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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF696 Gene

protein-coding   GIFtS: 44
GCID: GC08P144373

Zinc Finger Protein 696

  Search for ZNF696
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 6961 2

External Ids:    HGNC: 258721   Entrez Gene: 799432   Ensembl: ENSG000001857307   UniProtKB: Q9H7X33   

Export aliases for ZNF696 gene to outside databases

Previous GC identifers: GC08P144445 GC08P144446 GC08P139627


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF696 Gene: 
ZNF696 (zinc finger protein 696) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZFP41.

UniProtKB/Swiss-Prot: ZN696_HUMAN, Q9H7X3
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF696 gene promoter:
         Bach2   AP-4   NF-E2 p45   NF-E2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ZNF696

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF696


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

ZNF696 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF696 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P144373:  view genomic region     (about GC identifiers)

Start:
144,371,846 bp from pter      End:
144,382,122 bp from pter
Size:
10,277 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN696_HUMAN, Q9H7X3 (See protein sequence)
Recommended Name: Zinc finger protein 696  
Size: 374 amino acids; 40575 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: A0AVE2

Explore the universe of human proteins at neXtProt for ZNF696: NX_Q9H7X3

Explore proteomics data for ZNF696 at MOPED 

ZNF696 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ZNF696 Protein Expression

REFSEQ proteins: NP_112157.2  
ENSEMBL proteins: 
 ENSP00000428163   ENSP00000427857   ENSP00000328515   ENSP00000429859   ENSP00000428856  
 ENSP00000430952  
Reactome Protein details: Q9H7X3
Human Recombinant Protein Products for ZNF696: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

ZNF696 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ZNF: Zinc fingers, C2H2-type

3 InterPro protein domains:
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q9H7X3

ProtoNet protein and cluster: Q9H7X3

1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZN696_HUMAN, Q9H7X3
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 9 C2H2-type zinc fingers


ZNF696 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZN696_HUMAN, Q9H7X3
Function: May be involved in transcriptional regulation

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0008270zinc ion binding ----
GO:0046872metal ion binding IEA--
     
ZNF696 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ZNF696 About                                                                                                See pathways by source

SuperPathContained pathways About
1Generic Transcription Pathway
Generic Transcription Pathway0.47
Gene Expression0.47

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2        Reactome Pathways for ZNF696
    Generic Transcription Pathway
Gene Expression



ZNF696 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF696

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ZNF696 (ENSP000003285154) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ELAVL1ENSP000003852694STRING: ENSP00000385269
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-dependent IEA--
GO:0006355regulation of transcription, DNA-dependent IEA--

ZNF696 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for ZNF696 (ZN696)

Search CenterWatch for drugs/clinical trials and news about ZNF696 / ZN696

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF696 gene: 
NM_030895.2  

Unigene Cluster for ZNF696:

Zinc finger protein 696
Hs.512740  [show with all ESTs]
Unigene Representative Sequence: NM_030895
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000523891 ENST00000518575 ENST00000330143(uc003yxy.4) ENST00000521537
ENST00000518432 ENST00000520333
miRNA
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Inhib. RNA
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Additional mRNA sequence: 

AK024191.1 BC126317.1 

4 DOTS entries:

DT.40270386  DT.95256483  DT.444665  DT.95331494 

24/36 AceView cDNA sequences (see all 36):

BF510457 AI278460 NM_030895 AI273629 AK024191 BQ898243 BE220484 AA357173 
BX282580 AU122554 BX390342 AI268981 BM504986 AI953671 BX375245 BI916005 
BM504664 CF146234 CD701748 AI452697 AI298974 BQ052481 CD674916 BX378282 

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF696 (see all 6)    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1:              -     -     -     -     -     -           -     -                           
SP2:                                            -           -                                 
SP3:                                            -           -     -                           
SP4:                                      -     -           -     -                           
SP5:                                                                                          


ECgene alternative splicing isoforms for ZNF696

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF696 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TAAATTAGAA
ZNF696 Expression
About this image


See ZNF696 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF696

SOURCE GeneReport for Unigene cluster: Hs.512740
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF696 gene from 2/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia ZNF6961 zinc finger protein 696 72.93(n)
67.3(a)
  100684211  XM_003431812.2  XP_003431860.2 
tropical clawed frog
(Xenopus tropicalis)
Amphibia CF591461.12   -- 74(n)    CF591461.1 


ENSEMBL Gene Tree for ZNF696 (if available)
TreeFam Gene Tree for ZNF696 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ZNF696 gene
ZFP412  GLI42  ENSG000002646682  
18/543 SIMAP similar genes for ZNF696 using alignment to 6 protein entries:     ZN696_HUMAN (see all proteins) (see all similar genes):
HZF36    ZFP41    DKFZp547L155    ZNF16    ZNF78L1    ZNF22
ZNF418    DKFZp571N1833    DKFZp686H20223    ZNF132    ZNF133    ZNF135
ZNF211    ZNF23    ZNF283    ZNF551    ZFP3    ZNF154

ZNF696 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/232 SNPs in ZNF696 are shown (see all 232)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1915820061,2
--144371576(+) AGGCCC/TCTCCT 1 -- us2k10--------
rs73866911,2
C,F--144371671(+) GGGTCT/GGCCTG 1 -- us2k15Minor allele frequency- G:0.38NA EA 246
rs285296701,2
C,F--144371727(+) GAGCCA/GGCGGG 1 -- us2k16Minor allele frequency- G:0.48NA CSA WA EA 364
rs1143903841,2
F--144371854(+) AGCGGC/TACAGG 1 -- us2k11Minor allele frequency- T:0.08WA 118
rs578231351,2
C,F--144371988(+) CCCGGG/AGTAAG 1 -- us2k18Minor allele frequency- A:0.44WA NA CSA EA 366
rs1411961581,2
--144372009(+) TGTGTC/GTAGGA 1 -- us2k10--------
rs1461120751,2
C--144372175(+) TTAGA-/TGTGTGT 1 -- us2k10--------
rs789480471,2
--144372201(+) GTTGTC/TGTTGT 1 -- us2k10--------
rs1453004771,2
--144372211(+) TTGTTG/TTTGTT 1 -- us2k10--------
rs78458031,2
C--144372252(+) agtgcA/Ggtgcc 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ZNF696 (144371846 - 144382122 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for ZNF696:    About this table     
Variant IDTypeSubtypePubMed ID
dgv7921n71CNV Loss21882294
nsv891673CNV Loss21882294
dgv7920n71CNV Loss21882294
dgv7922n71CNV Loss21882294
nsv470247CNV Loss18288195
nsv891671CNV Loss21882294
nsv891674CNV Loss21882294
nsv891669CNV Loss21882294
dgv7923n71CNV Loss21882294
esv33151CNV Gain17666407

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ZNF696 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF696)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  5. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 79943 HGNC: 25872 AceView: FLJ14129 Ensembl:ENSG00000185730 euGenes: HUgn79943
ECgene: ZNF696 H-InvDB: ZNF696

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ZNF696 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ZNF696 gene:
Search GeneIP for patents involving ZNF696

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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