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Aliases for ZNF683 Gene

Aliases for ZNF683 Gene

  • Zinc Finger Protein 683 2 3 4 5
  • Homolog Of Blimp-1 In T Cells 2 3
  • Homolog Of Blimp-1 In T-Cell 3 4
  • Hobit 3 4
  • Tissue-Resident T-Cell Transcription Regulator Protein ZNF683 3
  • Hypothetical Protein MGC33414 3

External Ids for ZNF683 Gene

Previous GeneCards Identifiers for ZNF683 Gene

  • GC01M026560
  • GC01M026688
  • GC01M024942

Summaries for ZNF683 Gene

GeneCards Summary for ZNF683 Gene

ZNF683 (Zinc Finger Protein 683) is a Protein Coding gene. An important paralog of this gene is PRDM1.

UniProtKB/Swiss-Prot for ZNF683 Gene

  • Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Plays also a role in the differentiation of both thymic and peripheral NKT cells. Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation. Positively regulates granzyme B production in NKT cells after innate stimulation. Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions.

  • Isoform 1: Lacks transcriptional repressor activity. Binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Unable to regulate interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T-cells.

  • Isoform 2: Transcriptional repressor that binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Regulates interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T cells.

Additional gene information for ZNF683 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF683 Gene

Genomics for ZNF683 Gene

GeneHancer (GH) Regulatory Elements for ZNF683 Gene

Promoters and enhancers for ZNF683 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I026370 Promoter/Enhancer 1 EPDnew ENCODE 550.8 +3.7 3725 1.1 SMARCA5 ZNF280A CBX1 CBX5 TRIM24 TRIM28 ZNF683 CD52 CNKSR1 CEP85 CRYBG2
GH01I026372 Promoter 0.8 EPDnew 550.8 +1.8 1763 0.1 MEIS2 ATF1 ZBTB21 ZNF629 CREB1 CREM ZNF683 CRYBG2
GH01I026375 Enhancer 0.2 ENCODE 550.8 -0.8 -752 0.2 ZNF683 LIN28A
GH01I026374 Enhancer 0.2 ENCODE 550.8 +1.1 1068 0.2 ZNF683 CRYBG2
GH01I026313 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 11.5 +56.4 56363 8.4 HDGF PKNOX1 ATF1 SMAD1 ARNT ARID4B ZNF2 IRF4 BRCA1 ZNF48 CD52 UBXN11 SH3BGRL3 ZNF683 CRYBG2 LIN28A CEP85 ZNF593 ENSG00000236782 FAM110D
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF683 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF683 gene promoter:

Genomic Locations for ZNF683 Gene

Genomic Locations for ZNF683 Gene
chr1:26,361,632-26,374,533
(GRCh38/hg38)
Size:
12,902 bases
Orientation:
Minus strand
chr1:26,688,125-26,701,013
(GRCh37/hg19)

Genomic View for ZNF683 Gene

Genes around ZNF683 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF683 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF683 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF683 Gene

Proteins for ZNF683 Gene

  • Protein details for ZNF683 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ20-ZN683_HUMAN
    Recommended name:
    Tissue-resident T-cell transcription regulator protein ZNF683
    Protein Accession:
    Q8IZ20
    Secondary Accessions:
    • Q5T141
    • Q5T146
    • Q5T147
    • Q5T149
    • Q8NEN4

    Protein attributes for ZNF683 Gene

    Size:
    524 amino acids
    Molecular mass:
    56905 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH28731.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH29505.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15857.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15858.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF683 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF683 Gene

Post-translational modifications for ZNF683 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF683 Gene

Domains & Families for ZNF683 Gene

Gene Families for ZNF683 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF683 Gene

Suggested Antigen Peptide Sequences for ZNF683 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IZ20

UniProtKB/Swiss-Prot:

ZN683_HUMAN :
  • The C2H2-type zinc finger are necessary for DNA-binding (PubMed:26179882).
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The C2H2-type zinc finger are necessary for DNA-binding (PubMed:26179882).
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF683: view

Function for ZNF683 Gene

Molecular function for ZNF683 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Plays also a role in the differentiation of both thymic and peripheral NKT cells. Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation. Positively regulates granzyme B production in NKT cells after innate stimulation. Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions.
UniProtKB/Swiss-Prot Function:
Isoform 1: Lacks transcriptional repressor activity. Binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Unable to regulate interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T-cells.
UniProtKB/Swiss-Prot Function:
Isoform 2: Transcriptional repressor that binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Regulates interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T cells.
UniProtKB/Swiss-Prot Induction:
(Microbial infection) Up-regulated by cytomegalovirus (CMV) infection in long-lived effector CD8(+) T-cells (PubMed:20921622).

Phenotypes From GWAS Catalog for ZNF683 Gene

Gene Ontology (GO) - Molecular Function for ZNF683 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
GO:1990841 promoter-specific chromatin binding ISS --
genes like me logo Genes that share ontologies with ZNF683: view
genes like me logo Genes that share phenotypes with ZNF683: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF683 Gene

Localization for ZNF683 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF683 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF683 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ZNF683 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF683: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF683 Gene

Pathways & Interactions for ZNF683 Gene

SuperPathways for ZNF683 Gene

No Data Available

Interacting Proteins for ZNF683 Gene

Gene Ontology (GO) - Biological Process for ZNF683 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010468 regulation of gene expression ISS --
genes like me logo Genes that share ontologies with ZNF683: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF683 Gene

Drugs & Compounds for ZNF683 Gene

No Compound Related Data Available

Transcripts for ZNF683 Gene

Unigene Clusters for ZNF683 Gene

Zinc finger protein 683:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF683 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - -
SP7: -
SP8:
SP9:
SP10: - - - -
SP11: - -

Relevant External Links for ZNF683 Gene

GeneLoc Exon Structure for
ZNF683
ECgene alternative splicing isoforms for
ZNF683

Expression for ZNF683 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF683 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF683 Gene

This gene is overexpressed in Testis (x39.1) and Whole Blood (x6.7).

Protein differential expression in normal tissues from HIPED for ZNF683 Gene

This gene is overexpressed in Plasma (56.2), Heart (6.5), and Adipocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF683 Gene



Protein tissue co-expression partners for ZNF683 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF683 Gene:

ZNF683

SOURCE GeneReport for Unigene cluster for ZNF683 Gene:

Hs.353208

mRNA Expression by UniProt/SwissProt for ZNF683 Gene:

Q8IZ20-ZN683_HUMAN
Tissue specificity: Expressed in terminally differentiated effector CD8(+) T-cells, but not in naive and central memory cells (PubMed:26179882). Expressed in terminally differentiated natural killer (NK) cells and natural killer (NKT) T-cells (at protein level) (PubMed:26179882). Expressed strongly in effector-type CD8(+) T-cells and weakly in naive and memory CD8(+) T-cells (PubMed:26179882). Expressed in terminally differentiated natural killer (NK) cells (PubMed:26179882). Isoform 2 is strongly expressed in effector CD8(+) T and natural killer (NK) cells (PubMed:26179882). Isoform 1 is expressed in effector CD8(+) T and natural killer (NK) cells (PubMed:26179882).

Evidence on tissue expression from TISSUES for ZNF683 Gene

  • Bone(2)
genes like me logo Genes that share expression patterns with ZNF683: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF683 Gene

Orthologs for ZNF683 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF683 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF683 33 34
  • 99.54 (n)
cow
(Bos Taurus)
Mammalia ZNF683 33 34
  • 79.14 (n)
dog
(Canis familiaris)
Mammalia ZNF683 33 34
  • 76.81 (n)
rat
(Rattus norvegicus)
Mammalia LOC100359438 33
  • 72.49 (n)
mouse
(Mus musculus)
Mammalia Zfp683 34
  • 51 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 2 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01072143.1 34
  • 11 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4374 34
  • 1 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 58 (a)
OneToOne
Species where no ortholog for ZNF683 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF683 Gene

ENSEMBL:
Gene Tree for ZNF683 (if available)
TreeFam:
Gene Tree for ZNF683 (if available)

Paralogs for ZNF683 Gene

Paralogs for ZNF683 Gene

genes like me logo Genes that share paralogs with ZNF683: view

Variants for ZNF683 Gene

Sequence variations from dbSNP and Humsavar for ZNF683 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000083207 -- 26,373,586(-) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000148673 -- 26,361,615(-) C/T downstream_transcript_variant
rs1000178584 -- 26,366,271(-) G/A intron_variant
rs1000357740 -- 26,372,420(-) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000834320 -- 26,371,959(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF683 Gene

Variant ID Type Subtype PubMed ID
nsv545907 CNV loss 21841781

Variation tolerance for ZNF683 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.37; 94.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF683 Gene

Human Gene Mutation Database (HGMD)
ZNF683
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF683

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF683 Gene

Disorders for ZNF683 Gene

Additional Disease Information for ZNF683

No disorders were found for ZNF683 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF683 Gene

Publications for ZNF683 Gene

  1. Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans. (PMID: 26179882) Vieira Braga FA … van Lier RA (European journal of immunology 2015) 3 4 58
  2. Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation. (PMID: 22885984) van Gisbergen KP … van Lier RA (Nature immunology 2012) 2 3 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Hobit and human effector T-cell differentiation: The beginning of a long journey. (PMID: 26440905) Braun J … Thiel A (European journal of immunology 2015) 3 58

Products for ZNF683 Gene

Sources for ZNF683 Gene

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