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Aliases for ZNF696 Gene

Aliases for ZNF696 Gene

  • Zinc Finger Protein 696 2 3 5

External Ids for ZNF696 Gene

Previous GeneCards Identifiers for ZNF696 Gene

  • GC08P144445
  • GC08P144446
  • GC08P144373
  • GC08P139627

Summaries for ZNF696 Gene

GeneCards Summary for ZNF696 Gene

ZNF696 (Zinc Finger Protein 696) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF180.

UniProtKB/Swiss-Prot for ZNF696 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF696 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF696 Gene

Genomics for ZNF696 Gene

Regulatory Elements for ZNF696 Gene

Enhancers for ZNF696 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H144101 1.2 ENCODE 35.3 +814.2 814236 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZNF623 ZNF7 ZNF16 ZNF251 ZNF250 ZNF517 CPSF1 VPS28 ZNF696 LRRC14
GH08H142725 1.7 FANTOM5 ENCODE dbSUPER 20.9 -562.4 -562448 3 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 ZNF143 JRK LY6K ZNF623 ZNF696 TSNARE1 GLI4 ZNF707 AK3P2 THEM6 LYNX1
GH08H143460 1.4 Ensembl ENCODE dbSUPER 18.9 +172.6 172577 3 HDGF PKNOX1 ZNF493 SIN3A ZNF207 ATF7 RUNX3 ZNF202 JUNB REST ZNF623 CPSF1 VPS28 SLC52A2 JRK GPAA1 ADCK5 TIGD5 ZNF707 ZNF696
GH08H143493 2.2 Ensembl ENCODE dbSUPER 11.5 +204.8 204782 2 RING1 MAZ GFI1B ZBTB8A ZIC2 ZFHX2 GLIS2 GLIS1 CREB1 FOXP2 ENSG00000254859 JRK ZNF696 ZNF623 CYHR1 CPSF1 VPS28 ZC3H3 GC08P143506 PIR44330
GH08H143914 2.2 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +647.5 647455 45 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 MEF2D ZNF610 GLIS1 RCOR2 PLEC ZNF251 ZNF517 ZNF250 ZNF7 LOC105375803 EEF1D ZNF623 CPSF1 VPS28
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF696 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF696 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000333946 -176 201 PKNOX1 ZNF2 ZNF121 GLIS2 ELK1 KLF7 ATF7 SP3 NCOA1 ZNF610
ENSR00000232053 1824 1401 PKNOX1 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF766 CBX5 ZNF207 ZNF143

Genomic Location for ZNF696 Gene

Chromosome:
8
Start:
143,289,676 bp from pter
End:
143,299,952 bp from pter
Size:
10,277 bases
Orientation:
Plus strand

Genomic View for ZNF696 Gene

Genes around ZNF696 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF696 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF696 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF696 Gene

Proteins for ZNF696 Gene

  • Protein details for ZNF696 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7X3-ZN696_HUMAN
    Recommended name:
    Zinc finger protein 696
    Protein Accession:
    Q9H7X3
    Secondary Accessions:
    • A0AVE2

    Protein attributes for ZNF696 Gene

    Size:
    374 amino acids
    Molecular mass:
    40575 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF696 Gene

Post-translational modifications for ZNF696 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF696 Gene

No data available for DME Specific Peptides for ZNF696 Gene

Domains & Families for ZNF696 Gene

Gene Families for ZNF696 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF696 Gene

Suggested Antigen Peptide Sequences for ZNF696 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7X3

UniProtKB/Swiss-Prot:

ZN696_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF696: view

Function for ZNF696 Gene

Molecular function for ZNF696 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF696 Gene

Gene Ontology (GO) - Molecular Function for ZNF696 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF696: view
genes like me logo Genes that share phenotypes with ZNF696: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF696
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF696 Gene

Localization for ZNF696 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF696 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF696 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF696 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF696: view

Pathways & Interactions for ZNF696 Gene

SuperPathways for ZNF696 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF696: view

Pathways by source for ZNF696 Gene

2 Reactome pathways for ZNF696 Gene

Gene Ontology (GO) - Biological Process for ZNF696 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF696: view

No data available for SIGNOR curated interactions for ZNF696 Gene

Drugs & Compounds for ZNF696 Gene

No Compound Related Data Available

Transcripts for ZNF696 Gene

Unigene Clusters for ZNF696 Gene

Zinc finger protein 696:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF696
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF696 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - - - - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5:
SP6: -

Relevant External Links for ZNF696 Gene

GeneLoc Exon Structure for
ZNF696
ECgene alternative splicing isoforms for
ZNF696

Expression for ZNF696 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF696 Gene

Protein differential expression in normal tissues from HIPED for ZNF696 Gene

This gene is overexpressed in Cerebrospinal fluid (58.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF696 Gene



Protein tissue co-expression partners for ZNF696 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF696 Gene:

ZNF696

SOURCE GeneReport for Unigene cluster for ZNF696 Gene:

Hs.512740

Evidence on tissue expression from TISSUES for ZNF696 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF696: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF696 Gene

Orthologs for ZNF696 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF696 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF696 33 34
  • 99.11 (n)
dog
(Canis familiaris)
Mammalia ZNF696 33 34
  • 75.05 (n)
cow
(Bos Taurus)
Mammalia LOC511669 33
  • 72.34 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF696 34
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 44 (a)
OneToMany
-- 34
  • 41 (a)
OneToMany
-- 34
  • 36 (a)
OneToMany
-- 34
  • 25 (a)
OneToMany
mouse
(Mus musculus)
Mammalia 9130023H24Rik 34
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 52 (a)
OneToMany
-- 34
  • 44 (a)
OneToMany
-- 34
  • 44 (a)
OneToMany
Species where no ortholog for ZNF696 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF696 Gene

ENSEMBL:
Gene Tree for ZNF696 (if available)
TreeFam:
Gene Tree for ZNF696 (if available)

Paralogs for ZNF696 Gene

(542) SIMAP similar genes for ZNF696 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF696: view

Variants for ZNF696 Gene

Sequence variations from dbSNP and Humsavar for ZNF696 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000917159 -- 143,298,970(+) CCCTG(A/G)CCAAC utr-variant-3-prime
rs1000984964 -- 143,291,530(+) CCGCC(C/G)TGGCC utr-variant-5-prime
rs1001119856 -- 143,293,678(+) CTCCA(A/C)CACGT intron-variant
rs1001291641 -- 143,290,912(+) TGCAG(A/C)GGAGA upstream-variant-2KB
rs1001299250 -- 143,293,440(+) TGTCA(A/G)TAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF696 Gene

Variant ID Type Subtype PubMed ID
esv33151 CNV gain 17666407
esv3573029 CNV loss 25503493
esv3573030 CNV loss 25503493
nsv1016726 CNV loss 25217958
nsv470247 CNV loss 18288195
nsv473318 CNV novel sequence insertion 20440878
nsv950010 CNV deletion 24416366

Variation tolerance for ZNF696 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 19.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF696 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF696

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF696 Gene

Disorders for ZNF696 Gene

Relevant External Links for ZNF696

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF696

No disorders were found for ZNF696 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF696 Gene

Publications for ZNF696 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 60

Products for ZNF696 Gene

Sources for ZNF696 Gene

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