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Aliases for ZNF700 Gene

Aliases for ZNF700 Gene

  • Zinc Finger Protein 700 2 3 5

External Ids for ZNF700 Gene

Previous GeneCards Identifiers for ZNF700 Gene

  • GC19P011884
  • GC19P012035
  • GC19P011610

Summaries for ZNF700 Gene

GeneCards Summary for ZNF700 Gene

ZNF700 (Zinc Finger Protein 700) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF440.

UniProtKB/Swiss-Prot for ZNF700 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF700 Gene

Genomics for ZNF700 Gene

Regulatory Elements for ZNF700 Gene

Enhancers for ZNF700 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F012781 1.6 FANTOM5 ENCODE 64.9 +864.2 864230 16.0 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF136 CCDC130 ZNF564 ZNF442 ZNF844 ZNF44 WDR83OS ZNF799 TRMT1 ZNF625
GH19F011528 0.6 ENCODE 51.9 -396.1 -396127 1.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 ZNF700 ZNF44 ZNF136 PRKCSH ZNF799 ZNF878 ZNF763 ZNF627 SWSAP1 ZNF440
GH19F011420 1.1 Ensembl ENCODE 45.5 -503.2 -503225 3.1 ATF1 PKNOX1 ZNF493 ZFP64 SIN3A DMAP1 ZNF48 ETS1 ZNF121 GLIS2 ZNF627 ZNF136 ZNF442 ZNF844 ZNF625 ZNF44 ZNF799 ZNF763 ZNF441 ZNF491
GH19F011317 0.5 Ensembl ENCODE 45.5 -603.4 -603386 9.0 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D ZNF627 ZNF136 ZNF844 ZNF625 ENSG00000267174 ZNF44 ZNF441 ZNF491 ZNF700 ZNF763
GH19F011531 1.5 FANTOM5 Ensembl ENCODE 45.5 -392.6 -392630 1.6 PKNOX1 ATF1 ZFP64 ZNF493 FOS ZNF202 ZNF263 REST ZNF518A ZNF623 ZNF627 ZNF136 ZNF844 ZNF442 ZNF625 ZNF44 ZNF799 ZNF441 ZNF491 ZNF700
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF700 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF700 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000641037 32 2601 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS SP3

Genomic Location for ZNF700 Gene

Chromosome:
19
Start:
11,925,068 bp from pter
End:
11,950,773 bp from pter
Size:
25,706 bases
Orientation:
Plus strand

Genomic View for ZNF700 Gene

Genes around ZNF700 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF700 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF700 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF700 Gene

Proteins for ZNF700 Gene

  • Protein details for ZNF700 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0M5-ZN700_HUMAN
    Recommended name:
    Zinc finger protein 700
    Protein Accession:
    Q9H0M5
    Secondary Accessions:
    • B9EGU4

    Protein attributes for ZNF700 Gene

    Size:
    742 amino acids
    Molecular mass:
    86232 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF700 Gene

Post-translational modifications for ZNF700 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF700 Gene

No data available for DME Specific Peptides for ZNF700 Gene

Domains & Families for ZNF700 Gene

Gene Families for ZNF700 Gene

Suggested Antigen Peptide Sequences for ZNF700 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0M5

UniProtKB/Swiss-Prot:

ZN700_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 18 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 18 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF700: view

Function for ZNF700 Gene

Molecular function for ZNF700 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF700 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF700: view

Phenotypes for ZNF700 Gene

GenomeRNAi human phenotypes for ZNF700:
genes like me logo Genes that share phenotypes with ZNF700: view

Animal Model Products

miRNA for ZNF700 Gene

miRTarBase miRNAs that target ZNF700

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF700 Gene

Localization for ZNF700 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF700 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF700 Gene COMPARTMENTS Subcellular localization image for ZNF700 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF700 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF700: view

Pathways & Interactions for ZNF700 Gene

SuperPathways for ZNF700 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF700: view

Pathways by source for ZNF700 Gene

2 Reactome pathways for ZNF700 Gene

Interacting Proteins for ZNF700 Gene

Gene Ontology (GO) - Biological Process for ZNF700 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF700: view

No data available for SIGNOR curated interactions for ZNF700 Gene

Transcripts for ZNF700 Gene

mRNA/cDNA for ZNF700 Gene

Unigene Clusters for ZNF700 Gene

Zinc finger protein 700:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF700 Gene

No ASD Table

Relevant External Links for ZNF700 Gene

GeneLoc Exon Structure for
ZNF700
ECgene alternative splicing isoforms for
ZNF700

Expression for ZNF700 Gene

mRNA expression in normal human tissues for ZNF700 Gene

Protein differential expression in normal tissues from HIPED for ZNF700 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF700 Gene



Protein tissue co-expression partners for ZNF700 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF700 Gene:

ZNF700

SOURCE GeneReport for Unigene cluster for ZNF700 Gene:

Hs.528486
genes like me logo Genes that share expression patterns with ZNF700: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF700 Gene

Orthologs for ZNF700 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF700 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF700 35
  • 99 (a)
OneToOne
LOC100614631 34
  • 98.37 (n)
rat
(Rattus norvegicus)
Mammalia LOC102550944 34
  • 67.92 (n)
mouse
(Mus musculus)
Mammalia Gm19428 34
  • 67.87 (n)
Gm7762 16
cow
(Bos Taurus)
Mammalia -- 35
  • 50 (a)
ManyToMany
Species where no ortholog for ZNF700 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF700 Gene

ENSEMBL:
Gene Tree for ZNF700 (if available)
TreeFam:
Gene Tree for ZNF700 (if available)

Paralogs for ZNF700 Gene

(536) SIMAP similar genes for ZNF700 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF700 Gene

genes like me logo Genes that share paralogs with ZNF700: view

Variants for ZNF700 Gene

Sequence variations from dbSNP and Humsavar for ZNF700 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10404066 -- 11,923,791(+) CGATG(C/G)GGTGA intron-variant, upstream-variant-2KB
rs10407721 -- 11,930,721(+) CCAGA(C/T)TGGGT intron-variant
rs10413462 -- 11,943,821(+) ggaga(A/C)taagt intron-variant
rs1082499 -- 11,950,898(+) ctgta(A/C)tccca intron-variant, downstream-variant-500B
rs1082500 -- 11,950,940(+) gaggt(C/G)aagag intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZNF700 Gene

Variant ID Type Subtype PubMed ID
dgv3428n100 CNV gain 25217958
dgv3429n100 CNV loss 25217958
dgv623e199 CNV deletion 23128226
dgv6268n54 CNV loss 21841781
dgv6269n54 CNV loss 21841781
esv23756 CNV loss 19812545
esv2660126 CNV deletion 23128226
esv2662395 CNV deletion 23128226
esv2718185 CNV deletion 23290073
esv2718187 CNV deletion 23290073
esv2718188 CNV deletion 23290073
esv2718189 CNV deletion 23290073
esv3096012 CNV deletion 24192839
esv3556034 CNV deletion 23714750
esv3556035 CNV deletion 23714750
esv3583245 CNV loss 25503493
esv3643677 CNV gain 21293372
esv3643684 CNV loss 21293372
esv3643685 CNV gain 21293372
esv3643686 CNV loss 21293372
esv3643687 CNV gain 21293372
nsv1076465 CNV duplication 25765185
nsv2417 CNV deletion 18451855
nsv482215 CNV gain 20164927
nsv507887 OTHER sequence alteration 20534489
nsv525966 CNV gain 19592680
nsv578619 CNV loss 21841781
nsv960791 CNV duplication 23825009

Variation tolerance for ZNF700 Gene

Residual Variation Intolerance Score: 29.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.79; 66.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF700 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF700

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF700 Gene

Disorders for ZNF700 Gene

Relevant External Links for ZNF700

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF700

No disorders were found for ZNF700 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF700 Gene

Publications for ZNF700 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  2. Diagnostic potential of zinc finger protein-specific autoantibodies and associated linear B-cell epitopes in colorectal cancer. (PMID: 25875936) O'Reilly J.A. … Kijanka G.S. (PLoS ONE 2015) 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZNF700 Gene

Sources for ZNF700 Gene

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