ZNF682 Gene
protein-coding GIFtS: 43
GCID: GC19M020115
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zinc finger protein 682
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Aliases
for ZNF682 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6821 2 | | BC39498_31 2 |
Export aliases for ZNF682 gene to outside databasesPrevious GC identifers: GC19M019978 GC19M019677 |
Summaries
for ZNF682 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN682_HUMAN, O95780Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF682 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF682 gene promoter:
S8 HTF LCR-F1 Evi-1 Egr-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF682
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF682 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p12 Ensembl cytogenetic band: 19p12 HGNC cytogenetic band: 19p12ZNF682 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M020115: view genomic region
(about GC identifiers)
Start:
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20,115,227 bp from pter |
End:
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20,150,277 bp from pter |
Size:
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35,051 bases |
Orientation:
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minus strand |
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Proteins
for ZNF682 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN682_HUMAN, O95780 (See
protein sequence)Recommended Name: Zinc finger protein 682 Size: 498 amino acids; 58361 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB55408.1; Type=Frameshift; Positions=441;
Secondary accessions: B3KU64 E9PFJ5 Q96JV9Alternative splicing: 3 isoforms: O95780-1 O95780-2 O95780-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF682: NX_O95780
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95780
ZNF682 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001070817.1 NP_149973.1
ENSEMBL proteins: ENSP00000380351 ENSP00000380348 ENSP00000351324 Reactome Protein details: O95780
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF682 for ontologies About GeneDecksing
ZNF682 Antibody Products:
Assay Products for ZNF682: |
Protein
Domains /
Families
for ZNF682 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF682 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95780ProtoNet protein and cluster: O95780 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN682_HUMAN, O95780Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 11 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF682 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN682_HUMAN, O95780Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF682 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF682 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZNF682 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF682 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF682 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF682 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF682 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF682
ZNF682 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF682
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF682 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF682 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF682
Search CenterWatch for drugs/clinical trials and news about ZNF682 / ZN682
|
Transcripts
for ZNF682 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF682 gene (2 alternative transcripts): NM_001077349.1 NM_033196.2 Unigene Cluster for ZNF682: Zinc finger protein 682 Hs.306298 [show with all ESTs]Unigene Representative Sequence: AK1270153 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397165(uc002noq.3 uc010eck.3) ENST00000397162(uc002noo.3 uc002nop.3)
ENST00000358523
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF682 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF682 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF682 (NM_001077349) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF682 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF682 |
Additional cDNA sequence: AK027845.1 AK074843.1 AK096571.1 AK098164.1 AK127015.1 BC136304.1 10 DOTS entries: DT.121493182 DT.91665271 DT.121493259 DT.75117522 DT.91841371 DT.100020145 DT.75158609 DT.121492517 DT.121492982 DT.91877505 19 AceView cDNA sequences: AW237009 AW300489 AK098164 NM_033196 AK027845 CA413972 AK127015 BX283797 BG826709 BG485458 AK074843 AI680077 AK096571 AI831819 N84282 AA603590 AW293232 N87781 AA210630
GeneLoc Exon Structure
|
Expression
for ZNF682 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF682 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGATAGATGT
About this image
See ZNF682 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF682
SOURCE GeneReport for Unigene cluster: Hs.306298
SABiosciences Custom PCR Arrays for ZNF682
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF682
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF682 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF682 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF682 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF682 |
Orthologs
for ZNF682 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF682 gene from 1/4 species (see all 4) About this table
ENSEMBL Gene Tree for ZNF682 (if available)
TreeFam Gene Tree for ZNF682 (if available) |
Paralogs
for ZNF682 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF682 gene
- ZNF852 ZNF4932 ZNF4862 ZNF1002 ZNF922 ZNF7322 ZNF1382 ZNF6752
- ZNF5062 ZNF2732 ZNF66P2 ZNF6952 ZNF6262 ZNF6802 ZNF2532 ZNF4792
- ZNF932 ZNF4922 ZNF6762 ZNF1412 ZNF6812 ZNF6792 ZNF2572 ZNF2542
- ZNF7372 ZNF724P2 ZNF982 ZNF849P2 ZNF7162 ZNF7142 ZNF4292 ZNF4302
- ZNF7302 ZNF6782 ZNF1172 ZNF7082 ZNF1072 ZNF4312 ZNF902
18/521 SIMAP similar genes for ZNF682 using alignment to 9 protein entries: ZN682_HUMAN (see all proteins)
(see all similar genes):ZNF66 MGC12518 ZNF232 ZNF738 kr-znf3 ZNF300P1
ZNF78L1 ZFS-4 DKFZp686M04222 HZF30 HZF36 ZFS-6
ZNF702P zf30 ZNF93 ZNF273 DKFZp762K012 ZFS-1
ZNF682 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for ZNF682
PGOHUM00000234229 PGOHUM00000244540 PGOHUM00000232732 PGOHUM00000233345
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Genomic Variants
for ZNF682 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF682 (20115227 - 20150277 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF682: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF682 |
|
Disorders
/ Diseases
for ZNF682 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF682 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF682 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF682) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ZNF682 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF682 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF682 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF682 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF682 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF682 gene:
Search GeneIP for patents involving ZNF682
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF682 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF682 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF682 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF682 | | | OriGene Protein Over-expression Lysate for ZNF682 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF682 | | OriGene 3'-UTR Clone for ZNF682 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF682 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF682 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF682 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF682 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF682 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF682 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF682 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF682 |
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| | | | Search Tocris compounds for ZNF682 |
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 | | | ZNF682 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF682 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF682 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF682 |
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