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Aliases for ZNF69 Gene

Aliases for ZNF69 Gene

  • Zinc Finger Protein 69 2 3
  • HZNF3 3 4
  • Zinc Finger Protein 69 (Cos5) 2
  • Cos5 3

External Ids for ZNF69 Gene

Previous GeneCards Identifiers for ZNF69 Gene

  • GC22U990054
  • GC19P011802
  • GC19P011654
  • GC19P011998
  • GC19P011573

Summaries for ZNF69 Gene

GeneCards Summary for ZNF69 Gene

ZNF69 (Zinc Finger Protein 69) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZNF709.

UniProtKB/Swiss-Prot for ZNF69 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF69 Gene

Genomics for ZNF69 Gene

Regulatory Elements for ZNF69 Gene

Transcription factor binding sites by QIAGEN in the ZNF69 gene promoter:

Genomic Location for ZNF69 Gene

Start:
11,887,784 bp from pter
End:
11,914,551 bp from pter
Size:
26,768 bases
Orientation:
Plus strand

Genomic View for ZNF69 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF69 Gene

Proteins for ZNF69 Gene

  • Protein details for ZNF69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UC07-ZNF69_HUMAN
    Recommended name:
    Zinc finger protein 69
    Protein Accession:
    Q9UC07
    Secondary Accessions:
    • Q86VA7

    Protein attributes for ZNF69 Gene

    Size:
    566 amino acids
    Molecular mass:
    65761 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK001669; Type=Frameshift; Positions=415; Evidence={ECO:0000305}; Sequence=CAC16147.1; Type=Frameshift; Positions=367, 369; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF69 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF69 Gene

Proteomics data for ZNF69 Gene at MOPED

Post-translational modifications for ZNF69 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF69 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF69 Gene

Domains for ZNF69 Gene

Gene Families for ZNF69 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF69 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UC07

UniProtKB/Swiss-Prot:

ZNF69_HUMAN :
  • Q9UC07
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 14 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF69: view

Function for ZNF69 Gene

Molecular function for ZNF69 Gene

GENATLAS Biochemistry: zinc finger protein 69 (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF69: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF69 Gene

Localization for ZNF69 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF69 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF69 Gene COMPARTMENTS Subcellular localization image for ZNF69 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ZNF69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF69: view

Pathways for ZNF69 Gene

SuperPathways for ZNF69 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF69: view

No data available for Pathways by source for ZNF69 Gene

Transcripts for ZNF69 Gene

mRNA/cDNA for ZNF69 Gene

(8) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF69 Gene

Zinc finger protein 69:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF69

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF69 Gene

No ASD Table

Relevant External Links for ZNF69 Gene

GeneLoc Exon Structure for
ZNF69
ECgene alternative splicing isoforms for
ZNF69

Expression for ZNF69 Gene

mRNA expression in normal human tissues for ZNF69 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF69 Gene

SOURCE GeneReport for Unigene cluster for ZNF69 Gene Hs.661955

genes like me logo Genes that share expressions with ZNF69: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF69 Gene

Orthologs for ZNF69 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF69 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF69 36
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 15 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 9 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp867 36
  • 8 (a)
ManyToMany
Species with no ortholog for ZNF69:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF69 Gene

ENSEMBL:
Gene Tree for ZNF69 (if available)
TreeFam:
Gene Tree for ZNF69 (if available)

Paralogs for ZNF69 Gene

Selected SIMAP similar genes for ZNF69 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF69: view

Variants for ZNF69 Gene

Sequence variations from dbSNP and Humsavar for ZNF69 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs169403 -- 11,886,176(+) cgccc(A/G)ccacc upstream-variant-2KB
rs169404 -- 11,913,640(+) TGCCT(C/T)GGCCT utr-variant-3-prime, downstream-variant-500B
rs183951 -- 11,886,251(+) ctcga(A/T)ctcct upstream-variant-2KB
rs279175 -- 11,886,000(+) aatTG(C/T)AACAT upstream-variant-2KB
rs279176 -- 11,886,088(+) gtggc(A/G)tgatc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF69 Gene

Variant ID Type Subtype PubMed ID
nsv525966 CNV Gain 19592680
nsv911068 CNV Gain 21882294
nsv458356 CNV Gain 19166990
esv2718185 CNV Deletion 23290073
esv2718186 CNV Deletion 23290073
nsv911069 CNV Loss 21882294

Relevant External Links for ZNF69 Gene

HapMap Linkage Disequilibrium report
ZNF69

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF69 Gene

Disorders for ZNF69 Gene

No disorders were found for ZNF69 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF69 Gene

Publications for ZNF69 Gene

  1. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). (PMID: 1639391) Aubry M. … Rouleau G.A. (Genomics 1992) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for ZNF69 Gene

Sources for ZNF69 Gene

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