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Aliases for ZNF69 Gene

Aliases for ZNF69 Gene

  • Zinc Finger Protein 69 2 3 5
  • HZNF3 3 4
  • Zinc Finger Protein 69 (Cos5) 2
  • Cos5 3
  • ZNF3 3

External Ids for ZNF69 Gene

Previous GeneCards Identifiers for ZNF69 Gene

  • GC22U990054
  • GC19P011802
  • GC19P011654
  • GC19P011998
  • GC19P011573

Summaries for ZNF69 Gene

GeneCards Summary for ZNF69 Gene

ZNF69 (Zinc Finger Protein 69) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF625-ZNF20.

UniProtKB/Swiss-Prot for ZNF69 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF69 Gene

Genomics for ZNF69 Gene

Regulatory Elements for ZNF69 Gene

Enhancers for ZNF69 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF69 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF69 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF69 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF69 gene promoter:

Genomic Location for ZNF69 Gene

11,887,784 bp from pter
11,914,551 bp from pter
26,768 bases
Plus strand

Genomic View for ZNF69 Gene

Genes around ZNF69 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF69 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF69 Gene

Proteins for ZNF69 Gene

  • Protein details for ZNF69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 69
    Protein Accession:
    Secondary Accessions:
    • Q86VA7

    Protein attributes for ZNF69 Gene

    566 amino acids
    Molecular mass:
    65761 Da
    Quaternary structure:
    No Data Available
    • Sequence=AK001669; Type=Frameshift; Positions=415; Evidence={ECO:0000305}; Sequence=CAC16147.1; Type=Frameshift; Positions=367, 369; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF69 Gene


neXtProt entry for ZNF69 Gene

Proteomics data for ZNF69 Gene at MOPED

Post-translational modifications for ZNF69 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF69 Gene

No data available for DME Specific Peptides for ZNF69 Gene

Domains & Families for ZNF69 Gene

Gene Families for ZNF69 Gene

Protein Domains for ZNF69 Gene

Suggested Antigen Peptide Sequences for ZNF69 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 14 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 14 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF69: view

Function for ZNF69 Gene

Molecular function for ZNF69 Gene

GENATLAS Biochemistry:
zinc finger protein 69 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF69 Gene

genes like me logo Genes that share phenotypes with ZNF69: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF69 Gene

Localization for ZNF69 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF69 Gene

Subcellular locations from

Jensen Localization Image for ZNF69 Gene COMPARTMENTS Subcellular localization image for ZNF69 gene
Compartment Confidence
nucleus 5
extracellular 2
chloroplast 1
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for ZNF69 Gene

Pathways & Interactions for ZNF69 Gene

SuperPathways for ZNF69 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF69 Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF69 Gene

Drugs & Compounds for ZNF69 Gene

No Compound Related Data Available

Transcripts for ZNF69 Gene

mRNA/cDNA for ZNF69 Gene

(9) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF69 Gene

Zinc finger protein 69:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF69 Gene

No ASD Table

Relevant External Links for ZNF69 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF69 Gene

mRNA expression in normal human tissues for ZNF69 Gene

Protein differential expression in normal tissues from HIPED for ZNF69 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF69 Gene

SOURCE GeneReport for Unigene cluster for ZNF69 Gene Hs.661955

genes like me logo Genes that share expression patterns with ZNF69: view

Protein tissue co-expression partners for ZNF69 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF69 Gene

Orthologs for ZNF69 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF69 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 36
  • 15 (a)
(Canis familiaris)
Mammalia -- 36
  • 9 (a)
(Mus musculus)
Mammalia Zfp867 36
  • 8 (a)
(Pan troglodytes)
Mammalia ZNF69 36
  • 82 (a)
Species with no ortholog for ZNF69:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF69 Gene

Gene Tree for ZNF69 (if available)
Gene Tree for ZNF69 (if available)

Paralogs for ZNF69 Gene

Paralogs for ZNF69 Gene

(471) SIMAP similar genes for ZNF69 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF69: view

Variants for ZNF69 Gene

Sequence variations from dbSNP and Humsavar for ZNF69 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs812868 -- 11,886,225(+) ggttt(C/T)accat upstream-variant-2KB
rs7258792 -- 11,914,263(+) gtgag(C/T)cgagg utr-variant-3-prime
rs8102458 -- 11,893,971(+) AGGAA(A/C)AGCCA intron-variant
rs12986199 -- 11,910,467(+) accaa(A/C)cagag intron-variant
rs8106238 -- 11,903,812(+) AATGA(A/G)GTATG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF69 Gene

Variant ID Type Subtype PubMed ID
nsv525966 CNV Gain 19592680
nsv911068 CNV Gain 21882294
nsv458356 CNV Gain 19166990
esv2718185 CNV Deletion 23290073
esv2718186 CNV Deletion 23290073
nsv911069 CNV Loss 21882294

Variation tolerance for ZNF69 Gene

Residual Variation Intolerance Score: 62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF69 Gene

Disorders for ZNF69 Gene

Relevant External Links for ZNF69

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF69 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF69 Gene

Publications for ZNF69 Gene

  1. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). (PMID: 1639391) Aubry M. … Rouleau G.A. (Genomics 1992) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF69 Gene

Sources for ZNF69 Gene