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Aliases for ZNF7 Gene

Aliases for ZNF7 Gene

  • Zinc Finger Protein 7 2 3 5
  • Zinc Finger Protein 7 (KOX 4, Clone HF.16) 2 3
  • Zinc Finger Protein HF.16 3 4
  • Zinc Finger Protein KOX4 3 4
  • KOX4 3 4
  • C2-H2 Type Zinc Finger Protein 3
  • Zinc Finger Protein-7 (KOX4) 3
  • Zinc Finger Protein Zfp30 3
  • HF.16 3
  • Zf30 3

External Ids for ZNF7 Gene

Previous GeneCards Identifiers for ZNF7 Gene

  • GC08P143660
  • GC08P146090
  • GC08P145633
  • GC08P146057
  • GC08P146023
  • GC08P146052
  • GC08P141168

Summaries for ZNF7 Gene

GeneCards Summary for ZNF7 Gene

ZNF7 (Zinc Finger Protein 7) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF251.

UniProtKB/Swiss-Prot for ZNF7 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF7 Gene

Genomics for ZNF7 Gene

Regulatory Elements for ZNF7 Gene

Enhancers for ZNF7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G144899 1.5 FANTOM5 ENCODE 11.1 +74.2 74156 3.5 HDGF PKNOX1 FOXA2 MLX CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 RPL8 ZNF250 ZNF252P ZNF252P-AS1 TMED10P1 ENSG00000255164 ZNF7 ZNF517 VPS28 ZNF251
GH08G144851 1.1 ENCODE 12.1 +25.6 25565 2.4 CREB3L1 AGO1 ARID4B SIN3A ZNF2 ZBTB7B YY1 SLC30A9 ZNF143 KLF13 RPL8 ZNF7 ZNF34 COMMD5 PIR55168
GH08G144877 1.1 Ensembl ENCODE 11.5 +51.2 51191 2.4 TBP PKNOX1 FOXA2 WRNIP1 BMI1 ZBTB40 ZNF366 RELB ETV6 IKZF2 RPL8 ZNF7 PIR34087 ZNF250
GH08G144848 0.9 ENCODE 12.6 +21.5 21472 1.7 ELF3 FOXA2 MLX AGO1 ARID4B DMAP1 ZSCAN9 RARA SLC30A9 CREM RPL8 ZNF7 ZNF517 SLC39A4 COMMD5 PIR55168
GH08G144948 1 ENCODE 10.7 +122.7 122736 2.6 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZBTB7B YY1 ETS1 ZNF252P ZNF7 C8orf33 SLC39A4 ZNF34 RPL8 ZNF250 GPT ZNF16 GC08M144931
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF7 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000232299 -64 2001 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF207 ZNF143

Genomic Location for ZNF7 Gene

Chromosome:
8
Start:
144,827,464 bp from pter
End:
144,847,509 bp from pter
Size:
20,046 bases
Orientation:
Plus strand

Genomic View for ZNF7 Gene

Genes around ZNF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF7 Gene

Proteins for ZNF7 Gene

  • Protein details for ZNF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17097-ZNF7_HUMAN
    Recommended name:
    Zinc finger protein 7
    Protein Accession:
    P17097
    Secondary Accessions:
    • B4DT08
    • D3DWN6
    • P17015
    • Q8N8Y4

    Protein attributes for ZNF7 Gene

    Size:
    686 amino acids
    Molecular mass:
    77887 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF7 Gene

Post-translational modifications for ZNF7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF7 Gene

Domains & Families for ZNF7 Gene

Gene Families for ZNF7 Gene

Graphical View of Domain Structure for InterPro Entry

P17097

UniProtKB/Swiss-Prot:

ZNF7_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF7: view

Function for ZNF7 Gene

Molecular function for ZNF7 Gene

GENATLAS Biochemistry:
zinc finger protein 7 (clone ZFP.16,KOX4),Kruppel-like
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,TAS --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF7: view
genes like me logo Genes that share phenotypes with ZNF7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF7 Gene

Localization for ZNF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF7 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ZNF7: view

Pathways & Interactions for ZNF7 Gene

No Data Available

Interacting Proteins for ZNF7 Gene

Selected Interacting proteins: P17097-ZNF7_HUMAN for ZNF7 Gene via IID

Gene Ontology (GO) - Biological Process for ZNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
GO:0007275 multicellular organism development TAS 2106481
genes like me logo Genes that share ontologies with ZNF7: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF7 Gene

Drugs & Compounds for ZNF7 Gene

No Compound Related Data Available

Transcripts for ZNF7 Gene

Unigene Clusters for ZNF7 Gene

Zinc finger protein 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - -

Relevant External Links for ZNF7 Gene

GeneLoc Exon Structure for
ZNF7
ECgene alternative splicing isoforms for
ZNF7

Expression for ZNF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF7 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF7 Gene:

ZNF7

SOURCE GeneReport for Unigene cluster for ZNF7 Gene:

Hs.493218

mRNA Expression by UniProt/SwissProt for ZNF7 Gene:

P17097-ZNF7_HUMAN
Tissue specificity: Ubiquitously present in many human cell lines of different embryological derivation.

Evidence on tissue expression from TISSUES for ZNF7 Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with ZNF7: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF7 Gene

Orthologs for ZNF7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF7 34 35
  • 99.09 (n)
dog
(Canis familiaris)
Mammalia ZNF7 34 35
  • 83.5 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910444 34
  • 81.41 (n)
cow
(Bos Taurus)
Mammalia ZNF7 34 35
  • 81 (n)
mouse
(Mus musculus)
Mammalia Zfp7 34 16 35
  • 76.73 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF7 35
  • 55 (a)
OneToOne
Species where no ortholog for ZNF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF7 Gene

ENSEMBL:
Gene Tree for ZNF7 (if available)
TreeFam:
Gene Tree for ZNF7 (if available)

Paralogs for ZNF7 Gene

Paralogs for ZNF7 Gene

(548) SIMAP similar genes for ZNF7 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ZNF7: view

Variants for ZNF7 Gene

Sequence variations from dbSNP and Humsavar for ZNF7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000025187 -- 144,839,454(+) CAGCC(A/G)CCCAT intron-variant, nc-transcript-variant
rs1000078481 -- 144,839,663(+) AGTCC(A/G)GGGCA intron-variant, nc-transcript-variant
rs1000119752 -- 144,838,619(+) GGGAA(C/G)CAAGT intron-variant, nc-transcript-variant
rs1000231786 -- 144,834,837(+) CCAGG(C/T)TCACG intron-variant
rs1000338509 -- 144,844,275(+) CCAAC(A/C)CCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF7 Gene

Variant ID Type Subtype PubMed ID
dgv3937n106 CNV deletion 24896259
esv2506190 CNV deletion 19546169
esv2674326 CNV deletion 23128226
esv3269274 CNV deletion 24192839
esv3544406 CNV deletion 23714750
esv3619142 CNV loss 21293372
nsv1023752 CNV gain 25217958
nsv1031737 CNV gain 25217958
nsv469809 CNV loss 16826518
nsv522459 CNV loss 19592680
nsv612969 CNV loss 21841781

Variation tolerance for ZNF7 Gene

Residual Variation Intolerance Score: 5.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF7 Gene

Disorders for ZNF7 Gene

Relevant External Links for ZNF7

Genetic Association Database (GAD)
ZNF7
Human Genome Epidemiology (HuGE) Navigator
ZNF7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF7

No disorders were found for ZNF7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF7 Gene

Publications for ZNF7 Gene

  1. cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes. (PMID: 2106481) Lania L. … Pelicci P.-G. (Genomics 1990) 2 3 4 64
  2. Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group. (PMID: 19795399) Malhotra A. … Hanson R.L. (Diabetes Metab. Res. Rev. 2009) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Characterization and mapping of human genes encoding zinc finger proteins. (PMID: 1946370) Bray P.L. … Dawid I.B. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 64

Products for ZNF7 Gene

Sources for ZNF7 Gene

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