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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF692 Gene

protein-coding   GIFtS: 48
GCID: GC01M249144

zinc finger protein 692

 Explore 2 diseases affiliated with
ZNF692 via our new
 Human Malady Compendium 
Biological research products
for ZNF692
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Zinc Finger Protein 6921 2
Zfp6921 2
FLJ205311
AREBP2
AICAR Responsive Element Binding Protein2

External Ids:    HGNC: 260491   Entrez Gene: 556572   Ensembl: ENSG000001711637   UniProtKB: Q9BU193   

Export aliases for ZNF692 gene to outside databases

Previous GC identifers: GC01M245354 GC01M247110 GC01M219385


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN692_HUMAN, Q9BU19
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032968.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF692 gene promoter:
         AREB6   NF-1   CUTL1   Nkx2-5   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF692 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF692

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF692


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

ZNF692 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF692 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M249144:  view genomic region     (about GC identifiers)

Start:
249,144,203 bp from pter      End:
249,153,343 bp from pter
Size:
9,141 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN692_HUMAN, Q9BU19 (See protein sequence)
Recommended Name: Zinc finger protein 692  
Size: 519 amino acids; 56968 Da
Subcellular location: Nucleus (Probable)
2 PDB 3D structures from and Proteopedia for ZNF692:
2D9H (3D)        2DLK (3D)    
Secondary accessions: B4DXZ0 Q5SRA5 Q5SRA6 Q9HBC9 Q9NW93 Q9NWY6 Q9UF97
Alternative splicing: 5 isoforms:  Q9BU19-1   Q9BU19-2   Q9BU19-3   Q9BU19-4   Q9BU19-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF692: NX_Q9BU19

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BU19

  • ZNF692 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129508.1  NP_001180257.1  NP_060335.2  

    ENSEMBL proteins: 
     ENSP00000436308   ENSP00000305483   ENSP00000355427   ENSP00000431582   ENSP00000355425  
     ENSP00000436814   ENSP00000433522   ENSP00000393552   ENSP00000391200   ENSP00000431343  
     ENSP00000434484   ENSP00000437104   ENSP00000432300   ENSP00000434221   ENSP00000431338  
     ENSP00000390044   ENSP00000375696  
    Reactome Protein details: Q9BU19
    Human Recombinant Protein Products: 
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    Novus Biologicals ZNF692 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF692

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    ZNF692 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF692 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9BU19

    ProtoNet protein and cluster: Q9BU19

    UniProtKB/Swiss-Prot: ZN692_HUMAN, Q9BU19
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZN692_HUMAN, Q9BU19
    Function: May be involved in transcriptional regulation

    miRNA
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    hsa-miR-664*
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    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--


    ZNF692 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF692
        Generic Transcription Pathway
    Gene Expression



    ZNF692 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF692

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for ZNF692 (Q9BU193 ENSP000003912004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3GLB2Q9NR463I2D: score=1 
    LCE3DENSP000003577764STRING: ENSP00000357776
    FAM107BENSP000001817964STRING: ENSP00000181796
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--


    ZNF692 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF692
    Search CenterWatch for drugs/clinical trials and news about ZNF692 / ZN692 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF692 gene (3 alternative transcripts): 
    NM_001136036.2  NM_001193328.1  NM_017865.3  

    Unigene Cluster for ZNF692:

    Zinc finger protein 692
    Hs.377705  [show with all ESTs]
    Unigene Representative Sequence: AK126079
    18/33 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):
    ENST00000463519(uc001ifb.2) ENST00000306601(uc001ifc.2) ENST00000366471(uc001iff.2)
    ENST00000533927(uc001iez.2) ENST00000476503 ENST00000366469 ENST00000477070
    ENST00000482023 ENST00000412341 ENST00000451251(uc010pzr.2) ENST00000470787
    ENST00000462037 ENST00000474351 ENST00000478107 ENST00000491971 ENST00000496411
    ENST00000468455 ENST00000483223

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate ZNF692:
    hsa-miR-664*
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    Inhib. RNA
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    OriGene siRNA: ZNF692
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF692
    Clone
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    Additional cDNA sequence: 

    AB209706.1 AF256175.1 AK000538.1 AK001070.1 AK126079.1 AK225535.1 AK298899.1 AK302187.1 
    AK309421.1 AL133100.1 BC002948.1 

    24/26 DOTS entries (see all 26):

    DT.100776507  DT.121352010  DT.100776511  DT.454315  DT.97841860  DT.121351975  DT.100726612  DT.121352099 
    DT.92431934  DT.97801805  DT.95294884  DT.100776505  DT.100776510  DT.102836555  DT.121352111  DT.100776504 
    DT.121351960  DT.92058838  DT.92431937  DT.101981195  DT.101954501  DT.95227071  DT.100776512  DT.121352096 

    24/169 AceView cDNA sequences (see all 169):

    AL539035 BM970586 AL537255 AL040306 CB305386 CR605596 AA324184 F31181 
    CB850667 BC002948 BE794704 CA429950 BP364074 BM817550 AI962174 BU619037 
    AW128960 BQ024137 CA389223 BE156864 AI453571 CB159586 NM_017865 BQ026000 

    GeneLoc Exon Structure

    5/31 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF692 (see all 31)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g · 5h · 5i ^ 6a · 6b · 6c ·
    SP1:                                                  -     -     -     -     -           -     -     -     -     -     -     -     -     -     -               
    SP2:                                            -     -     -     -     -     -           -     -     -     -     -     -     -     -     -     -               
    SP3:                                                  -     -     -     -     -           -     -     -     -     -     -     -     -     -     -               
    SP4:                                                                                                                                                            
    SP5:                                                  -     -     -     -     -           -     -     -     -     -     -     -     -     -     -               

    ExUns: 6d · 6e · 6f · 6g ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a ·
    SP1:  -     -     -     -     -                                                                             -     -                 -           -               
    SP2:  -     -     -     -     -                                               -     -                       -     -                 -           -               
    SP3:  -     -     -     -     -                       -     -     -     -     -     -     -                 -     -                 -           -               
    SP4:                                                                                                                                -           -               
    SP5:  -     -     -     -     -     -     -     -                                   -                                                                           


    ECgene alternative splicing isoforms for ZNF692

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF692 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGAGACGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ZNF692 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF692

    SOURCE GeneReport for Unigene cluster: Hs.377705
        SABiosciences Custom PCR Arrays for ZNF692
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF692 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ZNF6921 zinc finger protein 692 60.03(n)
    56.71(a)
      427095  NM_001099356.1  NP_001092826.1 
    lizard
    (Anolis carolinensis)
    Reptilia ZNF6926
    --
    46(a)
    1 ↔ 1
    2(189149373-189165312)
    zebrafish
    (Danio rerio)
    Actinopterygii znf6921 zinc finger protein 692 53.51(n)
    46.49(a)
      565874  NM_001123276.1  NP_001116748.1 


    ENSEMBL Gene Tree for ZNF692 (if available)
    TreeFam Gene Tree for ZNF692 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF692 gene
    ZNF6532  ZFP912  ENSG000002674772  ZFP91-CNTF2  ZNF2762  
    18/106 SIMAP similar genes for ZNF692 using alignment to 9 protein entries:     ZN692_HUMAN (see all proteins) (see all similar genes):
    ZNF285    ZEB1    ZNF195    ZFP112    ZFP69B    ZNF133
    ZNF420    ZNF653    ZFS-5    ZNF529    kr-znf3    HKR1
    HZF16    PRDM9    ZNF480    ZNF79    ZNF19    ZFP91-CNTF

    ZNF692 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/229 NCBI SNPs in ZNF692 are shown (see all 229    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406616141,2
    --249143734(+) CCTTTA/GTCAAA 4 -- int10--------
    rs1500914891,2
    --249143738(+) TATCAA/GACCTA 4 -- int10--------
    rs1143300491,2
    C,--249143739(+) NNNNAA/GCCTAA 4 -- int11Minor allele frequency- G:0.01WA 118
    rs1903197691,2
    --249143916(+) AAGTAC/GAAGAT 4 -- int10--------
    rs1825633371,2
    --249144114(+) AGGACA/CTGCAC 4 -- int10--------
    rs1881464711,2
    --249144351(+) CTCCTC/TGTTGC 3 -- ut310--------
    rs1470596251,2
    C,--249144386(+) TTCCC-/AAAAGC 3 -- ut310--------
    rs1997253321,2
    --249144405(+) GAGGAC/GAGCTC 3 -- ut310--------
    rs2017829451,2
    --249144513(+) CTCTAA/GGGGAC 6 L syn10--------
    rs124073621,2
    C,F,H,--249144610(+) TTGCCG/ACAGAA 6 /C syn1 ese37Minor allele frequency- A:0.00NS NA 5056

    HapMap Linkage Disequilibrium report for ZNF692 (249144203 - 249153343 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for ZNF692
         3 CNVs: 8355 71816 8354

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF692 for disorders           About GeneDecksing

    2 diseases for ZNF692:    About MalaCards
    hyperopia    keratitis


    Export disorders for ZNF692 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF692 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF692)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. AMP-activated protein kinase regulates PEPCK gene expression by direct phosphorylation of a novel zinc finger transcription factor. (PubMed id 17097062)1 Inoue E. and Yamauchi J. (2006)
    8. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55657 HGNC: 26049 AceView: FLJ20531 Ensembl:ENSG00000171163 euGenes: HUgn55657
    ECgene: ZNF692 H-InvDB: ZNF692

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF692 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF692 gene:
    Search GeneIP for patents involving ZNF692

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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