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Aliases for ZNF70 Gene

Aliases for ZNF70 Gene

  • Zinc Finger Protein 70 2 3 5
  • Zinc Finger Protein N27C7-1 3 4
  • Zinc Finger Protein 70 (Cos17) 2
  • Cos17 3

External Ids for ZNF70 Gene

Previous GeneCards Identifiers for ZNF70 Gene

  • GC22U990055
  • GC22M022408
  • GC22M024083
  • GC22M007071

Summaries for ZNF70 Gene

GeneCards Summary for ZNF70 Gene

ZNF70 (Zinc Finger Protein 70) is a Protein Coding gene. Among its related pathways are Gene Expression.

UniProtKB/Swiss-Prot for ZNF70 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF70 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF70 Gene

Genomics for ZNF70 Gene

Regulatory Elements for ZNF70 Gene

Enhancers for ZNF70 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H024632 1.2 Ensembl ENCODE 46 -882.0 -882010 1 HDGF ARNT GLI4 TCF12 ZNF121 ZNF207 ZNF488 ZNF662 MEF2D ZNF184 SPECC1L ENSG00000272977 ZNF70 ENSG00000272578 SMARCB1 ENSG00000232545 GGT1 MIF-AS1 CRYBB2P1 SNRPD3
GH22H024242 1.6 FANTOM5 Ensembl ENCODE 34.3 -494.1 -494137 6 HDGF ARNT ZNF493 ZFP64 ARID4B SIN3A GLI4 ZBTB7B ZNF207 ZNF143 ENSG00000272578 ZNF70 SPECC1L POM121L9P ENSG00000232545 ENSG00000272973 SNRPD3 MIF-AS1 RN7SL268P SUSD2
GH22H024548 2 FANTOM5 Ensembl ENCODE dbSUPER 22.6 -802.4 -802370 8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A SPECC1L ENSG00000272973 ZNF70 SGSM1 UPB1 ADORA2A LOC100421614 ARL5AP4 CRIP1P4 RPS10P29
GH22H024010 1.4 ENCODE dbSUPER 26.5 -260.6 -260551 2 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 ZNF207 FOS ENSG00000272973 ZDHHC8P1 ZNF70 SPECC1L MIF-AS1 SNRPD3 SUSD2 RN7SL268P GNAZ ENSG00000272578
GH22H022901 1.1 ENCODE dbSUPER 30 +848.3 848262 2 HNRNPUL1 TBL1XR1 RB1 BACH1 BMI1 EBF1 EGR1 POLR2A EED NFE2 ZNF70 MMP11 TOP3B MIF-AS1 IGLC2 IGLV2-5 IGLV3-4 IGLC7 IGLV10-54 IGLJ3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF70 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF70 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000144282 92 1601 ZFP64 SIN3A ZNF2 ZBTB7B YY1 GLIS2 ELK1 ZNF207 ZNF143 KLF7

Genomic Location for ZNF70 Gene

Chromosome:
22
Start:
23,738,678 bp from pter
End:
23,751,092 bp from pter
Size:
12,415 bases
Orientation:
Minus strand

Genomic View for ZNF70 Gene

Genes around ZNF70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF70 Gene

Proteins for ZNF70 Gene

  • Protein details for ZNF70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UC06-ZNF70_HUMAN
    Recommended name:
    Zinc finger protein 70
    Protein Accession:
    Q9UC06

    Protein attributes for ZNF70 Gene

    Size:
    446 amino acids
    Molecular mass:
    50802 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF70 Gene

Post-translational modifications for ZNF70 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF70 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF70 Gene

Domains & Families for ZNF70 Gene

Gene Families for ZNF70 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF70 Gene

Suggested Antigen Peptide Sequences for ZNF70 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UC06

UniProtKB/Swiss-Prot:

ZNF70_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF70: view

Function for ZNF70 Gene

Molecular function for ZNF70 Gene

GENATLAS Biochemistry:
zinc finger protein 70 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF70: view
genes like me logo Genes that share phenotypes with ZNF70: view

Animal Model Products

CRISPR Products

miRNA for ZNF70 Gene

miRTarBase miRNAs that target ZNF70

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF70
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF70 Gene

Localization for ZNF70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF70 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF70 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF70: view

Pathways & Interactions for ZNF70 Gene

SuperPathways for ZNF70 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF70: view

Pathways by source for ZNF70 Gene

2 Reactome pathways for ZNF70 Gene

Gene Ontology (GO) - Biological Process for ZNF70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF70: view

No data available for SIGNOR curated interactions for ZNF70 Gene

Drugs & Compounds for ZNF70 Gene

No Compound Related Data Available

Transcripts for ZNF70 Gene

mRNA/cDNA for ZNF70 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF70 Gene

Zinc finger protein 70:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF70
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF70 Gene

No ASD Table

Relevant External Links for ZNF70 Gene

GeneLoc Exon Structure for
ZNF70
ECgene alternative splicing isoforms for
ZNF70

Expression for ZNF70 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF70 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF70 Gene:

ZNF70

SOURCE GeneReport for Unigene cluster for ZNF70 Gene:

Hs.382874

Evidence on tissue expression from TISSUES for ZNF70 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with ZNF70: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF70 Gene

Orthologs for ZNF70 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF70 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF70 33 34
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia ZNF70 33 34
  • 86.85 (n)
cow
(Bos Taurus)
Mammalia ZNF70 33 34
  • 76.53 (n)
zebrafish
(Danio rerio)
Actinopterygii ZNF70 34
  • 10 (a)
OneToOne
Species where no ortholog for ZNF70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF70 Gene

ENSEMBL:
Gene Tree for ZNF70 (if available)
TreeFam:
Gene Tree for ZNF70 (if available)

Paralogs for ZNF70 Gene

(489) SIMAP similar genes for ZNF70 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF70: view

No data available for Paralogs for ZNF70 Gene

Variants for ZNF70 Gene

Sequence variations from dbSNP and Humsavar for ZNF70 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000402895 -- 23,750,991(+) CCGGG(A/G)CGGGG utr-variant-5-prime
rs1000406583 -- 23,752,297(+) GCGCT(C/T)GAGTG downstream-variant-500B, upstream-variant-2KB
rs1000423977 -- 23,746,891(+) TCTCA(C/G)ACTGC intron-variant
rs1000465349 -- 23,751,137(+) GCACC(C/G)AGAGC upstream-variant-2KB
rs1001007253 -- 23,745,879(+) GGAAA(C/G)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF70 Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv2724041 CNV deletion 23290073
esv3575443 CNV gain 25503493
esv3893457 CNV gain 25118596
esv3893461 CNV gain 25118596
nsv1062411 CNV gain 25217958
nsv1066891 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv526567 CNV gain 19592680
nsv7350 OTHER inversion 18451855

Variation tolerance for ZNF70 Gene

Residual Variation Intolerance Score: 13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF70 Gene

Disorders for ZNF70 Gene

Relevant External Links for ZNF70

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF70

No disorders were found for ZNF70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF70 Gene

Publications for ZNF70 Gene

  1. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). (PMID: 1639391) Aubry M … Rouleau GA (Genomics 1992) 2 3 4 60
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression. (PMID: 27353377) Watanabe K … Iwamoto S (Biochemical and biophysical research communications 2016) 3 60

Products for ZNF70 Gene

Sources for ZNF70 Gene

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