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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF687 Gene

protein-coding GIFtS: 49
GCID: GC01P151254

Zinc Finger Protein 687

Search for ZNF687
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Zinc Finger Protein 687¹ ²
KIAA1441³ ⁵

External Ids:	HGNC: 29277¹	Entrez Gene: 57592²	Ensembl: ENSG00000143373⁷	OMIM: 610568⁵	UniProtKB: Q8N1G0³

Export aliases for ZNF687 gene to outside databases

Previous GC identifers: GC01P148069 GC01P149520 GC01P122632

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF687 Gene:

ZNF687 (zinc finger protein 687) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF532.

UniProtKB/Swiss-Prot: ZN687_HUMAN, Q8N1G0

Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF687 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NT_004487.19 NC_018912.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF687 gene promoter:
E2F-4 E2F-3a E2F-5 Spz1 MyoD E2F-2 MZF-1 E2F E2F-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF687 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF687

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF687

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.2

ZNF687 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF687 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P151254: view genomic region (about GC identifiers)

Start:	151,254,094 bp from pter	End:	151,264,656 bp from pter
Size:	10,563 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN687_HUMAN, Q8N1G0 (See protein sequence)

Recommended Name: Zinc finger protein 687

Size: 1237 amino acids; 129529 Da

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=BAA92679.1; Type=Erroneous initiation; Sequence=BAB14406.1; Type=Erroneous initiation;

Sequence=CAH18162.1; Type=Frameshift; Positions=1062;

Secondary accessions: D3DV17 Q68DQ8 Q9H937 Q9P2A7

Alternative splicing: 2 isoforms: Q8N1G0-1 Q8N1G0-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF687: NX_Q8N1G0

Explore proteomics data for ZNF687 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q8N1G0

ZNF687 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_065883.1

ENSEMBL proteins:

ENSP00000395261 ENSP00000336620 ENSP00000415286 ENSP00000319829 ENSP00000398821

ENSP00000416942 ENSP00000357874

Human Recombinant Protein Products for ZNF687:

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	Cloud-Clone Corp. Proteins for ZNF687

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	nucleolus	IDA	--

ZNF687 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro protein domains:

IPR015880 Znf_C2H2-like

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q8N1G0

ProtoNet protein and cluster: Q8N1G0

UniProtKB/Swiss-Prot: ZN687_HUMAN, Q8N1G0

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 10 C2H2-type zinc fingers

ZNF687 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZN687_HUMAN, Q8N1G0

Function: May be involved in transcriptional regulation

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	--	--
GO:0046872	metal ion binding	IEA	--

ZNF687 for ontologies About GeneDecksing

Animal Models:

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miRNA Products:
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		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF687 (see all 24):
		hsa-miR-4328 hsa-miR-509-5p hsa-miR-488 hsa-miR-1205 hsa-miR-29b-1* hsa-miR-103a hsa-miR-124 hsa-miR-1184

		SwitchGear 3'UTR luciferase reporter plasmid: ZNF687 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF687

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF687

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/7 Interacting proteins for ZNF687 (Q8N1G0³ ENSP00000319829⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
INTS5	Q6P9B9³, ENSP00000327889⁴	I2D: score=1 STRING: ENSP00000327889
SUMO1	P63165³, ENSP00000376076⁴	I2D: score=1 STRING: ENSP00000376076
INTS1	Q8N201³, ENSP00000385722⁴	I2D: score=1 STRING: ENSP00000385722
INTS3	Q68E01³, ENSP00000318641⁴	I2D: score=1 STRING: ENSP00000318641
INTS6	Q9UL03³, ENSP00000310260⁴	I2D: score=1 STRING: ENSP00000310260

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF687 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF687 (ZN687)

Search CenterWatch for drugs/clinical trials and news about ZNF687 / ZN687

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF687 gene:

NM_020832.1

Unigene Cluster for ZNF687:

Zinc finger protein 687

Hs.186756 [show with all ESTs]

Unigene Representative Sequence: AB037862

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000443959 ENST00000336715(uc001exq.3) ENST00000449313(uc001exp.1)

ENST00000324048(uc009wmo.3) ENST00000426871 ENST00000459919 ENST00000436614

ENST00000368879(uc009wmp.3)

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF687
		8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF687 (see all 24):
		hsa-miR-4328 hsa-miR-509-5p hsa-miR-488 hsa-miR-1205 hsa-miR-29b-1* hsa-miR-103a hsa-miR-124 hsa-miR-1184

		SwitchGear 3'UTR luciferase reporter plasmid: ZNF687 3' UTR sequence

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Additional mRNA sequence:

AB037862.1 AK023105.1 BC020245.1 BC032463.1 CR749307.1

8 DOTS entries:

DT.95164401 DT.91732673 DT.121443513 DT.97848306 DT.402459 DT.102832727 DT.121443529 DT.99943313

24/126 AceView cDNA sequences (see all 126):

CA488781 BU729994 BI753953 AB037862 BQ217249 AK023105 CD366120 CB305718

BC032463 BM721303 AL603613 BM704083 AI951587 BM718164 BM671840 NM_020832

BM677037 BF510047 W84724 AI745167 BQ231483 BQ212546 BI753085 AI185962

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF687 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9
SP1:															-
SP2:

ECgene alternative splicing isoforms for ZNF687

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF687 expression in normal human tissues (normalized intensities) ZNF687 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GACTGGAACT

About this image

ZNF687 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/1 selected tissues (see all 1) fully expand


Heart (Cardiovascular System) fully expand to see all 2 entries
Atrioventricular Canal Cells Atrioventricular Canal
Outflow Tract

See ZNF687 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF687

SOURCE GeneReport for Unigene cluster: Hs.186756

SABiosciences Custom PCR Arrays for ZNF687

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF687

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF687 gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zfp687^{1 , 5}	zinc finger protein 687^{1, 5}	85.59(n)¹ 86.84(a)¹		3 (40.74 cM)⁵ 78266¹ NM_030074.2¹ NP_084350.1¹ 95006590⁵
chicken (Gallus gallus)	Aves	ZNF687⁶	zinc finger protein 687	58(a)	1 ↔ 1	25(1990146-1996328)
lizard (Anolis carolinensis)	Reptilia	ZNF687⁶	zinc finger protein 687	50(a)	1 ↔ 1	GL343616.1(374779-404583)
zebrafish (Danio rerio)	Actinopterygii	Dr.16948²	Transcribed sequence with weak similarity to protein more	75.28(n)		BI982637.1

ENSEMBL Gene Tree for ZNF687 (if available)
TreeFam Gene Tree for ZNF687 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF687 gene

ZNF532² ZNF592²

1 SIMAP similar gene for ZNF687 using alignment to 5 protein entries: ZN687_HUMAN (see all proteins):

ZNF532

ZNF687 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs185683004^1,2	C	--	151256788(+)	`GGAGGA/GGTGGA`	1	--	int¹		0	--	--	--	--
rs72708501^1,2	C	--	151256990(+)	`AATTTC/TCTTGA`	1	--	int¹		0	--	--	--	--
rs190400574^1,2		--	151257072(+)	`CTGCAC/TGACCC`	1	--	int¹		0	--	--	--	--
rs182202026^1,2		--	151257092(+)	`GCCTCC/TGACCC`	1	--	int¹		0	--	--	--	--
rs140417989^1,2		--	151257102(+)	`CCAGCC/TCTAGA`	1	--	int¹		0	--	--	--	--
rs111737413^1,2	F	--	151257135(+)	`AGTTCC/TTCCTT`	1	--	int¹		1		CSA	2
rs191867502^1,2		--	151257147(+)	`ACCTGA/GCATGT`	1	--	int¹		0	--	--	--	--
rs184109794^1,2	C	--	151257183(+)	`AAATCA/GTATTC`	1	--	int¹		0	--	--	--	--
rs12754257^1,2		--	151257278(+)	`CTTGtC/Tttttt`	1	--	int¹ trp³		0	--	--	--	--
rs74125915^1,2	C,F	--	151257551(+)	`CGGCCA/TTTTGT`	1	--	int¹		2		WA	120

HapMap Linkage Disequilibrium report for ZNF687 (151254094 - 151264656 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for ZNF687: About this table

Variant ID	Type	Subtype	PubMed ID
dgv2n68	CNV	Loss	17160897
esv34461	CNV	Gain	17911159
nsv522840	CNV	Gain	19592680

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF687 for disorders About MalaCards

ZNF687 for disorders About GeneDecksing

OMIM gene information: 610568 OMIM disorders: --

Export disorders for ZNF687 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF687 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with ZNF687)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2, 3} Nagase T.... Ohara O. (2000)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)¹ Varjosalo M....Superti-Furga G. (2013)
The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)¹ Cox J.L....Rizzino A. (2013)
The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)¹ Joshi P....Cristea I.M. (2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
The global gene-expression profiles of U-937 human mac rophages treated with Tat peptide and Tat-FITC conjugate. (PubMed id 22632162)¹ Lin C.W....Jan M.S. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57592	HGNC: 29277	AceView: KIAA1441	Ensembl:ENSG00000143373	euGenes: HUgn57592
ECgene: ZNF687	H-InvDB: ZNF687

(According to HUGE)
About This Section

HUGE: KIAA1441

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF687	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF687 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF687 gene:
Search GeneIP for patents involving ZNF687

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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LSBio Antibodies in human, mouse, rat for ZNF687

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Hot genes Disease genes ZNF687 gene at Home site.

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ZNF687 Gene

Zinc Finger Protein 687

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ZNF687 Gene

Zinc Finger Protein 687

Aliasesfor ZNF687 gene

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Genomic Viewsfor ZNF687 gene

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Protein Domains /Familiesfor ZNF687 gene

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