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Aliases for ZNF704 Gene

Aliases for ZNF704 Gene

  • Zinc Finger Protein 704 2 3 5
  • GIG1 3

External Ids for ZNF704 Gene

Previous GeneCards Identifiers for ZNF704 Gene

  • GC08U900620
  • GC08M081714
  • GC08M081550
  • GC08M077030

Summaries for ZNF704 Gene

GeneCards Summary for ZNF704 Gene

ZNF704 (Zinc Finger Protein 704) is a Protein Coding gene. Among its related pathways are Gene Expression. An important paralog of this gene is SLC2A4RG.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF704 Gene

Genomics for ZNF704 Gene

Regulatory Elements for ZNF704 Gene

Enhancers for ZNF704 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G080900 0.9 Ensembl ENCODE 17.6 -25.1 -25134 1.2 GATAD2A TEAD1 NFIA CEBPB CEBPG ZNF384 NR2F2 CEBPA MAFK ZNF704 FTH1P11 ENSG00000254060
GH08G080820 1.1 ENCODE 8.1 +54.0 53995 2.1 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF143 HNRNPA1P36 ZNF704 HMGB1P41
GH08G080807 1 Ensembl ENCODE 8.1 +66.7 66718 0.3 HDAC1 PKNOX1 MLX ETV1 SAP30 BACH1 SIN3A RAD21 CTBP1 GATA3 RNU11-6P ZNF704 HMGB1P41 GC08M080788
GH08G080871 1 ENCODE 8 +1.2 1244 3.4 FOXA2 ATF1 ARID4B SIN3A ZNF2 YY1 GLIS2 FOS MXD4 NFYC ZNF704 HMGB1P41
GH08G080724 1.4 FANTOM5 Ensembl ENCODE 5 +147.9 147923 4.3 INSM2 RAD21 ZNF366 KLF7 FOS ZEB2 REST PRDM6 SMARCA4 ZNF341 ZNF704 PIR36752 GC08M080664
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF704 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF704 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000226339 981 2001 ARID4B ZNF2 YY1 MXD4 REST KAT8 ZNF579 MYNN SP7 CTCF

Genomic Location for ZNF704 Gene

Chromosome:
8
Start:
80,628,451 bp from pter
End:
80,874,781 bp from pter
Size:
246,331 bases
Orientation:
Minus strand

Genomic View for ZNF704 Gene

Genes around ZNF704 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF704 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF704 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF704 Gene

Proteins for ZNF704 Gene

  • Protein details for ZNF704 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNC4-ZN704_HUMAN
    Recommended name:
    Zinc finger protein 704
    Protein Accession:
    Q6ZNC4
    Secondary Accessions:
    • B2RNE6
    • B9EGW6

    Protein attributes for ZNF704 Gene

    Size:
    412 amino acids
    Molecular mass:
    45276 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF704 Gene

Post-translational modifications for ZNF704 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF704 Gene

No data available for DME Specific Peptides for ZNF704 Gene

Domains & Families for ZNF704 Gene

Protein Domains for ZNF704 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF704 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF704: view

No data available for Gene Families and UniProtKB/Swiss-Prot for ZNF704 Gene

Function for ZNF704 Gene

Gene Ontology (GO) - Molecular Function for ZNF704 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001158 enhancer sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF704: view

Phenotypes for ZNF704 Gene

genes like me logo Genes that share phenotypes with ZNF704: view

Animal Models for ZNF704 Gene

MGI Knock Outs for ZNF704:

Animal Model Products

CRISPR Products

miRNA for ZNF704 Gene

miRTarBase miRNAs that target ZNF704

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF704 Gene

Localization for ZNF704 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF704 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF704 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF704: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZNF704 Gene

Pathways & Interactions for ZNF704 Gene

SuperPathways for ZNF704 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF704: view

Pathways by source for ZNF704 Gene

2 Reactome pathways for ZNF704 Gene

Interacting Proteins for ZNF704 Gene

Gene Ontology (GO) - Biological Process for ZNF704 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ZNF704: view

No data available for SIGNOR curated interactions for ZNF704 Gene

Drugs & Compounds for ZNF704 Gene

No Compound Related Data Available

Transcripts for ZNF704 Gene

mRNA/cDNA for ZNF704 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF704 Gene

Zinc finger protein 704:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF704 Gene

No ASD Table

Relevant External Links for ZNF704 Gene

GeneLoc Exon Structure for
ZNF704
ECgene alternative splicing isoforms for
ZNF704

Expression for ZNF704 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF704 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF704 Gene

This gene is overexpressed in Heart (61.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF704 Gene



Protein tissue co-expression partners for ZNF704 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF704 Gene:

ZNF704

SOURCE GeneReport for Unigene cluster for ZNF704 Gene:

Hs.434957

Evidence on tissue expression from TISSUES for ZNF704 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with ZNF704: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF704 Gene

Orthologs for ZNF704 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF704 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF704 34 35
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia ZNF704 34 35
  • 92.23 (n)
cow
(Bos Taurus)
Mammalia ZNF704 34 35
  • 90.21 (n)
rat
(Rattus norvegicus)
Mammalia Zfp704 34
  • 86.27 (n)
mouse
(Mus musculus)
Mammalia Zfp704 34 16 35
  • 85.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF704 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF704 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF704 34 35
  • 78.73 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF704 35
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii znf704 34 35
  • 68.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta Glut4EF 35
  • 13 (a)
OneToMany
Species where no ortholog for ZNF704 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF704 Gene

ENSEMBL:
Gene Tree for ZNF704 (if available)
TreeFam:
Gene Tree for ZNF704 (if available)

Paralogs for ZNF704 Gene

Paralogs for ZNF704 Gene

(3) SIMAP similar genes for ZNF704 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF704: view

Variants for ZNF704 Gene

Sequence variations from dbSNP and Humsavar for ZNF704 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000007419 -- 80,870,472(+) AGTAA(G/T)TTCCA intron-variant
rs1000018860 -- 80,817,180(+) CAGCC(C/T)AGGGC intron-variant
rs1000022630 -- 80,856,623(+) GGACT(G/T)TTAGT intron-variant
rs1000024029 -- 80,741,645(+) ACTGC(A/G)CACTT intron-variant
rs1000043167 -- 80,785,984(+) GCCAG(A/G)TGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF704 Gene

Variant ID Type Subtype PubMed ID
esv2678182 CNV deletion 23128226
esv2737218 CNV deletion 23290073
esv3617784 CNV loss 21293372
esv5734 CNV gain 19470904
nsv1075152 CNV deletion 25765185
nsv1076092 CNV deletion 25765185
nsv1119182 CNV deletion 24896259
nsv1136048 CNV deletion 24896259
nsv1152674 CNV deletion 26484159
nsv476087 CNV novel sequence insertion 20440878
nsv476661 CNV novel sequence insertion 20440878
nsv831366 CNV loss 17160897
nsv951448 CNV deletion 24416366
nsv971672 CNV duplication 23825009
nsv981956 CNV duplication 23825009

Variation tolerance for ZNF704 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.69; 82.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF704 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF704

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF704 Gene

Disorders for ZNF704 Gene

Relevant External Links for ZNF704

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF704

No disorders were found for ZNF704 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF704 Gene

Publications for ZNF704 Gene

  1. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3 64
  2. DNA Damage Regulates Translation through I^-TRCP Targeting of CReP. (PMID: 26091241) Loveless T.B. … Toczyski D.P. (PLoS Genet. 2015) 3 64
  3. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for ZNF704 Gene

Sources for ZNF704 Gene

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