ZNF699 Gene
protein-coding GIFtS: 46
GCID: GC19M009404
|
|
zinc finger protein 699
| |
Aliases
for ZNF699 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6991 2 | | Hang1 | | Hangover Homolog2 3 | | FLJ381441 | | Hangover, Drosophila, Homolog Of2 |
Export aliases for ZNF699 gene to outside databasesPrevious GC identifers: GC19M009269 GC19M008987 |
Summaries
for ZNF699 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN699_HUMAN, Q32M78Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF699 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF699 gene promoter:
Ik-2 Ik-1 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF699
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF699 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2ZNF699 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M009404: view genomic region
(about GC identifiers)
Start:
|
9,404,951 bp from pter |
End:
|
9,420,514 bp from pter |
Size:
|
15,564 bases |
Orientation:
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minus strand |
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Proteins
for ZNF699 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN699_HUMAN, Q32M78 (See
protein sequence)Recommended Name: Zinc finger protein 699 Size: 642 amino acids; 73956 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAC04552.1; Type=Erroneous initiation;
Secondary accessions: Q8N9A1Explore the universe of human proteins at neXtProt for ZNF699: NX_Q32M78
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q32M78
ZNF699 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_940937.1
ENSEMBL proteins: ENSP00000467723 ENSP00000311596 Reactome Protein details: Q32M78
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF699 for ontologies About GeneDecksing
ZNF699 Antibody Products:
Assay Products for ZNF699: |
Protein
Domains /
Families
for ZNF699 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF699 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q32M78ProtoNet protein and cluster: Q32M78 2 Blocks protein families: IPB001909 KRAB box IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN699_HUMAN, Q32M78Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 16 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF699 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN699_HUMAN, Q32M78Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF699
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF699
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ZNF699 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF699 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF699 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF699 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF699 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF699
ZNF699 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF699
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF699 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF699 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF699
Search CenterWatch for drugs/clinical trials and news about ZNF699 / ZN699
|
Transcripts
for ZNF699 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF699 gene: NM_198535.1 Unigene Cluster for ZNF699: Zinc finger protein 699 Hs.633842 [show with all ESTs]Unigene Representative Sequence: AK0954633 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000591998 ENST00000588336 ENST00000308650(uc002mlc.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF699
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF699
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF699 (NM_198535) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF699 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF699 |
Additional cDNA sequence: AK095463.1 BC109267.1 BC109268.1 3 DOTS entries: DT.91971704 DT.121425462 DT.95328684 8 AceView cDNA sequences: AK095463 AI760414 BX280105 BQ890117 AI681659 BE179499 BG388783 BE175091
GeneLoc Exon Structure
|
Expression
for ZNF699 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF699 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAGATAATG
About this image
See ZNF699 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.633842
SABiosciences Custom PCR Arrays for ZNF699
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF699
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF699 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF699 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF699 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF699 |
Orthologs
for ZNF699 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF699 gene from 3/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
African clawed frog
(Xenopus laevis) |
Amphibia |
BU900403.12 |
-- |
74.83(n) |
|
BU900403.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG178296 |
-- |
15(a) |
1 → many |
X(519588-522052) |
worm
(Caenorhabditis elegans) |
Secernentea |
F39B2.16 |
-- |
15(a) |
1 → many |
I(14791027-14793977) |
Species with no ortholog for ZNF699
ENSEMBL Gene Tree for ZNF699 (if available)
TreeFam Gene Tree for ZNF699 (if available) |
Paralogs
for ZNF699 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF699 gene
- ZNF6692 ZNF4902 ZNF5642 ZNF4412 ZNF8782 ENSG000002671792 ZNF142 ENSG000001968262
- ZNF7002 ZNF692 ZNF4402 ZNF4432 ZNF442 ZNF4392 ZNF8232 ZNF4912
- ENSG000001884742 ZNF5552 ZNF7092 ZNF6252 ZNF7992 ZNF202 ZNF1012 ZNF7912
- ZNF4422 ZNF4332 ZNF572 ZNF5632 ZNF6272 ENSG000002573552 ZNF1362 ZNF5562
- ZNF6702 ZNF7632 ZNF1242 ZNF8442 ZNF772
18/436 SIMAP similar genes for ZNF699 using alignment to 1 protein entry: ZN699_HUMAN(see all similar genes):ZNF232 HZF36 ZFS-1 ZNF146 ZSCAN16 DKFZp666M039
ZNF702P ZNF345 ZNF436 DKFZp762K012 HZF30 ZFP3
ZNF32 ZNF35 ZNF358 ZNF660 ZNF833P ZSCAN21
ZNF699 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF699 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF699 (9404951 - 9420514 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF699
1 CNV: 50244 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF699 |
|
Disorders
/ Diseases
for ZNF699 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF699 for disorders About GeneDecksing
OMIM gene information: 609571
OMIM disorders: --
6  diseases for ZNF699: About MalaCardsaccommodative esotropia hangover anisometropia esotropia
alcohol dependence alcoholism
2 diseases from the University of Copenhagen DISEASES database for ZNF699:Accommodative esotropia Anisometropia Human Genome Epidemiology (HuGE) Navigator: ZNF699 (1 document)
Export disorders for ZNF699 gene to outside databases
|
Publications
for ZNF699 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF699 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF699) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Alcohol dependence is associated with the ZNF699 gene, a human locus related to Drosophila hangover, in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD) sample. (PubMed id 16940975)1, 3 Riley B.P....Prescott C.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF699 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF699 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF699 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF699 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF699 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF699 gene:
Search GeneIP for patents involving ZNF699
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF699 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF699 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF699 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF699 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF699 | | OriGene 3'-UTR Clone for ZNF699 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF699 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF699 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF699 | | OriGene Custom Protein Services for ZNF699 | | | OriGene Custom Immunoassay Development | | |
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 |  |  |  | |
| | | | Search Tocris compounds for ZNF699 |
| |  |  |  |  | | | | |
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 | | | ZNF699 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF699 |
|  |  |  | | | | ThermoFisher Antibodies for ZNF699 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF699 |
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