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Aliases for ZNF684 Gene

Aliases for ZNF684 Gene

  • Zinc Finger Protein 684 2 3
  • Hypothetical Protein MGC27466 2

External Ids for ZNF684 Gene

Previous GeneCards Identifiers for ZNF684 Gene

  • GC01P040667
  • GC01P040769
  • GC01P040997
  • GC01P039115

Summaries for ZNF684 Gene

GeneCards Summary for ZNF684 Gene

ZNF684 (Zinc Finger Protein 684) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression.

UniProtKB/Swiss-Prot for ZNF684 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF684 Gene

Genomics for ZNF684 Gene

Regulatory Elements for ZNF684 Gene

Genomic Location for ZNF684 Gene

40,531,561 bp from pter
40,548,169 bp from pter
16,609 bases
Plus strand

Genomic View for ZNF684 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF684 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF684 Gene

Proteins for ZNF684 Gene

  • Protein details for ZNF684 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 684
    Protein Accession:
    Secondary Accessions:
    • Q2NKY4

    Protein attributes for ZNF684 Gene

    378 amino acids
    Molecular mass:
    43945 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF684 Gene

Proteomics data for ZNF684 Gene at MOPED

Post-translational modifications for ZNF684 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF684 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF684 Gene

Domains for ZNF684 Gene

Gene Families for ZNF684 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF684 Gene

Suggested Antigen Peptide Sequences for ZNF684 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q5T5D7
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF684: view

Function for ZNF684 Gene

Molecular function for ZNF684 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF684 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF684: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF684 Gene

Localization for ZNF684 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF684 Gene

Subcellular locations from

Jensen Localization Image for ZNF684 Gene COMPARTMENTS Subcellular localization image for ZNF684 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF684 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF684: view

Pathways for ZNF684 Gene

SuperPathways for ZNF684 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF684: view

Pathways by source for ZNF684 Gene

2 Reactome pathways for ZNF684 Gene

Interacting Proteins for ZNF684 Gene

Gene Ontology (GO) - Biological Process for ZNF684 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF684: view

Transcripts for ZNF684 Gene

Unigene Clusters for ZNF684 Gene

Zinc finger protein 684:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF684

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF684
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF684 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - -
SP2: -
SP3: - -
SP4: - - - - -
SP5: - -

Relevant External Links for ZNF684 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF684 Gene

mRNA expression in normal human tissues for ZNF684 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF684 Gene

This gene is overexpressed in Liver (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF684 Gene

SOURCE GeneReport for Unigene cluster for ZNF684 Gene Hs.524767

genes like me logo Genes that share expressions with ZNF684: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF684 Gene

Orthologs for ZNF684 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF684 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF684 35
  • 99.38 (n)
  • 98.94 (a)
ZNF684 36
  • 99 (a)
(Bos Taurus)
Mammalia ZNF684 36
  • 81 (a)
(Canis familiaris)
Mammalia ZNF684 35
  • 89.24 (n)
  • 86.24 (a)
ZNF684 36
  • 73 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 33 (a)
-- 36
  • 28 (a)
-- 36
  • 21 (a)
-- 36
  • 14 (a)
-- 36
  • 30 (a)
Species with no ortholog for ZNF684:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF684 Gene

Gene Tree for ZNF684 (if available)
Gene Tree for ZNF684 (if available)

Paralogs for ZNF684 Gene

Selected SIMAP similar genes for ZNF684 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF684: view

No data available for Paralogs for ZNF684 Gene

Variants for ZNF684 Gene

Sequence variations from dbSNP and Humsavar for ZNF684 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1000370 -- 40,532,734(+) CCAGC(G/T)TCAGA intron-variant
rs1001400 -- 40,533,230(+) AATCC(A/G)TATGA intron-variant
rs2184876 -- 40,530,895(+) GAATT(A/T)AAAAA upstream-variant-2KB
rs2184877 -- 40,531,260(+) TCCTA(C/T)TTTTC upstream-variant-2KB
rs2297755 -- 40,547,343(+) AAGTC(C/T)CATCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNF684 Gene

Variant ID Type Subtype PubMed ID
nsv870632 CNV Gain 21882294
nsv871000 CNV Loss 21882294

Relevant External Links for ZNF684 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF684 Gene

Disorders for ZNF684 Gene

Relevant External Links for ZNF684

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with ZNF684: view

No data available for UniProtKB/Swiss-Prot for ZNF684 Gene

Publications for ZNF684 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF684 Gene

Sources for ZNF684 Gene

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