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Aliases for ZNF689 Gene

Aliases for ZNF689 Gene

  • Zinc Finger Protein 689 2 3 5
  • Transcription-Involved Protein Upregulated In HCC 1 3
  • TIPUH1 3

External Ids for ZNF689 Gene

Previous GeneCards Identifiers for ZNF689 Gene

  • GC16M030523
  • GC16M030613
  • GC16M028178

Summaries for ZNF689 Gene

GeneCards Summary for ZNF689 Gene

ZNF689 (Zinc Finger Protein 689) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF785.

UniProtKB/Swiss-Prot for ZNF689 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF689 Gene

Genomics for ZNF689 Gene

Regulatory Elements for ZNF689 Gene

Enhancers for ZNF689 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G030555 1.5 ENCODE dbSUPER 23.6 +65.9 65941 4.2 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 ENSG00000260267 ZNF764 SMG1P2 NPIPB13 ENSG00000260304 BCL7C PRR14 CDIPT ZNF785 ZNF689
GH16G030547 1.5 Ensembl ENCODE dbSUPER 22.4 +75.0 75040 2.4 PKNOX1 ATF1 ARNT FEZF1 GLI4 ZNF2 TCF12 FOS JUNB NCOA1 ZNF689 ZNF764 ENSG00000239791 ZNF688 ZNF785 DCTPP1 ENSG00000222701 ITGAL SEPHS2 ZNF768
GH16G030566 2.1 FANTOM5 Ensembl ENCODE dbSUPER 14.1 +54.1 54138 6.0 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 ENSG00000260267 ZNF747 NPIPB13 ENSG00000260304 SMG1P2 BCL7C ZNF764 ZNF785 CDIPT PRR14
GH16G030488 1 ENCODE 25.3 +135.1 135138 0.2 FOXA2 ATF1 ZFP64 ARID4B DMAP1 ZNF48 YY1 ZNF302 KLF7 ZNF202 ZNF747 ENSG00000260267 BCL7C NPIPB13 ENSG00000260304 SMG1P2 ZNF689 ZNF785 ZNF764 PRR14
GH16G029942 1.7 FANTOM5 Ensembl ENCODE 14.1 +680.0 680030 3.7 CREB3L1 ZFP64 FEZF1 ZNF263 SP3 MEF2D ZNF610 GLIS1 RCOR2 NBN ZNF785 ENSG00000260853 NPIPB13 MIR762HG BCL7C ENSG00000260114 NFATC2IP SMG1P2 INO80E ENSG00000260367
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF689 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF689 Gene

30,602,558 bp from pter
30,624,012 bp from pter
21,455 bases
Minus strand

Genomic View for ZNF689 Gene

Genes around ZNF689 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF689 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF689 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF689 Gene

Proteins for ZNF689 Gene

  • Protein details for ZNF689 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 689
    Protein Accession:
    Secondary Accessions:
    • Q658J5

    Protein attributes for ZNF689 Gene

    500 amino acids
    Molecular mass:
    56907 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF689 Gene

Post-translational modifications for ZNF689 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF689 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF689 Gene

Domains & Families for ZNF689 Gene

Gene Families for ZNF689 Gene

Protein Domains for ZNF689 Gene

Suggested Antigen Peptide Sequences for ZNF689 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF689: view

Function for ZNF689 Gene

Molecular function for ZNF689 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF689 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF689: view
genes like me logo Genes that share phenotypes with ZNF689: view

Animal Models for ZNF689 Gene

MGI Knock Outs for ZNF689:

Animal Model Products

CRISPR Products

miRNA for ZNF689 Gene

miRTarBase miRNAs that target ZNF689

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF689 Gene

Localization for ZNF689 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF689 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF689 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF689 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF689: view

Pathways & Interactions for ZNF689 Gene

SuperPathways for ZNF689 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF689: view

Pathways by source for ZNF689 Gene

2 Reactome pathways for ZNF689 Gene

Gene Ontology (GO) - Biological Process for ZNF689 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0035914 skeletal muscle cell differentiation IEA --
genes like me logo Genes that share ontologies with ZNF689: view

No data available for SIGNOR curated interactions for ZNF689 Gene

Drugs & Compounds for ZNF689 Gene

No Compound Related Data Available

Transcripts for ZNF689 Gene

Unigene Clusters for ZNF689 Gene

Zinc finger protein 689:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF689 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - - - -
SP2: - -
SP3: -

Relevant External Links for ZNF689 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF689 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF689 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF689 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF689 Gene

Protein tissue co-expression partners for ZNF689 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF689 Gene:


SOURCE GeneReport for Unigene cluster for ZNF689 Gene:


Evidence on tissue expression from TISSUES for ZNF689 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF689: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF689 Gene

Orthologs for ZNF689 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF689 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF689 34 35
  • 99.6 (n)
(Canis familiaris)
Mammalia ZNF689 34 35
  • 90.98 (n)
(Bos Taurus)
Mammalia ZNF689 34 35
  • 89.67 (n)
(Mus musculus)
Mammalia Zfp689 34 16 35
  • 88.11 (n)
(Rattus norvegicus)
Mammalia Zfp689 34
  • 87.37 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 36 (a)
Species where no ortholog for ZNF689 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF689 Gene

Gene Tree for ZNF689 (if available)
Gene Tree for ZNF689 (if available)

Paralogs for ZNF689 Gene

(350) SIMAP similar genes for ZNF689 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF689: view

Variants for ZNF689 Gene

Sequence variations from dbSNP and Humsavar for ZNF689 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000208497 -- 30,607,177(+) CTGGG(A/G)GGCGG intron-variant
rs1000303067 -- 30,607,352(+) CTTTG(A/G)GAGGC intron-variant
rs1001264920 -- 30,602,535(+) GTAAA(A/C)AGTAA downstream-variant-500B
rs1001490718 -- 30,608,378(+) GGATC(A/C)AGCAA intron-variant
rs1001711275 -- 30,608,704(+) ACCAA(C/G)TTCCC intron-variant

Variation tolerance for ZNF689 Gene

Residual Variation Intolerance Score: 8.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF689 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF689 Gene

Disorders for ZNF689 Gene

Relevant External Links for ZNF689

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF689 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF689 Gene

Publications for ZNF689 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Maintenance of silent chromatin through replication requires SWI/SNF- like chromatin remodeler SMARCAD1. (PMID: 21549307) Rowbotham S.P. … Mermoud J.E. (Mol. Cell 2011) 3 64
  5. ZNF689 suppresses apoptosis of hepatocellular carcinoma cells through the down-regulation of Bcl-2 family members. (PMID: 21624362) Shigematsu S. … Higashiyama S. (Exp. Cell Res. 2011) 3 64

Products for ZNF689 Gene

Sources for ZNF689 Gene

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