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Aliases for ZNF70 Gene

Aliases for ZNF70 Gene

  • Zinc Finger Protein 70 2 3
  • Zinc Finger Protein N27C7-1 3 4
  • Zinc Finger Protein 70 (Cos17) 2
  • Cos17 3

External Ids for ZNF70 Gene

Previous GeneCards Identifiers for ZNF70 Gene

  • GC22U990055
  • GC22M022408
  • GC22M024083
  • GC22M007071

Summaries for ZNF70 Gene

GeneCards Summary for ZNF70 Gene

ZNF70 (Zinc Finger Protein 70) is a Protein Coding gene. Among its related pathways are Gene Expression. An important paralog of this gene is ZNF648.

UniProtKB/Swiss-Prot for ZNF70 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF70 Gene

Genomics for ZNF70 Gene

Regulatory Elements for ZNF70 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF70 Gene

Chromosome:
22
Start:
23,738,678 bp from pter
End:
23,751,092 bp from pter
Size:
12,415 bases
Orientation:
Minus strand

Genomic View for ZNF70 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for ZNF70 Gene

Proteins for ZNF70 Gene

  • Protein details for ZNF70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UC06-ZNF70_HUMAN
    Recommended name:
    Zinc finger protein 70
    Protein Accession:
    Q9UC06

    Protein attributes for ZNF70 Gene

    Size:
    446 amino acids
    Molecular mass:
    50802 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF70 Gene

Proteomics data for ZNF70 Gene at MOPED

Post-translational modifications for ZNF70 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF70 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF70 Gene

Domains & Families for ZNF70 Gene

Gene Families for ZNF70 Gene

Protein Domains for ZNF70 Gene

Suggested Antigen Peptide Sequences for ZNF70 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UC06

UniProtKB/Swiss-Prot:

ZNF70_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF70: view

Function for ZNF70 Gene

Molecular function for ZNF70 Gene

GENATLAS Biochemistry:
zinc finger protein 70 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF70: view

Phenotypes for ZNF70 Gene

GenomeRNAi human phenotypes for ZNF70:
genes like me logo Genes that share phenotypes with ZNF70: view

Animal Model Products

CRISPR Products

miRNA for ZNF70 Gene

miRTarBase miRNAs that target ZNF70

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF70 Gene

Localization for ZNF70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF70 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF70 Gene COMPARTMENTS Subcellular localization image for ZNF70 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF70: view

Pathways & Interactions for ZNF70 Gene

SuperPathways for ZNF70 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF70: view

Pathways by source for ZNF70 Gene

2 Reactome pathways for ZNF70 Gene

Gene Ontology (GO) - Biological Process for ZNF70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF70: view

No data available for SIGNOR curated interactions for ZNF70 Gene

Drugs & Compounds for ZNF70 Gene

No Compound Related Data Available

Transcripts for ZNF70 Gene

mRNA/cDNA for ZNF70 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF70 Gene

Zinc finger protein 70:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF70 Gene

No ASD Table

Relevant External Links for ZNF70 Gene

GeneLoc Exon Structure for
ZNF70
ECgene alternative splicing isoforms for
ZNF70

Expression for ZNF70 Gene

mRNA expression in normal human tissues for ZNF70 Gene

SOURCE GeneReport for Unigene cluster for ZNF70 Gene Hs.382874

genes like me logo Genes that share expression patterns with ZNF70: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF70 Gene

Orthologs for ZNF70 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF70 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF70 35
  • 76.53 (n)
  • 78.7 (a)
ZNF70 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF70 35
  • 86.85 (n)
  • 91.03 (a)
ZNF70 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF70 35
  • 99.25 (n)
  • 99.78 (a)
ZNF70 36
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ZNF70 36
  • 10 (a)
OneToOne
Species with no ortholog for ZNF70:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF70 Gene

ENSEMBL:
Gene Tree for ZNF70 (if available)
TreeFam:
Gene Tree for ZNF70 (if available)

Paralogs for ZNF70 Gene

Paralogs for ZNF70 Gene

(489) SIMAP similar genes for ZNF70 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF70 Gene

genes like me logo Genes that share paralogs with ZNF70: view

Variants for ZNF70 Gene

Sequence variations from dbSNP and Humsavar for ZNF70 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs738788 -- 23,748,182(+) CCTCA(A/G)AAAAA intron-variant
rs2067621 -- 23,743,667(+) AGTGG(G/T)ATGTT utr-variant-3-prime
rs2070451 -- 23,745,132(+) GGGGG(A/C)ACCTC synonymous-codon, reference
rs2096524 -- 23,750,952(+) CTCAG(A/G)TCACA utr-variant-5-prime
rs2275976 -- 23,743,803(+) TTCTA(C/T)AGCTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNF70 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
dgv4906n71 CNV Gain 21882294

Variation tolerance for ZNF70 Gene

Residual Variation Intolerance Score: 13.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF70 Gene

HapMap Linkage Disequilibrium report
ZNF70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF70 Gene

Disorders for ZNF70 Gene

Relevant External Links for ZNF70

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF70
genes like me logo Genes that share disorders with ZNF70: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF70 Gene

Publications for ZNF70 Gene

  1. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). (PMID: 1639391) Aubry M. … Rouleau G.A. (Genomics 1992) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 67

Products for ZNF70 Gene

Sources for ZNF70 Gene

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