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Aliases for ZNF701 Gene

Aliases for ZNF701 Gene

  • Zinc Finger Protein 701 2 3 5

External Ids for ZNF701 Gene

Previous GeneCards Identifiers for ZNF701 Gene

  • GC19P057766
  • GC19P053073
  • GC19P049404
  • GC19P053059

Summaries for ZNF701 Gene

GeneCards Summary for ZNF701 Gene

ZNF701 (Zinc Finger Protein 701) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF888.

UniProtKB/Swiss-Prot for ZNF701 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF701 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF701 Gene

Genomics for ZNF701 Gene

Regulatory Elements for ZNF701 Gene

Enhancers for ZNF701 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H051570 1.6 FANTOM5 ENCODE dbSUPER 14.1 -983.2 -983230 3.6 HDGF PKNOX1 ARNT SIN3A ARID4B ZNF2 YY1 ZNF766 ZNF143 ZNF207 ZNF175 ZNF766 ZNF701 ZNF350 ZNF616 ZNF808 ZNF841 SIGLEC14 SIGLEC5 RPL7P51
GH19H052733 1.4 FANTOM5 ENCODE 15.4 +179.8 179813 2.8 HDGF ARID4B SIN3A ELK1 ATF7 SP3 SP5 REST ZNF518A ZNF592 ZNF611 ZNF613 ZNF137P ENSG00000268970 ZNF701 ENSG00000269001 TPM3P9 ZNF525 ZNF665 TPM3P6
GH19H053466 1 ENCODE 20.8 +912.4 912430 1.8 PKNOX1 ATF1 ARID4B DMAP1 SLC30A9 ATF7 SP3 SP5 MXD4 KAT8 CNOT3 ZNF701 ZNF600 LENG8 ZNF845 ZNF808 ENSG00000269001 LENG8-AS1 ZNF160 ENSG00000268970
GH19H052637 0.9 ENCODE 21 +82.8 82764 2.2 HDAC1 TBP HDGF ARID4B SIN3A ZBTB40 SCRT2 ATF7 CREM SP3 ZNF83 ZNF701 ZNF600 ZNF845 ZNF28 ZNF808 ENSG00000269001 ZNF350 ZNF160 ENSG00000268970
GH19H051784 1.5 Ensembl ENCODE dbSUPER 12.6 -769.5 -769470 3.8 PKNOX1 ATF1 TCF12 ZNF766 GATA2 ELK1 ATF7 CAVIN1 NCOA1 JUNB FPR3 ZNF577 ZNF175 ZNF841 ZNF137P ZNF616 ZNF432 ZNF649 ZNF578 ZNF766
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF701 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF701 Gene

Genomic Locations for ZNF701 Gene
31,718 bases
Plus strand

Genomic View for ZNF701 Gene

Genes around ZNF701 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF701 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF701 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF701 Gene

Proteins for ZNF701 Gene

  • Protein details for ZNF701 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 701
    Protein Accession:
    Secondary Accessions:
    • A2RRM8
    • B9EGF2
    • F5GZM6
    • Q66K42

    Protein attributes for ZNF701 Gene

    531 amino acids
    Molecular mass:
    60903 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF701 Gene


neXtProt entry for ZNF701 Gene

Post-translational modifications for ZNF701 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF701 Gene

No data available for DME Specific Peptides for ZNF701 Gene

Domains & Families for ZNF701 Gene

Gene Families for ZNF701 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF701 Gene

Suggested Antigen Peptide Sequences for ZNF701 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF701: view

Function for ZNF701 Gene

Molecular function for ZNF701 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF701 Gene

Gene Ontology (GO) - Molecular Function for ZNF701 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF701: view
genes like me logo Genes that share phenotypes with ZNF701: view

miRNA for ZNF701 Gene

miRTarBase miRNAs that target ZNF701

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF701 Gene

Localization for ZNF701 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF701 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF701 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF701 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF701: view

Pathways & Interactions for ZNF701 Gene

SuperPathways for ZNF701 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF701: view

Pathways by source for ZNF701 Gene

2 Reactome pathways for ZNF701 Gene

Interacting Proteins for ZNF701 Gene

Gene Ontology (GO) - Biological Process for ZNF701 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF701: view

No data available for SIGNOR curated interactions for ZNF701 Gene

Drugs & Compounds for ZNF701 Gene

No Compound Related Data Available

Transcripts for ZNF701 Gene

Unigene Clusters for ZNF701 Gene

Zinc finger protein 701:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF701 Gene

No ASD Table

Relevant External Links for ZNF701 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF701 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF701 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF701 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF701 Gene

Protein tissue co-expression partners for ZNF701 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF701 Gene:


SOURCE GeneReport for Unigene cluster for ZNF701 Gene:

genes like me logo Genes that share expression patterns with ZNF701: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF701 Gene

Orthologs for ZNF701 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF701 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF701 33
  • 98.57 (n)
-- 34
  • 46 (a)
(Canis familiaris)
Mammalia -- 34
  • 46 (a)
(Bos Taurus)
Mammalia -- 34
  • 32 (a)
Species where no ortholog for ZNF701 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF701 Gene

Gene Tree for ZNF701 (if available)
Gene Tree for ZNF701 (if available)

Paralogs for ZNF701 Gene

(525) SIMAP similar genes for ZNF701 Gene using alignment to 7 proteins: Pseudogenes for ZNF701 Gene

genes like me logo Genes that share paralogs with ZNF701: view

Variants for ZNF701 Gene

Sequence variations from dbSNP and Humsavar for ZNF701 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs575275768 untested 52,613,741(+) CAAGG(G/T)GTGAA intron-variant, reference, missense
rs1000014948 -- 52,611,558(+) TGCAC(C/T)CCAGT intron-variant
rs1000020316 -- 52,606,092(+) TAATC(C/T)CAGCA intron-variant
rs1000079959 -- 52,600,642(+) ATCAA(A/G)ATTTT intron-variant, downstream-variant-500B
rs1000152012 -- 52,570,141(+) GCACA(A/G)GTCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF701 Gene

Variant ID Type Subtype PubMed ID
nsv978841 CNV duplication 23825009
nsv954661 CNV deletion 24416366
nsv833874 CNV loss 17160897
nsv580027 CNV loss 21841781
nsv510772 CNV deletion 20534489
nsv458743 CNV loss 19166990
nsv1146332 OTHER inversion 26484159
nsv1117221 CNV tandem duplication 24896259
nsv1065584 CNV loss 25217958
esv4313 CNV loss 18987735
esv3893233 CNV loss 25118596
esv3644702 CNV loss 21293372
esv3644700 CNV loss 21293372
esv3644699 CNV loss 21293372
esv3556569 CNV deletion 23714750
esv2718790 CNV deletion 23290073
esv2718789 CNV deletion 23290073
esv2718788 CNV deletion 23290073
esv2718787 CNV deletion 23290073
esv2718786 CNV deletion 23290073
esv2662022 CNV deletion 23128226
esv2658669 CNV deletion 23128226
esv2545014 CNV deletion 19546169
dgv659e199 CNV deletion 23128226
dgv228e215 CNV deletion 23714750

Variation tolerance for ZNF701 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF701 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF701 Gene

Disorders for ZNF701 Gene

Relevant External Links for ZNF701

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF701 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF701 Gene

Publications for ZNF701 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  5. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung ML … Jeang KT (The Journal of biological chemistry 2009) 3 60

Products for ZNF701 Gene

Sources for ZNF701 Gene

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