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ZNF7 Gene

protein-coding   GIFtS: 54
GCID: GC08P146052

Zinc Finger Protein 7

(Previous names: zinc finger protein 7 (KOX 4, clone HF.16))
  Search for ZNF7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 71 2     HF.162
KOX42 3 5     C2-H2 Type Zinc Finger Protein2
Zinc Finger Protein 7 (KOX 4, Clone HF.16)1 2     zf302
Zinc Finger Protein HF.162 3     Zinc Finger Protein Zfp302
Zinc Finger Protein KOX42 3     Zinc Finger Protein-7 (KOX4)2

External Ids:    HGNC: 131391   Entrez Gene: 75532   Ensembl: ENSG000001477897   OMIM: 1945315   UniProtKB: P170973   

Export aliases for ZNF7 gene to outside databases

Previous GC identifers: GC08P143660 GC08P146090 GC08P145633 GC08P146057 GC08P146023 GC08P141168


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF7 Gene:
ZNF7 (zinc finger protein 7) is a protein-coding gene. An important paralog of this gene is ZNF334.

UniProtKB/Swiss-Prot: ZNF7_HUMAN, P17097
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF7 gene promoter:
         Elk-1   NRSF form 1   p300   Pax-6   STAT5A   NRSF form 2   GATA-1   C/EBPalpha   AREB6   Ik-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF7 promoter sequence
   Search Chromatin IP Primers for ZNF7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24

ZNF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF7 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P146052:  view genomic region     (about GC identifiers)

Start:
146,052,849 bp from pter      End:
146,072,894 bp from pter
Size:
20,046 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZNF7_HUMAN, P17097 (See protein sequence)
Recommended Name: Zinc finger protein 7  
Size: 686 amino acids; 77887 Da
Secondary accessions: D3DWN6 P17015

Explore the universe of human proteins at neXtProt for ZNF7: NX_P17097

Explore proteomics data for ZNF7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001269724.1  NP_001269725.1  NP_001269726.1  NP_003407.1  

    ENSEMBL proteins: 
     ENSP00000432641   ENSP00000393260   ENSP00000435252   ENSP00000318848   ENSP00000433630  
     ENSP00000433656   ENSP00000436231   ENSP00000432724   ENSP00000433218   ENSP00000320627  
     ENSP00000439424  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry P17097

    ProtoNet protein and cluster: P17097

    2 Blocks protein domains:
    IPB001909 KRAB box
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: ZNF7_HUMAN, P17097
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 15 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNF7_HUMAN, P17097
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for ZNF7:
    zinc finger protein 7 (clone ZFP.16,KOX4),Kruppel-like

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF7           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF7
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNF7_HUMAN, P17097: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF7
    Interactions:

        Search GeneGlobe Interaction Network for ZNF7

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ZNF7 (P170973 ENSP000003206274) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TADA3O755283, ENSP000003076844I2D: score=4 STRING: ENSP00000307684
    MAPK3P273613, ENSP000002630254I2D: score=3 STRING: ENSP00000263025
    RPL7P181243, ENSP000003397954I2D: score=3 STRING: ENSP00000339795
    GRB2ENSP000003390074STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--
    GO:0007275multicellular organismal development TAS2106481

    Find genes that share ontologies with ZNF7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF7 gene (4 alternative transcripts): 
    NM_001282795.1  NM_001282796.1  NM_001282797.1  NM_003416.3  

    Unigene Cluster for ZNF7:

    Zinc finger protein 7
    Hs.493218  [show with all ESTs]
    Unigene Representative Sequence: AB209619
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000532777 ENST00000532382 ENST00000446747 ENST00000525266(uc003zeh.2)
    ENST00000530776 ENST00000325217 ENST00000530682 ENST00000529767 ENST00000532051
    ENST00000533314 ENST00000527218 ENST00000529819 ENST00000532393 ENST00000530082
    ENST00000528372 ENST00000528130 ENST00000528017(uc003zek.4) ENST00000325241(uc003zeg.4 uc010mge.3 uc011lln.2)

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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF7
      QuantiFast Probe-based Assays in human, mouse, rat ZNF7

    Additional mRNA sequence: 

    AB209619.1 AF027146.1 AK022466.1 AK092477.1 AK096025.1 AK300001.1 AK301561.1 AK308002.1 
    AK313745.1 BC058923.1 BX647998.1 M29580.1 U71599.1 X52335.1 

    13 DOTS entries:

    DT.101983211  DT.111773  DT.40246869  DT.95118551  DT.95161771  DT.100012130  DT.102842581  DT.75193462 
    DT.120630986  DT.101983210  DT.91711591  DT.100819077  DT.86858394 

    Selected AceView cDNA sequences (see all 101):

    AA346649 BU180698 AU121729 CA394640 AA659725 CR625704 BX280317 BF197152 
    AU279993 AL534040 BQ053335 BG259605 BM857392 AU142758 BM469977 BC058923 
    X52335 BI964834 AI628903 BV190111 BG291385 NM_003416 BX642377 AU122660 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF7    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b
    SP1:                    -                 -           -                     
    SP2:                          -           -     -     -                     
    SP3:                    -     -                       -                     
    SP4:                    -     -                                             


    ECgene alternative splicing isoforms for ZNF7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATAGACCA
    ZNF7 Expression
    About this image


    ZNF7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Kidney (Urinary System)
             Metanephros
    ZNF7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.493218

    UniProtKB/Swiss-Prot: ZNF7_HUMAN, P17097
    Tissue specificity: Ubiquitously present in many human cell lines of different embryological derivation

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF7 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp71 , 5 zinc finger protein 71, 5 76.73(n)1
    71(a)1
      15 (36.28 cM)5
    2236691  NM_145916.21  NP_666021.21 
     768792765 


    ENSEMBL Gene Tree for ZNF7 (if available)
    TreeFam Gene Tree for ZNF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF7 gene
    ZNF3342  ZNF4202  ZNF780A2  ZNF6652  ZNF232  ZNF33A2  RBAK2  ZNF7172  
    ZNF302  ZNF5732  ZNF33B2  ZNF5402  ZNF2512  ZNF6052  ZNF842  ZNF1892  
    ZNF5712  ZNF6302  ZNF3372  ZNF2832  ZNF4042  ZNF1352  ZNF4842  ZNF122  
    ZNF3452  ZNF1842  ZNF6992  ZNF412  ZNF6152  ZNF4702  ZNF5692  
    Selected SIMAP similar genes for ZNF7 using alignment to 10 protein entries:     ZNF7_HUMAN (see all proteins) (see all similar genes):
    zf30    ZNF818P    ZNF83    ZNF320    ZNF78L1    ZNF525
    ZNF616    kr-znf3    ZNF677    ZNF331    ZNF721    ZNF28
    ZNF845    ZFP57    ZNF3    ZNF347    DKFZp666C237    ZFP41

    Find genes that share paralogs with ZNF7           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF7
    PGOHUM00000258379


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF7 (see all 681)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs17354331,2
    C,F,A,H--146050996(-) TTTAGA/GGCTTC 1 -- us2k125Minor allele frequency- G:0.45NS EA NA WA CSA 2487
    rs1891272121,2
    --146050999(+) GCTCTA/GAACGC 1 -- us2k10--------
    rs1181314931,2
    C,F--146051033(+) TCTTCC/TGGAAA 1 -- us2k11Minor allele frequency- T:0.02NA 120
    rs17351541,2
    C,F,H--146051158(+) ATTGGA/GCTCAG 1 -- us2k112Minor allele frequency- G:0.46NS NA WA CSA EA 492
    rs27272371,2
    C,F,A,H--146051203(-) AACACA/GATCAA 1 -- us2k124Minor allele frequency- G:0.45NS EA NA WA CSA 2491
    rs733792861,2
    C,F--146051246(+) GTGCCC/TGGCCC 1 -- us2k12Minor allele frequency- T:0.07WA 120
    rs1928655441,2
    --146051267(+) GGTTCA/CAGGCT 1 -- us2k10--------
    rs1453753311,2
    C--146051287(+) ACGCAA/GTGGCC 1 -- us2k10--------
    rs27272361,2
    C,F,H--146051445(-) GGCACG/ACTCAG 1 -- us2k113Minor allele frequency- A:0.42EA NS NA WA CSA 1395
    rs16275381,2
    C,F,A--146051682(+) CAGGTG/TGGGGC 1 -- us2k18Minor allele frequency- T:0.48MN NA WA CSA EA 549

    HapMap Linkage Disequilibrium report for ZNF7 (146052849 - 146072894 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ZNF7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674326CNV Deletion23128226
    esv2506190CNV Deletion19546169
    nsv891897CNV Loss21882294
    nsv469809CNV Loss16826518
    nsv522459CNV Loss19592680
    nsv891929CNV Loss21882294
    dgv7985n71CNV Loss21882294
    nsv891807CNV Loss21882294
    nsv891925CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF7
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 194531    OMIM disorders: --


    Find genes that share disorders with ZNF7           About GenesLikeMe

    Genetic Association Database (GAD): ZNF7
    Human Genome Epidemiology (HuGE) Navigator: ZNF7 (1 document)

    Export disorders for ZNF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF7 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ZNF7)
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    1. cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes. (PubMed id 2106481)1, 2, 3 Lania L.... Pelicci P.-G. (Genomics 1990)
    2. Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group. (PubMed id 19795399)1, 4 Malhotra A....Hanson R.L. (Diabetes Metab. Res. Rev. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Characterization and mapping of human genes encoding zinc finger proteins. (PubMed id 1946370)1, 3 Bray P.L.... Dawid I.B. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    5. Multiple genes encoding zinc finger domains are expressed in human T cells. (PubMed id 2288909)1, 2 Thiesen H.-J. (New Biol. 1990)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7553 HGNC: 13139 AceView: ZNF7 Ensembl:ENSG00000147789 euGenes: HUgn7553
    ECgene: ZNF7 H-InvDB: ZNF7

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF7 gene:
    Search GeneIP for patents involving ZNF7

    GeneCards and IP:
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