ZNF688 Gene
protein-coding GIFtS: 40
GCID: GC16M030581
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zinc finger protein 688
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Aliases
for ZNF688 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6881 2 |
Export aliases for ZNF688 gene to outside databasesPrevious GC identifers: GC16M030489 GC16M030009 GC16M028144 |
Summaries
for ZNF688 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN688_HUMAN, P0C7X2Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF688 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF688 gene promoter:
E2F-4 E2F-3a STAT1 E2F-5 E2F E2F-1 deltaCREB STAT1beta E2F-2 STAT1alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF688
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF688 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2ZNF688 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M030581: view genomic region
(about GC identifiers)
Start:
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30,580,667 bp from pter |
End:
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30,584,055 bp from pter |
Size:
|
3,389 bases |
Orientation:
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minus strand |
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Proteins
for ZNF688 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN688_HUMAN, P0C7X2 (See
protein sequence)Recommended Name: Zinc finger protein 688 Size: 276 amino acids; 30575 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAC31673.1; Type=Erroneous gene model prediction; Note=The predicted gene has been splitinto 2 genes: ZNF688 and ZNF785;
Secondary accessions: B3KV51 O75701 Q8IW91 Q8WV14 Q96MN0Explore the universe of human proteins at neXtProt for ZNF688: NX_P0C7X2
ZNF688 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001019854.1 NP_660314.1
ENSEMBL proteins: ENSP00000223459 ENSP00000455227 ENSP00000456047 ENSP00000457222 ENSP00000456070 ENSP00000378645 Reactome Protein details: P0C7X2
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ZNF688 for ontologies About GeneDecksing
ZNF688 Antibody Products:
Assay Products for ZNF688: |
Protein
Domains /
Families
for ZNF688 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF688 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P0C7X2ProtoNet protein and cluster: P0C7X2 UniProtKB/Swiss-Prot: ZN688_HUMAN, P0C7X2Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 2 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF688 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN688_HUMAN, P0C7X2Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF688 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF688 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZNF688 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF688 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF688 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZNF688 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF688 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF688
ZNF688 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF688
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ZNF688 (ENSP000002234594) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
ZNF688 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF688 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF688
Search CenterWatch for drugs/clinical trials and news about ZNF688 / ZN688
|
Transcripts
for ZNF688 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF688 gene (2 alternative transcripts): NM_001024683.1 NM_145271.3 Unigene Cluster for ZNF688: Zinc finger protein 688 Hs.301463 [show with all ESTs]Unigene Representative Sequence: AK1226808 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000223459(uc002dys.2 uc002dyt.2) ENST00000563276 ENST00000563665
ENST00000562455 ENST00000566632 ENST00000567855 ENST00000563707 ENST00000395219
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF688 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF688 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF688 (NM_001024683) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF688 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF688 |
Additional cDNA sequence: AF085979.1 AK122680.1 BC018997.2 8 DOTS entries: DT.111369 DT.111480 DT.95375454 DT.95375456 DT.40130689 DT.92424550 DT.100020481 DT.100752383 24/90 AceView cDNA sequences (see all 90): BF116047 AI829953 AI394188 AI738773 AI366701 CB046736 BQ668914 AW964994 BC018997 NM_145271 BM931992 BM931887 BU146335 BI711240 AA808291 AI394187 BM714269 AI803197 BM975012 BU069333 CD370940 CD674907 BQ187361 AW294482
GeneLoc Exon Structure
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Expression
for ZNF688 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF688 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTGGGCTT
About this image
See ZNF688 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF688
SOURCE GeneReport for Unigene cluster: Hs.301463
SABiosciences Custom PCR Arrays for ZNF688
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF688
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF688 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF688 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF688 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF688 |
Orthologs
for ZNF688 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF688 (if available)
TreeFam Gene Tree for ZNF688 (if available) |
Paralogs
for ZNF688 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF688 gene
- ZNF7642 ZNF7472 ENSG000002614592 ENSG000002608692 ZNF7852 ZNF6892
18/169 SIMAP similar genes for ZNF688 using alignment to 7 protein entries: ZN688_HUMAN (see all proteins)
(see all similar genes):ZNF619 ZNF627 ZNF791 ZNF707 ZNF823 ZNF433
ZNF3 ZNF571 ZNF785 ZNF780A ZNF383 ZNF525
ZNF177 ZNF28 ZNF519 ZNF761 ZNF124 ZNF565
ZNF688 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF688 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF688 (30580667 - 30584055 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF688: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF688 |
|
Disorders
/ Diseases
for ZNF688 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF688 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF688 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF688) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2, 3 Loftus B.J.... Adams M.D. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for ZNF688 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF688 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF688 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF688 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF688 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF688 gene:
Search GeneIP for patents involving ZNF688
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF688 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF688 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF688 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF688 | | | OriGene Protein Over-expression Lysate for ZNF688 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF688 | | OriGene 3'-UTR Clone for ZNF688 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF688 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF688 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF688 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF688 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF688 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF688 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF688 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF688 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZNF688 |
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 | | | ZNF688 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF688 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF688 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF688 |
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