Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF684 Gene

Aliases for ZNF684 Gene

  • Zinc Finger Protein 684 2 3 5
  • Hypothetical Protein MGC27466 2

External Ids for ZNF684 Gene

Previous GeneCards Identifiers for ZNF684 Gene

  • GC01P040667
  • GC01P040769
  • GC01P040997
  • GC01P039115

Summaries for ZNF684 Gene

GeneCards Summary for ZNF684 Gene

ZNF684 (Zinc Finger Protein 684) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF487.

UniProtKB/Swiss-Prot for ZNF684 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF684 Gene

Genomics for ZNF684 Gene

Regulatory Elements for ZNF684 Gene

Enhancers for ZNF684 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF684 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF684 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF684 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF684 Gene

40,531,155 bp from pter
40,548,169 bp from pter
17,015 bases
Plus strand

Genomic View for ZNF684 Gene

Genes around ZNF684 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF684 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF684 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF684 Gene

Proteins for ZNF684 Gene

  • Protein details for ZNF684 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 684
    Protein Accession:
    Secondary Accessions:
    • Q2NKY4

    Protein attributes for ZNF684 Gene

    378 amino acids
    Molecular mass:
    43945 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF684 Gene

Proteomics data for ZNF684 Gene at MOPED

Post-translational modifications for ZNF684 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF684 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF684 Gene

Domains & Families for ZNF684 Gene

Gene Families for ZNF684 Gene

Protein Domains for ZNF684 Gene

Suggested Antigen Peptide Sequences for ZNF684 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 8 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF684: view

Function for ZNF684 Gene

Molecular function for ZNF684 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF684: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF684 Gene

Localization for ZNF684 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF684 Gene

Subcellular locations from

Jensen Localization Image for ZNF684 Gene COMPARTMENTS Subcellular localization image for ZNF684 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF684 Gene

Pathways & Interactions for ZNF684 Gene

SuperPathways for ZNF684 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF684: view

Pathways by source for ZNF684 Gene

2 Reactome pathways for ZNF684 Gene

Interacting Proteins for ZNF684 Gene

Gene Ontology (GO) - Biological Process for ZNF684 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF684: view

No data available for SIGNOR curated interactions for ZNF684 Gene

Drugs & Compounds for ZNF684 Gene

No Compound Related Data Available

Transcripts for ZNF684 Gene

Unigene Clusters for ZNF684 Gene

Zinc finger protein 684:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF684 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - -
SP2: -
SP3: - -
SP4: - - - - -
SP5: - -

Relevant External Links for ZNF684 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF684 Gene

mRNA expression in normal human tissues for ZNF684 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF684 Gene

This gene is overexpressed in Liver (x4.6).

Protein differential expression in normal tissues from HIPED for ZNF684 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF684 Gene

SOURCE GeneReport for Unigene cluster for ZNF684 Gene Hs.524767

genes like me logo Genes that share expression patterns with ZNF684: view

Protein tissue co-expression partners for ZNF684 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF684 Gene

Orthologs for ZNF684 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF684 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ZNF684 35
  • 89.24 (n)
  • 86.24 (a)
ZNF684 36
  • 73 (a)
(Pan troglodytes)
Mammalia ZNF684 35
  • 99.38 (n)
  • 98.94 (a)
ZNF684 36
  • 99 (a)
(Bos Taurus)
Mammalia ZNF684 36
  • 81 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 33 (a)
-- 36
  • 28 (a)
-- 36
  • 21 (a)
-- 36
  • 14 (a)
-- 36
  • 30 (a)
Species with no ortholog for ZNF684:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF684 Gene

Gene Tree for ZNF684 (if available)
Gene Tree for ZNF684 (if available)

Paralogs for ZNF684 Gene

Paralogs for ZNF684 Gene

(532) SIMAP similar genes for ZNF684 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF684: view

Variants for ZNF684 Gene

Sequence variations from dbSNP and Humsavar for ZNF684 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000370 -- 40,532,734(+) CCAGC(G/T)TCAGA intron-variant, utr-variant-5-prime
rs1001400 -- 40,533,230(+) AATCC(A/G)TATGA intron-variant
rs2297755 -- 40,547,343(+) AAGTC(C/T)CATCT reference, synonymous-codon
rs2297756 -- 40,547,588(+) AACAA(C/T)CAATG utr-variant-3-prime
rs2184876 -- 40,530,895(+) GAATT(A/T)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF684 Gene

Variant ID Type Subtype PubMed ID
nsv870632 CNV Gain 21882294
nsv871000 CNV Loss 21882294

Variation tolerance for ZNF684 Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF684 Gene

Disorders for ZNF684 Gene

Relevant External Links for ZNF684

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF684 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF684 Gene

Publications for ZNF684 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF684 Gene

Sources for ZNF684 Gene