Aliases for ZNF687 Gene
External Ids for ZNF687 Gene
- HGNC: 29277
- Entrez Gene: 57592
- Ensembl: ENSG00000143373
- OMIM: 610568
- UniProtKB: Q8N1G0
Previous GeneCards Identifiers for ZNF687 Gene
- GC01P148069
- GC01P149520
- GC01P122632
Summaries for ZNF687 Gene
-
This gene encodes C2H2 zinc finger protein. The encoded protein may play a role in bone differentiation and development. Mutations in this gene are the cause of Paget disease of bone-6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
GeneCards Summary for ZNF687 Gene
ZNF687 (Zinc Finger Protein 687) is a Protein Coding gene. Diseases associated with ZNF687 include Paget Disease Of Bone 6 and Giant Cell Tumor. An important paralog of this gene is ZNF532.
UniProtKB/Swiss-Prot for ZNF687 Gene
-
May be involved in transcriptional regulation.
Additional gene information for ZNF687 Gene
- Monarch Initiative
- Search for ZNF687 at DataMed
- Search for ZNF687 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF687 Gene
Genomics for ZNF687 Gene
GeneHancer (GH) Regulatory Elements for ZNF687 Gene
Promoters and enhancers for ZNF687 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ZNF687 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ZNF687 Gene
Genomic Locations for ZNF687 Gene
- chr1:151,281,555-151,292,180
- (GRCh38/hg38)
- Size:
- 10,626 bases
- Orientation:
- Plus strand
- chr1:151,254,094-151,264,656
- (GRCh37/hg19)
Genomic View for ZNF687 Gene
Genes around ZNF687 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC
ZNF687 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF687 Gene
Proteins for ZNF687 Gene
-
Protein details for ZNF687 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N1G0-ZN687_HUMAN
- Recommended name:
- Zinc finger protein 687
- Protein Accession:
- Q8N1G0
- D3DV17
- Q68DQ8
- Q9H937
- Q9P2A7
Protein attributes for ZNF687 Gene
- Size:
- 1237 amino acids
- Molecular mass:
- 129529 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA92679.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14406.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH18162.1; Type=Frameshift; Positions=1062; Evidence={ECO:0000305};
Protein Expression for ZNF687 Gene
Post-translational modifications for ZNF687 Gene
No Post-translational modifications
Other Protein References for ZNF687 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ZNF687
-
Abcam antibodies for ZNF687
- Invitrogen Antibodies for ZNF687
- Search GeneTex for Antibodies for ZNF687
-
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Protein Products
-
OriGene Purified Proteins for ZNF687
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- Search GeneTex for Proteins for ZNF687
Assay Products
No data available for DME Specific Peptides for ZNF687 Gene
Domains & Families for ZNF687 Gene
Gene Families for ZNF687 Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZNF687 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF687 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N1G0- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZNF687 Gene
Molecular function for ZNF687 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in transcriptional regulation.
Phenotypes From GWAS Catalog for ZNF687 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 26496610 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for ZNF687 Gene
- GenomeRNAi human phenotypes for ZNF687:
Animal Model Products
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-
-
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-
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CRISPR Products
-
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Vectors and viruses for KO, Activation, Repression, and more
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Santa Cruz Biotechnology (SCBT) CRISPR for ZNF687
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miRNA for ZNF687 Gene
- miRTarBase miRNAs that target ZNF687
miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ZNF687 gene related products
- orf clones - Search results for available ZNF687 gene related products
- Applied Biological Materials Clones for ZNF687
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ZNF687
-
ViGene Biosciences adenoviral particle packaged cDNA for ZNF687 gene
-
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-
ViGene Biosciences ready-to-package AAV shRNAs for ZNF687 gene
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF687 Gene
Localization for ZNF687 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF687 Gene
- Cytoplasm. Nucleus. Note=Predominantly nuclear. {ECO:0000269 PubMed:26849110}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for ZNF687 Gene
No Data Available
Interacting Proteins for ZNF687 Gene
Selected Interacting proteins:
ENSP00000319829
Q8N1G0-ZN687_HUMAN
for ZNF687 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ZNF687 Gene
Transcripts for ZNF687 Gene
mRNA/cDNA for ZNF687 Gene
- (7) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (126) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ZNF687 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ZNF687
- genomics-online: gRNA clones - Search results for available ZNF687 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF687
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miRNA Products
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Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF687
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- genomics-online: shRNA clones - Search results for available ZNF687 gene related products
-
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Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ZNF687
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ZNF687 gene related products
- orf clones - Search results for available ZNF687 gene related products
- Applied Biological Materials Clones for ZNF687
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||
| SP2: |
Expression for ZNF687 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
- Outflow Tract
This gene is overexpressed in Placenta (14.3), Peripheral blood mononuclear cells (12.9), Pancreas (9.2), Retina (8.4), and Blymphocyte (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF687 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ZNF687 Gene:
ZNF687SOURCE GeneReport for Unigene cluster for ZNF687 Gene:
Hs.186756mRNA Expression by UniProt/SwissProt for ZNF687 Gene:
Q8N1G0-ZN687_HUMAN
Tissue specificity:
Widely expressed with highest levels in obvary, muscle, blood and lung.
Evidence on tissue expression from TISSUES for ZNF687 Gene
- Nervous system(4.2)
- Liver(4.1)
Primer Products
-
OriGene qPCR primer pairs for ZNF687
- genomics-online: primer clones - Search results for available ZNF687 gene related products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF687 Gene
Orthologs for ZNF687 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF687 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ZNF687 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ZNF687 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Zfp687 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100363361 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZNF687 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | ZNF687 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ZNF687 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | znf687 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:dkey-204a24.9 33 |
|
||
| znf687a 34 |
|
OneToMany | |||
| znf687b 34 |
|
OneToMany | |||
| Dr.16948 33 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for ZNF687 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ZNF687 Gene
(1) SIMAP similar genes for ZNF687 Gene using alignment to 5 proteins:
Variants for ZNF687 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs148402804 | pathogenic, Paget disease of bone 6, Paget disease of bone 6 (PDB6) [MIM:616833] | 151,289,853(+) | C/A/G/T | coding_sequence_variant, missense_variant | |
| rs869025582 | pathogenic, Paget disease of bone 6, Paget disease of bone 6 (PDB6) [MIM:616833] | 151,287,016(+) | G/T | coding_sequence_variant, missense_variant | |
| rs1000179997 | -- | 151,291,336(+) | GAAGAAGAAGA/GAAGAAGA | 3_prime_UTR_variant | |
| rs1000187800 | -- | 151,287,873(+) | C/G/T | coding_sequence_variant, missense_variant, synonymous_variant | |
| rs1000230908 | -- | 151,291,651(+) | C/T | 3_prime_UTR_variant |
Residual Variation Intolerance Score:
20.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.63;
65.59% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF687 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF687 Gene
Disorders for ZNF687 Gene
(3) MalaCards diseases for ZNF687 Gene - From: HGMD, OMIM, ClinVar, GTR, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| paget disease of bone 6 |
|
|
| giant cell tumor |
|
|
| paget's disease of bone |
|
|
Search ZNF687 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ZN687_HUMAN- Paget disease of bone 6 (PDB6) [MIM:616833]: An autosomal dominant form of Paget disease, a disorder of bone remodeling characterized by increased bone turnover affecting one or more sites throughout the skeleton, primarily the axial skeleton. Osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone. PDB6 is characterized by adult onset of bone pain associated with polyostotic bone lesions primarily affecting the axial skeleton. In some cases, the pagetic tissue undergoes neoplastic transformation, resulting in osteosarcoma and, less frequently, in giant cell tumor of bone. {ECO:0000269 PubMed:26849110}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for ZNF687
No data available for Genatlas for ZNF687 Gene
Publications for ZNF687 Gene
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
- ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor. (PMID: 26849110) Divisato G … Gianfrancesco F (American journal of human genetics 2016) 3 4 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 27 available ZNF687 Antibodies ranked by validation data
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Sources for ZNF687 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
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- (133) ENCODE
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- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew