Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF680 Gene

Aliases for ZNF680 Gene

  • Zinc Finger Protein 680 2 3 5
  • Hypothetical Protein FLJ90430 2

External Ids for ZNF680 Gene

Previous GeneCards Identifiers for ZNF680 Gene

  • GC07M063427
  • GC07M063617
  • GC07M063980
  • GC07M060361

Summaries for ZNF680 Gene

GeneCards Summary for ZNF680 Gene

ZNF680 (Zinc Finger Protein 680) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot for ZNF680 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF680 Gene

Genomics for ZNF680 Gene

Regulatory Elements for ZNF680 Gene

Enhancers for ZNF680 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F064305 1.2 FANTOM5 ENCODE 9 +255.9 255897 2.6 HDGF ATF1 CREB3L1 ZNF2 ETS1 YY1 ZNF143 ZNF263 SP3 REST GUSBP6 ZNF680 YWHAEP1 ZNF680P1 TRIM60P18 SEPHS1P1 CCT6P3 ZNF107 ZNF736 LOC105375323
GH07F064995 1 Ensembl ENCODE 4.3 -438.8 -438758 11.8 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 GTF2IP14 CCT6P3 ERV3-1 INTS4P1 ZNF117 VKORC1L1 ENSG00000227113 CCT6P1 EEF1DP4 ZNF680
GH07F064875 0.5 FANTOM5 4.2 -312.0 -311979 0.1 EEF1DP4 ZNF117 ZNF680 ZNF273 LOC441239
GH07F064835 0.5 FANTOM5 1.5 -272.3 -272301 0.2 MAFG MAFK EMSY CHAMP1 LOC101929322 ZNF680 ENSG00000234338 PIR39219
GH07F064558 1.1 Ensembl ENCODE 0.8 +3.7 3672 2.9 HLF MAFG BACH1 ZNF316 SMARCA4 NFE2L1 NFE2 MAFK EMSY NFE2L2 ZNF107 YWHAEP1 ZNF680P1 ZNF680 BNIP3P42
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF680 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF680 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000067016 126 1999 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 ELK1 FOS

Genomic Location for ZNF680 Gene

Chromosome:
7
Start:
64,501,290 bp from pter
End:
64,563,127 bp from pter
Size:
61,838 bases
Orientation:
Minus strand

Genomic View for ZNF680 Gene

Genes around ZNF680 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF680 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF680 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF680 Gene

Proteins for ZNF680 Gene

  • Protein details for ZNF680 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEM1-ZN680_HUMAN
    Recommended name:
    Zinc finger protein 680
    Protein Accession:
    Q8NEM1
    Secondary Accessions:
    • B3KVJ4
    • Q6ZNF3
    • Q8NC79

    Protein attributes for ZNF680 Gene

    Size:
    530 amino acids
    Molecular mass:
    61798 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11286.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF680 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF680 Gene

Post-translational modifications for ZNF680 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF680 Gene

No data available for DME Specific Peptides for ZNF680 Gene

Domains & Families for ZNF680 Gene

Gene Families for ZNF680 Gene

Protein Domains for ZNF680 Gene

Suggested Antigen Peptide Sequences for ZNF680 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEM1

UniProtKB/Swiss-Prot:

ZN680_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF680: view

Function for ZNF680 Gene

Molecular function for ZNF680 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF680 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF680: view
genes like me logo Genes that share phenotypes with ZNF680: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF680 Gene

Localization for ZNF680 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF680 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF680 Gene COMPARTMENTS Subcellular localization image for ZNF680 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF680 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with ZNF680: view

Pathways & Interactions for ZNF680 Gene

SuperPathways for ZNF680 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF680: view

Pathways by source for ZNF680 Gene

2 Reactome pathways for ZNF680 Gene

Interacting Proteins for ZNF680 Gene

Gene Ontology (GO) - Biological Process for ZNF680 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF680: view

No data available for SIGNOR curated interactions for ZNF680 Gene

Transcripts for ZNF680 Gene

Unigene Clusters for ZNF680 Gene

Zinc finger protein 680:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF680 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - -
SP8:
SP9:

Relevant External Links for ZNF680 Gene

GeneLoc Exon Structure for
ZNF680
ECgene alternative splicing isoforms for
ZNF680

Expression for ZNF680 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF680 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF680 Gene:

ZNF680

SOURCE GeneReport for Unigene cluster for ZNF680 Gene:

Hs.520886
genes like me logo Genes that share expression patterns with ZNF680: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF680 Gene

Orthologs for ZNF680 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF680 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF680 34 35
  • 99.43 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 52 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp953 35
  • 52 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 48 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
Species where no ortholog for ZNF680 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF680 Gene

ENSEMBL:
Gene Tree for ZNF680 (if available)
TreeFam:
Gene Tree for ZNF680 (if available)

Paralogs for ZNF680 Gene

(491) SIMAP similar genes for ZNF680 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF680 Gene

genes like me logo Genes that share paralogs with ZNF680: view

Variants for ZNF680 Gene

Sequence variations from dbSNP and Humsavar for ZNF680 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10215113 -- 64,547,775(+) AGTAA(C/T)AGAAA intron-variant
rs10223908 -- 64,510,816(+) gaggc(A/G)ggaga intron-variant
rs10225784 -- 64,536,395(+) tcatg(A/G)tggaa intron-variant
rs10228292 -- 64,520,810(+) AAACA(C/T)GCTTC intron-variant, utr-variant-3-prime
rs10228601 -- 64,536,212(+) AAGAT(G/T)AATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF680 Gene

Variant ID Type Subtype PubMed ID
dgv1099e201 CNV deletion 23290073
dgv241n111 CNV duplication 26073780
esv2422405 CNV duplication 17116639
esv2764000 CNV gain+loss 21179565
esv3891131 CNV gain+loss 25118596
nsv1018445 CNV gain 25217958
nsv464518 CNV gain 19166990
nsv607312 CNV gain 21841781
nsv970855 CNV duplication 23825009

Variation tolerance for ZNF680 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF680 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF680

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF680 Gene

Disorders for ZNF680 Gene

Relevant External Links for ZNF680

Genetic Association Database (GAD)
ZNF680
Human Genome Epidemiology (HuGE) Navigator
ZNF680
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF680

No disorders were found for ZNF680 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF680 Gene

Publications for ZNF680 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for ZNF680 Gene

Sources for ZNF680 Gene

Content
Loading form....