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Aliases for ZNF683 Gene

Aliases for ZNF683 Gene

  • Zinc Finger Protein 683 2 3
  • Homolog Of Blimp-1 In T Cells 2 3
  • Hypothetical Protein MGC33414 3
  • Hobit 3

External Ids for ZNF683 Gene

Previous GeneCards Identifiers for ZNF683 Gene

  • GC01M026560
  • GC01M026688
  • GC01M024942

Summaries for ZNF683 Gene

GeneCards Summary for ZNF683 Gene

ZNF683 (Zinc Finger Protein 683) is a Protein Coding gene. An important paralog of this gene is PRDM1.

UniProtKB/Swiss-Prot for ZNF683 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF683 Gene

Genomics for ZNF683 Gene

Regulatory Elements for ZNF683 Gene

Genomic Location for ZNF683 Gene

Start:
26,361,634 bp from pter
End:
26,374,532 bp from pter
Size:
12,899 bases
Orientation:
Minus strand

Genomic View for ZNF683 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF683 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF683 Gene

Proteins for ZNF683 Gene

  • Protein details for ZNF683 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ20-ZN683_HUMAN
    Recommended name:
    Zinc finger protein 683
    Protein Accession:
    Q8IZ20
    Secondary Accessions:
    • Q5T141
    • Q5T146
    • Q5T147
    • Q5T149
    • Q8NEN4

    Protein attributes for ZNF683 Gene

    Size:
    524 amino acids
    Molecular mass:
    56905 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH28731.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH29505.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15857.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15858.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF683 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF683 Gene

Proteomics data for ZNF683 Gene at MOPED

Post-translational modifications for ZNF683 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF683 Gene

Domains for ZNF683 Gene

Gene Families for ZNF683 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF683 Gene

Suggested Antigen Peptide Sequences for ZNF683 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IZ20

UniProtKB/Swiss-Prot:

ZN683_HUMAN :
  • Q8IZ20
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF683: view

Function for ZNF683 Gene

Molecular function for ZNF683 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF683 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF683: view

Phenotypes for ZNF683 Gene

MGI mutant phenotypes for ZNF683:
inferred from 1 alleles
GenomeRNAi human phenotypes for ZNF683:
genes like me logo Genes that share phenotypes with ZNF683: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF683 Gene

Localization for ZNF683 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF683 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF683 Gene COMPARTMENTS Subcellular localization image for ZNF683 gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for ZNF683 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF683: view

Pathways for ZNF683 Gene

SuperPathways for ZNF683 Gene

No Data Available

Interacting Proteins for ZNF683 Gene

Gene Ontology (GO) - Biological Process for ZNF683 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001779 natural killer cell differentiation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF683: view

No data available for Pathways by source for ZNF683 Gene

Transcripts for ZNF683 Gene

Unigene Clusters for ZNF683 Gene

Zinc finger protein 683:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF683

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ZNF683
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF683 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - -
SP7: -
SP8:
SP9:
SP10: - - - -
SP11: - -

Relevant External Links for ZNF683 Gene

GeneLoc Exon Structure for
ZNF683
ECgene alternative splicing isoforms for
ZNF683

Expression for ZNF683 Gene

mRNA expression in normal human tissues for ZNF683 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF683 Gene

This gene is overexpressed in Testis (39.1) and Whole Blood (6.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ZNF683 Gene

SOURCE GeneReport for Unigene cluster for ZNF683 Gene Hs.353208

genes like me logo Genes that share expressions with ZNF683: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF683 Gene

Orthologs for ZNF683 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF683 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF683 35
  • 99.54 (n)
  • 99.01 (a)
ZNF683 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF683 35
  • 79.14 (n)
  • 67.78 (a)
ZNF683 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF683 35
  • 76.81 (n)
  • 66.33 (a)
ZNF683 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp683 16
Zfp683 36
  • 51 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 2 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100359438 35
  • 72.49 (n)
  • 59.06 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01072143.1 36
  • 11 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4374 36
  • 1 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToOne
Species with no ortholog for ZNF683:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF683 Gene

ENSEMBL:
Gene Tree for ZNF683 (if available)
TreeFam:
Gene Tree for ZNF683 (if available)

Paralogs for ZNF683 Gene

Paralogs for ZNF683 Gene

genes like me logo Genes that share paralogs with ZNF683: view

Variants for ZNF683 Gene

Sequence variations from dbSNP and Humsavar for ZNF683 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4354529 -- 26,365,559(+) gatgc(A/G)tgact intron-variant
rs4659437 -- 26,373,777(+) TCCAG(C/G)TGGAA upstream-variant-2KB, intron-variant
rs4659438 -- 26,375,362(+) gtggt(C/G)cccgt upstream-variant-2KB
rs4659439 -- 26,375,410(+) tcctg(C/G)gactg upstream-variant-2KB
rs6690804 -- 26,362,595(+) ACTCA(A/T)AATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF683 Gene

Variant ID Type Subtype PubMed ID
nsv871165 CNV Loss 21882294

Relevant External Links for ZNF683 Gene

HapMap Linkage Disequilibrium report
ZNF683
Human Gene Mutation Database (HGMD)
ZNF683

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF683 Gene

Disorders for ZNF683 Gene

Relevant External Links for ZNF683

Genetic Association Database (GAD)
ZNF683
genes like me logo Genes that share disorders with ZNF683: view

No data available for UniProtKB/Swiss-Prot for ZNF683 Gene

Publications for ZNF683 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation. (PMID: 22885984) van Gisbergen K.P. … van Lier R.A. (Nat. Immunol. 2012) 2 3
  4. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PMID: 17903293) Benjamin E.J. … Vasan R.S. (BMC Med. Genet. 2007) 48
  5. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 48

Products for ZNF683 Gene

Sources for ZNF683 Gene

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