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Aliases for ZNF687 Gene

Aliases for ZNF687 Gene

  • Zinc Finger Protein 687 2 3 5
  • KIAA1441 4
  • PDB6 3

External Ids for ZNF687 Gene

Previous GeneCards Identifiers for ZNF687 Gene

  • GC01P148069
  • GC01P149520
  • GC01P122632

Summaries for ZNF687 Gene

GeneCards Summary for ZNF687 Gene

ZNF687 (Zinc Finger Protein 687) is a Protein Coding gene. An important paralog of this gene is ZNF592.

UniProtKB/Swiss-Prot for ZNF687 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF687 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF687 Gene

Genomics for ZNF687 Gene

Regulatory Elements for ZNF687 Gene

Promoters for ZNF687 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF687 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF687 Gene

Chromosome:
1
Start:
151,281,555 bp from pter
End:
151,292,180 bp from pter
Size:
10,626 bases
Orientation:
Plus strand

Genomic View for ZNF687 Gene

Genes around ZNF687 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF687 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF687 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF687 Gene

Proteins for ZNF687 Gene

  • Protein details for ZNF687 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1G0-ZN687_HUMAN
    Recommended name:
    Zinc finger protein 687
    Protein Accession:
    Q8N1G0
    Secondary Accessions:
    • D3DV17
    • Q68DQ8
    • Q9H937
    • Q9P2A7

    Protein attributes for ZNF687 Gene

    Size:
    1237 amino acids
    Molecular mass:
    129529 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92679.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14406.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH18162.1; Type=Frameshift; Positions=1062; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF687 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF687 Gene

Proteomics data for ZNF687 Gene at MOPED

Post-translational modifications for ZNF687 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF687 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF687

No data available for DME Specific Peptides for ZNF687 Gene

Domains & Families for ZNF687 Gene

Protein Domains for ZNF687 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF687 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N1G0

UniProtKB/Swiss-Prot:

ZN687_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF687: view

No data available for Gene Families for ZNF687 Gene

Function for ZNF687 Gene

Molecular function for ZNF687 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF687: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF687 Gene

Localization for ZNF687 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF687 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF687 Gene COMPARTMENTS Subcellular localization image for ZNF687 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF687 Gene

Pathways & Interactions for ZNF687 Gene

SuperPathways for ZNF687 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF687 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF687: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF687 Gene

Drugs & Compounds for ZNF687 Gene

No Compound Related Data Available

Transcripts for ZNF687 Gene

Unigene Clusters for ZNF687 Gene

Zinc finger protein 687:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF687 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: -
SP2:

Relevant External Links for ZNF687 Gene

GeneLoc Exon Structure for
ZNF687
ECgene alternative splicing isoforms for
ZNF687

Expression for ZNF687 Gene

mRNA expression in normal human tissues for ZNF687 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF687 Gene

This gene is overexpressed in Placenta (14.3), Peripheral blood mononuclear cells (12.9), Pancreas (9.2), Retina (8.4), and Blymphocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF687 Gene



SOURCE GeneReport for Unigene cluster for ZNF687 Gene Hs.186756

genes like me logo Genes that share expression patterns with ZNF687: view

Protein tissue co-expression partners for ZNF687 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF687 Gene

Orthologs for ZNF687 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF687 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF687 35
  • 99.65 (n)
  • 99.68 (a)
ZNF687 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF687 36
  • 90 (a)
OneToOne
ZNF687 35
  • 89.03 (n)
  • 91 (a)
dog
(Canis familiaris)
Mammalia ZNF687 35
  • 87.75 (n)
  • 89.13 (a)
ZNF687 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp687 16
Zfp687 35
  • 84.93 (n)
  • 85.88 (a)
Zfp687 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF687 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 27 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100363361 35
  • 83.71 (n)
  • 85.69 (a)
chicken
(Gallus gallus)
Aves ZNF687 35
  • 65.04 (n)
  • 64.75 (a)
ZNF687 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF687 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf687 35
  • 65.66 (n)
  • 65.04 (a)
zebrafish
(Danio rerio)
Actinopterygii znf687a 36
  • 36 (a)
OneToMany
znf687b 36
  • 34 (a)
OneToMany
Dr.16948 35
si:dkey-204a24.9 35
  • 55.17 (n)
  • 52.31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for ZNF687:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF687 Gene

ENSEMBL:
Gene Tree for ZNF687 (if available)
TreeFam:
Gene Tree for ZNF687 (if available)

Paralogs for ZNF687 Gene

Paralogs for ZNF687 Gene

(1) SIMAP similar genes for ZNF687 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF687: view

Variants for ZNF687 Gene

Sequence variations from dbSNP and Humsavar for ZNF687 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3748545 - 151,287,067(+) TGCTG(A/G)GGTGC reference, missense
rs12045766 - 151,287,322(+) CACAA(C/G)GACTG reference, missense
rs2298264 -- 151,286,816(-) AGCGG(A/G)TCTGA reference, synonymous-codon
rs7366902 -- 151,285,471(+) tgcag(G/T)ggcac intron-variant, utr-variant-5-prime
rs11204797 -- 151,285,312(+) CCTCC(C/T)TAATA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF687 Gene

Variant ID Type Subtype PubMed ID
nsv522840 CNV Gain 19592680
dgv2n68 CNV Loss 17160897
esv34461 CNV Gain 17911159

Variation tolerance for ZNF687 Gene

Residual Variation Intolerance Score: 20.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.63; 65.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF687 Gene

HapMap Linkage Disequilibrium report
ZNF687

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF687 Gene

Disorders for ZNF687 Gene

Relevant External Links for ZNF687

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF687

No disorders were found for ZNF687 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF687 Gene

Publications for ZNF687 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  4. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3
  5. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3

Products for ZNF687 Gene

Sources for ZNF687 Gene

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