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Aliases for ZNF689 Gene

Aliases for ZNF689 Gene

  • Zinc Finger Protein 689 2 3 5
  • Transcription-Involved Protein Upregulated In HCC 1 3
  • TIPUH1 3

External Ids for ZNF689 Gene

Previous GeneCards Identifiers for ZNF689 Gene

  • GC16M030523
  • GC16M030613
  • GC16M028178

Summaries for ZNF689 Gene

GeneCards Summary for ZNF689 Gene

ZNF689 (Zinc Finger Protein 689) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF764.

UniProtKB/Swiss-Prot for ZNF689 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF689 Gene

Genomics for ZNF689 Gene

Regulatory Elements for ZNF689 Gene

Genomic Location for ZNF689 Gene

Chromosome:
16
Start:
30,602,558 bp from pter
End:
30,624,012 bp from pter
Size:
21,455 bases
Orientation:
Minus strand

Genomic View for ZNF689 Gene

Genes around ZNF689 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF689 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF689 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF689 Gene

Proteins for ZNF689 Gene

  • Protein details for ZNF689 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CS4-ZN689_HUMAN
    Recommended name:
    Zinc finger protein 689
    Protein Accession:
    Q96CS4
    Secondary Accessions:
    • Q658J5

    Protein attributes for ZNF689 Gene

    Size:
    500 amino acids
    Molecular mass:
    56907 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF689 Gene

Proteomics data for ZNF689 Gene at MOPED

Post-translational modifications for ZNF689 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF689 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZNF689 Gene

Domains & Families for ZNF689 Gene

Gene Families for ZNF689 Gene

Protein Domains for ZNF689 Gene

Suggested Antigen Peptide Sequences for ZNF689 Gene

Graphical View of Domain Structure for InterPro Entry

Q96CS4

UniProtKB/Swiss-Prot:

ZN689_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF689: view

Function for ZNF689 Gene

Molecular function for ZNF689 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF689: view

Animal Models for ZNF689 Gene

MGI Knock Outs for ZNF689:

Animal Model Products

CRISPR Products

miRNA for ZNF689 Gene

miRTarBase miRNAs that target ZNF689

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF689 Gene

Localization for ZNF689 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF689 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF689 Gene COMPARTMENTS Subcellular localization image for ZNF689 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF689 Gene

Pathways & Interactions for ZNF689 Gene

SuperPathways for ZNF689 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF689: view

Pathways by source for ZNF689 Gene

2 Reactome pathways for ZNF689 Gene

Gene Ontology (GO) - Biological Process for ZNF689 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0035914 skeletal muscle cell differentiation IEA --
genes like me logo Genes that share ontologies with ZNF689: view

No data available for SIGNOR curated interactions for ZNF689 Gene

Drugs & Compounds for ZNF689 Gene

No Compound Related Data Available

Transcripts for ZNF689 Gene

Unigene Clusters for ZNF689 Gene

Zinc finger protein 689:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF689 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for ZNF689 Gene

GeneLoc Exon Structure for
ZNF689
ECgene alternative splicing isoforms for
ZNF689

Expression for ZNF689 Gene

mRNA expression in normal human tissues for ZNF689 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF689 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF689 Gene



SOURCE GeneReport for Unigene cluster for ZNF689 Gene Hs.454685

genes like me logo Genes that share expression patterns with ZNF689: view

Protein tissue co-expression partners for ZNF689 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF689 Gene

Orthologs for ZNF689 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF689 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF689 35
  • 89.67 (n)
  • 93.56 (a)
ZNF689 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF689 35
  • 90.98 (n)
  • 95.59 (a)
ZNF689 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp689 35
  • 88.11 (n)
  • 92.59 (a)
Zfp689 16
Zfp689 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF689 35
  • 99.6 (n)
  • 100 (a)
ZNF689 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp689 35
  • 87.37 (n)
  • 92.18 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
OneToMany
Species with no ortholog for ZNF689:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF689 Gene

ENSEMBL:
Gene Tree for ZNF689 (if available)
TreeFam:
Gene Tree for ZNF689 (if available)

Paralogs for ZNF689 Gene

(350) SIMAP similar genes for ZNF689 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF689 Gene

genes like me logo Genes that share paralogs with ZNF689: view

Variants for ZNF689 Gene

Sequence variations from dbSNP and Humsavar for ZNF689 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs8061986 -- 30,611,099(+) tcgaa(C/T)ttctg upstream-variant-2KB
rs8044106 -- 30,606,367(+) TTTCC(A/G)ATCTA intron-variant
rs8063005 -- 30,606,377(+) ACCTT(A/G)TAGAA intron-variant
rs9937653 -- 30,605,167(+) TCGCC(A/G)GAGTG nc-transcript-variant, reference, synonymous-codon
rs12920734 -- 30,612,723(+) gtctc(A/G)aactc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF689 Gene

Variant ID Type Subtype PubMed ID
nsv905727 CNV Loss 21882294

Variation tolerance for ZNF689 Gene

Residual Variation Intolerance Score: 8.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF689 Gene

HapMap Linkage Disequilibrium report
ZNF689

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF689 Gene

Disorders for ZNF689 Gene

Relevant External Links for ZNF689

Genetic Association Database (GAD)
ZNF689
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF689

No disorders were found for ZNF689 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF689 Gene

Publications for ZNF689 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Maintenance of silent chromatin through replication requires SWI/SNF- like chromatin remodeler SMARCAD1. (PMID: 21549307) Rowbotham S.P. … Mermoud J.E. (Mol. Cell 2011) 3
  4. ZNF689 suppresses apoptosis of hepatocellular carcinoma cells through the down-regulation of Bcl-2 family members. (PMID: 21624362) Shigematsu S. … Higashiyama S. (Exp. Cell Res. 2011) 3
  5. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3

Products for ZNF689 Gene

Sources for ZNF689 Gene

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