ZNF689 Gene
protein-coding GIFtS : 48
GCID: GC16 M030613
zinc finger protein 689
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Aliasesfor ZNF689 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Zinc Finger Protein 689 1 2 FLJ904151 TIPUH12 Transcription-Involved Protein Upregulated In HCC 12
Export aliases for ZNF689 gene to outside databases Previous GC identifers: GC16M030523 GC16M028178
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Summariesfor ZNF689 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: ZN689_HUMAN, Q96CS4 Function : May be involved in transcriptional regulation
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Genomic Viewsfor ZNF689 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000016.9 NC_018927.1 NT_010393.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF689 gene promoter: HSF1 (long) NF-kappaB GATA-2 E2F E2F-1 Ik-2 HSF1short ZIC2/Zic2 NF-kappaB1 ATF6 Other transcription factors Search SABiosciences Chromatin IP Primers for ZNF689 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ZNF689
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2 ZNF689 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16M030613: view genomic region
(about GC identifiers )
Start:
30,613,879 bp from pter
End:
30,635,333 bp from pter
Size:
21,455 bases
Orientation:
minus strand
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Proteinsfor ZNF689 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ZN689_HUMAN, Q96CS4 (See
protein sequence )Recommended Name: Zinc finger protein 689 Size : 500 amino acids; 56907 Da
Subcellular location : Nucleus (Probable)
Secondary accessions : Q658J5Explore the universe of human proteins at neXtProt for ZNF689: NX_Q96CS4 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96CS4 ZNF689 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_612456.1 ENSEMBL proteins: ENSP00000287461 Reactome Protein details: Q96CS4 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
ZNF689 for ontologies About GeneDecksing ZNF689 Antibody Products: Assay Products for ZNF689:
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Protein
Domains / Familiesfor ZNF689 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ZNF689 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q96CS4 ProtoNet protein and cluster: Q96CS4
1 Blocks protein family : IPB001909 KRAB box UniProtKB/Swiss-Prot: ZN689_HUMAN, Q96CS4 Similarity : Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity : Contains 12 C2H2-type zinc fingersSimilarity : Contains 1 KRAB domain
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Functionfor ZNF689 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ZN689_HUMAN, Q96CS4 Function : May be involved in transcriptional regulation
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF689 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF689OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ZNF689 (NM_138447 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF689 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZNF689
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF689
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
ZNF689 for ontologies About GeneDecksing
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Pathways & Interactionsfor ZNF689 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Generic Transcription Pathway
Pathway sources See GeneCards unified pathways Show all pathways 2
Reactome Pathways for ZNF689
ZNF689 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF689 STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)5/6 Interacting proteins for ZNF689 (Q96CS4 3 ENSP00000287461 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 6 )About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006351 transcription, DNA-dependent
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA --
ZNF689 for ontologies About GeneDecksing
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Drugs & Compoundsfor ZNF689 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for ZNF689 Search CenterWatch for drugs/clinical trials and news about ZNF689 / ZN689
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Transcriptsfor ZNF689 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ZNF689 gene: NM_138447.2 Unigene Cluster for ZNF689:
Zinc finger protein 689 Hs.454685 [show with all ESTs ] Unigene Representative Sequence: NM_138447 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000287461 (uc010bzy.3 uc002dyx.3 ) ENST00000563304 ENST00000565440 ENST00000566673 ENST00000564262 ENST00000565710 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF689 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF689OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ZNF689 (NM_138447 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF689 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ZNF689
Additional cDNA sequence: AB065282.1 AF086510.1 AK074896.1 AK310459.1 AL834299.1 BC014000.2 NR_073480.1 NR_073481.1 NR_073482.1
8 DOTS entries : DT.91743272 DT.75138913
DT.120723113 DT.87017436 DT.91686953 DT.91812962 DT.95181067 DT.87017898 24/180 AceView cDNA sequences (see all 180 ):
BM909599 BP872885 BQ055890 BQ932666 NM_138447 BQ058990 AA731425 AA883880 BQ055845 BQ215357 BQ787008 BQ065597 AA953222 BQ061040 BF447827 BQ059114 AA913311 BQ956977 AW016348 BQ057937 BQ066431 AA588247 BQ059819 T36140 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF689 About this scheme ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d SP1 :   -   -   -     -           SP2 :       -     -           SP3 :           -           SP4 :                    
ECgene alternative splicing isoforms for ZNF689
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Expression for ZNF689 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ZNF689 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTACCAGGGG
About this image ZNF689 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Ovary Antral Follicle Secondary Oocyte Female Gametocytes, Germ Cells Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See ZNF689 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZNF689 SOURCE GeneReport for Unigene cluster: Hs.454685 SABiosciences Custom PCR Arrays for ZNF689 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZNF689Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ZNF689 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZNF689 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZNF689 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF689
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Orthologsfor ZNF689 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of human and mouse.
Orthologs for ZNF689 gene from 1/6 species (see all 6 ) About this table
ENSEMBL Gene Tree for ZNF689 (if available)TreeFam Gene Tree for ZNF689 (if available)
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Paralogsfor ZNF689 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ZNF689 gene ZNF764 2 ZNF747 2 ZNF688 2 ENSG00000261459 2 ENSG00000260869 2 ZNF785 2 18/364 SIMAP similar genes for ZNF689 using alignment to 1 protein entry: ZN689_HUMAN (see all similar genes ):TIPUH1 ZNF771 ZNF32 ZNF160 ZNF493 ZNF510 DKFZp434G1930 DKFZp686B16128 ZFS-1 ZNF146 ZNF397 ZNF484 ZNF614 ZNF665 ZNF776 ZNF83 ZSCAN2 PRMD9
ZNF689 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for ZNF689 PGOHUM00000248806
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Genomic Variantsfor ZNF689 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 16 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ZNF689 (30613879 - 30635333 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ZNF689: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZNF689
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Disorders
/ Diseasesfor ZNF689 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ZNF689 for disorders About GeneDecksing 2 diseases for ZNF689 : About MalaCards hepatocellular carcinoma carcinoma Export disorders for ZNF689 gene to outside databases
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Publicationsfor ZNF689 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ZNF689 gene integrated from 9 sources : (articles sorted by number of sources associating them with ZNF689) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Maintenance of silent chromatin through replication r equires SWI/SNF-like chromatin remodeler SMARCAD1. (PubMed id 21549307) 1 Rowbotham S.P....Mermoud J.E. (2011) ZNF689 suppresses apoptosis of hepatocellular carcino ma cells through the down-regulation of Bcl-2 family members. (PubMed id 21624362) 1 Shigematsu S....Higashiyama S. (2011) Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864) 1 Nozawa R.S....Obuse C. (2010) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776) 1 Girard A....Carmell M.A. (2006) TIPUH1 encodes a novel KRAB zinc-finger protein highly expressed in human hepatocellular carcinomas. (PubMed id 16568080) 1 Silva FP.... Nakamura Y. (2006) Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197) 1 Brandenberger R.... Stanton L.W. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ZNF689 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ZNF689 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ZNF689 gene
(According to HUGE )
About This Section --
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Specialized Databases showing ZNF689 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ZNF689 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ZNF689 gene: Search GeneIP for patents involving ZNF689 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ZNF689 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ZNF689 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ZNF689 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ZNF689 OriGene Protein Over-expression Lysate for ZNF689 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ZNF689 OriGene 3'-UTR Clone for ZNF689 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF689 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ZNF689 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF689 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ZNF689 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat ZNF689 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ZNF689 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ZNF689 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ZNF689
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ZNF689 Proteins, Antibodies, CLIAs, and ELISAs
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