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Aliases for ZNF683 Gene

Aliases for ZNF683 Gene

  • Zinc Finger Protein 683 2 3 5
  • Homolog Of Blimp-1 In T Cells 2 3
  • Hypothetical Protein MGC33414 3
  • Hobit 3

External Ids for ZNF683 Gene

Previous GeneCards Identifiers for ZNF683 Gene

  • GC01M026560
  • GC01M026688
  • GC01M024942

Summaries for ZNF683 Gene

GeneCards Summary for ZNF683 Gene

ZNF683 (Zinc Finger Protein 683) is a Protein Coding gene. An important paralog of this gene is PRDM1.

UniProtKB/Swiss-Prot for ZNF683 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF683 Gene

Genomics for ZNF683 Gene

Regulatory Elements for ZNF683 Gene

Enhancers for ZNF683 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF683 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF683 Gene

Chromosome:
1
Start:
26,361,632 bp from pter
End:
26,374,533 bp from pter
Size:
12,902 bases
Orientation:
Minus strand

Genomic View for ZNF683 Gene

Genes around ZNF683 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF683 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF683 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF683 Gene

Proteins for ZNF683 Gene

  • Protein details for ZNF683 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ20-ZN683_HUMAN
    Recommended name:
    Zinc finger protein 683
    Protein Accession:
    Q8IZ20
    Secondary Accessions:
    • Q5T141
    • Q5T146
    • Q5T147
    • Q5T149
    • Q8NEN4

    Protein attributes for ZNF683 Gene

    Size:
    524 amino acids
    Molecular mass:
    56905 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH28731.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH29505.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15857.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15858.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF683 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF683 Gene

Proteomics data for ZNF683 Gene at MOPED

Post-translational modifications for ZNF683 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ZNF683 Gene

Domains & Families for ZNF683 Gene

Gene Families for ZNF683 Gene

Protein Domains for ZNF683 Gene

Suggested Antigen Peptide Sequences for ZNF683 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IZ20

UniProtKB/Swiss-Prot:

ZN683_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF683: view

Function for ZNF683 Gene

Molecular function for ZNF683 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF683: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF683 Gene

Localization for ZNF683 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF683 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF683 Gene COMPARTMENTS Subcellular localization image for ZNF683 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF683 Gene

Pathways & Interactions for ZNF683 Gene

SuperPathways for ZNF683 Gene

No Data Available

Interacting Proteins for ZNF683 Gene

Gene Ontology (GO) - Biological Process for ZNF683 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001779 natural killer cell differentiation IEA --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF683: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF683 Gene

Drugs & Compounds for ZNF683 Gene

No Compound Related Data Available

Transcripts for ZNF683 Gene

Unigene Clusters for ZNF683 Gene

Zinc finger protein 683:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF683 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - -
SP7: -
SP8:
SP9:
SP10: - - - -
SP11: - -

Relevant External Links for ZNF683 Gene

GeneLoc Exon Structure for
ZNF683
ECgene alternative splicing isoforms for
ZNF683

Expression for ZNF683 Gene

mRNA expression in normal human tissues for ZNF683 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF683 Gene

This gene is overexpressed in Testis (x39.1) and Whole Blood (x6.7).

Protein differential expression in normal tissues from HIPED for ZNF683 Gene

This gene is overexpressed in Plasma (56.2), Heart (6.5), and Adipocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF683 Gene



SOURCE GeneReport for Unigene cluster for ZNF683 Gene Hs.353208

genes like me logo Genes that share expression patterns with ZNF683: view

Protein tissue co-expression partners for ZNF683 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF683 Gene

Orthologs for ZNF683 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF683 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF683 35
  • 79.14 (n)
  • 67.78 (a)
ZNF683 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF683 35
  • 76.81 (n)
  • 66.33 (a)
ZNF683 36
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF683 35
  • 99.54 (n)
  • 99.01 (a)
ZNF683 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100359438 35
  • 72.49 (n)
  • 59.06 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 2 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp683 36
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01072143.1 36
  • 11 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4374 36
  • 1 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToOne
Species with no ortholog for ZNF683:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF683 Gene

ENSEMBL:
Gene Tree for ZNF683 (if available)
TreeFam:
Gene Tree for ZNF683 (if available)

Paralogs for ZNF683 Gene

Paralogs for ZNF683 Gene

genes like me logo Genes that share paralogs with ZNF683: view

Variants for ZNF683 Gene

Sequence variations from dbSNP and Humsavar for ZNF683 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17852672 - 26,364,936(+) CAGGT(G/T)GGGTG intron-variant, reference, missense
rs35040247 - 26,368,507(-) TACAG(A/G/T)GGGCT reference, missense
rs10794532 - 26,367,769(+) CCATG(A/C/G/T)CTGGA intron-variant, reference, missense
rs10794531 - 26,367,754(+) GGCCA(C/T)GAGCA intron-variant, reference, missense
rs11247933 - 26,364,683(+) CACCA(A/C/T)GCTCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ZNF683 Gene

Variant ID Type Subtype PubMed ID
nsv871165 CNV Loss 21882294

Variation tolerance for ZNF683 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.37; 94.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF683 Gene

Human Gene Mutation Database (HGMD)
ZNF683

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF683 Gene

Disorders for ZNF683 Gene

Relevant External Links for ZNF683

Genetic Association Database (GAD)
ZNF683
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF683

No disorders were found for ZNF683 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF683 Gene

Publications for ZNF683 Gene

  1. Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation. (PMID: 22885984) van Gisbergen K.P. … van Lier R.A. (Nat. Immunol. 2012) 2 3 67
  2. Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans. (PMID: 26179882) Vieira Braga F.A. … van Lier R.A. (Eur. J. Immunol. 2015) 3
  3. Hobit and human effector T-cell differentiation: The beginning of a long journey. (PMID: 26440905) Braun J. … Thiel A. (Eur. J. Immunol. 2015) 3
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for ZNF683 Gene

Sources for ZNF683 Gene

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