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ZNF704 Gene

protein-coding   GIFtS: 45
GCID: GC08M081550

Zinc Finger Protein 704

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 7041 2
Gig12

External Ids:    HGNC: 322911   Entrez Gene: 6192792   Ensembl: ENSG000001646847   UniProtKB: Q6ZNC43   

Export aliases for ZNF704 gene to outside databases

Previous GC identifers: GC08U900620 GC08M081714 GC08M077030


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF704 Gene:
ZNF704 (zinc finger protein 704) is a protein-coding gene. An important paralog of this gene is SLC2A4RG.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008183.20  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF704 gene promoter:
         MEF-2A   FAC1   E2F   E2F-1   p53   MEF-2   c-Myb   MyoD   aMEF-2   AP-2gamma   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF704 promoter sequence
   Search Chromatin IP Primers for ZNF704

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF704


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.13   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21.13

ZNF704 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF704 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M081550:  view genomic region     (about GC identifiers)

Start:
81,540,686 bp from pter      End:
81,787,016 bp from pter
Size:
246,331 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN704_HUMAN, Q6ZNC4 (See protein sequence)
Recommended Name: Zinc finger protein 704  
Size: 412 amino acids; 45276 Da
Secondary accessions: B2RNE6 B9EGW6

Explore the universe of human proteins at neXtProt for ZNF704: NX_Q6ZNC4

Explore proteomics data for ZNF704 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF704 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001028895.1  
    ENSEMBL proteins: 
     ENSP00000331462   ENSP00000427715  
    Reactome Protein details: Q6ZNC4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6ZNC4

    ProtoNet protein and cluster: Q6ZNC4

    UniProtKB/Swiss-Prot: ZN704_HUMAN, Q6ZNC4
    Similarity: Contains 1 C2H2-type zinc finger


    Find genes that share domains with ZNF704           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF704           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Zfp704):
     homeostasis/metabolism  normal 

    Find genes that share phenotypes with ZNF704           About GenesLikeMe

    Animal Models:
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF704 (see all 213):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-361-5p hsa-miR-1914* hsa-miR-106a hsa-miR-128 hsa-miR-519a hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidZNF704 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF704 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF704           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF704
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF704
    Interactions:

        Search GeneGlobe Interaction Network for ZNF704

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF704 (ENSP000003314624) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZWINTENSP000003630554STRING: ENSP00000363055
    MYCENSP000003672074STRING: ENSP00000367207
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF704 (ZN704)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF704 gene (2 alternative transcripts): 
    NM_032651.1  NM_001033723.2  

    Unigene Cluster for ZNF704:

    Zinc finger protein 704
    Hs.434957  [show with all ESTs]
    Unigene Representative Sequence: NM_001033723
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327835(uc003yby.2) ENST00000517379 ENST00000517986 ENST00000522040
    ENST00000520336 ENST00000519936
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF704 (see all 213):
    hsa-miR-579 hsa-miR-26a-2* hsa-miR-361-5p hsa-miR-1914* hsa-miR-106a hsa-miR-128 hsa-miR-519a hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidZNF704 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF704
      QuantiFast Probe-based Assays in human, mouse, rat ZNF704

    Additional mRNA sequence: 

    AK131274.1 BC004287.1 BC017966.1 BC136844.1 BC136845.1 

    9 DOTS entries:

    DT.316088  DT.213123  DT.65285487  DT.100741814  DT.86858116  DT.91682104  DT.91696468  DT.97796724 
    DT.97800058 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF704 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTAAGTCT
    ZNF704 Expression
    About this image


    ZNF704 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    ZNF704 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF704 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.434957
        Custom PCR Arrays for ZNF704
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF704

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF704 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp7041 , 5 zinc finger protein 7041, 5 85.54(n)1
    90.2(a)1
      3 (2.31 cM)5
    1707531  NM_133218.21  NP_573481.11 
     94270115 
    chicken
    (Gallus gallus)
    Aves ZNF7041 zinc finger protein 704 78.73(n)
    86.06(a)
      420194  XM_004939931.1  XP_004939988.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF7046
    zinc finger protein 704
    69(a)
    1 ↔ 1
    4(24818640-24877323)
    zebrafish
    (Danio rerio)
    Actinopterygii znf7041 zinc finger protein 704 68.49(n)
    73.2(a)
      560056  NM_001044918.2  NP_001038383.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Glut4EF6
    Glucose transporter 4 enhancer factor
    13(a)
    1 → many
    3R(5700403-5821086)


    ENSEMBL Gene Tree for ZNF704 (if available)
    TreeFam Gene Tree for ZNF704 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF704 gene
    SLC2A4RG2  ZNF3952  
    3 SIMAP similar genes for ZNF704 using alignment to 2 protein entries:     ZN704_HUMAN (see all proteins):
    ZNF395    SLC2A4RG    Si-1-2-19

    Find genes that share paralogs with ZNF704           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF704 (see all 4329)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3774081121,2
    C--81540239(+) AGAGGC/TCACTT 1 -- ds50010--------
    rs1123669381,2
    F--81540242(+) GGCGCG/ACTTAC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1908399381,2
    --81540333(+) AGAAAA/CCCACC 1 -- ds50010--------
    rs1822567531,2
    --81540348(+) GGAGCC/TCGAGG 1 -- ds50010--------
    rs1139316091,2
    F--81540499(+) GGAATG/CGGTTG 1 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs1495949331,2
    --81540649(+) TCTTGG/TTATAG 1 -- ds50010--------
    rs132658791,2
    C,F,H--81540674(+) ATAAAT/CTGGTC 1 -- ds50018Minor allele frequency- C:0.01NS EA NA 544
    rs1439910681,2
    --81540806(+) GTCTTC/TTGAAA 1 -- ut310--------
    rs1482493961,2
    --81540819(+) CCAGTA/GTTCTG 1 -- ut310--------
    rs1877602531,2
    --81540878(+) GTACAA/GGTCAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF704 (81540686 - 81787016 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF704:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678182CNV Deletion23128226
    esv2737218CNV Deletion23290073
    nsv831366CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF704
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF704 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF704)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 619279 HGNC: 32291 Ensembl:ENSG00000164684 euGenes: HUgn619279 ECgene: ZNF704
    H-InvDB: ZNF704

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF704 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF704 gene:
    Search GeneIP for patents involving ZNF704

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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