ZNF684 Gene
protein-coding GIFtS: 44
GCID: GC01P040997
|
|
zinc finger protein 684
| |
Aliases
for ZNF684 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6841 2 | | MGC274661 | | Hypothetical Protein MGC274662 |
Export aliases for ZNF684 gene to outside databasesPrevious GC identifers: GC01P040667 GC01P040769 GC01P039115 |
Summaries
for ZNF684 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN684_HUMAN, Q5T5D7Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF684 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF684 gene promoter:
HFH-3 AML1a Brachyury GCNF XBP-1 C/EBPalpha FOXI1 GCNF-1 deltaCREB GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF684
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF684 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34.2 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34.2ZNF684 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P040997: view genomic region
(about GC identifiers)
Start:
|
40,997,233 bp from pter |
End:
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41,013,841 bp from pter |
Size:
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16,609 bases |
Orientation:
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plus strand |
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Proteins
for ZNF684 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN684_HUMAN, Q5T5D7 (See
protein sequence)Recommended Name: Zinc finger protein 684 Size: 378 amino acids; 43945 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q2NKY4Explore the universe of human proteins at neXtProt for ZNF684: NX_Q5T5D7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T5D7
ZNF684 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689586.3
ENSEMBL proteins: ENSP00000361784 ENSP00000361782 ENSP00000361781 Reactome Protein details: Q5T5D7
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF684 for ontologies About GeneDecksing
ZNF684 Antibody Products:
Assay Products for ZNF684: |
Protein
Domains /
Families
for ZNF684 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF684 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5T5D7ProtoNet protein and cluster: Q5T5D7 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN684_HUMAN, Q5T5D7Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 8 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF684 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN684_HUMAN, Q5T5D7Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF684
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF684
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZNF684 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF684 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF684 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF684 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF684 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF684
ZNF684 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF684
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF684 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF684 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF684
Search CenterWatch for drugs/clinical trials and news about ZNF684 / ZN684
|
Transcripts
for ZNF684 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF684 gene: NM_152373.3 Unigene Cluster for ZNF684: Zinc finger protein 684 Hs.524767 [show with all ESTs]Unigene Representative Sequence: NM_1523736 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372699(uc001cft.2) ENST00000465152 ENST00000372697 ENST00000372696
ENST00000493756 ENST00000472043
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF684
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF684
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF684 (NM_152373) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF684 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF684 |
Additional cDNA sequence: AK094072.1 BC016016.1 BC091518.1 BC111463.1 4 DOTS entries: DT.100022577 DT.100008123 DT.100022578 DT.40308412 24/35 AceView cDNA sequences (see all 35): BQ635334 BQ635333 BX113881 BQ635332 AA174196 BF593409 BE328243 BG698459 AI261368 NM_152373 BG563662 BX497485 AL602305 BM285392 BQ632362 BQ632655 BC016016 BF447631 AW469259 AK094072 AA745611 AI200415 AW275016 BG116229
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF684 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | | | | | | | | | - | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | | | | | | |
ECgene alternative splicing isoforms for ZNF684
|
Expression
for ZNF684 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF684 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAGTGTTTC
About this image
See ZNF684 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF684
SOURCE GeneReport for Unigene cluster: Hs.524767
SABiosciences Custom PCR Arrays for ZNF684
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF684
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF684 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF684 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF684 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF684 |
Orthologs
for ZNF684 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF684 (if available)
TreeFam Gene Tree for ZNF684 (if available) |
Paralogs
for ZNF684 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF684 gene
- ZNF1572 ZNF252
18/517 SIMAP similar genes for ZNF684 using alignment to 3 protein entries: ZN684_HUMAN (see all proteins)
(see all similar genes):ZNF78L1 ZNF818P kr-znf3 ZNF677 ZNF559 ZNF55
ZNF519 ZNF124 ZNF624 ZFS-5 ZNF28 ZFP90
DKFZp547L155 ZFP41 ZNF16 ZNF232 ZNF283 ZNF567
ZNF684 for paralogs About GeneDecksing
|
Genomic Variants
for ZNF684 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF684 (40997233 - 41013841 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF684: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF684 |
|
Disorders
/ Diseases
for ZNF684 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF684 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF684 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF684) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
|
External Searches for ZNF684 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF684 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF684 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF684 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF684 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF684 gene:
Search GeneIP for patents involving ZNF684
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF684 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF684 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF684 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF684 | | | OriGene Protein Over-expression Lysate for ZNF684 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF684 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF684 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF684 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF684 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF684 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF684 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF684 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF684 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF684 |
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 |  |  |  | |
| | | | Search Tocris compounds for ZNF684 |
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 | | | ZNF684 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF684 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF684 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF684 |
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