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Aliases for ZNF70 Gene

Aliases for ZNF70 Gene

  • Zinc Finger Protein 70 2 3 5
  • Zinc Finger Protein N27C7-1 3 4
  • Zinc Finger Protein 70 (Cos17) 2
  • Cos17 3

External Ids for ZNF70 Gene

Previous GeneCards Identifiers for ZNF70 Gene

  • GC22U990055
  • GC22M022408
  • GC22M024083
  • GC22M007071

Summaries for ZNF70 Gene

GeneCards Summary for ZNF70 Gene

ZNF70 (Zinc Finger Protein 70) is a Protein Coding gene. Among its related pathways are Gene Expression.

UniProtKB/Swiss-Prot for ZNF70 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF70 Gene

Genomics for ZNF70 Gene

Regulatory Elements for ZNF70 Gene

Enhancers for ZNF70 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F022899 0.9 Ensembl ENCODE 33.6 +849.3 849288 4.8 TBL1XR1 WRNIP1 BMI1 ZNF335 GLIS2 EGR1 ZNF548 ZNF263 MCM3 CEBPZ ZNF70 IGLC2 IGLV3-4 IGLV2-5 IGLV5-52 ENSG00000272779 IGLC7 IGLJ2 IGLC5 IGLV10-54
GH22F022800 0.2 ENCODE 31.9 +950.2 950165 0.2 ZFP64 ZNF140 ZNF266 ZNF101 ZNF664 ZNF791 ZNF138 ZNF433 ZNF639 ZNF654 IGLV5-52 ENSG00000234630 ENSG00000272779 ZNF70 ENSG00000272578 IGLV2-5 IGLV3-4 ZDHHC8P1 GNAZ ENSG00000274381
GH22F024548 1.2 FANTOM5 Ensembl ENCODE 29 -802.4 -802370 8.9 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF70 SNRPD3 GGTLC4P POM121L9P MIF-AS1 ARL5AP4 LOC100421614 CRIP1P4 RPS10P29 ENSG00000228039
GH22F023278 1.6 FANTOM5 Ensembl ENCODE 23.2 +470.0 470047 5.8 HDGF ATF1 PKNOX1 CREB3L1 ARID4B YBX1 ZNF48 ZNF2 GLIS2 ZNF143 ZNF70 RAB36 FBXW4P1 RSPH14 IGLV5-52 ENSG00000272779 BCR PIR39869 GC22P023342
GH22F023716 1.1 ENCODE 22.7 +33.9 33864 1.4 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF70 ENSG00000234353 VPREB3 C22orf15 RGL4 CHCHD10 MMP11 SNRPD3 SMARCB1 GGTLC4P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF70 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF70 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001531511 92 2001 ATF1 PKNOX1 CREB3L1 ZFP64 SIN3A ZNF48 ZNF2 YY1 GTF3C2 ZNF766

Genomic Location for ZNF70 Gene

Chromosome:
22
Start:
23,738,678 bp from pter
End:
23,751,092 bp from pter
Size:
12,415 bases
Orientation:
Minus strand

Genomic View for ZNF70 Gene

Genes around ZNF70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF70 Gene

Proteins for ZNF70 Gene

  • Protein details for ZNF70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UC06-ZNF70_HUMAN
    Recommended name:
    Zinc finger protein 70
    Protein Accession:
    Q9UC06

    Protein attributes for ZNF70 Gene

    Size:
    446 amino acids
    Molecular mass:
    50802 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF70 Gene

Post-translational modifications for ZNF70 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF70 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF70 Gene

Domains & Families for ZNF70 Gene

Gene Families for ZNF70 Gene

Protein Domains for ZNF70 Gene

Suggested Antigen Peptide Sequences for ZNF70 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UC06

UniProtKB/Swiss-Prot:

ZNF70_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF70: view

Function for ZNF70 Gene

Molecular function for ZNF70 Gene

GENATLAS Biochemistry:
zinc finger protein 70 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF70: view
genes like me logo Genes that share phenotypes with ZNF70: view

Animal Model Products

miRNA for ZNF70 Gene

miRTarBase miRNAs that target ZNF70

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF70 Gene

Localization for ZNF70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF70 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF70 Gene COMPARTMENTS Subcellular localization image for ZNF70 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ZNF70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF70: view

Pathways & Interactions for ZNF70 Gene

SuperPathways for ZNF70 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF70: view

Pathways by source for ZNF70 Gene

2 Reactome pathways for ZNF70 Gene

Gene Ontology (GO) - Biological Process for ZNF70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF70: view

No data available for SIGNOR curated interactions for ZNF70 Gene

Transcripts for ZNF70 Gene

mRNA/cDNA for ZNF70 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF70 Gene

Zinc finger protein 70:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF70 Gene

No ASD Table

Relevant External Links for ZNF70 Gene

GeneLoc Exon Structure for
ZNF70
ECgene alternative splicing isoforms for
ZNF70

Expression for ZNF70 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF70 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF70 Gene:

ZNF70

SOURCE GeneReport for Unigene cluster for ZNF70 Gene:

Hs.382874
genes like me logo Genes that share expression patterns with ZNF70: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF70 Gene

Orthologs for ZNF70 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF70 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF70 34 35
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia ZNF70 34 35
  • 86.85 (n)
cow
(Bos Taurus)
Mammalia ZNF70 34 35
  • 76.53 (n)
zebrafish
(Danio rerio)
Actinopterygii ZNF70 35
  • 10 (a)
OneToOne
Species where no ortholog for ZNF70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF70 Gene

ENSEMBL:
Gene Tree for ZNF70 (if available)
TreeFam:
Gene Tree for ZNF70 (if available)

Paralogs for ZNF70 Gene

(489) SIMAP similar genes for ZNF70 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF70: view

No data available for Paralogs for ZNF70 Gene

Variants for ZNF70 Gene

Sequence variations from dbSNP and Humsavar for ZNF70 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10470287 -- 23,750,961(+) CACCG(A/G)CGGAC utr-variant-5-prime
rs10470288 -- 23,751,102(+) CAGCA(A/G)CTGCT upstream-variant-2KB
rs111550650 -- 23,752,601(+) AATAG(C/T)CTCAG downstream-variant-500B, upstream-variant-2KB
rs111628598 -- 23,745,111(+) GTCTC(A/G)CCAAA reference, synonymous-codon
rs112294375 -- 23,744,163(+) TTGCG(A/G)TGCTC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNF70 Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv2724041 CNV deletion 23290073
esv3575443 CNV gain 25503493
esv3893457 CNV gain 25118596
esv3893461 CNV gain 25118596
nsv1062411 CNV gain 25217958
nsv1066891 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv526567 CNV gain 19592680
nsv7350 OTHER inversion 18451855

Variation tolerance for ZNF70 Gene

Residual Variation Intolerance Score: 13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF70 Gene

Disorders for ZNF70 Gene

Relevant External Links for ZNF70

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF70

No disorders were found for ZNF70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF70 Gene

Publications for ZNF70 Gene

  1. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). (PMID: 1639391) Aubry M. … Rouleau G.A. (Genomics 1992) 2 3 4 64
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3 64

Products for ZNF70 Gene

Sources for ZNF70 Gene

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