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Aliases for ZNF699 Gene

Aliases for ZNF699 Gene

  • Zinc Finger Protein 699 2 3 5
  • Hangover Homolog 3 4
  • Hangover, Drosophila, Homolog Of 3
  • Hangover Homolog (Drosophila) 2
  • Hang 3

External Ids for ZNF699 Gene

Previous GeneCards Identifiers for ZNF699 Gene

  • GC19M009269
  • GC19M009404
  • GC19M008987

Summaries for ZNF699 Gene

GeneCards Summary for ZNF699 Gene

ZNF699 (Zinc Finger Protein 699) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF555.

UniProtKB/Swiss-Prot for ZNF699 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF699 Gene

Genomics for ZNF699 Gene

Regulatory Elements for ZNF699 Gene

Enhancers for ZNF699 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G010100 1.8 FANTOM5 ENCODE dbSUPER 65.9 -794.6 -794550 8.3 MLX CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 TBX21 ZNF699 ZNF561 FBXL12 LOC100419831 ZNF562 ZNF559 TIMM29 EIF3G RAVER1 ZNF846
GH19G010267 1.4 ENCODE dbSUPER 63.7 -960.5 -960500 5.6 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 ZNF699 FBXL12 LOC100419831 ZNF559 ZNF561 ZNF846 RAVER1 ZNF562 TIMM29 EIF3G
GH19G008388 1.7 Ensembl ENCODE dbSUPER 39.7 +917.0 916994 10.3 MLX CREB3L1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 GLIS1 HNRNPM ZNF699 ZNF558 ELAVL1 XAB2 MARCH2 ZNF177 ZNF559 RAB11B-AS1 LOC100128428
GH19G008608 1.4 FANTOM5 ENCODE 40.3 +699.0 699042 4.7 HDGF ATF1 FOXA2 SIN3A DMAP1 ZNF2 ZNF48 ZNF121 GLIS2 KLF7 ZNF699 ZNF558 ZNF559 HNRNPM ZNF177 XAB2 ELAVL1 ADAMTS10 ENSG00000267510 ZNF426
GH19G008524 1.3 ENCODE dbSUPER 33.3 +783.7 783699 2.4 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF416 ZNF143 ELAVL1 HNRNPM ZNF558 ZNF699 ZNF414 ZNF559 XAB2 MYO1F ENSG00000269300 ADAMTS10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF699 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF699 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106894 338 2200 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF48 YY1 TCF12 ZNF121 SP3

Genomic Location for ZNF699 Gene

9,293,925 bp from pter
9,309,838 bp from pter
15,914 bases
Minus strand

Genomic View for ZNF699 Gene

Genes around ZNF699 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF699 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF699 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF699 Gene

Proteins for ZNF699 Gene

  • Protein details for ZNF699 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 699
    Protein Accession:
    Secondary Accessions:
    • Q8N9A1

    Protein attributes for ZNF699 Gene

    642 amino acids
    Molecular mass:
    73956 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04552.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF699 Gene

Post-translational modifications for ZNF699 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF699 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF699 Gene

Domains & Families for ZNF699 Gene

Gene Families for ZNF699 Gene

Suggested Antigen Peptide Sequences for ZNF699 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF699: view

Function for ZNF699 Gene

Molecular function for ZNF699 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF699 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF699: view

Phenotypes for ZNF699 Gene

genes like me logo Genes that share phenotypes with ZNF699: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF699 Gene

Localization for ZNF699 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF699 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF699 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF699 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF699: view

Pathways & Interactions for ZNF699 Gene

SuperPathways for ZNF699 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF699: view

Pathways by source for ZNF699 Gene

2 Reactome pathways for ZNF699 Gene

Gene Ontology (GO) - Biological Process for ZNF699 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF699: view

No data available for SIGNOR curated interactions for ZNF699 Gene

Drugs & Compounds for ZNF699 Gene

No Compound Related Data Available

Transcripts for ZNF699 Gene

mRNA/cDNA for ZNF699 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF699 Gene

Zinc finger protein 699:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF699 Gene

No ASD Table

Relevant External Links for ZNF699 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF699 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF699 Gene

Protein differential expression in normal tissues from HIPED for ZNF699 Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF699 Gene

Protein tissue co-expression partners for ZNF699 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF699 Gene:


SOURCE GeneReport for Unigene cluster for ZNF699 Gene:

genes like me logo Genes that share expression patterns with ZNF699: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF699 Gene

Orthologs for ZNF699 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF699 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZNF699 34
  • 89.97 (n)
(Bos Taurus)
Mammalia ZNF699 34 35
  • 84.15 (n)
(Mus musculus)
Mammalia Gm14419 35
  • 53 (a)
Gm2004 35
  • 53 (a)
Gm10324 35
  • 51 (a)
Zfp433 35
  • 49 (a)
5430403G16Rik 35
  • 43 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 44 (a)
Species where no ortholog for ZNF699 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF699 Gene

Gene Tree for ZNF699 (if available)
Gene Tree for ZNF699 (if available)

Paralogs for ZNF699 Gene

(439) SIMAP similar genes for ZNF699 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF699: view

Variants for ZNF699 Gene

Sequence variations from dbSNP and Humsavar for ZNF699 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000177678 -- 9,301,403(+) AAGGG(A/G)GTCTT intron-variant
rs1000316447 -- 9,307,144(+) TGCAG(C/T)AAGCC intron-variant
rs1000535525 -- 9,309,319(+) GGGAC(C/G)GAGCC intron-variant
rs1000541152 -- 9,294,446(+) CATTC(A/G)GTTTT utr-variant-3-prime
rs1000651569 -- 9,308,965(+) TCAAA(C/T)TGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF699 Gene

Variant ID Type Subtype PubMed ID
esv3643632 CNV gain 21293372
nsv521091 CNV loss 19592680
nsv523472 CNV loss 19592680

Variation tolerance for ZNF699 Gene

Residual Variation Intolerance Score: 13.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF699 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF699 Gene

Disorders for ZNF699 Gene

Relevant External Links for ZNF699

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF699 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF699 Gene

Publications for ZNF699 Gene

  1. Alcohol dependence is associated with the ZNF699 gene, a human locus related to Drosophila hangover, in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) sample. (PMID: 16940975) Riley B.P. … Prescott C.A. (Mol. Psychiatry 2006) 2 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Phenotypic heterogeneity in study populations may significantly confound the results of genetic association studies on alcohol dependence. (PMID: 26368818) Ali M.A. … Morgan M.Y. (Psychiatr. Genet. 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for ZNF699 Gene

Sources for ZNF699 Gene

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