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ZNF70 Gene

protein-coding   GIFtS: 45
GCID: GC22M024083

Zinc Finger Protein 70

(Previous name: zinc finger protein 70 (Cos17))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 701 2
Zinc Finger Protein N27C7-12 3
Zinc Finger Protein 70 (Cos17)1
Cos172

External Ids:    HGNC: 131401   Entrez Gene: 76212   Ensembl: ENSG000001877927   OMIM: 1945445   UniProtKB: Q9UC063   

Export aliases for ZNF70 gene to outside databases

Previous GC identifers: GC22U990055 GC22M022408 GC22M007071


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF70 Gene:
ZNF70 (zinc finger protein 70) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF648.

UniProtKB/Swiss-Prot: ZNF70_HUMAN, Q9UC06
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF70 gene promoter:
         AML1a   LCR-F1   HEN1   RORalpha1   c-Rel   FOXJ2 (long isoform)   FOXJ2   Pax-4a   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF70 promoter sequence
   Search Chromatin IP Primers for ZNF70

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF70


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23   Ensembl cytogenetic band:  22q11.23   HGNC cytogenetic band: 22q11.23

ZNF70 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF70 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M024083:  view genomic region     (about GC identifiers)

Start:
24,083,769 bp from pter      End:
24,093,279 bp from pter
Size:
9,511 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZNF70_HUMAN, Q9UC06 (See protein sequence)
Recommended Name: Zinc finger protein 70  
Size: 446 amino acids; 50802 Da

Explore the universe of human proteins at neXtProt for ZNF70: NX_Q9UC06

Explore proteomics data for ZNF70 at MOPED


See ZNF70 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_068735.1  
ENSEMBL proteins: 
 ENSP00000339314  
Reactome Protein details: Q9UC06

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ZNF: Zinc fingers, C2H2-type

3 InterPro protein domains:
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q9UC06

ProtoNet protein and cluster: Q9UC06

UniProtKB/Swiss-Prot: ZNF70_HUMAN, Q9UC06
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 11 C2H2-type zinc fingers


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(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZNF70_HUMAN, Q9UC06
Function: May be involved in transcriptional regulation

     Genatlas biochemistry entry for ZNF70:
zinc finger protein 70 (C2H2 type,Kruppel-like)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0003700sequence-specific DNA binding transcription factor activity ----
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with ZNF70           About GenesLikeMe


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SwitchGear 3'UTR luciferase reporter plasmidZNF70 3' UTR sequence
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZNF70_HUMAN, Q9UC06: Nucleus (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ZNF70 About    
See pathways by source

SuperPathContained pathways About
1Gene Expression
Generic Transcription Pathway0.40
Gene Expression0.40


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Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for ZNF70
    Generic Transcription Pathway


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Interactions:

    Search GeneGlobe Interaction Network for ZNF70

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ZNF70 (Q9UC063 ENSP000003393144) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ZFP64Q9NPA53, ENSP000002169234I2D: score=1 STRING: ENSP00000216923
About this table

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ZNF70



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZNF70 gene: 
NM_021916.2  

Unigene Cluster for ZNF70:

Zinc finger protein 70
Hs.382874  [show with all ESTs]
Unigene Representative Sequence: NM_021916
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000341976(uc002zxs.3)
miRNA
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hsa-miR-4254 hsa-miR-4311 hsa-miR-106a hsa-miR-583 hsa-miR-1276 hsa-miR-629* hsa-miR-1323 hsa-miR-93
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  QuantiFast Probe-based Assays in human, mouse, rat ZNF70

Additional mRNA sequence: 

AK122721.1 AK126511.1 BC040161.1 CR456615.1 

2 DOTS entries:

DT.100019675  DT.100019676 

Selected AceView cDNA sequences (see all 27):

BX103774 AW188095 CR456615 NM_021916 CA431484 BU584335 BX095903 AF086087 
AK122721 BU584117 BC040161 BM558840 AK126511 BG387590 BQ048937 AA379563 
BU584118 BU584630 AI040613 BE884024 BU585004 BE261478 AA379689 N62996 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF70 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGAAAGCCAT
ZNF70 Expression
About this image

ZNF70 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF70 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.382874
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF70

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ZNF70 gene from Selected species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia ZNF701 zinc finger protein 70 86.85(n)
91.03(a)
  486410  XM_005636562.1  XP_005636619.1 
zebrafish
(Danio rerio)
Actinopterygii ZNF706
zinc finger protein 70
10(a)
1 ↔ 1
16(26973034-26980693) ENSDARG00000078018


ENSEMBL Gene Tree for ZNF70 (if available)
TreeFam Gene Tree for ZNF70 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF70 gene
ZNF6482  
Selected SIMAP similar genes for ZNF70 using alignment to 1 protein entry:     ZNF70_HUMAN(see all similar genes):
DKFZp686M04222    DKFZp686N14223    ZNF566    ZNF3    ZSCAN16    DKFZp762K012
HZF36    ZNF383    DKFZp686H10254    HZF30    ZNF211    ZNF331
ZNF485    ZNF662    ZNF702P    ZSCAN21    DKFZp666C237    ZNF146

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1 Pseudogenes.org Pseudogene for ZNF70
PGOHUM00000243592


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF70 (see all 296)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs797714781,2
F--24083353(+) CTGGGG/ATGTGC 1 -- int11Minor allele frequency- A:0.03WA 118
rs1398924331,2
--24083388(+) AAAGAC/TAGGTA 1 -- int10--------
rs57599841,2
C,H--24083503(+) TCCTAG/ACATTC 1 -- int14Minor allele frequency- A:0.00NS EA 416
rs1928573201,2
--24083557(+) TTGCAA/GGCAAT 1 -- int10--------
rs1432607661,2
--24083762(+) ACTTAA/GTAACA 1 -- int10--------
rs1838016611,2
--24083789(+) GTTTAC/TTCATC 1 -- ut310--------
rs1876033301,2
--24083847(+) CCAGTA/GTTACC 1 -- ut310--------
rs1925810531,2
--24083865(+) GTTCAC/TGTTAG 1 -- ut310--------
rs96124131,2
C,F,H--24083873(+) TAGCCC/TAGCCA 1 -- ut3116Minor allele frequency- T:0.13NS EA NA WA 2338
rs1834538131,2
--24083937(+) CTGAGA/GAGCCC 1 -- ut310--------

HapMap Linkage Disequilibrium report for ZNF70 (24083769 - 24093279 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for ZNF70:    About this table    
Variant IDTypeSubtypePubMed ID
esv2724041CNV Deletion23290073
nsv526567CNV Gain19592680
dgv4906n71CNV Gain21882294
nsv7350OTHER Inversion18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 194544    OMIM disorders: --


Find genes that share disorders with ZNF70           About GenesLikeMe


Export disorders for ZNF70 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF70 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF70)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). (PubMed id 1639391)1, 2, 3 Aubry M.... Rouleau G.A. (Genomics 1992)
  2. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  7. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7621 HGNC: 13140 AceView: ZNF70 Ensembl:ENSG00000187792 euGenes: HUgn7621
ECgene: ZNF70 H-InvDB: ZNF70

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF70 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF70 gene:
Search GeneIP for patents involving ZNF70

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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