ZNF706 Gene

SuperPathways for ZNF706 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF706: view

Pathways by source for ZNF706 Gene

2 Reactome pathways for ZNF706 Gene

Interacting Proteins for ZNF706 Gene

Gene Ontology (GO) - Biological Process for ZNF706 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated ISS --
genes like me logo Genes that share ontologies with ZNF706: view

No data available for SIGNOR curated interactions for ZNF706 Gene

Drugs & Compounds for ZNF706 Gene

No Compound Related Data Available

Transcripts for ZNF706 Gene

Unigene Clusters for ZNF706 Gene

Zinc finger protein 706:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF706 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1:
SP2: -
SP3:

Relevant External Links for ZNF706 Gene

GeneLoc Exon Structure for
ZNF706
ECgene alternative splicing isoforms for
ZNF706

Expression for ZNF706 Gene

mRNA expression in normal human tissues for ZNF706 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF706 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.6), Blymphocyte (12.3), and Islet of Langerhans (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF706 Gene



SOURCE GeneReport for Unigene cluster for ZNF706 Gene Hs.374485

genes like me logo Genes that share expression patterns with ZNF706: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF706 Gene

Orthologs for ZNF706 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF706 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF706 35
  • 99.12 (n)
  • 100 (a)
MGC133632 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF706 35
  • 97.37 (n)
  • 100 (a)
ZNF706 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp706 35
  • 97.37 (n)
  • 100 (a)
Zfp706 16
Zfp706 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF706 35
  • 100 (n)
  • 100 (a)
ZNF706 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF706 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF706 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF706 35
  • 90.35 (n)
  • 98.68 (a)
ZNF706 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF706 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.186 35
znf706 35
  • 81.14 (n)
  • 86.84 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13706 35
zebrafish
(Danio rerio)
Actinopterygii Dr.7909 35
znf706 35
  • 76.75 (n)
  • 81.58 (a)
znf706 36
  • 82 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005603 35
  • 64.86 (n)
  • 67.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG18081 35
  • 67.12 (n)
  • 67.57 (a)
CG15715 36
  • 65 (a)
OneToMany
CG18081 36
  • 65 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K10B3.1 35
  • 64.04 (n)
  • 67.11 (a)
C01F6.9 36
  • 70 (a)
OneToMany
K10B3.1 36
  • 67 (a)
OneToMany
Species with no ortholog for ZNF706:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZNF706 Gene

ENSEMBL:
Gene Tree for ZNF706 (if available)
TreeFam:
Gene Tree for ZNF706 (if available)

Paralogs for ZNF706 Gene

No data available for Paralogs for ZNF706 Gene

Variants for ZNF706 Gene

Sequence variations from dbSNP and Humsavar for ZNF706 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1108839 -- 101,203,851(+) TTTTT(A/T)AAAGT intron-variant
rs1447013 -- 101,207,788(-) TGAGG(A/G)TAAGT upstream-variant-2KB
rs1447014 -- 101,206,942(-) AATTA(A/G)AAACG upstream-variant-2KB
rs2514614 -- 101,197,129(+) GGATG(A/T)ATATC utr-variant-3-prime
rs2212702 -- 101,201,557(-) TTTGG(C/T)TTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF706 Gene

Variant ID Type Subtype PubMed ID
nsv831410 CNV Gain 17160897

Variation tolerance for ZNF706 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF706 Gene

HapMap Linkage Disequilibrium report
ZNF706

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF706 Gene

Disorders for ZNF706 Gene

Relevant External Links for ZNF706

Genetic Association Database (GAD)
ZNF706
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF706

No disorders were found for ZNF706 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF706 Gene

Publications for ZNF706 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 67
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  3. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay J.L. … van den Oord E.J. (Neuropsychopharmacology 2011) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. The molecular and functional interaction between ICln and HSPC038 proteins modulates the regulation of cell volume. (PMID: 21917931) Dossena S. … Paulmichl M. (J. Biol. Chem. 2011) 3

Products for ZNF706 Gene

Sources for ZNF706 Gene

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