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Aliases for ZNF688 Gene

Aliases for ZNF688 Gene

  • Zinc Finger Protein 688 2 3

External Ids for ZNF688 Gene

Previous GeneCards Identifiers for ZNF688 Gene

  • GC16M030489
  • GC16M030009
  • GC16M028144

Summaries for ZNF688 Gene

GeneCards Summary for ZNF688 Gene

ZNF688 (Zinc Finger Protein 688) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF785.

UniProtKB/Swiss-Prot for ZNF688 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF688 Gene

Genomics for ZNF688 Gene

Regulatory Elements for ZNF688 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF688 Gene

30,569,346 bp from pter
30,572,734 bp from pter
3,389 bases
Minus strand

Genomic View for ZNF688 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF688 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF688 Gene

Proteins for ZNF688 Gene

  • Protein details for ZNF688 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 688
    Protein Accession:
    Secondary Accessions:
    • A8MV39
    • B3KV51
    • O75701
    • Q8IW91
    • Q8WV14
    • Q96MN0

    Protein attributes for ZNF688 Gene

    276 amino acids
    Molecular mass:
    30575 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC31673.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: ZNF688 and ZNF785.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF688 Gene


neXtProt entry for ZNF688 Gene

Proteomics data for ZNF688 Gene at MOPED

Post-translational modifications for ZNF688 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF688 Gene

Antibody Products

No data available for DME Specific Peptides for ZNF688 Gene

Domains for ZNF688 Gene

Gene Families for ZNF688 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF688 Gene

Suggested Antigen Peptide Sequences for ZNF688 Gene

Graphical View of Domain Structure for InterPro Entry



  • P0C7X2
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF688: view

Function for ZNF688 Gene

Molecular function for ZNF688 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF688 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF688: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF688 Gene

Localization for ZNF688 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF688 Gene

Subcellular locations from

Jensen Localization Image for ZNF688 Gene COMPARTMENTS Subcellular localization image for ZNF688 gene
Compartment Confidence
nucleus 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ZNF688 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF688: view

Pathways for ZNF688 Gene

SuperPathways for ZNF688 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF688: view

Pathways by source for ZNF688 Gene

2 Reactome pathways for ZNF688 Gene

Interacting Proteins for ZNF688 Gene

Gene Ontology (GO) - Biological Process for ZNF688 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF688: view

Transcripts for ZNF688 Gene

Unigene Clusters for ZNF688 Gene

Zinc finger protein 688:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF688

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF688 Gene

No ASD Table

Relevant External Links for ZNF688 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF688 Gene

mRNA expression in normal human tissues for ZNF688 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF688 Gene

SOURCE GeneReport for Unigene cluster for ZNF688 Gene Hs.301463

genes like me logo Genes that share expressions with ZNF688: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF688 Gene

Orthologs for ZNF688 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF688 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF688 35
  • 99.76 (n)
  • 100 (a)
ZNF688 36
  • 100 (a)
(Bos Taurus)
Mammalia ZNF688 35
  • 86.55 (n)
  • 83.19 (a)
ZNF688 36
  • 81 (a)
(Canis familiaris)
Mammalia ZNF688 35
  • 87.18 (n)
  • 86.08 (a)
ZNF688 36
  • 85 (a)
(Mus musculus)
Mammalia Zfp688 35
  • 79.82 (n)
  • 75.1 (a)
Zfp688 16
Zfp688 36
  • 74 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
(Rattus norvegicus)
Mammalia LOC102554302 35
  • 79.31 (n)
  • 74.71 (a)
Species with no ortholog for ZNF688:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF688 Gene

Gene Tree for ZNF688 (if available)
Gene Tree for ZNF688 (if available)

Paralogs for ZNF688 Gene

Selected SIMAP similar genes for ZNF688 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF688: view

Variants for ZNF688 Gene

Sequence variations from dbSNP and Humsavar for ZNF688 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1064754 -- 30,570,021(+) CTCCG(C/G)CCCCG reference, synonymous-codon
rs3072029 -- 30,570,722(-) aataa(-/ATAA)taGCC intron-variant
rs6565192 -- 30,574,214(+) gcact(C/T)caacc upstream-variant-2KB
rs7193647 -- 30,572,928(+) gtgca(A/G)tggcg upstream-variant-2KB
rs10553018 -- 30,569,281(+) GTTCA(-/T)TTTTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ZNF688 Gene

Variant ID Type Subtype PubMed ID
nsv905727 CNV Loss 21882294

Relevant External Links for ZNF688 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF688 Gene

Disorders for ZNF688 Gene

No disorders were found for ZNF688 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF688 Gene

Publications for ZNF688 Gene

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3
  5. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PMID: 20562864) Nozawa R.S. … Obuse C. (Nat. Cell Biol. 2010) 3

Products for ZNF688 Gene

Sources for ZNF688 Gene

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