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Aliases for ZNF689 Gene

Aliases for ZNF689 Gene

  • Zinc Finger Protein 689 2 3
  • Transcription-Involved Protein Upregulated In HCC 1 3
  • TIPUH1 3

External Ids for ZNF689 Gene

Previous GeneCards Identifiers for ZNF689 Gene

  • GC16M030523
  • GC16M030613
  • GC16M028178

Summaries for ZNF689 Gene

GeneCards Summary for ZNF689 Gene

ZNF689 (Zinc Finger Protein 689) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF785.

UniProtKB/Swiss-Prot for ZNF689 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF689 Gene

Genomics for ZNF689 Gene

Regulatory Elements for ZNF689 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF689 Gene

30,602,558 bp from pter
30,624,012 bp from pter
21,455 bases
Minus strand

Genomic View for ZNF689 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF689 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF689 Gene

Proteins for ZNF689 Gene

  • Protein details for ZNF689 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 689
    Protein Accession:
    Secondary Accessions:
    • Q658J5

    Protein attributes for ZNF689 Gene

    500 amino acids
    Molecular mass:
    56907 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF689 Gene

Proteomics data for ZNF689 Gene at MOPED

Post-translational modifications for ZNF689 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF689 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZNF689 Gene

Domains for ZNF689 Gene

Gene Families for ZNF689 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF689 Gene

Suggested Antigen Peptide Sequences for ZNF689 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96CS4
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF689: view

Function for ZNF689 Gene

Molecular function for ZNF689 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF689 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF689: view

Animal Model Products

CRISPR Products

miRNA for ZNF689 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF689 Gene

Localization for ZNF689 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF689 Gene

Subcellular locations from

Jensen Localization Image for ZNF689 Gene COMPARTMENTS Subcellular localization image for ZNF689 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF689 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF689: view

Pathways for ZNF689 Gene

SuperPathways for ZNF689 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF689: view

Pathways by source for ZNF689 Gene

2 Reactome pathways for ZNF689 Gene

Gene Ontology (GO) - Biological Process for ZNF689 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0035914 skeletal muscle cell differentiation IEA --
genes like me logo Genes that share ontologies with ZNF689: view

Transcripts for ZNF689 Gene

Unigene Clusters for ZNF689 Gene

Zinc finger protein 689:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF689

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF689 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - - - -
SP2: - -
SP3: -

Relevant External Links for ZNF689 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF689 Gene

mRNA expression in normal human tissues for ZNF689 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ZNF689 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF689 Gene

SOURCE GeneReport for Unigene cluster for ZNF689 Gene Hs.454685

genes like me logo Genes that share expressions with ZNF689: view

Expression partners for ZNF689 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF689 Gene

Orthologs for ZNF689 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF689 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF689 35
  • 89.67 (n)
  • 93.56 (a)
ZNF689 36
  • 93 (a)
(Canis familiaris)
Mammalia ZNF689 35
  • 90.98 (n)
  • 95.59 (a)
ZNF689 36
  • 85 (a)
(Mus musculus)
Mammalia Zfp689 35
  • 88.11 (n)
  • 92.59 (a)
Zfp689 16
Zfp689 36
  • 92 (a)
(Pan troglodytes)
Mammalia ZNF689 35
  • 99.6 (n)
  • 100 (a)
ZNF689 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zfp689 35
  • 87.37 (n)
  • 92.18 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
Species with no ortholog for ZNF689:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF689 Gene

Gene Tree for ZNF689 (if available)
Gene Tree for ZNF689 (if available)

Paralogs for ZNF689 Gene

Selected SIMAP similar genes for ZNF689 Gene using alignment to 1 proteins: Pseudogenes for ZNF689 Gene

genes like me logo Genes that share paralogs with ZNF689: view

Variants for ZNF689 Gene

Sequence variations from dbSNP and Humsavar for ZNF689 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs8044106 -- 30,606,367(+) TTTCC(A/G)ATCTA intron-variant
rs8061986 -- 30,611,099(+) tcgaa(C/T)ttctg upstream-variant-2KB
rs8063005 -- 30,606,377(+) ACCTT(A/G)TAGAA intron-variant
rs9937653 -- 30,605,167(+) TCGCC(A/G)GAGTG reference, synonymous-codon, nc-transcript-variant
rs12920734 -- 30,612,723(+) gtctc(A/G)aactc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF689 Gene

Variant ID Type Subtype PubMed ID
nsv905727 CNV Loss 21882294

Relevant External Links for ZNF689 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF689 Gene

Disorders for ZNF689 Gene

Relevant External Links for ZNF689

Genetic Association Database (GAD)

No disorders were found for ZNF689 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZNF689 Gene

Publications for ZNF689 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. TIPUH1 encodes a novel KRAB zinc-finger protein highly expressed in human hepatocellular carcinomas. (PMID: 16568080) Silva FP. … Nakamura Y. (Oncogene 2006) 3

Products for ZNF689 Gene

Sources for ZNF689 Gene

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