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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF695 Gene

protein-coding GIFtS: 43
GCID: GC01M247109

zinc finger protein 695

Search for ZNF695
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 695¹ ²
SBZF3¹ ²
Zinc Finger Protein SBZF3² ³
RP11-551G24.1²

External Ids:	HGNC: 30954¹	Entrez Gene: 57116²	Ensembl: ENSG00000197472⁷	UniProtKB: Q8IW36³

ORGUL members:
	NONCODE:n410652 n410650

Export aliases for ZNF695 gene to outside databases

Previous GC identifers: GC01M243435 GC01M245175 GC01M217542

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN695_HUMAN, Q8IW36

Function: May be involved in transcriptional regulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF695 gene promoter:
AREB6 Meis-1a GATA-1 Meis-1b Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF695 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF695

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF695

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44

ZNF695 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF695 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M247109: view genomic region (about GC identifiers)

Start:	247,108,849 bp from pter	End:	247,171,395 bp from pter
Size:	62,547 bases	Orientation:	minus strand

ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ZNF695

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN695_HUMAN, Q8IW36 (See protein sequence)

Recommended Name: Zinc finger protein 695

Size: 515 amino acids; 60149 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: Q5T0N9 Q5T0P1 Q5T0P3 Q7Z2W8 Q7Z648

Alternative splicing: 4 isoforms: Q8IW36-4 Q8IW36-1 Q8IW36-2 Q8IW36-3

Explore the universe of human proteins at neXtProt for ZNF695: NX_Q8IW36

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IW36

ZNF695 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001191150.1 NP_065127.4

ENSEMBL proteins:

ENSP00000430580 ENSP00000355460 ENSP00000429540 ENSP00000429736 ENSP00000341236

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF695 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF695 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q8IW36

ProtoNet protein and cluster: Q8IW36

1 Blocks protein family: IPB001909 KRAB box

UniProtKB/Swiss-Prot: ZN695_HUMAN, Q8IW36

Similarity: Contains 13 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZN695_HUMAN, Q8IW36

Function: May be involved in transcriptional regulation

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF695 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ZNF695:

Synthetic lethal with Ras

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF695

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF695 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for ZNF695 gene (2 alternative transcripts):

NM_001204221.1 NM_020394.4

Unigene Cluster for ZNF695:

Zinc finger protein 695

Hs.669893 [show with all ESTs]

Unigene Representative Sequence: NM_020394

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000479214(uc009xgt.2 uc001ibx.3 uc001iby.3) ENST00000366504

ENST00000491337 ENST00000487338(uc001icc.3) ENST00000498046 ENST00000339986(uc009xgu.3)

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Additional cDNA sequence:

BC023527.2 BC041082.1 NR_037892.1

5 DOTS entries:

DT.91917983 DT.100775479 DT.40260669 DT.75178905 DT.101980512

24/40 AceView cDNA sequences (see all 40):

BU178715 BQ897766 CR597038 BU165067 AA333614 AK074774 BC005360 BM069899

BG532425 NM_033213 BX283936 AW304314 BF683074 NM_020394 BC041082 AK126366

BU158458 BX475993 AL524527 BC023527 BC055096 BX099966 BM463812 BQ226925

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF695 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGATAGGTCT

About this image
See ZNF695 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF695

SOURCE GeneReport for Unigene cluster: Hs.669893
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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF695 gene from 1/4 species (see all 4) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 7)	--	42(a) 37(a) (see all 7)	many ↔ many many ↔ many (see all 7)	GL343330.1(1093706-1292239) AAWZ02037240(11818-13836)

ENSEMBL Gene Tree for ZNF695 (if available)
TreeFam Gene Tree for ZNF695 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF695 gene

ZNF85² ZNF493² ZNF486² ZNF100² ZNF92² ZNF732² ZNF138² ZNF675²

ZNF506² ZNF273² ZNF66P² ZNF626² ZNF680² ZNF253² ZNF479² ZNF93²

ZNF492² ZNF682² ZNF676² ZNF141² ZNF681² ZNF679² ZNF257² ZNF254²

ZNF737² ZNF724P² ZNF98² ZNF849P² ZNF716² ZNF714² ZNF429² ZNF430²

ZNF730² ZNF678² ZNF117² ZNF708² ZNF107² ZNF431² ZNF90²

18/495 SIMAP similar genes for ZNF695 using alignment to 3 protein entries: ZN695_HUMAN (see all proteins) (see all similar genes):

ZNF519 ZNF761 ZNF818P kr-znf3 ZNF525 ZNF28

ZNF283 ZNF670 ZNF232 ZNF78L1 HZF30 ZFS-6

ZNF534 ZNF554 ZNF726 DKFZp686M04222 HZF36 ZNF702P

ZNF695 for paralogs About GeneDecksing

5 Pseudogenes.org Pseudogenes for ZNF695
PGOHUM00000238429 PGOHUM00000244541 PGOHUM00000246374 PGOHUM00000232809 PGOHUM00000260324

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs199705348^1,2	C	--	217530365(+)	`TGTGTA/GTNNNN`	1	--	int¹		0	--	--	--	--
rs10633188^1,2	C	--	247108443(+)	`ctGttTTTG/- tttgt`	3	--	ds500¹		1		CSA	2
rs58398172^1,2	C	--	247108455(+)	`GTTTGTTTG/- CTTGT`	3	--	ds500¹		1		NA	2
rs113220401^1,2	C,F	--	247108471(+)	`TTGAGT/ACGGAG`	3	--	ds500¹		2		WA NA	4
rs112991289^1,2	C,F	--	247108481(+)	`GTCTCG/ACTCTG`	3	--	ds500¹		2		WA NA	4
rs12750906^1,2	C,A	--	247108504(+)	`GAGTGC/TAGTGG`	3	--	ds500¹		7		NA WA CSA	15
rs61854052^1,2	C,F	--	247108519(+)	`ATCTCA/GGCTCA`	3	--	ds500¹		4		NA CSA	7
rs61854053^1,2	C,F	--	247108527(+)	`TCACTG/ACAACC`	3	--	ds500¹		3		NA	6
rs79482968^1,2	C,F	--	247108543(+)	`CTCCCG/AGGTTC`	3	--	ds500¹		4		NA WA	8
rs78006679^1,2	C,F	--	247108552(+)	`TCAAGC/TGATTC`	3	--	ds500¹		3		NA	6

HapMap Linkage Disequilibrium report for ZNF695 (247108849 - 247171395 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ZNF695
1 CNV: 6816

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF695 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF695)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)¹ Brandenberger R.... Stanton L.W. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57116	HGNC: 30954	AceView: SBZF3andMGC12466	Ensembl:ENSG00000197472	euGenes: HUgn57116
ECgene: ZNF695	H-InvDB: ZNF695

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF695	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF695 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF695 gene:
Search GeneIP for patents involving ZNF695

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF695 gene at Home site.

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ZNF695 Gene

zinc finger protein 695

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ZNF695 Gene

zinc finger protein 695

Aliasesfor ZNF695 gene

Summariesfor ZNF695 gene

Genomic Viewsfor ZNF695 gene

Proteinsfor ZNF695 gene

Protein Domains /Familiesfor ZNF695 gene

Functionfor ZNF695 gene

Pathways & Interactionsfor ZNF695 gene

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Other Databases showing ZNF695 gene

Specialized Databases showing ZNF695 gene

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for ZNF695 gene

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for ZNF695 gene

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for ZNF695 gene

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for ZNF695 gene

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for ZNF695 gene

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for ZNF695 gene

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