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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF688 Gene

protein-coding   GIFtS: 43
GCID: GC16M030581

Zinc Finger Protein 688

  Search for ZNF688
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 6881 2

External Ids:    HGNC: 304891   Entrez Gene: 1465422   Ensembl: ENSG000002298097   UniProtKB: P0C7X23   

Export aliases for ZNF688 gene to outside databases

Previous GC identifers: GC16M030489 GC16M030009 GC16M028144


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF688 Gene: 
ZNF688 (zinc finger protein 688) is a protein-coding gene. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and molecular_function. An important paralog of this gene is ZNF747.

UniProtKB/Swiss-Prot: ZN688_HUMAN, P0C7X2
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF688 gene promoter:
         E2F-4   E2F-3a   STAT1   E2F-5   E2F   E2F-1   deltaCREB   STAT1beta   E2F-2   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF688 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF688

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF688


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

ZNF688 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF688 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030581:  view genomic region     (about GC identifiers)

Start:
30,580,667 bp from pter      End:
30,584,055 bp from pter
Size:
3,389 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN688_HUMAN, P0C7X2 (See protein sequence)
Recommended Name: Zinc finger protein 688  
Size: 276 amino acids; 30575 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAC31673.1; Type=Erroneous gene model prediction; Note=The predicted gene has been
split into 2 genes: ZNF688 and ZNF785;
Secondary accessions: A8MV39 B3KV51 O75701 Q8IW91 Q8WV14 Q96MN0
Alternative splicing: 2 isoforms:  P0C7X2-1   P0C7X2-5   

Explore the universe of human proteins at neXtProt for ZNF688: NX_P0C7X2

Explore proteomics data for ZNF688 at MOPED 

ZNF688 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ZNF688 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001019854.1  NP_660314.1  

ENSEMBL proteins: 
 ENSP00000223459   ENSP00000455227   ENSP00000456047   ENSP00000457222   ENSP00000456070  
 ENSP00000378645  
Reactome Protein details: P0C7X2
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Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--
GO:0005622intracellular ----
GO:0005634nucleus IEA--

ZNF688 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:
 IPR015880 Znf_C2H2-like
 IPR001909 Krueppel-associated_box
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry P0C7X2

ProtoNet protein and cluster: P0C7X2

UniProtKB/Swiss-Prot: ZN688_HUMAN, P0C7X2
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 2 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


ZNF688 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZN688_HUMAN, P0C7X2
Function: May be involved in transcriptional regulation

     Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0008270zinc ion binding ----
GO:0046872metal ion binding IEA--
     
ZNF688 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ZNF688 About                                                                                                See pathways by source

SuperPathContained pathways About
1Generic Transcription Pathway
Generic Transcription Pathway0.47
Gene Expression0.47

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2        Reactome Pathways for ZNF688
    Generic Transcription Pathway
Gene Expression



ZNF688 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF688

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ZNF688 (ENSP000002234594) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CBX5ENSP000002098754STRING: ENSP00000209875
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-dependent IEA--
GO:0006355regulation of transcription, DNA-dependent IEA--
GO:0008150biological_process ND--

ZNF688 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF688 (ZN688)

Search CenterWatch for drugs/clinical trials and news about ZNF688 / ZN688

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF688 gene (2 alternative transcripts): 
NM_001024683.1  NM_145271.3  

Unigene Cluster for ZNF688:

Zinc finger protein 688
Hs.301463  [show with all ESTs]
Unigene Representative Sequence: AK122680
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000223459(uc002dys.2 uc002dyt.2) ENST00000563276 ENST00000563665
ENST00000562455 ENST00000566632 ENST00000567855 ENST00000563707 ENST00000395219

miRNA
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Inhib. RNA
Products:
     
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF688

Additional mRNA sequence: 

AF085979.1 AK122680.1 BC018997.2 

8 DOTS entries:

DT.111369  DT.111480  DT.95375454  DT.95375456  DT.40130689  DT.92424550  DT.100020481  DT.100752383 

24/90 AceView cDNA sequences (see all 90):

AA808291 CB046736 BQ187361 BQ668914 CD674907 AI829953 AI394188 AI540123 
AI803197 BM975012 AI738773 AI394187 BI711240 BF116047 AW294482 BC018997 
AA341947 CD370940 AI366701 BM676643 BM931887 AW964994 BU069333 BM931992 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF688 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCCTGGGCTT
ZNF688 Expression
About this image


See ZNF688 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF688

SOURCE GeneReport for Unigene cluster: Hs.301463
    SABiosciences Custom PCR Arrays for ZNF688
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF688

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for ZNF688 gene from 1/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Zfp6881 , 5 zinc finger protein 6881, 5 79.68(n)1
75.18(a)1
  7 (69.51 cM)5
692341  NM_026999.41  NP_081275.31 
 1274189675 


ENSEMBL Gene Tree for ZNF688 (if available)
TreeFam Gene Tree for ZNF688 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ZNF688 gene
ZNF7472  ZNF7642  ENSG000002614592  ENSG000002608692  ZNF6892  ZNF7852  
18/221 SIMAP similar genes for ZNF688 using alignment to 6 protein entries:     ZN688_HUMAN (see all proteins) (see all similar genes):
ZNF619    ZNF627    ZNF707    ZNF823    ZNF75A    ZNF616
ZNF433    ZNF3    ZNF571    ZNF785    ZNF383    ZNF320
ZNF177    ZNF519    ZNF649    ZNF761    ZNF780A    ZNF780B

ZNF688 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/126 SNPs in ZNF688 are shown (see all 126)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs777844101,2
C--30580572(+) GACCAC/TAGGCA 2 -- ds50010--------
rs1928130761,2
--30580585(+) ATGTGC/TCACTA 2 -- ds50010--------
rs105530181,2
C--30580602(+) GTTCA-/T/TT  
        
TTTTT
2 -- ds50010--------
rs1840865871,2
--30580730(+) CCTCCC/TTCCTT 2 -- ds50010--------
rs1432453191,2
C--30580862(+) CCCTCC/TCCAGG 2 -- ds50010--------
rs1141705731,2
F--30580945(+) CTGTTG/ACACCT 2 -- ds50011Minor allele frequency- A:0.03WA 118
rs1174283421,2
C,F--30580955(+) TGATCT/CTCAGA 2 -- ds50011Minor allele frequency- C:0.03EA 120
rs129314951,2
C--30580995(+) CTCTCC/TTCttt 2 -- ds50010--------
rs2019297171,2
C--30580997(+) CTCTTC/TTTTTT 2 -- ds50010--------
rs129314981,2
C--30580998(+) TCttcC/Tttttt 2 -- ds50010--------

HapMap Linkage Disequilibrium report for ZNF688 (30580667 - 30584055 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for ZNF688:    About this table     
Variant IDTypeSubtypePubMed ID
nsv905727CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ZNF688 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF688)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2, 3 Loftus B.J.... Adams M.D. (1999)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  4. Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)1 Nozawa R.S....Obuse C. (2010)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  6. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 146542 HGNC: 30489 AceView: LOC146542 Ensembl:ENSG00000229809 euGenes: HUgn146542
ECgene: ZNF688 H-InvDB: ZNF688

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ZNF688 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ZNF688 gene:
Search GeneIP for patents involving ZNF688

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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