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Aliases for ZNF691 Gene

Aliases for ZNF691 Gene

  • Zinc Finger Protein 691 2 3 5
  • Zfp691 3

External Ids for ZNF691 Gene

Previous GeneCards Identifiers for ZNF691 Gene

  • GC01P042982
  • GC01P043085
  • GC01P043312
  • GC01P041432

Summaries for ZNF691 Gene

GeneCards Summary for ZNF691 Gene

ZNF691 (Zinc Finger Protein 691) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF205.

UniProtKB/Swiss-Prot for ZNF691 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF691 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF691 Gene

Genomics for ZNF691 Gene

Regulatory Elements for ZNF691 Gene

Enhancers for ZNF691 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H042177 1.2 Ensembl ENCODE 19.7 -669.0 -668959 0.4 FEZF1 ZNF2 FOS YY2 TSHZ1 ZNF488 ZNF662 ZNF518A GLIS1 MYNN FOXJ3 P3H1 ZNF691 HNRNPFP1 MKRN8P ENSG00000213987 PPIH GC01P042164 PIR49391 GC01M042279
GH01H042923 1.6 Ensembl ENCODE dbSUPER 10.5 +78.2 78180 3.9 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 FOXJ3 SZT2 HYI MKRN8P HNRNPFP1 PPIH P3H1 RNU6-880P CCDC30 ZNF691
GH01H042164 1.3 Ensembl ENCODE 11.6 -681.1 -681059 2.4 FOXA2 ZNF493 ARID4B SIN3A ZNF2 ZNF121 GLIS2 FOS KLF7 ZNF548 PPIH FOXJ3 P3H1 CCDC30 ZNF691 SCMH1 ENSG00000227527 GC01P042164 GC01M042279 PIR49391
GH01H042824 1.3 ENCODE dbSUPER 11.1 -21.2 -21230 2 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 NCOA1 ZNF691 ENSG00000228192 C1orf50 P3H1 KDM4A SVBP SZT2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF691 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF691 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for ZNF691 Gene

Genomic Locations for ZNF691 Gene
5,905 bases
Plus strand

Genomic View for ZNF691 Gene

Genes around ZNF691 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF691 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF691 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF691 Gene

Proteins for ZNF691 Gene

  • Protein details for ZNF691 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 691
    Protein Accession:
    Secondary Accessions:
    • A8MXP6
    • B4DJR7
    • O95878
    • Q9NWE8

    Protein attributes for ZNF691 Gene

    312 amino acids
    Molecular mass:
    35681 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF691 Gene


neXtProt entry for ZNF691 Gene

Post-translational modifications for ZNF691 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF691 Gene

Domains & Families for ZNF691 Gene

Gene Families for ZNF691 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transcription factors

Protein Domains for ZNF691 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF691: view

Function for ZNF691 Gene

Molecular function for ZNF691 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF691 Gene

Gene Ontology (GO) - Molecular Function for ZNF691 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF691: view
genes like me logo Genes that share phenotypes with ZNF691: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF691 Gene

Localization for ZNF691 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF691 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF691 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF691 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF691: view

Pathways & Interactions for ZNF691 Gene

SuperPathways for ZNF691 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF691: view

Pathways by source for ZNF691 Gene

2 Reactome pathways for ZNF691 Gene

Interacting Proteins for ZNF691 Gene

Selected Interacting proteins: Q5VV52-ZN691_HUMAN for ZNF691 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ZNF691 Gene


No data available for SIGNOR curated interactions for ZNF691 Gene

Drugs & Compounds for ZNF691 Gene

No Compound Related Data Available

Transcripts for ZNF691 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF691 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e
SP1: - -
SP2: - -
SP3: - - - -
SP4: - - - -
SP5: - - - - - -

Relevant External Links for ZNF691 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF691 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF691 Gene

Protein differential expression in normal tissues from HIPED for ZNF691 Gene

This gene is overexpressed in Monocytes (61.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF691 Gene

Protein tissue co-expression partners for ZNF691 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF691 Gene:


SOURCE GeneReport for Unigene cluster for ZNF691 Gene:


Evidence on tissue expression from TISSUES for ZNF691 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF691: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF691 Gene

Orthologs for ZNF691 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF691 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF691 33 34
  • 99.77 (n)
(Canis familiaris)
Mammalia ZNF691 33 34
  • 90.73 (n)
(Mus musculus)
Mammalia Zfp691 33 16 34
  • 86.57 (n)
(Rattus norvegicus)
Mammalia Zfp691 33
  • 86.1 (n)
(Bos Taurus)
Mammalia ZNF691 33 34
  • 83.75 (n)
(Ornithorhynchus anatinus)
Mammalia ZNF691 34
  • 43 (a)
Species where no ortholog for ZNF691 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF691 Gene

Gene Tree for ZNF691 (if available)
Gene Tree for ZNF691 (if available)

Paralogs for ZNF691 Gene

Paralogs for ZNF691 Gene

(424) SIMAP similar genes for ZNF691 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF691: view

Variants for ZNF691 Gene

Sequence variations from dbSNP and Humsavar for ZNF691 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000135457 -- 42,846,974(+) CCGCC(A/G)GCAAT intron-variant, utr-variant-5-prime
rs1000736104 -- 42,848,291(+) ATGGT(A/G)GCGTG intron-variant, utr-variant-5-prime
rs1000892530 -- 42,845,194(+) CAACC(A/G)TATTC downstream-variant-500B, upstream-variant-2KB
rs1000941393 -- 42,845,350(+) ACACA(C/T)GTATA downstream-variant-500B, upstream-variant-2KB
rs1001189350 -- 42,848,024(+) TGAAC(C/T)TAACC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF691 Gene

Variant ID Type Subtype PubMed ID
esv3577249 CNV gain 25503493

Variation tolerance for ZNF691 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF691 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF691 Gene

Disorders for ZNF691 Gene

Relevant External Links for ZNF691

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF691 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF691 Gene

Publications for ZNF691 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 60
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 60

Products for ZNF691 Gene

Sources for ZNF691 Gene

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