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ZNF706 Gene

protein-coding   GIFtS: 50
GCID: GC08M102190

Zinc Finger Protein 706

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7061 2
PNAS-1062
PNAS-1132

External Ids:    HGNC: 249921   Entrez Gene: 511232   Ensembl: ENSG000001209637   UniProtKB: Q9Y5V03   

Export aliases for ZNF706 gene to outside databases

Previous GC identifers: GC08M102280 GC08M097407


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF706 Gene:
ZNF706 (zinc finger protein 706) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF706 gene promoter:
         FOXO3a   FOXO3   FOXJ2   ZID   Pax-4a   FOXO3b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF706 promoter sequence
   Search Chromatin IP Primers for ZNF706

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF706


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.3   Ensembl cytogenetic band:  8q22.3   HGNC cytogenetic band: 8q22.3

ZNF706 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF706 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M102190:  view genomic region     (about GC identifiers)

Start:
102,190,106 bp from pter      End:
102,218,421 bp from pter
Size:
28,316 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN706_HUMAN, Q9Y5V0 (See protein sequence)
Recommended Name: Zinc finger protein 706  
Size: 76 amino acids; 8498 Da
Secondary accessions: A8K362

Explore the universe of human proteins at neXtProt for ZNF706: NX_Q9Y5V0

Explore proteomics data for ZNF706 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF706 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001035975.1  NP_001254637.1  NP_001254638.1  NP_057180.1  

    ENSEMBL proteins: 
     ENSP00000427761   ENSP00000431059   ENSP00000311768   ENSP00000429645   ENSP00000428227  
     ENSP00000427803   ENSP00000430823   ENSP00000428985   ENSP00000430165   ENSP00000428696  
     ENSP00000430845   ENSP00000429260   ENSP00000430090  
    Reactome Protein details: Q9Y5V0

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    antibodies-online peptides for ZNF706

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    antibodies-online antibodies for ZNF706 (7 products) 

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    antibodies-online kits for ZNF706 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR026939 At2g23090_like
     IPR007513 Uncharacterised_SERF
     IPR015880 Znf_C2H2-like

    Graphical View of Domain Structure for InterPro Entry Q9Y5V0

    ProtoNet protein and cluster: Q9Y5V0

    UniProtKB/Swiss-Prot: ZN706_HUMAN, Q9Y5V0
    Similarity: Contains 1 C2H2-type zinc finger


    Find genes that share domains with ZNF706           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF706           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF706

    miRNA
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    miRTarBase miRNAs that target ZNF706:
    hsa-mir-20a-5p (MIRT050614), hsa-mir-106b-5p (MIRT044353), hsa-mir-93-5p (MIRT048877)

    Block miRNA regulation of human, mouse, rat ZNF706 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF706 (see all 57):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-548k hsa-miR-30d hsa-miR-223 hsa-miR-124 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidZNF706 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF706

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF706 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF706           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF706
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF706
    Interactions:

        Search GeneGlobe Interaction Network for ZNF706

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for ZNF706 (Q9Y5V03 ENSP000003117684) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAC3P607633I2D: score=1 
    SNRPGENSP000002723484STRING: ENSP00000272348
    C4orf27ENSP000004065984STRING: ENSP00000406598
    WDR82ENSP000002964904STRING: ENSP00000296490
    GLOD4ENSP000003013294STRING: ENSP00000301329
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF706 (ZN706)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF706 gene (4 alternative transcripts): 
    NM_001042510.1  NM_001267708.1  NM_001267709.1  NM_016096.3  

    Unigene Cluster for ZNF706:

    Zinc finger protein 706
    Hs.374485  [show with all ESTs]
    Unigene Representative Sequence: NM_001267708
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000520984 ENST00000518071 ENST00000311212(uc003yka.3 uc003ykb.3)
    ENST00000519744 ENST00000520498 ENST00000517844 ENST00000519103 ENST00000520347
    ENST00000519882 ENST00000521272 ENST00000518336 ENST00000523146 ENST00000519916
    ENST00000523922 ENST00000520454
    miRNA
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    Block miRNA regulation of human, mouse, rat ZNF706 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ZNF706 (see all 57):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-548k hsa-miR-30d hsa-miR-223 hsa-miR-124 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidZNF706 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ZNF706
    Predesigned siRNA for gene silencing in human, mouse, rat ZNF706
    Clone
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    OriGene clones in human, mouse for ZNF706 (see all 17)
    OriGene ORF clones in mouse, rat for ZNF706
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    GenScript: all cDNA clones in your preferred vector (see all 3): ZNF706 (NM_016096)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF706
    Primer
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    OriGene qPCR primer pairs and template standards for ZNF706
    OriGene qSTAR qPCR primer pairs in human, mouse for ZNF706
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF706
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF706
      QuantiFast Probe-based Assays in human, mouse, rat ZNF706

    Additional mRNA sequence: 

    AF125099.1 AF275802.1 AF275809.1 AK129859.1 AK290477.1 BC015925.1 BC068524.1 

    19 DOTS entries:

    DT.91987058  DT.448346  DT.95177681  DT.100037906  DT.91646352  DT.91751429  DT.100795093  DT.95177683 
    DT.121485951  DT.91751423  DT.100037904  DT.100736092  DT.100795096  DT.40215756  DT.91696954  DT.91744107 
    DT.100795095  DT.91751425  DT.91848003 

    Selected AceView cDNA sequences (see all 321):

    AI091132 BQ437810 BU902897 CD678663 AA719806 CB178336 AA970862 AI279571 
    BI712441 BC015925 AI286284 AA305255 BI963040 BU737311 AI139325 AI635237 
    AI274254 BG058731 BM689956 AA459765 BG034955 N39264 AI095636 AA736608 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF706    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
    SP1:                              
    SP2:        -                     
    SP3:                              


    ECgene alternative splicing isoforms for ZNF706

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF706 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAAGACAAT
    ZNF706 Expression
    About this image


    ZNF706 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
    ZNF706 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF706 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.374485
        Custom PCR Arrays for ZNF706
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF706

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF706 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp7061 , 5 zinc finger protein 7061, 5 97.37(n)1
    100(a)1
      15 (14.59 cM)5
    680361  NM_026521.41  NP_080797.11 
     369970315 
    chicken
    (Gallus gallus)
    Aves ZNF7061 zinc finger protein 706 90.35(n)
    98.68(a)
      768824  NM_001097531.1  NP_001091000.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF7066
    zinc finger protein 706
    100(a)
    1 ↔ 1
    4(14440731-14445970)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.137062 Xenopus laevis transcribed sequence with moderate similarity more 81.27(n)    BJ615823.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.79092 Danio rerio clone RK123A2A07 HSPC038 protein (LOC51123) more 80.34(n)    AY398376.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG180811 CG18081 67.12(n)
    67.57(a)
      39725  NM_001259848.1  NP_001246777.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K10B3.11 K10B3.1 64.04(n)
    67.11(a)
      187247  NM_001029612.2  NP_001024783.1 


    ENSEMBL Gene Tree for ZNF706 (if available)
    TreeFam Gene Tree for ZNF706 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF706 (see all 197)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114396361,2
    C--102211679(+) AAAAA-/ATCCAA 3 -- int10--------
    rs786911761,2
    C--102211711(+) AGTGA-/ATAACT 3 -- int10--------
    rs1913252121,2
    --102486471(+) CATGGA/GTTTTC 1 -- int10--------
    rs1837142681,2
    --102486495(+) TAATGC/TTGATA 1 -- int10--------
    rs1873073401,2
    --102486511(+) TATCTC/TATGCT 1 -- int10--------
    rs70181791,2
    C,F,A,H--102486516(+) TATGCT/CGCATC 1 -- int124Minor allele frequency- C:0.49NS EA NA WA CSA 2484
    rs1928990551,2
    --102486562(+) TAGTAC/TCTTTA 1 -- int10--------
    rs1853462971,2
    C--102486692(+) CTTTCA/CAACAA 1 -- int10--------
    rs1996280681,2
    C--102486737(+) ACAAG-/TTTTTT 1 -- int10--------
    rs1900478311,2
    --102486836(+) ACCAAA/CCTATA 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF706 (102190106 - 102218421 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF706:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831410CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF706
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF706

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for ZNF706:
    Laryngeal squamous cell carcinoma

    Find genes that share disorders with ZNF706           About GenesLikeMe

    Genetic Association Database (GAD): ZNF706

    Export disorders for ZNF706 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF706 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ZNF706)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    2. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PubMed id 21107309)1, 4 McClay J.L....van den Oord E.J. (Neuropsychopharmacology 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. The molecular and functional interaction between ICln and HSPC038 proteins modulates the regulation of cell volume. (PubMed id 21917931)1 Dossena S....Paulmichl M. (J. Biol. Chem. 2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51123 HGNC: 24992 AceView: LOC51123 Ensembl:ENSG00000120963 euGenes: HUgn51123
    ECgene: ZNF706 H-InvDB: ZNF706

    (According to HUGE)
    About This Section

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF706 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF706 gene:
    Search GeneIP for patents involving ZNF706

    GeneCards and IP:
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