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Aliases for ZNF682 Gene

Aliases for ZNF682 Gene

  • Zinc Finger Protein 682 2 3 5
  • BC39498_3 3

External Ids for ZNF682 Gene

Previous GeneCards Identifiers for ZNF682 Gene

  • GC19M019978
  • GC19M020115
  • GC19M019677
  • GC19M020696
  • GC19M020952
  • GC19M020180
  • GC19M020383

Summaries for ZNF682 Gene

GeneCards Summary for ZNF682 Gene

ZNF682 (Zinc Finger Protein 682) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF718.

UniProtKB/Swiss-Prot for ZNF682 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF682 Gene

Genomics for ZNF682 Gene

Regulatory Elements for ZNF682 Gene

Enhancers for ZNF682 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF682 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF682 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF682 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF682 Gene

Chromosome:
19
Start:
19,997,058 bp from pter
End:
20,039,526 bp from pter
Size:
42,469 bases
Orientation:
Minus strand

Genomic View for ZNF682 Gene

Genes around ZNF682 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF682 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF682 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF682 Gene

Proteins for ZNF682 Gene

  • Protein details for ZNF682 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95780-ZN682_HUMAN
    Recommended name:
    Zinc finger protein 682
    Protein Accession:
    O95780
    Secondary Accessions:
    • B3KU64
    • E9PFJ5
    • Q96JV9

    Protein attributes for ZNF682 Gene

    Size:
    498 amino acids
    Molecular mass:
    58361 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55408.1; Type=Frameshift; Positions=441; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF682 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF682 Gene

Proteomics data for ZNF682 Gene at MOPED

Post-translational modifications for ZNF682 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF682 Gene

Domains & Families for ZNF682 Gene

Gene Families for ZNF682 Gene

Protein Domains for ZNF682 Gene

Suggested Antigen Peptide Sequences for ZNF682 Gene

Graphical View of Domain Structure for InterPro Entry

O95780

UniProtKB/Swiss-Prot:

ZN682_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF682: view

Function for ZNF682 Gene

Molecular function for ZNF682 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF682 Gene

genes like me logo Genes that share phenotypes with ZNF682: view

Animal Model Products

CRISPR Products

miRNA for ZNF682 Gene

miRTarBase miRNAs that target ZNF682

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF682 Gene

Localization for ZNF682 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF682 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF682 Gene COMPARTMENTS Subcellular localization image for ZNF682 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF682 Gene

Pathways & Interactions for ZNF682 Gene

SuperPathways for ZNF682 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF682: view

Pathways by source for ZNF682 Gene

2 Reactome pathways for ZNF682 Gene

Interacting Proteins for ZNF682 Gene

Gene Ontology (GO) - Biological Process for ZNF682 Gene

None

No data available for SIGNOR curated interactions for ZNF682 Gene

Drugs & Compounds for ZNF682 Gene

No Compound Related Data Available

Transcripts for ZNF682 Gene

Unigene Clusters for ZNF682 Gene

Zinc finger protein 682:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF682 Gene

No ASD Table

Relevant External Links for ZNF682 Gene

GeneLoc Exon Structure for
ZNF682
ECgene alternative splicing isoforms for
ZNF682

Expression for ZNF682 Gene

mRNA expression in normal human tissues for ZNF682 Gene

Protein differential expression in normal tissues from HIPED for ZNF682 Gene

This gene is overexpressed in Plasma (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF682 Gene



SOURCE GeneReport for Unigene cluster for ZNF682 Gene Hs.306298

genes like me logo Genes that share expression patterns with ZNF682: view

Protein tissue co-expression partners for ZNF682 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF682 Gene

Orthologs for ZNF682 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF682 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF682 35
  • 99.46 (n)
  • 99.4 (a)
ZNF682 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 49 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 35 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp708 36
  • 42 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
Species with no ortholog for ZNF682:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF682 Gene

ENSEMBL:
Gene Tree for ZNF682 (if available)
TreeFam:
Gene Tree for ZNF682 (if available)

Paralogs for ZNF682 Gene

(526) SIMAP similar genes for ZNF682 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for ZNF682 Gene

genes like me logo Genes that share paralogs with ZNF682: view

Variants for ZNF682 Gene

Sequence variations from dbSNP and Humsavar for ZNF682 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7255165 - 20,023,037(+) CTTCA(C/T)ATTCC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs2075090 - 20,006,876(+) TAAAG(A/G)TTTTG nc-transcript-variant, reference, missense
rs17679334 - 20,006,154(+) TTTGA(C/T)GGCAG nc-transcript-variant, reference, missense
rs7258247 -- 20,014,720(+) ggttg(A/C)agtga intron-variant
rs12975788 -- 20,027,773(+) aaaaa(A/G)aaaaa intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF682 Gene

Variant ID Type Subtype PubMed ID
nsv519535 CNV Gain 19592680
esv2718296 CNV Deletion 23290073
dgv550e201 CNV Deletion 23290073
dgv3792n71 CNV Gain 21882294
esv2718298 CNV Deletion 23290073
nsv458376 CNV Gain 19166990
nsv911319 CNV Gain 21882294
esv2718300 CNV Deletion 23290073
nsv911320 CNV Gain 21882294
dgv630e199 CNV Deletion 23128226
nsv911321 CNV Gain 21882294
nsv911322 CNV Gain 21882294
dgv3793n71 CNV Gain 21882294

Variation tolerance for ZNF682 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.92; 87.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF682 Gene

Disorders for ZNF682 Gene

Relevant External Links for ZNF682

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF682

No disorders were found for ZNF682 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF682 Gene

Publications for ZNF682 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF682 Gene

Sources for ZNF682 Gene

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