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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF705D Gene

protein-coding   GIFtS: 34
GCID: GC08P011946

Zinc Finger Protein 705D

  Search for ZNF705D
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 705D1 2
ZNF705C2
Putative Zinc Finger Protein 705C2
Zinc Finger Protein 705C2

External Ids:    HGNC: 332021   Entrez Gene: 7289572   Ensembl: ENSG000002153437   UniProtKB: P0CH993   

Export aliases for ZNF705D gene to outside databases

Previous GC identifers: GC08U900805 GC08P011985


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF705D Gene: 
ZNF705D (zinc finger protein 705D) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF705A.

UniProtKB/Swiss-Prot: Z705D_HUMAN, P0CH99
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_077531.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF705D gene promoter:
         Tal-1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Tal-1beta   POU3F2   E47   ITF-2   Pax-4a   
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF705D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

ZNF705D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF705D gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P011946:  view genomic region     (about GC identifiers)

Start:
11,946,847 bp from pter      End:
11,973,025 bp from pter
Size:
26,179 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: Z705D_HUMAN, P0CH99 (See protein sequence)
Recommended Name: Zinc finger protein 705D  
Size: 300 amino acids; 34712 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: A8K971 A8MY01 Q2TAN0

Explore the universe of human proteins at neXtProt for ZNF705D: NX_P0CH99

Explore proteomics data for ZNF705D at MOPED 

ZNF705D Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ZNF705D Protein Expression

REFSEQ proteins: NP_001034704.2  
ENSEMBL proteins: 
 ENSP00000382957  
Reactome Protein details: P0CH99
Human Recombinant Protein Products for ZNF705D: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus IEA--

ZNF705D for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:
 IPR015880 Znf_C2H2-like
 IPR001909 Krueppel-associated_box
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry P0CH99

ProtoNet protein and cluster: P0CH99

UniProtKB/Swiss-Prot: Z705D_HUMAN, P0CH99
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 4 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


ZNF705D for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: Z705D_HUMAN, P0CH99
Function: May be involved in transcriptional regulation (By similarity)

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0008270zinc ion binding ----
GO:0046872metal ion binding IEA--
     
ZNF705D for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ZNF705D About                                                                                                See pathways by source

SuperPathContained pathways About
1Generic Transcription Pathway
Generic Transcription Pathway0.47
Gene Expression0.47

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2        Reactome Pathways for ZNF705D
    Generic Transcription Pathway
Gene Expression



ZNF705D for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF705D

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-dependent IEA--
GO:0006355regulation of transcription, DNA-dependent IEA--

ZNF705D for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF705D (Z705D)

Search CenterWatch for drugs/clinical trials and news about ZNF705D / Z705D

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF705D gene: 
NM_001039615.3  

Unigene Cluster for ZNF705D:

Zinc finger protein 705D
Hs.652228
Unigene Representative Sequence: BC110823
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000400085(uc003wva.3)
miRNA
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Additional mRNA sequence: BC110823.1 

1 DOTS entry:

DT.70103494 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF705D expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTGGCAGATC
ZNF705D Expression
About this image


See ZNF705D Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.652228
    SABiosciences Custom PCR Arrays for ZNF705D
Primer
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of mammals.

Orthologs for ZNF705D gene from 1/3 species (see all 3)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia --
--
(see all 3)
--
61(a)
56(a)
(see all 3)
possible ortholog
1 ↔ many
(see all 3)
16(54008655-54028773)
16(53978452-53983839)


ENSEMBL Gene Tree for ZNF705D (if available)
TreeFam Gene Tree for ZNF705D (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ZNF705D gene
ZNF705B1 2  ZNF705A2  ZNF705G2  LOC7284292  ZNF5962  
18/335 SIMAP similar genes for ZNF705D using alignment to 1 protein entry:     Z705D_HUMAN(see all similar genes):
ZNF705B    ZNF705F    ZNF705A    ZNF705G    ZNF705E    ZNF248
MGC12518    ZNF78L1    kr-znf3    ZNF81    ZFS-4    ZNF738
ZNF    ZNF818P    ZNF331    DKFZp434J0650    ZNF224    ZNF55

ZNF705D for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/75 SNPs in ZNF705D are shown (see all 75)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1446517841,2
--11947331(+) TGCCTC/GTGCTG 1 -- int10--------
rs1862900261,2
C--11947361(+) GAAGTG/TGGGGA 1 -- int10--------
rs1906731871,2
--11947380(+) TTCCAG/TGCACG 1 -- int10--------
rs1815126591,2
C--11947395(+) AAGGCG/TGGTCT 1 -- int10--------
rs1480487501,2
--11947399(+) CGGGTC/GTCACT 1 -- int10--------
rs1501607011,2
C--11947577(+) TGGCCA/GGGAGG 1 -- int10--------
rs558810901,2
C,F--11947673(+) CCCCCT/CGATGG 1 -- int12Minor allele frequency- C:0.35WA NA 238
rs1418457821,2
C--11948159(+) AGAAGC/TGTCTG 1 -- int10--------
rs1866898401,2
--11948169(+) GATCAA/TGTTTT 1 -- int10--------
rs1911208591,2
C--11948190(+) TAAAGG/TTTTTT 1 -- int10--------

HapMap Linkage Disequilibrium report for ZNF705D (11946847 - 11973025 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/17 variations for ZNF705D (see all 17):    About this table     
Variant IDTypeSubtypePubMed ID
esv2660145CNV Deletion23128226
esv2736614CNV Deletion23290073
dgv1270e199CNV Deletion23128226
nsv471461CNV Duplication19718026
dgv27n31CNV Duplication19718026
nsv890373CNV Loss21882294
nsv890372CNV Gain21882294
nsv428195CNV Gain18775914
nsv890374CNV Gain21882294
dgv244e55CNV Gain17911159

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ZNF705D gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF705D)
    Utopia: connect your pdf to the dynamic
world of online information

  1. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 728957 HGNC: 33202 Ensembl:ENSG00000215343 euGenes: HUgn728957 ECgene: ZNF705D
H-InvDB: ZNF705D

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ZNF705D Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ZNF705D gene:
Search GeneIP for patents involving ZNF705D

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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