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Aliases for ZNF681 Gene

Aliases for ZNF681 Gene

  • Zinc Finger Protein 681 2 3
  • Hypothetical Protein FLJ31526 2

External Ids for ZNF681 Gene

Previous GeneCards Identifiers for ZNF681 Gene

  • GC19M023719
  • GC19M023921
  • GC19M023470

Summaries for ZNF681 Gene

GeneCards Summary for ZNF681 Gene

ZNF681 (Zinc Finger Protein 681) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF681 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF681 Gene

Genomics for ZNF681 Gene

Regulatory Elements for ZNF681 Gene

Genomic Location for ZNF681 Gene

23,739,195 bp from pter
23,758,891 bp from pter
19,697 bases
Minus strand

Genomic View for ZNF681 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF681 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF681 Gene

Proteins for ZNF681 Gene

  • Protein details for ZNF681 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 681
    Protein Accession:
    Secondary Accessions:
    • B3KVF7

    Protein attributes for ZNF681 Gene

    645 amino acids
    Molecular mass:
    75059 Da
    Quaternary structure:
    No Data Available
    • Sequence=BC062216; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF681 Gene


neXtProt entry for ZNF681 Gene

Proteomics data for ZNF681 Gene at MOPED

Post-translational modifications for ZNF681 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF681 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF681 Gene

Domains for ZNF681 Gene

Gene Families for ZNF681 Gene

  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF681 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96N22
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF681: view

Function for ZNF681 Gene

Molecular function for ZNF681 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF681 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF681: view
genes like me logo Genes that share phenotypes with ZNF681: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF681 Gene

Localization for ZNF681 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF681 Gene

Subcellular locations from

Jensen Localization Image for ZNF681 Gene COMPARTMENTS Subcellular localization image for ZNF681 gene
Compartment Confidence
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ZNF681 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF681: view

Pathways for ZNF681 Gene

SuperPathways for ZNF681 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF681: view

Pathways by source for ZNF681 Gene

2 Reactome pathways for ZNF681 Gene

Interacting Proteins for ZNF681 Gene

Gene Ontology (GO) - Biological Process for ZNF681 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF681: view

Transcripts for ZNF681 Gene

mRNA/cDNA for ZNF681 Gene

Unigene Clusters for ZNF681 Gene

Zinc finger protein 681:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF681 Gene

No ASD Table

Relevant External Links for ZNF681 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF681 Gene

mRNA expression in normal human tissues for ZNF681 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for ZNF681 Gene Hs.399952

genes like me logo Genes that share expressions with ZNF681: view

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for ZNF681 Gene

Orthologs for ZNF681 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF681 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF681 35
  • 99.12 (n)
  • 98.6 (a)
ZNF681 36
  • 99 (a)
(Bos Taurus)
Mammalia -- 36
  • 54 (a)
(Canis familiaris)
Mammalia -- 36
  • 41 (a)
(Mus musculus)
Mammalia Zfp874a 36
  • 49 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 42 (a)
-- 36
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
-- 36
  • 36 (a)
-- 36
  • 44 (a)
-- 36
  • 40 (a)
-- 36
  • 34 (a)
-- 36
  • 33 (a)
-- 36
  • 33 (a)
-- 36
  • 30 (a)
Species with no ortholog for ZNF681:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF681 Gene

Gene Tree for ZNF681 (if available)
Gene Tree for ZNF681 (if available)

Paralogs for ZNF681 Gene

Selected SIMAP similar genes for ZNF681 Gene using alignment to 4 proteins: Pseudogenes for ZNF681 Gene

genes like me logo Genes that share paralogs with ZNF681: view

Variants for ZNF681 Gene

Sequence variations from dbSNP and Humsavar for ZNF681 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1818985 -- 23,749,203(-) ataat(A/G)attct intron-variant
rs1818986 -- 23,749,196(-) ttctc(A/G)aagtt intron-variant
rs1818987 -- 23,749,045(-) tcaat(A/G)ttcaa intron-variant
rs1818988 -- 23,748,752(-) tttcc(A/G)atttt intron-variant
rs1818989 - 23,744,666(-) GTCCT(C/T)AACCC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ZNF681 Gene

Variant ID Type Subtype PubMed ID
esv731 CNV CNV 17122850
esv2751784 CNV Gain 17911159
essv17031 CNV CNV 17122850
dgv3819n71 CNV Loss 21882294
nsv911466 CNV Gain 21882294
nsv524183 CNV Gain 19592680
nsv458528 CNV Loss 19166990
esv2718381 CNV Deletion 23290073
nsv911471 CNV Loss 21882294
dgv3821n71 CNV Gain 21882294
esv1418599 CNV Insertion 17803354

Relevant External Links for ZNF681 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF681 Gene

Disorders for ZNF681 Gene

No disorders were found for ZNF681 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF681 Gene

Publications for ZNF681 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3
  3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  4. Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling. (PMID: 25391492) Lamoliatte F. … Thibault P. (Nat Commun 2014) 3
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4

Products for ZNF681 Gene

Sources for ZNF681 Gene

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