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Aliases for ZNF703 Gene

Aliases for ZNF703 Gene

  • Zinc Finger Protein 703 2 3
  • Zinc Finger Elbow-Related Proline Domain Protein 1 2 3 4
  • ZEPPO1 3 4
  • ZPO1 3 4
  • ZNF503L 3
  • NLZ1 3

External Ids for ZNF703 Gene

Summaries for ZNF703 Gene

GeneCards Summary for ZNF703 Gene

ZNF703 (Zinc Finger Protein 703) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include nucleic acid binding and repressing transcription factor binding. An important paralog of this gene is ZNF503.

UniProtKB/Swiss-Prot for ZNF703 Gene

  • Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF703 Gene

Genomics for ZNF703 Gene

Genomic Location for ZNF703 Gene

Start:
37,695,751 bp from pter
End:
37,700,021 bp from pter
Size:
4,271 bases
Orientation:
Plus strand

Genomic View for ZNF703 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF703 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF703 Gene

Regulatory Elements for ZNF703 Gene

Proteins for ZNF703 Gene

  • Protein details for ZNF703 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7S9-ZN703_HUMAN
    Recommended name:
    Zinc finger protein 703
    Protein Accession:
    Q9H7S9
    Secondary Accessions:
    • Q5XG76

    Protein attributes for ZNF703 Gene

    Size:
    590 amino acids
    Molecular mass:
    58222 Da
    Quaternary structure:
    • Interacts with TLE4; increases transcriptional repression (By similarity). Interacts with DCAF7 and PHB2. May interact with HSPD1.
    SequenceCaution:
    • Sequence=AAH84581.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for ZNF703 Gene

Proteomics data for ZNF703 Gene at MOPED

Post-translational modifications for ZNF703 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF703 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF703 Gene

Domains for ZNF703 Gene

Protein Domains for ZNF703 Gene

UniProtKB/Swiss-Prot:

ZN703_HUMAN
Family:
  • Belongs to the Elbow/Noc family.:
    • Q9H7S9
Similarity:
  • Contains 1 C2H2-type zinc finger.:
    • Q9H7S9
genes like me logo Genes that share domains with ZNF703: view

No data available for Gene Families for ZNF703 Gene

Function for ZNF703 Gene

Molecular function for ZNF703 Gene

UniProtKB/Swiss-Prot Function: Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.
UniProtKB/Swiss-Prot Induction: Up-regulated by 17-beta-estradiol.

Gene Ontology (GO) - Molecular Function for ZNF703 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 21328542
GO:0046872 metal ion binding IEA --
GO:0070491 repressing transcription factor binding IEA --
genes like me logo Genes that share ontologies with ZNF703: view

Phenotypes for ZNF703 Gene

GenomeRNAi human phenotypes for ZNF703:
genes like me logo Genes that share phenotypes with ZNF703: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF703 Gene

Localization for ZNF703 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF703 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF703 Gene COMPARTMENTS Subcellular localization image for ZNF703 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF703 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21328542
GO:0005737 cytoplasm ISS --
GO:0016363 nuclear matrix IDA 21328542
GO:0043234 protein complex IDA 21328542
genes like me logo Genes that share ontologies with ZNF703: view

Pathways for ZNF703 Gene

SuperPathways for ZNF703 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF703: view

Pathways by source for ZNF703 Gene

2 Reactome pathways for ZNF703 Gene

Gene Ontology (GO) - Biological Process for ZNF703 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 21328542
GO:0008284 positive regulation of cell proliferation IDA 21328542
GO:0010718 positive regulation of epithelial to mesenchymal transition ISS --
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway IDA 21337521
genes like me logo Genes that share ontologies with ZNF703: view

Transcripts for ZNF703 Gene

mRNA/cDNA for ZNF703 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(139) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF703 Gene

Zinc finger protein 703:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF703 Gene

No ASD Table

Relevant External Links for ZNF703 Gene

GeneLoc Exon Structure for
ZNF703
ECgene alternative splicing isoforms for
ZNF703

Expression for ZNF703 Gene

mRNA expression in normal human tissues for ZNF703 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF703 Gene

This gene is overexpressed in Muscle - Skeletal (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF703 Gene

SOURCE GeneReport for Unigene cluster for ZNF703 Gene Hs.744591

mRNA Expression by UniProt/SwissProt for ZNF703 Gene

Q9H7S9-ZN703_HUMAN
Tissue specificity: Expressed in mammary epithelium.
genes like me logo Genes that share expressions with ZNF703: view

Orthologs for ZNF703 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF703 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF703 36
  • 99.72 (n)
  • 99.83 (a)
ZNF703 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF703 36
  • 86.79 (n)
  • 88.68 (a)
ZNF703 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF703 36
  • 94.01 (n)
  • 95.59 (a)
ZNF703 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp703 36
  • 88.83 (n)
  • 94.9 (a)
Zfp703 16
Zfp703 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF703 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF703 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp703 36
  • 89.19 (n)
  • 94.91 (a)
chicken
(Gallus gallus)
Aves ZNF703 36
  • 76.56 (n)
  • 77.29 (a)
lizard
(Anolis carolinensis)
Reptilia ZNF703 37
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia FLJ14299 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15010 36
znf703 36
  • 65.34 (n)
  • 69.32 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1674 36
zebrafish
(Danio rerio)
Actinopterygii noz1 36
znf703 36
  • 60.26 (n)
  • 60.19 (a)
znf703 37
  • 52 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 41 (a)
OneToMany
Species with no ortholog for ZNF703:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF703 Gene

ENSEMBL:
Gene Tree for ZNF703 (if available)
TreeFam:
Gene Tree for ZNF703 (if available)

Paralogs for ZNF703 Gene

Paralogs for ZNF703 Gene

Selected SIMAP similar genes for ZNF703 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF703: view

Variants for ZNF703 Gene

Sequence variations from dbSNP and Humsavar for ZNF703 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1892607 -- 37,698,301(-) TGTCG(A/C)CCGGC reference, missense
rs1892608 -- 37,698,300(-) GTCGA(A/C)CGGCC frameshift-variant, reference
rs2407534 -- 37,694,959(+) CACGC(C/G)CCTCA upstream-variant-2KB
rs2407535 -- 37,695,325(+) CCAGC(G/T)GCCCA upstream-variant-2KB
rs3032970 -- 37,694,647(+) CGGAT(-/CCT)CCGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF703 Gene

Variant ID Type Subtype PubMed ID
nsv831294 CNV Gain 17160897
esv2662845 CNV Deletion 23128226

Relevant External Links for ZNF703 Gene

HapMap Linkage Disequilibrium report
ZNF703

Disorders for ZNF703 Gene

UniProtKB/Swiss-Prot

ZN703_HUMAN
  • Note=Luminal B breast cancers are the clinically more aggressive estrogen receptor-positive tumors. Amplification of a distal 8p12 locus occurs in around one third of the cases and ZNF703 is the single gene within the minimal amplicon. Amplification of the gene correlates with its protein expression in tumor cells. ZNF703 is a classical breast cancer oncogene since it is able to transform non-malignant cells and increase cellular proliferation.

Relevant External Links for ZNF703

Human Genome Epidemiology (HuGE) Navigator
ZNF703
genes like me logo Genes that share disorders with ZNF703: view

Publications for ZNF703 Gene

  1. Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. (PMID: 21317240) Slorach E.M. … Werb Z. (Genes Dev. 2011) 2 3 4
  2. ZNF703 gene amplification at 8p12 specifies luminal B breast cancer. (PMID: 21328542) Sircoulomb F. … Ginestier C. (EMBO Mol. Med. 2011) 3 4
  3. ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium. (PMID: 21337521) Holland D.G. … Caldas C. (EMBO Mol. Med. 2011) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ZNF703 Gene

Sources for ZNF703 Gene

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