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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF687 Gene

protein-coding   GIFtS: 49
GCID: GC01P151254

Zinc Finger Protein 687

  Search for ZNF687
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 6871 2
KIAA14413 5

External Ids:    HGNC: 292771   Entrez Gene: 575922   Ensembl: ENSG000001433737   OMIM: 6105685   UniProtKB: Q8N1G03   

Export aliases for ZNF687 gene to outside databases

Previous GC identifers: GC01P148069 GC01P149520 GC01P122632


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF687 Gene: 
ZNF687 (zinc finger protein 687) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF532.

UniProtKB/Swiss-Prot: ZN687_HUMAN, Q8N1G0
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF687 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF687 gene promoter:
         E2F-4   E2F-3a   E2F-5   Spz1   MyoD   E2F-2   MZF-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF687 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF687

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF687


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.2

ZNF687 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF687 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P151254:  view genomic region     (about GC identifiers)

Start:
151,254,094 bp from pter      End:
151,264,656 bp from pter
Size:
10,563 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN687_HUMAN, Q8N1G0 (See protein sequence)
Recommended Name: Zinc finger protein 687  
Size: 1237 amino acids; 129529 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA92679.1; Type=Erroneous initiation; Sequence=BAB14406.1; Type=Erroneous initiation;
Sequence=CAH18162.1; Type=Frameshift; Positions=1062;
Secondary accessions: D3DV17 Q68DQ8 Q9H937 Q9P2A7
Alternative splicing: 2 isoforms:  Q8N1G0-1   Q8N1G0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF687: NX_Q8N1G0

Explore proteomics data for ZNF687 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N1G0

  • ZNF687 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF687 Protein Expression
    REFSEQ proteins: NP_065883.1  
    ENSEMBL proteins: 
     ENSP00000395261   ENSP00000336620   ENSP00000415286   ENSP00000319829   ENSP00000398821  
     ENSP00000416942   ENSP00000357874  

    Human Recombinant Protein Products for ZNF687: 
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    Cloud-Clone Corp. Proteins for ZNF687 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--

    ZNF687 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N1G0

    ProtoNet protein and cluster: Q8N1G0

    UniProtKB/Swiss-Prot: ZN687_HUMAN, Q8N1G0
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers


    ZNF687 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN687_HUMAN, Q8N1G0
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF687 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidZNF687 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF687

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for ZNF687 (Q8N1G03 ENSP000003198294) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INTS5Q6P9B93, ENSP000003278894I2D: score=1 STRING: ENSP00000327889
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    INTS1Q8N2013, ENSP000003857224I2D: score=1 STRING: ENSP00000385722
    INTS3Q68E013, ENSP000003186414I2D: score=1 STRING: ENSP00000318641
    INTS6Q9UL033, ENSP000003102604I2D: score=1 STRING: ENSP00000310260
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF687 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF687 (ZN687)

    Search CenterWatch for drugs/clinical trials and news about ZNF687 / ZN687

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF687 gene: 
    NM_020832.1  

    Unigene Cluster for ZNF687:

    Zinc finger protein 687
    Hs.186756  [show with all ESTs]
    Unigene Representative Sequence: AB037862
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000443959 ENST00000336715(uc001exq.3) ENST00000449313(uc001exp.1)
    ENST00000324048(uc009wmo.3) ENST00000426871 ENST00000459919 ENST00000436614
    ENST00000368879(uc009wmp.3)
    miRNA
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    hsa-miR-4328 hsa-miR-509-5p hsa-miR-488 hsa-miR-1205 hsa-miR-29b-1* hsa-miR-103a hsa-miR-124 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidZNF687 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF687

    Additional mRNA sequence: 

    AB037862.1 AK023105.1 BC020245.1 BC032463.1 CR749307.1 

    8 DOTS entries:

    DT.95164401  DT.91732673  DT.121443513  DT.97848306  DT.402459  DT.102832727  DT.121443529  DT.99943313 

    24/126 AceView cDNA sequences (see all 126):

    CA488781 BU729994 BI753953 AB037862 BQ217249 AK023105 CD366120 CB305718 
    BC032463 BM721303 AL603613 BM704083 AI951587 BM718164 BM671840 NM_020832 
    BM677037 BF510047 W84724 AI745167 BQ231483 BQ212546 BI753085 AI185962 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF687    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
    SP1:                                            -               
    SP2:                                                            


    ECgene alternative splicing isoforms for ZNF687

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF687 expression in normal human tissues (normalized intensities)      ZNF687 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTGGAACT
    ZNF687 Expression
    About this image


    ZNF687 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract

    See ZNF687 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF687

    SOURCE GeneReport for Unigene cluster: Hs.186756
        SABiosciences Custom PCR Arrays for ZNF687
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF687

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF687 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6871 , 5 zinc finger protein 6871, 5 85.59(n)1
    86.84(a)1
      3 (40.74 cM)5
    782661  NM_030074.21  NP_084350.11 
     950065905 
    chicken
    (Gallus gallus)
    Aves ZNF6876
    zinc finger protein 687
    58(a)
    1 ↔ 1
    25(1990146-1996328)
    lizard
    (Anolis carolinensis)
    Reptilia ZNF6876
    zinc finger protein 687
    50(a)
    1 ↔ 1
    GL343616.1(374779-404583)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.169482 Transcribed sequence with weak similarity to protein more 75.28(n)    BI982637.1 


    ENSEMBL Gene Tree for ZNF687 (if available)
    TreeFam Gene Tree for ZNF687 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF687 gene
    ZNF5322  ZNF5922  
    1 SIMAP similar gene for ZNF687 using alignment to 5 protein entries:     ZN687_HUMAN (see all proteins):
    ZNF532

    ZNF687 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/277 SNPs in ZNF687 are shown (see all 277)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1856830041,2
    C--151256788(+) GGAGGA/GGTGGA 1 -- int10--------
    rs727085011,2
    C--151256990(+) AATTTC/TCTTGA 1 -- int10--------
    rs1904005741,2
    --151257072(+) CTGCAC/TGACCC 1 -- int10--------
    rs1822020261,2
    --151257092(+) GCCTCC/TGACCC 1 -- int10--------
    rs1404179891,2
    --151257102(+) CCAGCC/TCTAGA 1 -- int10--------
    rs1117374131,2
    F--151257135(+) AGTTCC/TTCCTT 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1918675021,2
    --151257147(+) ACCTGA/GCATGT 1 -- int10--------
    rs1841097941,2
    C--151257183(+) AAATCA/GTATTC 1 -- int10--------
    rs127542571,2
    --151257278(+) CTTGtC/Tttttt 1 -- int1 trp30--------
    rs741259151,2
    C,F--151257551(+) CGGCCA/TTTTGT 1 -- int12Minor allele frequency- T:0.06WA 120

    HapMap Linkage Disequilibrium report for ZNF687 (151254094 - 151264656 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF687:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2n68CNV Loss17160897
    esv34461CNV Gain17911159
    nsv522840CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF687 for disorders           About MalaCards
    OMIM gene information: 610568    OMIM disorders: --


    ZNF687 for disorders           About GeneDecksing


    Export disorders for ZNF687 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF687 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with ZNF687)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    7. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    8. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. The global gene-expression profiles of U-937 human mac rophages treated with Tat peptide and Tat-FITC conjugate. (PubMed id 22632162)1 Lin C.W....Jan M.S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57592 HGNC: 29277 AceView: KIAA1441 Ensembl:ENSG00000143373 euGenes: HUgn57592
    ECgene: ZNF687 H-InvDB: ZNF687

    (According to HUGE)
    About This Section
    HUGE: KIAA1441

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF687 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF687 gene:
    Search GeneIP for patents involving ZNF687

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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