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Aliases for ZNF704 Gene

Aliases for ZNF704 Gene

  • Zinc Finger Protein 704 2 3 5
  • GIG1 3

External Ids for ZNF704 Gene

Previous GeneCards Identifiers for ZNF704 Gene

  • GC08U900620
  • GC08M081714
  • GC08M081550
  • GC08M077030

Summaries for ZNF704 Gene

GeneCards Summary for ZNF704 Gene

ZNF704 (Zinc Finger Protein 704) is a Protein Coding gene. Among its related pathways are Gene Expression. An important paralog of this gene is SLC2A4RG.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF704 Gene

Genomics for ZNF704 Gene

Regulatory Elements for ZNF704 Gene

Promoters for ZNF704 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF704 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF704 Gene

Chromosome:
8
Start:
80,628,451 bp from pter
End:
80,874,781 bp from pter
Size:
246,331 bases
Orientation:
Minus strand

Genomic View for ZNF704 Gene

Genes around ZNF704 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF704 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF704 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF704 Gene

Proteins for ZNF704 Gene

  • Protein details for ZNF704 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNC4-ZN704_HUMAN
    Recommended name:
    Zinc finger protein 704
    Protein Accession:
    Q6ZNC4
    Secondary Accessions:
    • B2RNE6
    • B9EGW6

    Protein attributes for ZNF704 Gene

    Size:
    412 amino acids
    Molecular mass:
    45276 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF704 Gene

Proteomics data for ZNF704 Gene at MOPED

Post-translational modifications for ZNF704 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF704 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF704 Gene

Domains & Families for ZNF704 Gene

Protein Domains for ZNF704 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF704 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZNC4

UniProtKB/Swiss-Prot:

ZN704_HUMAN :
  • Contains 1 C2H2-type zinc finger.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with ZNF704: view

No data available for Gene Families for ZNF704 Gene

Function for ZNF704 Gene

Phenotypes for ZNF704 Gene

GenomeRNAi human phenotypes for ZNF704:
MGI mutant phenotypes for ZNF704:
inferred from 2 alleles
genes like me logo Genes that share phenotypes with ZNF704: view

Animal Models for ZNF704 Gene

MGI Knock Outs for ZNF704:

Animal Model Products

CRISPR Products

miRNA for ZNF704 Gene

miRTarBase miRNAs that target ZNF704

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF704 Gene

Localization for ZNF704 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF704 Gene COMPARTMENTS Subcellular localization image for ZNF704 gene
Compartment Confidence
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZNF704 Gene

Pathways & Interactions for ZNF704 Gene

SuperPathways for ZNF704 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF704: view

Pathways by source for ZNF704 Gene

2 Reactome pathways for ZNF704 Gene

Interacting Proteins for ZNF704 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000331462%0d%0a9606.ENSP00000265094%0d%0a
Selected Interacting proteins: ENSP00000331462 for ZNF704 Gene via STRING

Symbol External ID(s) Details
FBXW11

Gene Ontology (GO) - Biological Process for ZNF704 Gene

None

No data available for SIGNOR curated interactions for ZNF704 Gene

Drugs & Compounds for ZNF704 Gene

No Compound Related Data Available

Transcripts for ZNF704 Gene

mRNA/cDNA for ZNF704 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF704 Gene

Zinc finger protein 704:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF704 Gene

No ASD Table

Relevant External Links for ZNF704 Gene

GeneLoc Exon Structure for
ZNF704
ECgene alternative splicing isoforms for
ZNF704

Expression for ZNF704 Gene

mRNA expression in normal human tissues for ZNF704 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF704 Gene

This gene is overexpressed in Heart (61.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF704 Gene



SOURCE GeneReport for Unigene cluster for ZNF704 Gene Hs.434957

genes like me logo Genes that share expression patterns with ZNF704: view

Protein tissue co-expression partners for ZNF704 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF704 Gene

Orthologs for ZNF704 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF704 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF704 35
  • 99.51 (n)
  • 99.76 (a)
ZNF704 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF704 36
  • 96 (a)
OneToOne
ZNF704 35
  • 90.21 (n)
  • 95.39 (a)
dog
(Canis familiaris)
Mammalia ZNF704 35
  • 92.23 (n)
  • 96.36 (a)
ZNF704 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp704 16
Zfp704 36
  • 65 (a)
OneToOne
Zfp704 35
  • 85.54 (n)
  • 90.2 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF704 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF704 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp704 35
  • 86.27 (n)
  • 91.18 (a)
chicken
(Gallus gallus)
Aves ZNF704 35
  • 78.73 (n)
  • 86.06 (a)
ZNF704 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF704 36
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii znf704 36
  • 57 (a)
OneToOne
znf704 35
  • 68.49 (n)
  • 73.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta Glut4EF 36
  • 13 (a)
OneToMany
Species with no ortholog for ZNF704:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF704 Gene

ENSEMBL:
Gene Tree for ZNF704 (if available)
TreeFam:
Gene Tree for ZNF704 (if available)

Paralogs for ZNF704 Gene

Paralogs for ZNF704 Gene

(3) SIMAP similar genes for ZNF704 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF704: view

Variants for ZNF704 Gene

Sequence variations from dbSNP and Humsavar for ZNF704 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs3907424 - 80,821,492(-) AAACA(G/T)CAGAC nc-transcript-variant, reference, missense
rs747830 -- 80,628,700(-) GTTCT(A/G)TAATG nc-transcript-variant, utr-variant-3-prime
rs716349 -- 80,866,542(-) TAAAT(A/G)CATGA intron-variant
rs716350 -- 80,866,424(-) TTTTG(C/G)TCATT intron-variant
rs1132752 -- 80,629,058(-) TTTTT(A/T)AAAAA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF704 Gene

Variant ID Type Subtype PubMed ID
nsv831366 CNV Loss 17160897
esv2737218 CNV Deletion 23290073
esv2678182 CNV Deletion 23128226

Variation tolerance for ZNF704 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.69; 82.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF704 Gene

HapMap Linkage Disequilibrium report
ZNF704

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF704 Gene

Disorders for ZNF704 Gene

Relevant External Links for ZNF704

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF704

No disorders were found for ZNF704 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF704 Gene

Publications for ZNF704 Gene

  1. DNA Damage Regulates Translation through I^-TRCP Targeting of CReP. (PMID: 26091241) Loveless T.B. … Toczyski D.P. (PLoS Genet. 2015) 3 67
  2. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for ZNF704 Gene

Sources for ZNF704 Gene

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