ZNF681 Gene
protein-coding GIFtS: 45
GCID: GC19M023921
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zinc finger protein 681
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Aliases
for ZNF681 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6811 2 | | FLJ315261 |
Export aliases for ZNF681 gene to outside databasesPrevious GC identifers: GC19M023719 GC19M023470 |
Summaries
for ZNF681 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN681_HUMAN, Q96N22Function: May be involved in transcriptional regulation (By similarity)
|
Genomic Views
for ZNF681 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF681 gene promoter:
NF-YA AREB6 NF-YB CBF-A CBF-B CP1A NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF681
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF681 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p12 Ensembl cytogenetic band: 19p12 HGNC cytogenetic band: 19p12ZNF681 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M023921: view genomic region
(about GC identifiers)
Start:
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23,921,997 bp from pter |
End:
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23,941,693 bp from pter |
Size:
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19,697 bases |
Orientation:
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minus strand |
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Proteins
for ZNF681 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN681_HUMAN, Q96N22 (See
protein sequence)Recommended Name: Zinc finger protein 681 Size: 645 amino acids; 75059 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BC062216; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence;
Secondary accessions: B3KVF7Alternative splicing: 2 isoforms: Q96N22-1 Q96N22-2 Explore the universe of human proteins at neXtProt for ZNF681: NX_Q96N22
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96N22
ZNF681 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612143.2
ENSEMBL proteins: ENSP00000384000 ENSP00000433806 ENSP00000435824 ENSP00000378783 Reactome Protein details: Q96N22
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF681 for ontologies About GeneDecksing
ZNF681 Antibody Products:
Assay Products for ZNF681: |
Protein
Domains /
Families
for ZNF681 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF681 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96N22ProtoNet protein and cluster: Q96N22 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN681_HUMAN, Q96N22Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 16 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF681 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN681_HUMAN, Q96N22Function: May be involved in transcriptional regulation (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF681
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF681
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for ZNF681 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF681 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF681 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF681 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ZNF681:
|
Pathways & Interactions
for ZNF681 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF681
ZNF681 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF681
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF681 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF681 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF681
Search CenterWatch for drugs/clinical trials and news about ZNF681 / ZN681
|
Transcripts
for ZNF681 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF681 gene: NM_138286.2 Unigene Clusters for ZNF681: Zinc finger protein 681 Hs.399952 [show with all ESTs], Hs.735840 [show with all ESTs]Unigene Representative Sequences: NM_138286, BC0822334 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000402377(uc002nrk.4 uc002nrl.4 uc002nrj.4) ENST00000528059
ENST00000531570(uc002nrm.1) ENST00000395385
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF681
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF681
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF681 (NM_138286) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF681 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF681 |
Additional cDNA sequence: BC082233.1 7 DOTS entries: DT.402913 DT.40126817 DT.101980817 DT.91694568 DT.100016323 DT.121463910 DT.40203668 22 AceView cDNA sequences: BF914975 AI732980 NM_138286 BC062216 AK122869 AK056088 BE407279 AI588838 BC082233 BG281940 BE408585 BE391295 BU567947 BE730430 CD636357 CD636358 CD636355 BE389316 BE410836 BE387816 CD636356 AA937570
GeneLoc Exon Structure
|
Expression
for ZNF681 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF681 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACTTCTTGT
About this image
See ZNF681 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF681
SOURCE GeneReport for Unigene clusters: Hs.399952 Hs.735840
SABiosciences Custom PCR Arrays for ZNF681
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF681
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF681 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF681 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF681 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF681 |
Orthologs
for ZNF681 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF681 gene from 1/4 species (see all 4) About this table
ENSEMBL Gene Tree for ZNF681 (if available)
TreeFam Gene Tree for ZNF681 (if available) |
Paralogs
for ZNF681 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF681 gene
- ZNF852 ZNF4932 ZNF4862 ZNF1002 ZNF922 ZNF7322 ZNF1382 ZNF6752
- ZNF5062 ZNF2732 ZNF66P2 ZNF6952 ZNF6262 ZNF6802 ZNF2532 ZNF4792
- ZNF932 ZNF4922 ZNF6822 ZNF6762 ZNF1412 ZNF6792 ZNF2572 ZNF2542
- ZNF7372 ZNF724P2 ZNF982 ZNF849P2 ZNF7162 ZNF7142 ZNF4292 ZNF4302
- ZNF7302 ZNF6782 ZNF7082 ZNF1172 ZNF1072 ZNF4312 ZNF902
18/510 SIMAP similar genes for ZNF681 using alignment to 4 protein entries: ZN681_HUMAN (see all proteins)
(see all similar genes):MGC12518 ZNF818P ZNF738 ZNF85 ZFS-1 ZNF66
DKFZp762K012 ZNF273 HZF30 ZNF429 ZNF724P ZNF232
ZNF254 ZNF43 ZNF55 ZNF676 ZNF714 ZNF726
ZNF681 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF681
PGOHUM00000241329
|
Genomic Variants
for ZNF681 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF681 (23921997 - 23941693 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZNF681
2 CNVs: 4072 8869 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF681 |
|
Disorders
/ Diseases
for ZNF681 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF681 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF681 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF681) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for ZNF681 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF681 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF681 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF681 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF681 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF681 gene:
Search GeneIP for patents involving ZNF681
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF681 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF681 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF681 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF681 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF681 | | OriGene 3'-UTR Clone for ZNF681 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF681 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF681 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF681 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF681 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF681 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF681 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF681 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF681 |
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 | | | ZNF681 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF681 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF681 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF681 |
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