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ZNF705A Gene

protein-coding   GIFtS: 37
GCID: GC12P008290

Zinc Finger Protein 705A

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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 705A1 2

External Ids:    HGNC: 322811   Entrez Gene: 4400772   Ensembl: ENSG000001969467   UniProtKB: Q6ZN793   

Export aliases for ZNF705A gene to outside databases

Previous GC identifers: GC12P008217 GC12P008140 GC12P008218 GC12P008276 GC12P008137


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF705A Gene:
ZNF705A (zinc finger protein 705A) is a protein-coding gene. An important paralog of this gene is ENSG00000219492.

UniProtKB/Swiss-Prot: Z705A_HUMAN, Q6ZN79
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF705A gene promoter:
         AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF705A promoter sequence
   Search Chromatin IP Primers for ZNF705A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF705A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

ZNF705A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF705A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P008290:  view genomic region     (about GC identifiers)

Start:
8,290,733 bp from pter      End:
8,341,133 bp from pter
Size:
50,401 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: Z705A_HUMAN, Q6ZN79 (See protein sequence)
Recommended Name: Zinc finger protein 705A  
Size: 300 amino acids; 34734 Da

Explore the universe of human proteins at neXtProt for ZNF705A: NX_Q6ZN79

Explore proteomics data for ZNF705A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF705A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004328.1  
    ENSEMBL proteins: 
     ENSP00000384896   ENSP00000379816   ENSP00000352233   ENSP00000475525  
    Reactome Protein details: Q6ZN79

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6ZN79

    ProtoNet protein and cluster: Q6ZN79

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: Z705A_HUMAN, Q6ZN79
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF705A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: Z705A_HUMAN, Q6ZN79
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF705A for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    Z705A_HUMAN, Q6ZN79: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF705A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF705A About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF705A
        Generic Transcription Pathway



    ZNF705A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF705A
    Interactions:

        Search GeneGlobe Interaction Network for ZNF705A

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF705A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF705A (Z705A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF705A gene: 
    NM_001004328.2  

    Unigene Cluster for ZNF705A:

    Zinc finger protein 705A
    Hs.438536  [show with all ESTs]
    Unigene Representative Sequence: NM_001004328
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000402465 ENST00000396570 ENST00000359286(uc001qud.1) ENST00000398526

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    3 DOTS entries:

    DT.102842415  DT.121173719  DT.121173752 

    3 AceView cDNA sequences:

    NM_001004328 AK131339 BG203970 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF705A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF705A Expression
    About this image

    ZNF705A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF705A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.438536
        Custom PCR Arrays for ZNF705A
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF705A gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Clec4a11 C-type lectin domain family 4, member a1   --   269799  NM_199311.2  NP_955015.1 


    ENSEMBL Gene Tree for ZNF705A (if available)
    TreeFam Gene Tree for ZNF705A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF705A gene
    ENSG000002194922  ZNF705G2  ZNF705D2  ZNF705B2  ZNF5962  
    Selected SIMAP similar genes for ZNF705A using alignment to 4 protein entries:     Z705A_HUMAN (see all proteins) (see all similar genes):
    ZNF705G    ZNF705D    ZNF705B    ZNF705F    ZNF705E    ZNF20
    ZNF317    ZNF81    FIK    ZNF225    ZNF230    ZNF554
    ZNF776    ZFP90    ZNF350    ZNF677    ZNF761    ZNF224

    ZNF705A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ZNF705A
    PGOHUM00000258570 PGOHUM00000246011


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF705A (see all 141)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1890429841,2
    --8323211(+) ATATTC/TGAGGA 1 -- us2k10--------
    rs1399206271,2
    --8323241(+) TATTAA/GGGGTT 1 -- us2k10--------
    rs1821895231,2
    --8323685(+) GTTGAA/TCATTT 1 -- us2k10--------
    rs1861687221,2
    --8323771(+) GCACAA/GTGTCA 1 -- us2k10--------
    rs108409181,2
    C,F,A,H--8323921(+) ATACAC/TGCATG 1 -- us2k13Minor allele frequency- T:0.38NA 8
    rs1914597741,2
    --8323932(+) TTTCCC/TCCTGT 1 -- us2k10--------
    rs1132437571,2
    F--8324149(+) CCACCG/CCTACG 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1479184011,2
    --8324248(+) TGATGC/TAGGAG 1 -- us2k10--------
    rs352177011,2
    C--8324341(+) ACAGA-/TTTTTT 1 -- us2k11Minor allele frequency- T:0.00CSA 2
    rs1807387501,2
    --8324420(+) CTCTGC/TCTCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF705A (8290733 - 8341133 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF705A (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471365CNV Duplication19718026
    nsv826226CNV Gain20364138
    nsv428270CNV Gain18775914
    esv29886CNV Gain+Loss19812545
    nsv8899CNV Gain+Loss18304495
    dgv461e1CNV Complex17122850
    dgv455e1CNV Complex17122850
    dgv460e1CNV Complex17122850
    dgv459e1CNV Complex17122850
    dgv463e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF705A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF705A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 440077 HGNC: 32281 AceView: FLJ16353 Ensembl:ENSG00000196946 euGenes: HUgn440077
    ECgene: ZNF705A H-InvDB: ZNF705A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF705A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF705A gene:
    Search GeneIP for patents involving ZNF705A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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