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ZNF687 Gene(Protein Coding)

Zinc Finger Protein 687

GCID:
GC01P151254
GIFtS:
52
Genes Participants
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Aliases for ZNF687 Gene

Aliases for ZNF687 Gene

  • Zinc Finger Protein 687 2 3 5
  • KIAA1441 4
  • PDB6 3

External Ids for ZNF687 Gene

Previous GeneCards Identifiers for ZNF687 Gene

  • GC01P148069
  • GC01P149520
  • GC01P122632

Summaries for ZNF687 Gene

Entrez Gene Summary for ZNF687 Gene

  • This gene encodes C2H2 zinc finger protein. The encoded protein may play a role in bone differentiation and development. Mutations in this gene are the cause of Paget disease of bone-6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

GeneCards Summary for ZNF687 Gene

ZNF687 (Zinc Finger Protein 687) is a Protein Coding gene. Diseases associated with ZNF687 include Paget Disease Of Bone 6 and Paget's Disease Of Bone. An important paralog of this gene is ZNF532.

UniProtKB/Swiss-Prot for ZNF687 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF687 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF687 Gene

Genomics for ZNF687 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ZNF687 Gene

Enhancers for ZNF687 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F151308 1.8 FANTOM5 Ensembl ENCODE 14.5 +30.4 30382 6.1 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC GABPB2 SETDB1 MRPL9 GOLPH3L ZNF687 PRPF3 ADAMTSL4 RFX5 VPS72 UBE2D3P3
GH01F151193 1.5 FANTOM5 ENCODE 10.6 -83.9 -83909 7.7 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 SETDB1 GOLPH3L PRPF3 GABPB2 UBE2D3P3 MRPL9 RPS10P6 SCNM1 LYSMD1 RN7SL444P
GH01F150969 1.6 FANTOM5 ENCODE 8.3 -306.6 -306598 10.6 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 HORMAD1 ANXA9 GOLPH3L ARNT MCL1 GABPB2 MRPL9 CDC42SE1 ZNF687 CTSS
GH01F151276 1.3 FANTOM5 Ensembl ENCODE 2.7 -4.0 -3955 2.8 PKNOX1 ESRRA JUN GATA3 EED ETV6 CREM MTA2 NR2F1 CEBPB PSMD4 BNIPL PI4KB CDC42SE1 ZNF687 TNFAIP8L2 RFX5 FAM63A
GH01F151479 0.2 ENCODE 9.8 +198.1 198099 1.0 CGN ENSG00000252840 TUFT1 MIR554 RPS10P6 RNU6-1062P PSMB4 ENSG00000232536 MRPL9 OAZ3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF687 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF687 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000544880 745 3001 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Transcription factor binding sites by QIAGEN in the ZNF687 gene promoter:

Genomic Location for ZNF687 Gene

Chromosome:
1
Start:
151,281,555 bp from pter
End:
151,292,180 bp from pter
Size:
10,626 bases
Orientation:
Plus strand

Genomic View for ZNF687 Gene

Genes around ZNF687 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF687 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF687 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF687 Gene

Proteins for ZNF687 Gene

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  • Protein details for ZNF687 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1G0-ZN687_HUMAN
    Recommended name:
    Zinc finger protein 687
    Protein Accession:
    Q8N1G0
    Secondary Accessions:
    • D3DV17
    • Q68DQ8
    • Q9H937
    • Q9P2A7

    Protein attributes for ZNF687 Gene

    Size:
    1237 amino acids
    Molecular mass:
    129529 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92679.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14406.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH18162.1; Type=Frameshift; Positions=1062; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF687 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF687 Gene

Protein Expression for ZNF687 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF687 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF687 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF687 Gene

Domains & Families for ZNF687 Gene

Protein Domains for ZNF687 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF687 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N1G0

UniProtKB/Swiss-Prot:

ZN687_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF687: view

No data available for Gene Families for ZNF687 Gene

Function for ZNF687 Gene

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Molecular function for ZNF687 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF687 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 26496610
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF687: view
genes like me logo Genes that share phenotypes with ZNF687: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF687 Gene

Localization for ZNF687 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF687 Gene

Cytoplasm. Nucleus. Note=Predominantly nuclear. {ECO:0000269 PubMed:26849110}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF687 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for ZNF687 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZNF687: view

Pathways & Interactions for ZNF687 Gene

SuperPathways for ZNF687 Gene

PathCards logo More details on SuperPathways for ZNF687
No Data Available

Gene Ontology (GO) - Biological Process for ZNF687 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF687: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF687 Gene

Drugs & Compounds for ZNF687 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for ZNF687 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
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mRNA/cDNA for ZNF687 Gene

(7) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(126) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF687 Gene

Zinc finger protein 687:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF687 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: -
SP2:

Relevant External Links for ZNF687 Gene

GeneLoc Exon Structure for
ZNF687
ECgene alternative splicing isoforms for
ZNF687

Expression for ZNF687 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF687 Gene

mRNA expression in normal human tissues for ZNF687 Gene
mRNA expression by BioGPS for ZNF687 GenemRNA expression by GTEx for ZNF687 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF687 Gene

This gene is overexpressed in Placenta (14.3), Peripheral blood mononuclear cells (12.9), Pancreas (9.2), Retina (8.4), and Blymphocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF687 Gene



Protein tissue co-expression partners for ZNF687 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF687 Gene:

ZNF687

SOURCE GeneReport for Unigene cluster for ZNF687 Gene:

Hs.186756

mRNA Expression by UniProt/SwissProt for ZNF687 Gene:

Q8N1G0-ZN687_HUMAN
Tissue specificity: Widely expressed with highest levels in obvary, muscle, blood and lung.
genes like me logo Genes that share expression patterns with ZNF687: view

Primer Products

No data available for mRNA differential expression in normal tissues for ZNF687 Gene

Orthologs for ZNF687 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF687 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ZNF687 34 35
  • 99.65 (n)
cow
(Bos Taurus)
 Mammalia ZNF687 34 35
  • 89.03 (n)
dog
(Canis familiaris)
 Mammalia ZNF687 34 35
  • 87.75 (n)
mouse
(Mus musculus)
 Mammalia Zfp687 34 16 35
  • 84.93 (n)
rat
(Rattus norvegicus)
 Mammalia LOC100363361 34
  • 83.71 (n)
oppossum
(Monodelphis domestica)
 Mammalia ZNF687 35
  • 71 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 27 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves ZNF687 34 35
  • 65.04 (n)
lizard
(Anolis carolinensis)
 Reptilia ZNF687 35
  • 49 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia znf687 34
  • 65.66 (n)
zebrafish
(Danio rerio)
 Actinopterygii si:dkey-204a24.9 34
  • 55.17 (n)
znf687a 35
  • 36 (a)
 OneToMany
znf687b 35
  • 34 (a)
 OneToMany
Dr.16948 34
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 25 (a)
 OneToMany
Species where no ortholog for ZNF687 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF687 Gene

ENSEMBL:
Gene Tree for ZNF687 (if available)
TreeFam:
Gene Tree for ZNF687 (if available)

Paralogs for ZNF687 Gene

Paralogs for ZNF687 Gene

(1) SIMAP similar genes for ZNF687 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF687: view

Variants for ZNF687 Gene

Sequence variations from dbSNP and Humsavar for ZNF687 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs148402804 Paget disease of bone 6 (PDB6) [MIM:616833], Pathogenic 151,289,853(+) TGAGC(A/C/G/T)CCCCC reference, missense
rs869025582 Pathogenic 151,287,016(+) CTCCA(G/T)CCCTA reference, missense
rs10788802 -- 151,285,115(+) CTGAA(A/G)AAACT intron-variant
rs10788803 -- 151,291,306(+) CATTA(A/G)TATTT downstream-variant-500B, utr-variant-3-prime
rs111238381 -- 151,291,854(+) AGTTG(C/G)GGAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF687 Gene

Variant ID Type Subtype PubMed ID
dgv2n68 CNV loss 17160897
esv34461 CNV gain 17911159
nsv522840 CNV gain 19592680

Variation tolerance for ZNF687 Gene

Residual Variation Intolerance Score: 20.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.63; 65.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF687 Gene

Human Gene Mutation Database (HGMD)
ZNF687
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF687

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF687 Gene

Disorders for ZNF687 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF687 Gene - From: ClinVar, GeneTests, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
paget disease of bone 6
  • pdb6
paget's disease of bone
  • familial paget's disease of bone
giant cell tumor
  • giant cell neoplasm
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZN687_HUMAN
  • Paget disease of bone 6 (PDB6) [MIM:616833]: An autosomal dominant form of Paget disease, a disorder of bone remodeling characterized by increased bone turnover affecting one or more sites throughout the skeleton, primarily the axial skeleton. Osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone. PDB6 is characterized by adult onset of bone pain associated with polyostotic bone lesions primarily affecting the axial skeleton. In some cases, the pagetic tissue undergoes neoplastic transformation, resulting in osteosarcoma and, less frequently, in giant cell tumor of bone. {ECO:0000269 PubMed:26849110}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ZNF687

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF687
genes like me logo Genes that share disorders with ZNF687: view

No data available for Genatlas for ZNF687 Gene

Publications for ZNF687 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. ZNF687 mutations in severe paget disease of bone associated with giant cell tumor. (PMID: 26849110) Divisato G. … Gianfrancesco F. (Am. J. Hum. Genet. 2016) 3 4 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

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Sources for ZNF687 Gene

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