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Aliases for ZNF703 Gene

Aliases for ZNF703 Gene

  • Zinc Finger Protein 703 2 3 5
  • Zinc Finger Elbow-Related Proline Domain Protein 1 2 3 4
  • ZEPPO1 3 4
  • ZPO1 3 4
  • ZNF503L 3
  • NLZ1 3

External Ids for ZNF703 Gene

Previous GeneCards Identifiers for ZNF703 Gene

  • GC08P037553
  • GC08P036088

Summaries for ZNF703 Gene

GeneCards Summary for ZNF703 Gene

ZNF703 (Zinc Finger Protein 703) is a Protein Coding gene. Diseases associated with ZNF703 include Luminal Breast Carcinoma. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and repressing transcription factor binding. An important paralog of this gene is ZNF503.

UniProtKB/Swiss-Prot for ZNF703 Gene

  • Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.

Additional gene information for ZNF703 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF703 Gene

Genomics for ZNF703 Gene

GeneHancer (GH) Regulatory Elements for ZNF703 Gene

Promoters and enhancers for ZNF703 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I037693 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.8 1819 7.9 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF213 ZNF703 ERLIN2 ADGRA2 DDHD2 RPS20P22 ENSG00000255201 LOC728024 FGFR1 LOC102723716 NSD3
GH08I037588 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -100.2 -100155 13.7 PKNOX1 FOXA2 MLX ARNT ARID4B NEUROD1 FEZF1 DMAP1 ZNF2 ZNF766 ZNF703 LOC105379379 LINC01605 ENSG00000253388 ENSG00000253414 DDHD2 LOC728024 ERLIN2 LOC102723701 RAB11FIP1
GH08I037603 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.3 -91.2 -91248 1.2 PKNOX1 FOXA2 MLX ZNF493 ZNF133 ARID4B DMAP1 ZNF2 ZNF48 ETS1 DDHD2 RPS20P22 NSD3 ERLIN2 ADGRA2 LOC102723716 FGFR1 ENSG00000255201 ENSG00000260949 ENSG00000272128
GH08I037520 Enhancer 1.3 UCNEbase Ensembl ENCODE 9.6 -174.4 -174397 1.9 HDGF MEIS2 PKNOX1 JUN FOSL1 CTBP1 POLR2A VEZF1 FOS TCF7L2 LOC105379379 LINC01605 ENSG00000253388 ZNF703 ENSG00000253414
GH08I037747 Promoter/Enhancer 1.2 Ensembl ENCODE 10.2 +53.0 52983 2.8 HDAC1 PKNOX1 ATF1 SIN3A BMI1 POLR2A PHF20 ZNF207 ZNF143 ATF7 PIR57264 LOC728024 ADGRA2 RAB11FIP1 ZNF703 PLPBP ERLIN2 GC08M037706
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF703 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF703 gene promoter:

Genomic Locations for ZNF703 Gene

Genomic Locations for ZNF703 Gene
4,271 bases
Plus strand

Genomic View for ZNF703 Gene

Genes around ZNF703 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF703 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF703 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF703 Gene

Proteins for ZNF703 Gene

  • Protein details for ZNF703 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 703
    Protein Accession:
    Secondary Accessions:
    • Q5XG76

    Protein attributes for ZNF703 Gene

    590 amino acids
    Molecular mass:
    58222 Da
    Quaternary structure:
    • Interacts with TLE4; increases transcriptional repression (By similarity). Interacts with DCAF7 and PHB2. May interact with HSPD1.
    • Sequence=AAH84581.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for ZNF703 Gene

Post-translational modifications for ZNF703 Gene

No Post-translational modifications

Other Protein References for ZNF703 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF703 Gene

Domains & Families for ZNF703 Gene

Gene Families for ZNF703 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for ZNF703 Gene

Suggested Antigen Peptide Sequences for ZNF703 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Elbow/Noc family.
  • Belongs to the Elbow/Noc family.
genes like me logo Genes that share domains with ZNF703: view

Function for ZNF703 Gene

Molecular function for ZNF703 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.
UniProtKB/Swiss-Prot Induction:
Up-regulated by 17-beta-estradiol.

Phenotypes From GWAS Catalog for ZNF703 Gene

Gene Ontology (GO) - Molecular Function for ZNF703 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 21328542
GO:0046872 metal ion binding IEA --
GO:0070491 repressing transcription factor binding IEA --
genes like me logo Genes that share ontologies with ZNF703: view
genes like me logo Genes that share phenotypes with ZNF703: view

miRNA for ZNF703 Gene

miRTarBase miRNAs that target ZNF703

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF703 Gene

Localization for ZNF703 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF703 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF703 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF703 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21328542
GO:0005737 cytoplasm ISS --
GO:0016363 nuclear matrix IDA 21328542
GO:0043234 protein complex IDA 21328542
genes like me logo Genes that share ontologies with ZNF703: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF703 Gene

Pathways & Interactions for ZNF703 Gene

SuperPathways for ZNF703 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF703: view

Pathways by source for ZNF703 Gene

2 Reactome pathways for ZNF703 Gene

Gene Ontology (GO) - Biological Process for ZNF703 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IDA 21328542
GO:0008284 positive regulation of cell proliferation IDA 21328542
GO:0010718 positive regulation of epithelial to mesenchymal transition ISS,IEA --
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway IEA,IDA 21337521
genes like me logo Genes that share ontologies with ZNF703: view

No data available for SIGNOR curated interactions for ZNF703 Gene

Drugs & Compounds for ZNF703 Gene

No Compound Related Data Available

Transcripts for ZNF703 Gene

mRNA/cDNA for ZNF703 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(139) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF703 Gene

Zinc finger protein 703:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF703 Gene

No ASD Table

Relevant External Links for ZNF703 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF703 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF703 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF703 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for ZNF703 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF703 Gene

Protein tissue co-expression partners for ZNF703 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF703 Gene:


SOURCE GeneReport for Unigene cluster for ZNF703 Gene:


mRNA Expression by UniProt/SwissProt for ZNF703 Gene:

Tissue specificity: Expressed in mammary epithelium.

Evidence on tissue expression from TISSUES for ZNF703 Gene

  • Skin(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF703: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF703 Gene

Orthologs for ZNF703 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF703 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF703 33 34
  • 99.72 (n)
(Canis familiaris)
Mammalia ZNF703 33 34
  • 94.01 (n)
(Monodelphis domestica)
Mammalia ZNF703 34
  • 91 (a)
(Rattus norvegicus)
Mammalia Zfp703 33
  • 89.19 (n)
(Mus musculus)
Mammalia Zfp703 33 16 34
  • 88.83 (n)
(Bos Taurus)
Mammalia ZNF703 33 34
  • 86.79 (n)
(Ornithorhynchus anatinus)
Mammalia ZNF703 34
  • 70 (a)
(Gallus gallus)
Aves ZNF703 33
  • 76.56 (n)
(Anolis carolinensis)
Reptilia ZNF703 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf703 33
  • 65.34 (n)
Str.15010 33
African clawed frog
(Xenopus laevis)
Amphibia FLJ14299 33
(Danio rerio)
Actinopterygii znf703 33 34
  • 60.26 (n)
noz1 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1674 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
Species where no ortholog for ZNF703 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF703 Gene

Gene Tree for ZNF703 (if available)
Gene Tree for ZNF703 (if available)

Paralogs for ZNF703 Gene

Paralogs for ZNF703 Gene

(1) SIMAP similar genes for ZNF703 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF703: view

Variants for ZNF703 Gene

Sequence variations from dbSNP and Humsavar for ZNF703 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000393554 -- 37,697,947(+) G/A coding_sequence_variant, missense_variant
rs1000764521 -- 37,697,717(+) CGA/ coding_sequence_variant, inframe_deletion
rs1000870254 -- 37,695,006(+) C/T upstream_transcript_variant
rs1001797882 -- 37,697,325(+) C/A coding_sequence_variant, missense_variant
rs1001801392 -- 37,695,381(+) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF703 Gene

Variant ID Type Subtype PubMed ID
esv2662845 CNV deletion 23128226
nsv831294 CNV gain 17160897
nsv951125 CNV deletion 24416366

Variation tolerance for ZNF703 Gene

Gene Damage Index Score: 3.22; 52.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF703 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF703 Gene

Disorders for ZNF703 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF703 Gene - From: DISEASES

Disorder Aliases PubMed IDs
luminal breast carcinoma
  • breast tumor luminal
- elite association - COSMIC cancer census association via MalaCards


  • Note=Luminal B breast cancers are the clinically more aggressive estrogen receptor-positive tumors. Amplification of a distal 8p12 locus occurs in around one third of the cases and ZNF703 is the single gene within the minimal amplicon. Amplification of the gene correlates with its protein expression in tumor cells. ZNF703 is a classical breast cancer oncogene since it is able to transform non-malignant cells and increase cellular proliferation.

Additional Disease Information for ZNF703

genes like me logo Genes that share disorders with ZNF703: view

No data available for Genatlas for ZNF703 Gene

Publications for ZNF703 Gene

  1. Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. (PMID: 21317240) Slorach EM … Werb Z (Genes & development 2011) 2 3 4 58
  2. ZNF703 gene amplification at 8p12 specifies luminal B breast cancer. (PMID: 21328542) Sircoulomb F … Ginestier C (EMBO molecular medicine 2011) 3 4 58
  3. ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium. (PMID: 21337521) Holland DG … Caldas C (EMBO molecular medicine 2011) 3 4 58
  4. A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes. (PMID: 15897872) Garcia MJ … Caldas C (Oncogene 2005) 2 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for ZNF703 Gene

Sources for ZNF703 Gene

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