Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF688 Gene

Aliases for ZNF688 Gene

  • Zinc Finger Protein 688 2 3 5

External Ids for ZNF688 Gene

Previous GeneCards Identifiers for ZNF688 Gene

  • GC16M030489
  • GC16M030009
  • GC16M028144

Summaries for ZNF688 Gene

GeneCards Summary for ZNF688 Gene

ZNF688 (Zinc Finger Protein 688) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF785.

UniProtKB/Swiss-Prot for ZNF688 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF688 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF688 Gene

Genomics for ZNF688 Gene

Regulatory Elements for ZNF688 Gene

Enhancers for ZNF688 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H030367 2 FANTOM5 Ensembl ENCODE dbSUPER 30.7 +196.7 196702 17 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 SETD1A SRCAP INO80E NPIPB12 SMG1P5 SMG1P2 ZNF764 RNF40 ZNF747 ENSG00000260304
GH16H030633 1.8 FANTOM5 Ensembl ENCODE 29.8 -62.0 -61967 2.6 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF143 ZNF688 ZNF689 FBRS CCDC189 TGFB1I1 LOC730183 MIR762HG PHKG2 ZNF764 SRCAP
GH16H030566 2.1 FANTOM5 Ensembl ENCODE dbSUPER 20.6 +2.9 2860 6 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC ZC3H11A SETD1A SRCAP ENSG00000260267 ZNF747 NPIPB13 INO80E ZNF764 C16orf58 SMG1P5 SMG1P2
GH16H031071 1.4 ENCODE dbSUPER 26.8 -500.9 -500907 5 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 SETD1A ZNF785 SRCAP KAT8 ZNF720 FBRS ZNF688 ZNF764 ZNF689 RNF40
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF688 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF688 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for ZNF688 Gene

Genomic Locations for ZNF688 Gene
3,389 bases
Minus strand

Genomic View for ZNF688 Gene

Genes around ZNF688 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF688 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF688 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF688 Gene

Proteins for ZNF688 Gene

  • Protein details for ZNF688 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 688
    Protein Accession:
    Secondary Accessions:
    • A8MV39
    • B3KV51
    • O75701
    • Q8IW91
    • Q8WV14
    • Q96MN0

    Protein attributes for ZNF688 Gene

    276 amino acids
    Molecular mass:
    30575 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC31673.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: ZNF688 and ZNF785.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF688 Gene


neXtProt entry for ZNF688 Gene

Post-translational modifications for ZNF688 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF688 Gene

No data available for DME Specific Peptides for ZNF688 Gene

Domains & Families for ZNF688 Gene

Gene Families for ZNF688 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF688 Gene

Suggested Antigen Peptide Sequences for ZNF688 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF688: view

Function for ZNF688 Gene

Molecular function for ZNF688 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF688 Gene

Gene Ontology (GO) - Molecular Function for ZNF688 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF688: view
genes like me logo Genes that share phenotypes with ZNF688: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF688 Gene

Localization for ZNF688 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF688 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF688 gene
Compartment Confidence
nucleus 5
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF688 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF688: view

Pathways & Interactions for ZNF688 Gene

SuperPathways for ZNF688 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF688: view

Pathways by source for ZNF688 Gene

2 Reactome pathways for ZNF688 Gene

Gene Ontology (GO) - Biological Process for ZNF688 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF688: view

No data available for SIGNOR curated interactions for ZNF688 Gene

Drugs & Compounds for ZNF688 Gene

No Compound Related Data Available

Transcripts for ZNF688 Gene

Unigene Clusters for ZNF688 Gene

Zinc finger protein 688:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF688 Gene

No ASD Table

Relevant External Links for ZNF688 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF688 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF688 Gene

Protein differential expression in normal tissues from HIPED for ZNF688 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF688 Gene

Protein tissue co-expression partners for ZNF688 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF688 Gene:


SOURCE GeneReport for Unigene cluster for ZNF688 Gene:


Evidence on tissue expression from TISSUES for ZNF688 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF688: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF688 Gene

Orthologs for ZNF688 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF688 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF688 33 34
  • 99.76 (n)
(Canis familiaris)
Mammalia ZNF688 33 34
  • 87.18 (n)
(Bos Taurus)
Mammalia ZNF688 33 34
  • 86.55 (n)
(Mus musculus)
Mammalia Zfp688 33 16 34
  • 79.82 (n)
(Rattus norvegicus)
Mammalia LOC102554302 33
  • 79.31 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 29 (a)
Species where no ortholog for ZNF688 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF688 Gene

Gene Tree for ZNF688 (if available)
Gene Tree for ZNF688 (if available)

Paralogs for ZNF688 Gene

(224) SIMAP similar genes for ZNF688 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF688: view

Variants for ZNF688 Gene

Sequence variations from dbSNP and Humsavar for ZNF688 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1001038511 -- 30,573,195(+) AGCCA(C/T)GGCGC downstream-variant-500B, upstream-variant-2KB
rs1001123878 -- 30,574,327(+) GATCA(C/T)CTGAG intron-variant, upstream-variant-2KB
rs1002154695 -- 30,573,590(+) CTGTC(A/T)TTCTG nc-transcript-variant, upstream-variant-2KB
rs1002248114 -- 30,574,117(+) TGGTG(C/G)ACACC intron-variant, upstream-variant-2KB
rs1003006183 -- 30,570,127(+) GCTCC(C/T)CCGAG reference, missense

Variation tolerance for ZNF688 Gene

Residual Variation Intolerance Score: 35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF688 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF688 Gene

Disorders for ZNF688 Gene

Relevant External Links for ZNF688

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF688 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF688 Gene

Publications for ZNF688 Gene

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 60
  5. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa RS … Obuse C (Nature cell biology 2010) 3 60

Products for ZNF688 Gene

Sources for ZNF688 Gene

Loading form....