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Aliases for ZNF682 Gene

Aliases for ZNF682 Gene

  • Zinc Finger Protein 682 2 3 5
  • BC39498_3 3

External Ids for ZNF682 Gene

Previous GeneCards Identifiers for ZNF682 Gene

  • GC19M019978
  • GC19M020115
  • GC19M019677
  • GC19M020696
  • GC19M020952
  • GC19M020180
  • GC19M020383
  • GC19M021101
  • GC19M021326
  • GC19M021506

Summaries for ZNF682 Gene

GeneCards Summary for ZNF682 Gene

ZNF682 (Zinc Finger Protein 682) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF92.

UniProtKB/Swiss-Prot for ZNF682 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF682 Gene

Genomics for ZNF682 Gene

Regulatory Elements for ZNF682 Gene

Enhancers for ZNF682 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G020051 1.6 FANTOM5 Ensembl ENCODE 30.5 -12.8 -12811 1.9 ELF3 ATF1 NFIB SIN3A ZNF76 DMAP1 RAD21 YY1 ETS1 ZNF143 ZNF682 ZNF253 ZNF506 LOC105372309 GC19M021961
GH19G020038 0.9 ENCODE 30.7 +0.3 324 1.9 TBP PKNOX1 ATF1 ARID4B SIN3A KLF17 ZBTB40 YY1 SCRT2 FOS ZNF682 LINC00663 LOC101928960
GH19G020077 1 Ensembl ENCODE 11.7 -41.2 -41189 6.8 TFAP4 MXI1 PKNOX1 USF1 SAP130 ARID4B MAX RBBP5 ZSCAN9 YY1 ZNF682 BNIP3P15 CILP2 MEF2B ZNF506 LOC100419301 BNIP3P14
GH19G020067 0.4 ENCODE 11.9 -28.6 -28619 2.0 CUX1 ZNF682 GC19P020065 ZNF90
GH19G020102 0.4 ENCODE 11 -63.6 -63636 1.4 MAX ZNF682 ZNF506 ZNF253 PIR56356 PIR62950
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF682 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF682 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108300 325 1599 TBP PKNOX1 ATF1 ARID4B SIN3A KLF17 ZBTB40 YY1 SCRT2 FOS

Genomic Location for ZNF682 Gene

Chromosome:
19
Start:
19,997,058 bp from pter
End:
20,039,526 bp from pter
Size:
42,469 bases
Orientation:
Minus strand

Genomic View for ZNF682 Gene

Genes around ZNF682 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF682 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF682 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF682 Gene

Proteins for ZNF682 Gene

  • Protein details for ZNF682 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95780-ZN682_HUMAN
    Recommended name:
    Zinc finger protein 682
    Protein Accession:
    O95780
    Secondary Accessions:
    • B3KU64
    • E9PFJ5
    • Q96JV9

    Protein attributes for ZNF682 Gene

    Size:
    498 amino acids
    Molecular mass:
    58361 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55408.1; Type=Frameshift; Positions=441; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF682 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF682 Gene

Post-translational modifications for ZNF682 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF682 Gene

Domains & Families for ZNF682 Gene

Gene Families for ZNF682 Gene

Protein Domains for ZNF682 Gene

Suggested Antigen Peptide Sequences for ZNF682 Gene

Graphical View of Domain Structure for InterPro Entry

O95780

UniProtKB/Swiss-Prot:

ZN682_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF682: view

Function for ZNF682 Gene

Molecular function for ZNF682 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF682 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF682: view

Phenotypes for ZNF682 Gene

genes like me logo Genes that share phenotypes with ZNF682: view

Animal Model Products

CRISPR Products

miRNA for ZNF682 Gene

miRTarBase miRNAs that target ZNF682

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF682 Gene

Localization for ZNF682 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF682 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF682 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF682 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF682: view

Pathways & Interactions for ZNF682 Gene

SuperPathways for ZNF682 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF682: view

Pathways by source for ZNF682 Gene

2 Reactome pathways for ZNF682 Gene

Interacting Proteins for ZNF682 Gene

Gene Ontology (GO) - Biological Process for ZNF682 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF682: view

No data available for SIGNOR curated interactions for ZNF682 Gene

Drugs & Compounds for ZNF682 Gene

No Compound Related Data Available

Transcripts for ZNF682 Gene

Unigene Clusters for ZNF682 Gene

Zinc finger protein 682:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF682 Gene

No ASD Table

Relevant External Links for ZNF682 Gene

GeneLoc Exon Structure for
ZNF682
ECgene alternative splicing isoforms for
ZNF682

Expression for ZNF682 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF682 Gene

Protein differential expression in normal tissues from HIPED for ZNF682 Gene

This gene is overexpressed in Plasma (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF682 Gene



Protein tissue co-expression partners for ZNF682 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF682 Gene:

ZNF682

SOURCE GeneReport for Unigene cluster for ZNF682 Gene:

Hs.306298

Evidence on tissue expression from TISSUES for ZNF682 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF682: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF682 Gene

Orthologs for ZNF682 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF682 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF682 34 35
  • 99.46 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 51 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 49 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp708 35
  • 42 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 35 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 47 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
Species where no ortholog for ZNF682 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF682 Gene

ENSEMBL:
Gene Tree for ZNF682 (if available)
TreeFam:
Gene Tree for ZNF682 (if available)

Paralogs for ZNF682 Gene

(526) SIMAP similar genes for ZNF682 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ZNF682: view

Variants for ZNF682 Gene

Sequence variations from dbSNP and Humsavar for ZNF682 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000048855 -- 20,004,523(+) CAATT(C/T)ACTAA utr-variant-3-prime
rs1000113674 -- 20,004,336(+) GTTAC(C/T)GTCTG downstream-variant-500B
rs1000115836 -- 20,017,617(+) ATAGA(-/T)TTCAC intron-variant
rs1000145777 -- 20,008,136(+) TGATA(C/T)ATGTG intron-variant
rs1000308928 -- 20,040,742(+) CGCCA(C/T)TGCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF682 Gene

Variant ID Type Subtype PubMed ID
dgv1026e212 CNV loss 25503493
dgv3456n100 CNV gain 25217958
dgv3457n100 CNV gain 25217958
dgv509e201 CNV deletion 23290073
dgv6303n54 CNV loss 21841781
dgv630e199 CNV deletion 23128226
esv2718296 CNV deletion 23290073
esv2718298 CNV deletion 23290073
esv2718300 CNV deletion 23290073
esv3643864 CNV loss 21293372
nsv1061846 CNV loss 25217958
nsv1066045 CNV loss 25217958
nsv1066970 CNV gain 25217958
nsv458376 CNV gain 19166990
nsv519535 CNV gain 19592680
nsv578800 CNV gain 21841781
nsv578803 CNV gain 21841781

Variation tolerance for ZNF682 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.92; 87.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF682 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF682

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF682 Gene

Disorders for ZNF682 Gene

Relevant External Links for ZNF682

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF682

No disorders were found for ZNF682 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF682 Gene

Publications for ZNF682 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ZNF682 Gene

Sources for ZNF682 Gene

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