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ZNF682 Gene

protein-coding   GIFtS: 46
GCID: GC19M020952

Zinc Finger Protein 682

  Search for ZNF682
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6821 2
BC39498_32

External Ids:    HGNC: 288571   Entrez Gene: 911202   Ensembl: ENSG000001971247   UniProtKB: O957803   

Export aliases for ZNF682 gene to outside databases

Previous GC identifers: GC19M019978 GC19M020115 GC19M019677 GC19M020696


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF682 Gene:
ZNF682 (zinc finger protein 682) is a protein-coding gene. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot: ZN682_HUMAN, O95780
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF682 gene promoter:
         S8   HTF   LCR-F1   Evi-1   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF682 promoter sequence
   Search Chromatin IP Primers for ZNF682

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF682


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF682 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF682 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M020952:  view genomic region     (about GC identifiers)

Start:
20,107,867 bp from pter      End:
20,150,315 bp from pter
Size:
42,449 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN682_HUMAN, O95780 (See protein sequence)
Recommended Name: Zinc finger protein 682  
Size: 498 amino acids; 58361 Da
Sequence caution: Sequence=BAB55408.1; Type=Frameshift; Positions=441;
Secondary accessions: B3KU64 E9PFJ5 Q96JV9
Alternative splicing: 3 isoforms:  O95780-1   O95780-2   O95780-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF682: NX_O95780

Explore proteomics data for ZNF682 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys97, Lys432
  • Modification sites at PhosphoSitePlus

  • See ZNF682 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001070817.1  NP_149973.1  

    ENSEMBL proteins: 
     ENSP00000472444   ENSP00000380351   ENSP00000471745   ENSP00000469870   ENSP00000351324  
     ENSP00000471717   ENSP00000470718   ENSP00000471048   ENSP00000469042   ENSP00000470315  
     ENSP00000380348  
    Reactome Protein details: O95780

    ZNF682 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O95780

    ProtoNet protein and cluster: O95780

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN682_HUMAN, O95780
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF682           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN682_HUMAN, O95780
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF682           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF682
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    miRNA
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    miRTarBase miRNAs that target ZNF682:
    hsa-mir-25-3p (MIRT050232)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN682_HUMAN, O95780: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF682           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF682 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF682           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF682
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF682
    Interactions:

        Search GeneGlobe Interaction Network for ZNF682

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF682           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF682 (ZN682)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF682 gene (2 alternative transcripts): 
    NM_001077349.1  NM_033196.2  

    Unigene Cluster for ZNF682:

    Zinc finger protein 682
    Hs.306298  [show with all ESTs]
    Unigene Representative Sequence: AK127015
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000596019 ENST00000397165(uc002noq.3 uc010eck.3) ENST00000594127
    ENST00000601365 ENST00000602079 ENST00000358523 ENST00000595736 ENST00000597972
    ENST00000601100 ENST00000593468 ENST00000595534 ENST00000599240 ENST00000397162(uc002noo.3 uc002nop.3)

    miRNA
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    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ZNF682
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    GenScript: all cDNA clones in your preferred vector (see all 2): ZNF682 (NM_001077349)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF682
    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF682

    Additional mRNA sequence: 

    AK027845.1 AK074843.1 AK096571.1 AK098164.1 AK127015.1 BC136304.1 

    10 DOTS entries:

    DT.121493182  DT.91665271  DT.121493259  DT.75117522  DT.91841371  DT.100020145  DT.75158609  DT.121492517 
    DT.121492982  DT.91877505 

    19 AceView cDNA sequences:

    AK098164 AK027845 AW300489 AW237009 NM_033196 BX283797 BG485458 AK096571 
    CA413972 BG826709 AI680077 AK074843 AK127015 AA603590 AI831819 N84282 
    AW293232 AA210630 N87781 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF682 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATAGATGT
    ZNF682 Expression
    About this image

    ZNF682 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF682 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.306298
        Custom PCR Arrays for ZNF682
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF682

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF682 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 8)
    Uncharacterized protein
    (see all 8)
    47(a)
    36(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    AAWZ02037240(11818-13836)
    GL343434.1(292314-296903)
            Species with no ortholog for ZNF682

    ENSEMBL Gene Tree for ZNF682 (if available)
    TreeFam Gene Tree for ZNF682 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF682 gene
    ZNF852  ZNF4862  ZNF1952  ZNF922  ZNF1002  ZNF7322  ZNF6752  ZNF1382  
    ZNF5062  ZNF662  ZNF2732  ZNF6952  ZNF6262  ZNF6802  ZNF4792  ZNF2532  
    ZNF932  ZNF4922  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF6792  ZNF2572  
    ZNF2542  ZNF7372  ZNF724P2  ZNF982  ZNF7162  ZNF7142  ZNF4292  ZNF5192  
    ZNF4302  ZNF7302  ZNF1172  ZNF7082  ZNF4312  ZNF902  ZNF7262  ZNF7282  
    Selected SIMAP similar genes for ZNF682 using alignment to 9 protein entries:     ZN682_HUMAN (see all proteins) (see all similar genes):
    ZNF232    MGC12518    ZNF721    ZNF527    ZNF611    ZNF724P
    ZNF730    ZNF98    ZNF675    ZNF43    ZNF624    kr-znf3
    ZNF506    ZNF66    ZNF141    ZNF816    ZNF100    ZNF83

    Find genes that share paralogs with ZNF682           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for ZNF682
    PGOHUM00000234229 PGOHUM00000244540 PGOHUM00000232732 PGOHUM00000233345


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF682 (see all 803)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104077911,2
    C,F,H--20114781(+) AATTAC/TTTGCT 2 -- ds500117Minor allele frequency- T:0.13NS EA NA WA 2162
    rs1388251101,2
    C--20114799(+) TCCCTC/TACACT 2 -- ds50010--------
    rs793688341,2
    C,F--20114869(+) TCTATG/TTGTGT 2 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1426314901,2
    --20115114(+) GCCATA/TCCACT 2 -- ds50010--------
    rs1115443121,2
    C,F--20115166(+) ACTTGG/AGTAAG 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1866570021,2
    --20115167(+) CTTGAA/GTAAGG 2 -- ds50010--------
    rs1396480201,2
    --20115231(+) CTTAAC/TACATT 2 -- ut310--------
    rs792043411,2
    C,F--20115448(+) ACCTCA/GTATTT 2 -- ut311Minor allele frequency- G:0.04EA 120
    rs1492973531,2
    C--20115517(+) CAAACC/GCCGAG 2 -- ut310--------
    rs1904591831,2
    --20115549(+) TTTCAC/TACAGA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF682 (20107867 - 20150315 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF682 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv550e201CNV Deletion23290073
    esv2718300CNV Deletion23290073
    esv2718298CNV Deletion23290073
    esv2718296CNV Deletion23290073
    dgv630e199CNV Deletion23128226
    dgv3792n71CNV Gain21882294
    nsv911322CNV Gain21882294
    nsv911321CNV Gain21882294
    nsv458376CNV Gain19166990
    dgv3793n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF682 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF682)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 91120 HGNC: 28857 AceView: LOC91120 Ensembl:ENSG00000197124 euGenes: HUgn91120
    ECgene: ZNF682 H-InvDB: ZNF682

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF682 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF682 gene:
    Search GeneIP for patents involving ZNF682

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Block miRNA regulation of human, mouse, rat ZNF682 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ZNF682
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