ZNF687 Gene(Protein Coding)

Zinc Finger Protein 687

GCID:: GC01P151254

GIFtS:: 49

Genes Participants

Aliases for ZNF687 Gene

Zinc Finger Protein 687 ² ³ ⁵
KIAA1441 ⁴
PDB6 ³

External Ids for ZNF687 Gene

HGNC: 29277
Entrez Gene: 57592
Ensembl: ENSG00000143373
OMIM: 610568
UniProtKB: Q8N1G0

Previous GeneCards Identifiers for ZNF687 Gene

GC01P148069
GC01P149520
GC01P122632

Export aliases for ZNF687 gene to outside databases

Summaries for ZNF687 Gene

GeneCards Summary for ZNF687 Gene

ZNF687 (Zinc Finger Protein 687) is a Protein Coding gene. An important paralog of this gene is ZNF592.

UniProtKB/Swiss-Prot for ZNF687 Gene

ZN687_HUMAN,Q8N1G0

May be involved in transcriptional regulation.

Gene Wiki entry for ZNF687 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF687 Gene

Genomics for ZNF687 Gene

Regulatory Elements for ZNF687 Gene

Enhancers for ZNF687 Gene

GeneHancer Identifier	Score	Enhancer Sources	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites within enhancer	Other Gene Targets for Enhancer

Enhancers around ZNF687 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF687 Gene

Ensembl Regulatory Elements (ENSRs)	TSS Distance (bp)	Size (bp)	Binding Sites for Transcription Factors within promoters

ENSRs around ZNF687 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF687 gene promoter:

See All at QIAGEN

Regulatory Element Products

Genomic Location for ZNF687 Gene

Chromosome:: 1

Start:: 151,281,555 bp from pter
End:: 151,292,180 bp from pter

Size:: 10,626 bases
Orientation:: Plus strand

Genomic View for ZNF687 Gene

Genes around ZNF687 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

1q21.3 by Ensembl
1q21.3 by Entrez Gene
1q21.2 by HGNC

ZNF687 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for ZNF687 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF687 Gene

Proteins for ZNF687 Gene

Protein details for ZNF687 Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

Q8N1G0-ZN687_HUMAN

Recommended name:

Zinc finger protein 687

Protein Accession:

Q8N1G0

Secondary Accessions:
- D3DV17
- Q68DQ8
- Q9H937
- Q9P2A7
Protein attributes for ZNF687 Gene
Size:

1237 amino acids

Molecular mass:

129529 Da
Quaternary structure:

No Data Available

SequenceCaution:
Sequence=BAA92679.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14406.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH18162.1; Type=Frameshift; Positions=1062; Evidence={ECO:0000305};
Alternative splice isoforms for ZNF687 Gene
UniProtKB/Swiss-Prot:
Q8N1G0-1

Q8N1G0-2

neXtProt entry for ZNF687 Gene

Proteomics data for ZNF687 Gene at MOPED

Protein Expression for ZNF687 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF687 Gene

Modification sites at PhosphoSitePlus
- Q8N1G0
Modification sites at neXtProt
- NX_Q8N1G0

Other Protein References for ZNF687 Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

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OriGene Antibodies for ZNF687
- TA319090
- TA319984
- TA319985
- TA345300
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Novus Biologicals Antibodies for ZNF687

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Invitrogen Antibodies for ZNF687

antibodies-online Antibodies for ZNF687: See all 21

GeneTex Cyp2c11 antibody for ZNF687
GeneTex ZNF687 antibody for ZNF687

ProSci Antibodies for ZNF687
- ZNF687 Antibody
- ZNF687 Antibody
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Santa Cruz Biotechnology (SCBT) Antibodies for ZNF687
- ZNF687 (E-20)

Protein Products

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OriGene Purified Proteins for ZNF687
- NM_020832
- NM_020832
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Novus Biologicals proteins and lysates for ZNF687

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Search GeneTex for Proteins for ZNF687

Search for Proteins for ZNF687 at Abcam

Assay Products

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Search for Assays for ZNF687 at Abcam

No data available for DME Specific Peptides for ZNF687 Gene

Domains & Families for ZNF687 Gene

Protein Domains for ZNF687 Gene

InterPro:

ProtoNet:

Q8N1G0

Suggested Antigen Peptide Sequences for ZNF687 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N1G0

UniProtKB/Swiss-Prot:

ZN687_HUMAN :

Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 10 C2H2-type zinc fingers.

Family:

Belongs to the krueppel C2H2-type zinc-finger protein family.

Similarity:

Contains 10 C2H2-type zinc fingers.

No data available for Gene Families for ZNF687 Gene

Function for ZNF687 Gene

Molecular function for ZNF687 Gene

UniProtKB/Swiss-Prot Function:

May be involved in transcriptional regulation.

ZN687_HUMAN,Q8N1G0

Phenotypes for ZNF687 Gene

GenomeRNAi human phenotypes for ZNF687:

Animal Model Products

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ViGene Biosciences lentiviral particle packaged cDNA for ZNF687 gene
- LH862739
ViGene Biosciences ready-to-package AAV shRNAs for ZNF687 gene
- SH862739
Search ViGene Biosciences for ZNF687

CRISPR Products

OriGene CRISPR knockouts for ZNF687
- KN207127

Santa Cruz Biotechnology (SCBT) CRISPR for ZNF687

GenScript: Design CRISPR guide RNA sequences for ZNF687

miRNA for ZNF687 Gene

miRTarBase miRNAs that target ZNF687

miRNA Products

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Inhibitory RNA Products

Origene siRNA, shRNA, and RNAi products in human, mouse, rat for ZNF687
Browse OriGene Inhibitory RNA Products For ZNF687

ViGene Biosciences ready-to-package AAV shRNAs for ZNF687 gene
- SH862739

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No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF687 Gene

Localization for ZNF687 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF687 Gene

Nucleus.

Q8N1G0-ZN687_HUMAN

Subcellular locations from

COMPARTMENTS

Jensen Localization Image for ZNF687 Gene

Compartment	Confidence
nucleus	5

No data available for Gene Ontology (GO) - Cellular Components for ZNF687 Gene

Pathways & Interactions for ZNF687 Gene

SuperPathways for ZNF687 Gene

More details on SuperPathways for ZNF687

No Data Available

Interacting Proteins for ZNF687 Gene

http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000319829%0d%0a9606.ENSP00000327889%0d%0a9606.ENSP00000310260%0d%0a9606.ENSP00000385722%0d%0a9606.ENSP00000323687%0d%0a9606.ENSP00000408108%0d%0a — STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins: ENSP00000319829 Q8N1G0-ZN687_HUMAN for ZNF687 Gene via STRING I2D

Symbol	External ID(s)	Details
INTS1	ENSP00000385722 ²⁰ Q8N201 ²¹	STRING: ENSP00000385722 I2D: score=1
INTS5	ENSP00000327889 ²⁰ Q6P9B9 ²¹	STRING: ENSP00000327889 I2D: score=1
INTS6	ENSP00000310260 ²⁰ Q9UL03 ²¹	STRING: ENSP00000310260 I2D: score=1
RNF2	ENSP00000356480 ²⁰ Q99496 ²¹	STRING: ENSP00000356480 I2D: score=1
SUMO1	ENSP00000376076 ²⁰ P63165 ²¹	STRING: ENSP00000376076 I2D: score=1

Gene Ontology (GO) - Biological Process for ZNF687 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-templated	IEA	--

No data available for Pathways by source and SIGNOR curated interactions for ZNF687 Gene

Drugs & Compounds for ZNF687 Gene

No Compound Related Data Available

Drug Products

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Transcripts for ZNF687 Gene

mRNA/cDNA for ZNF687 Gene

(7) REFSEQ mRNAs :

(5) Additional mRNA sequences :

(126) Selected AceView cDNA sequences:

(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF687 Gene

Zinc finger protein 687:

Hs.186756

Representative Sequences:

AB037862

CRISPR Products

OriGene CRISPR knockouts for ZNF687
- KN207127

Santa Cruz Biotechnology (SCBT) CRISPR for ZNF687

GenScript: Design CRISPR guide RNA sequences for ZNF687

miRNA Products

Search ViGene Biosciences for ZNF687

Inhibitory RNA Products

Origene siRNA, shRNA, and RNAi products in human, mouse, rat for ZNF687
Browse OriGene Inhibitory RNA Products For ZNF687

ViGene Biosciences ready-to-package AAV shRNAs for ZNF687 gene
- SH862739

Search Santa Cruz Biotechnology (SCBT) for ZNF687 siRNA/shRNA

Clone Products

OriGene clones in human for ZNF687
OriGene ORF clones in human for ZNF687
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

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Flow Cytometry Products

eBioscience FlowRNA Probe Sets

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF687 Gene

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9
SP1:															-
SP2:

Relevant External Links for ZNF687 Gene

GeneLoc Exon Structure for: ZNF687
ECgene alternative splicing isoforms for: ZNF687

Expression for ZNF687 Gene

mRNA expression in normal human tissues for ZNF687 Gene

mRNA expression by BioGPS for ZNF687 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
- Outflow Tract

Protein differential expression in normal tissues from HIPED for ZNF687 Gene

This gene is overexpressed in Placenta (14.3), Peripheral blood mononuclear cells (12.9), Pancreas (9.2), Retina (8.4), and Blymphocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF687 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF687 Gene

Integrated proteomics: cell line protein expression from ProteomicsDB, MOPED and MaxQB for ZNF687 Gene

SOURCE GeneReport for Unigene cluster for ZNF687 Gene Hs.186756

Protein tissue co-expression partners for ZNF687 Gene

- Elite partner

Primer Products

OriGene qPCR primer pairs for ZNF687
- HP213872

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF687 Gene

Orthologs for ZNF687 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF687 Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
cow (Bos Taurus)	Mammalia	ZNF687 ³⁵	89.03 (n) 91 (a)		787675 NM_001205457.1 NP_001192386.1
cow (Bos Taurus)	Mammalia	ZNF687 ³⁶	90 (a)	OneToOne	3:19552536-19557450
dog (Canis familiaris)	Mammalia	ZNF687 ³⁵	87.75 (n) 89.13 (a)		483195 XM_005630796.1 XP_005630853.1
dog (Canis familiaris)	Mammalia	ZNF687 ³⁶	88 (a)	OneToOne	17:60353847-60358667
mouse (Mus musculus)	Mammalia	Zfp687 ³⁵	84.93 (n) 85.88 (a)		78266 NM_030074.2 NP_084350.1
		Zfp687 ¹⁶			95006590
		Zfp687 ³⁶	84 (a)	OneToOne	3:95006590-95015448
chimpanzee (Pan troglodytes)	Mammalia	ZNF687 ³⁵	99.65 (n) 99.68 (a)		457290 XM_513792.4 XP_513792.3
chimpanzee (Pan troglodytes)	Mammalia	ZNF687 ³⁶	99 (a)	OneToOne	1:129479411-129489001
rat (Rattus norvegicus)	Mammalia	LOC100363361 ³⁵	83.71 (n) 85.69 (a)		100363361 XM_006232933.1 XP_006232995.1
oppossum (Monodelphis domestica)	Mammalia	ZNF687 ³⁶	71 (a)	OneToOne	2:496461344-496470911
platypus (Ornithorhynchus anatinus)	Mammalia	-- ³⁶	27 (a)	ManyToMany	Contig39154:2774-3940
chicken (Gallus gallus)	Aves	ZNF687 ³⁵	65.04 (n) 64.75 (a)		429831 XM_427387.4 XP_427387.4
chicken (Gallus gallus)	Aves	ZNF687 ³⁶	56 (a)	OneToOne	25:1990146-1996328
lizard (Anolis carolinensis)	Reptilia	ZNF687 ³⁶	49 (a)	OneToOne	GL343616.1:374779-404583
tropical clawed frog (Silurana tropicalis)	Amphibia	znf687 ³⁵	65.66 (n) 65.04 (a)		100036627 NM_001097186.1 NP_001090655.1
zebrafish (Danio rerio)	Actinopterygii	Dr.16948 ³⁵			BI982637.1
		si:dkey-204a24.9 ³⁵	55.17 (n) 52.31 (a)		100006039 XM_001340700.4 XP_001340736.2
		znf687a ³⁶	36 (a)	OneToMany	16:24111674-24131058
		znf687b ³⁶	34 (a)	OneToMany	19:8442468-8454975
sea squirt (Ciona savignyi)	Ascidiacea	-- ³⁶	25 (a)	OneToMany	reftig_15:1163767-1170963

Species with no ortholog for ZNF687:

A. gosspyii yeast (Ashbya gossypii)
Actinobacteria (Mycobacterium tuberculosis)
African clawed frog (Xenopus laevis)
African malaria mosquito (Anopheles gambiae)
Alicante grape (Vitis vinifera)
alpha proteobacteria (Wolbachia pipientis)
amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
baker's yeast (Saccharomyces cerevisiae)
barley (Hordeum vulgare)
beta proteobacteria (Neisseria meningitidis)
bread mold (Neurospora crassa)
Chromalveolata (Phytophthora infestans)
common water flea (Daphnia pulex)
corn (Zea mays)
E. coli (Escherichia coli)
filamentous fungi (Aspergillus nidulans)
Firmicute bacteria (Streptococcus pneumoniae)
fission yeast (Schizosaccharomyces pombe)
fruit fly (Drosophila melanogaster)
green algae (Chlamydomonas reinhardtii)
honey bee (Apis mellifera)
K. lactis yeast (Kluyveromyces lactis)
loblloly pine (Pinus taeda)
malaria parasite (Plasmodium falciparum)
medicago trunc (Medicago Truncatula)
moss (Physcomitrella patens)
orangutan (Pongo pygmaeus)
pig (Sus scrofa)
rainbow trout (Oncorhynchus mykiss)
rice (Oryza sativa)
rice blast fungus (Magnaporthe grisea)
schistosome parasite (Schistosoma mansoni)
sea anemone (Nematostella vectensis)
sea urchin (Strongylocentrotus purpuratus)
sorghum (Sorghum bicolor)
soybean (Glycine max)
stem rust fungus (Puccinia graminis)
sugarcane (Saccharum officinarum)
thale cress (Arabidopsis thaliana)
tomato (Lycopersicon esculentum)
toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)
wheat (Triticum aestivum)
worm (Caenorhabditis elegans)

Evolution for ZNF687 Gene

ENSEMBL:: Gene Tree for ZNF687 (if available)
TreeFam:: Gene Tree for ZNF687 (if available)

Paralogs for ZNF687 Gene

ZNF592 ⁵
ZNF532 ⁵

(1) SIMAP similar genes for ZNF687 Gene using alignment to 5 proteins:

ZNF532

Variants for ZNF687 Gene

Sequence variations from dbSNP and Humsavar for ZNF687 Gene

SNP ID	Clin	Chr 01 pos	Sequence Context	Type
rs3748545	-	151,287,067(+)	TGCTG(A/G)GGTGC	reference, missense
rs12045766	-	151,287,322(+)	CACAA(C/G)GACTG	reference, missense
rs2298264	--	151,286,816(-)	AGCGG(A/G)TCTGA	reference, synonymous-codon
rs2298265	--	151,286,567(-)	TGCTC(A/G)GGACA	reference, synonymous-codon
rs3748546	--	151,287,257(+)	GCCTC(C/T)AGCTC	reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNF687 Gene

Variant ID	Type	Subtype	PubMed ID
nsv522840	CNV	Gain	19592680
dgv2n68	CNV	Loss	17160897
esv34461	CNV	Gain	17911159

Variation tolerance for ZNF687 Gene

Residual Variation Intolerance Score: 20.8% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 4.63; 65.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF687 Gene

Disorders for ZNF687 Gene

Relevant External Links for ZNF687

Atlas of Genetics and Cytogenetics in Oncology and Haematology:: ZNF687

No disorders were found for ZNF687 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF687 Gene

Publications for ZNF687 Gene

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) ² ³ ⁴ ⁶⁷
Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) ³
The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) ³
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) ³
The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) ³