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Aliases for ZNF683 Gene

Aliases for ZNF683 Gene

  • Zinc Finger Protein 683 2 3 4 5
  • Homolog Of Blimp-1 In T Cells 2 3
  • Homolog Of Blimp-1 In T-Cell 3 4
  • Hobit 3 4
  • Tissue-Resident T-Cell Transcription Regulator Protein ZNF683 3
  • Hypothetical Protein MGC33414 3

External Ids for ZNF683 Gene

Previous GeneCards Identifiers for ZNF683 Gene

  • GC01M026560
  • GC01M026688
  • GC01M024942

Summaries for ZNF683 Gene

GeneCards Summary for ZNF683 Gene

ZNF683 (Zinc Finger Protein 683) is a Protein Coding gene. An important paralog of this gene is PRDM1.

UniProtKB/Swiss-Prot for ZNF683 Gene

  • Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Plays also a role in the differentiation of both thymic and peripheral NKT cells. Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation. Positively regulates granzyme B production in NKT cells after innate stimulation. Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions.

  • Isoform 1: Lacks transcriptional repressor activity. Binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Unable to regulate interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T-cells.

  • Isoform 2: Transcriptional repressor that binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Regulates interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF683 Gene

Genomics for ZNF683 Gene

Regulatory Elements for ZNF683 Gene

Enhancers for ZNF683 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F026313 1.4 FANTOM5 ENCODE 11.4 +56.4 56364 8.4 HDGF ATF1 PKNOX1 WRNIP1 ARID4B ZNF48 BRCA1 ZNF2 GATA2 ZNF143 CD52 UBXN11 SH3BGRL3 ZNF683 AIM1L LIN28A CEP85 ENSG00000236782 ZNF593 FAM110D
GH01F026408 1.4 Ensembl ENCODE 11 -40.4 -40369 12.1 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 GPATCH3 ZNF683 CD52 UBXN11 ZDHHC18 HMGN2 ZNF593 ENSG00000236782 FAM110D RPS6KA1
GH01F026348 1.7 FANTOM5 Ensembl ENCODE 7.4 +19.6 19601 12.2 HDGF PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CD52 UBXN11 CEP85 NPM1P39 AIM1L CNKSR1 LOC101928728 RPL17P9 HMGN2 LOC101928324
GH01F026010 1.4 FANTOM5 ENCODE 5.3 +363.7 363676 1.5 HDGF ATF1 PKNOX1 ARNT CREB3L1 SIN3A GLIS2 ZNF766 KLF13 KDM4B SYF2 HMGN2 PDIK1L ZNF683 PAQR7 ENSG00000252691 GC01M026017
GH01F026856 1.6 FANTOM5 ENCODE 3.6 -487.2 -487210 9.6 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF143 FOS HMGN2 NPM1P39 RPL17P9 ENSG00000231344 ACTG1P20 LOC101928324 WASF2 PIGV RPS6KA1 NUDC
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF683 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF683 Gene

Chromosome:
1
Start:
26,361,632 bp from pter
End:
26,374,533 bp from pter
Size:
12,902 bases
Orientation:
Minus strand

Genomic View for ZNF683 Gene

Genes around ZNF683 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF683 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF683 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF683 Gene

Proteins for ZNF683 Gene

  • Protein details for ZNF683 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ20-ZN683_HUMAN
    Recommended name:
    Tissue-resident T-cell transcription regulator protein ZNF683
    Protein Accession:
    Q8IZ20
    Secondary Accessions:
    • Q5T141
    • Q5T146
    • Q5T147
    • Q5T149
    • Q8NEN4

    Protein attributes for ZNF683 Gene

    Size:
    524 amino acids
    Molecular mass:
    56905 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH28731.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH29505.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15857.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15858.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF683 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF683 Gene

Post-translational modifications for ZNF683 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF683 Gene

Domains & Families for ZNF683 Gene

Gene Families for ZNF683 Gene

Protein Domains for ZNF683 Gene

Suggested Antigen Peptide Sequences for ZNF683 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IZ20

UniProtKB/Swiss-Prot:

ZN683_HUMAN :
  • The C2H2-type zinc finger are necessary for DNA-binding (PubMed:26179882).
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 4 C2H2-type zinc fingers.
Domain:
  • The C2H2-type zinc finger are necessary for DNA-binding (PubMed:26179882).
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF683: view

Function for ZNF683 Gene

Molecular function for ZNF683 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Plays also a role in the differentiation of both thymic and peripheral NKT cells. Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation. Positively regulates granzyme B production in NKT cells after innate stimulation. Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions.
UniProtKB/Swiss-Prot Function:
Isoform 1: Lacks transcriptional repressor activity. Binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Unable to regulate interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T-cells.
UniProtKB/Swiss-Prot Function:
Isoform 2: Transcriptional repressor that binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Regulates interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T cells.
UniProtKB/Swiss-Prot Induction:
(Microbial infection) Up-regulated by cytomegalovirus (CMV) infection in long-lived effector CD8(+) T-cells (PubMed:20921622).

Gene Ontology (GO) - Molecular Function for ZNF683 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
GO:1990841 promoter-specific chromatin binding IEA,ISS --
genes like me logo Genes that share ontologies with ZNF683: view
genes like me logo Genes that share phenotypes with ZNF683: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF683 Gene

Localization for ZNF683 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF683 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF683 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ZNF683 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF683: view

Pathways & Interactions for ZNF683 Gene

SuperPathways for ZNF683 Gene

No Data Available

Interacting Proteins for ZNF683 Gene

Gene Ontology (GO) - Biological Process for ZNF683 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001779 natural killer cell differentiation IEA --
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF683: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF683 Gene

Transcripts for ZNF683 Gene

Unigene Clusters for ZNF683 Gene

Zinc finger protein 683:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF683 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - -
SP7: -
SP8:
SP9:
SP10: - - - -
SP11: - -

Relevant External Links for ZNF683 Gene

GeneLoc Exon Structure for
ZNF683
ECgene alternative splicing isoforms for
ZNF683

Expression for ZNF683 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF683 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF683 Gene

This gene is overexpressed in Testis (x39.1) and Whole Blood (x6.7).

Protein differential expression in normal tissues from HIPED for ZNF683 Gene

This gene is overexpressed in Plasma (56.2), Heart (6.5), and Adipocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF683 Gene



Protein tissue co-expression partners for ZNF683 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF683 Gene:

ZNF683

SOURCE GeneReport for Unigene cluster for ZNF683 Gene:

Hs.353208

mRNA Expression by UniProt/SwissProt for ZNF683 Gene:

Q8IZ20-ZN683_HUMAN
Tissue specificity: Expressed in terminally differentiated effector CD8(+) T-cells, but not in naive and central memory cells (PubMed:26179882). Expressed in terminally differentiated natural killer (NK) cells and natural killer (NKT) T-cells (at protein level) (PubMed:26179882). Expressed strongly in effector-type CD8(+) T-cells and weakly in naive and memory CD8(+) T-cells (PubMed:26179882). Expressed in terminally differentiated natural killer (NK) cells (PubMed:26179882). Isoform 2 is strongly expressed in effector CD8(+) T and natural killer (NK) cells (PubMed:26179882). Isoform 1 is expressed in effector CD8(+) T and natural killer (NK) cells (PubMed:26179882).
genes like me logo Genes that share expression patterns with ZNF683: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ZNF683 Gene

Orthologs for ZNF683 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF683 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF683 34 35
  • 99.54 (n)
cow
(Bos Taurus)
Mammalia ZNF683 34 35
  • 79.14 (n)
dog
(Canis familiaris)
Mammalia ZNF683 34 35
  • 76.81 (n)
rat
(Rattus norvegicus)
Mammalia LOC100359438 34
  • 72.49 (n)
mouse
(Mus musculus)
Mammalia Zfp683 35
  • 51 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 2 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01072143.1 35
  • 11 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4374 35
  • 1 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 58 (a)
OneToOne
Species where no ortholog for ZNF683 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF683 Gene

ENSEMBL:
Gene Tree for ZNF683 (if available)
TreeFam:
Gene Tree for ZNF683 (if available)

Paralogs for ZNF683 Gene

Paralogs for ZNF683 Gene

genes like me logo Genes that share paralogs with ZNF683: view

Variants for ZNF683 Gene

Sequence variations from dbSNP and Humsavar for ZNF683 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10794531 -- 26,367,754(+) GGCCA(C/T)GAGCA reference, missense
rs10794532 -- 26,367,769(+) CCATG(C/T)CTGGA reference, missense
rs10902746 -- 26,371,556(+) GATAT(C/T)GCCAC intron-variant, upstream-variant-2KB
rs111252310 -- 26,372,030(+) TTATT(C/T)TTGTG intron-variant, upstream-variant-2KB
rs111632057 -- 26,371,603(+) TCTTT(-/A)AAAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF683 Gene

Variant ID Type Subtype PubMed ID
nsv545907 CNV loss 21841781

Variation tolerance for ZNF683 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.37; 94.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF683 Gene

Human Gene Mutation Database (HGMD)
ZNF683
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF683

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF683 Gene

Disorders for ZNF683 Gene

Relevant External Links for ZNF683

Genetic Association Database (GAD)
ZNF683
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF683

No disorders were found for ZNF683 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF683 Gene

Publications for ZNF683 Gene

  1. Blimp-1 homolog Hobit identifies effector-type lymphocytes in humans. (PMID: 26179882) Vieira Braga F.A. … van Lier R.A. (Eur. J. Immunol. 2015) 3 4 64
  2. Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation. (PMID: 22885984) van Gisbergen K.P. … van Lier R.A. (Nat. Immunol. 2012) 2 3 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Hobit and human effector T-cell differentiation: The beginning of a long journey. (PMID: 26440905) Braun J. … Thiel A. (Eur. J. Immunol. 2015) 3 64

Products for ZNF683 Gene

Sources for ZNF683 Gene

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