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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF703 Gene

protein-coding   GIFtS: 47
GCID: GC08P037553

zinc finger protein 703

 Explore 1 disease affiliated with
ZNF703 via our new
 Human Malady Compendium 
Biological research products
for ZNF703
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 7031 2
ZNF503L1 2
Zinc Finger Elbow-Related Proline Domain Protein 12 3
ZEPPO12 3
ZPO12 3
FLJ142991

External Ids:    HGNC: 258831   Entrez Gene: 801392   Ensembl: ENSG000001837797   UniProtKB: Q9H7S93   

Export aliases for ZNF703 gene to outside databases

Previous GC identifers: GC08P037673 GC08P036088


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN703_HUMAN, Q9H7S9
Function: Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through
recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be
required for segmental gene expression during hindbrain development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF703 gene promoter:
         Elk-1   Spz1   LHX3b/Lhx3b   Pax-5   Olf-1   COMP1   FOXO4   LHX3a/Lhx3a   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF703 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF703

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF703


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.23   Ensembl cytogenetic band:  8p11.23   HGNC cytogenetic band: 8p12

ZNF703 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF703 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P037553:  view genomic region     (about GC identifiers)

Start:
37,553,269 bp from pter      End:
37,557,537 bp from pter
Size:
4,269 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN703_HUMAN, Q9H7S9 (See protein sequence)
Recommended Name: Zinc finger protein 703  
Size: 590 amino acids; 58222 Da
Subunit: Interacts with TLE4; increases transcriptional repression (By similarity). Interacts with DCAF7 and PHB2. May
interact with HSPD1
Subcellular location: Nucleus. Cytoplasm (By similarity)
Sequence caution: Sequence=AAH84581.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: Q5XG76

Explore the universe of human proteins at neXtProt for ZNF703: NX_Q9H7S9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H7S9

  • ZNF703 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_079345.1  
    ENSEMBL proteins: 
     ENSP00000332325  
    Reactome Protein details: Q9H7S9
    Human Recombinant Protein Products: 
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    Uscn Proteins for ZNF703

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm ISS--


    ZNF703 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZNF703


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF703 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR022129 Tscrpt_rep_NocA-like
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9H7S9

    ProtoNet protein and cluster: Q9H7S9

    UniProtKB/Swiss-Prot: ZN703_HUMAN, Q9H7S9
    Similarity: Belongs to the Elbow/Noc family
    Similarity: Contains 1 C2H2-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN703_HUMAN, Q9H7S9
    Function: Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through
    recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be
    required for segmental gene expression during hindbrain development
    Induction: Up-regulated by 17-beta-estradiol

    miRNA
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    hsa-miR-569 hsa-miR-3938 hsa-miR-4325 hsa-miR-155 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidZNF703 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0070491repressing transcription factor binding IEA--


    ZNF703 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ZNF703:
     Cell cycle / mitosis defect 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF703
        Generic Transcription Pathway
    Gene Expression



    ZNF703 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF703

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF703 (Q9H7S93 ENSP000003323254) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    TERF2Q155543, ENSP000002549424I2D: score=1 STRING: ENSP00000254942
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA--
    GO:0008284positive regulation of cell proliferation IDA--
    GO:0010718positive regulation of epithelial to mesenchymal transition ISS--
    GO:0017015regulation of transforming growth factor beta receptor signaling pathway IDA--


    ZNF703 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF703
    Search CenterWatch for drugs/clinical trials and news about ZNF703 / ZN703 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF703 gene: 
    NM_025069.1  

    Unigene Cluster for ZNF703:

    Zinc finger protein 703
    Hs.744591  [show with all ESTs]
    Unigene Representative Sequence: AK024361
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000331569(uc003xjy.1)

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    hsa-miR-569 hsa-miR-3938 hsa-miR-4325 hsa-miR-155 hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidZNF703 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF703
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF703

    Additional cDNA sequence: 

    AK024361.1 BC032534.1 BC084581.1 

    2 DOTS entries:

    DT.214526  DT.95159844 

    24/139 AceView cDNA sequences (see all 139):

    BF435432 BM758889 BM772542 BM770319 AI371143 CD671633 NM_025069 AI332458 
    BQ183618 BM758730 BM850846 BM758591 H49609 AW204573 CK904315 BM820420 
    AI304422 BQ878257 BM743888 BQ213043 BM770320 CA488448 BQ638329 AI288389 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF703 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    ZNF703 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ZNF703 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF703

    SOURCE GeneReport for Unigene cluster: Hs.744591

    UniProtKB/Swiss-Prot: ZN703_HUMAN, Q9H7S9
    Tissue specificity: Expressed in mammary epithelium

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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ZNF703

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ZNF703 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ZNF7031 zinc finger protein 703 81.13(n)
    84.56(a)
      770560  XM_001233898.2  XP_001233899.2 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF7036
    --
    65(a)
    1 ↔ 1
    GL343406.1(251850-253244)
    African clawed frog
    (Xenopus laevis)
    Amphibia FLJ142992 hypothetical protein FLJ14299 76.77(n)    BC046863.1 
    zebrafish
    (Danio rerio)
    Actinopterygii noz12 nocA related zinc finger 1 76.63(n)   114429  AY026937.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta noc1 no ocelli 46.14(n)
    39.51(a)
      34847  NM_057569.2  NP_476917.1 
    rice
    (Oryza sativa)
    Liliopsida AK066978.12   -- 70.28(n)    AK066978.1 


    ENSEMBL Gene Tree for ZNF703 (if available)
    TreeFam Gene Tree for ZNF703 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF703 gene
    ZNF5032  
    1 SIMAP similar gene for ZNF703 using alignment to 1 protein entry:     ZN703_HUMAN:
    ZNF503

    ZNF703 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/57 NCBI SNPs in ZNF703 are shown (see all 57    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs69953791,2
    C,F,H,--37551354(+) TTTCAC/TAGCCT 1 -- us2k126Minor allele frequency- T:0.07NS EA NA WA CSA 2068
    rs1854542351,2
    --37551660(+) GTCAGC/GGTACC 1 -- us2k10--------
    rs624883591,2
    --37551672(+) CTTTCC/TATTCG 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1897597431,2
    --37551754(+) TATAAA/GTGCTG 1 -- us2k10--------
    rs785084811,2
    --37551767(+) CAAAAT/AACAGT 1 -- us2k12Minor allele frequency- A:0.10CSA WA 120
    rs1146719111,2
    F,--37551961(+) GCGGCA/GGAGTC 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1131373461,2
    --37551980(+) GCCATT/CCTAGA 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1383705261,2
    --37552027(+) TGATGA/GATCGG 1 -- us2k10--------
    rs1415833281,2
    --37552075(+) CAGCGC/TGCCTC 1 -- us2k10--------
    rs1872133541,2
    --37552633(+) GACGGG/TCTCAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF703 (37553269 - 37557537 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZNF703: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF703 for disorders           About GeneDecksing

    UniProtKB/Swiss-Prot: ZN703_HUMAN, Q9H7S9
  • Note=Luminal B breast cancers are the clinically more aggressive estrogen receptor-positive tumors.
  • Amplification of a distal 8p12 locus occurs in around one third of the cases and ZNF703 is the single gene within the
    minimal amplicon. Amplification of the gene correlates with its protein expression in tumor cells. ZNF703 is a
    classical breast cancer oncogene since it is able to transform non-malignant cells and increase cellular proliferation

    1 disease for ZNF703:    About MalaCards
    breast cancer

    Human Genome Epidemiology (HuGE) Navigator: ZNF703 (1 document)

    Export disorders for ZNF703 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF703 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF703)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. (PubMed id 21317240)1, 2 Slorach E.M.... Werb Z. (2011)
    2. ZNF703 gene amplification at 8p12 specifies luminal B breast cancer. (PubMed id 21328542)1, 2 Sircoulomb F.... Ginestier C. (2011)
    3. ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium. (PubMed id 21337521)1, 2 Holland D.G.... Caldas C. (2011)
    4. A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes. (PubMed id 15897872)1, 3 Garcia M.J....Caldas C. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Genetic variants associated with breast size also infl uence breast cancer risk. (PubMed id 22747683)1 Eriksson N....Tung J.Y. (2012)
    8. The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (2010)
    9. Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis. (PubMed id 19330026)1 Kwek S.S....Albertson D.G. (2009)
    10. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80139 HGNC: 25883 AceView: FLJ14299 Ensembl:ENSG00000183779 euGenes: HUgn80139
    ECgene: ZNF703 H-InvDB: ZNF703

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF703 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF703 gene:
    Search GeneIP for patents involving ZNF703

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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