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ZNF680 Gene

protein-coding   GIFtS: 48
GCID: GC07M063980

Zinc Finger Protein 680

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6801 2
Hypothetical Protein FLJ904301

External Ids:    HGNC: 268971   Entrez Gene: 3402522   Ensembl: ENSG000001730417   UniProtKB: Q8NEM13   

Export aliases for ZNF680 gene to outside databases

Previous GC identifers: GC07M063427 GC07M063617 GC07M060361


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF680 Gene:
ZNF680 (zinc finger protein 680) is a protein-coding gene. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot: ZN680_HUMAN, Q8NEM1
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF680 gene promoter:
         GR   NF-1   RFX1   AML1a   GATA-3   MyoD   Pax-2   Pax-2a   E47   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF680 promoter sequence
   Search Chromatin IP Primers for ZNF680

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF680


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.21   Ensembl cytogenetic band:  7q11.21   HGNC cytogenetic band: 7q11.21

ZNF680 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF680 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M063980:  view genomic region     (about GC identifiers)

Start:
63,980,255 bp from pter      End:
64,023,505 bp from pter
Size:
43,251 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 63,317,849-63,361,099     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN680_HUMAN, Q8NEM1 (See protein sequence)
Recommended Name: Zinc finger protein 680  
Size: 530 amino acids; 61798 Da
Sequence caution: Sequence=BAC11286.1; Type=Erroneous initiation;
Secondary accessions: B3KVJ4 Q6ZNF3 Q8NC79
Alternative splicing: 2 isoforms:  Q8NEM1-1   Q8NEM1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF680: NX_Q8NEM1

Explore proteomics data for ZNF680 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys106, Lys497
  • Modification sites at PhosphoSitePlus

  • See ZNF680 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123494.1  NP_848653.2  

    ENSEMBL proteins: 
     ENSP00000309330   ENSP00000393506  
    Reactome Protein details: Q8NEM1

    ZNF680 Human Recombinant Protein Products:

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    antibodies-online antibodies for ZNF680 (11 products) 

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    antibodies-online kits for ZNF680 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8NEM1

    ProtoNet protein and cluster: Q8NEM1

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN680_HUMAN, Q8NEM1
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 12 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF680           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN680_HUMAN, Q8NEM1
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF680           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF680:
     Cell cycle / mitosis defect 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF680

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN680_HUMAN, Q8NEM1: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF680           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF680 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF680           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF680
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF680
    Interactions:

        Search GeneGlobe Interaction Network for ZNF680

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF680           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF680 (ZN680)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF680 gene (2 alternative transcripts): 
    NM_001130022.1  NM_178558.4  

    Unigene Cluster for ZNF680:

    Zinc finger protein 680
    Hs.520886  [show with all ESTs]
    Unigene Representative Sequence: NM_178558
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309683(uc003tta.2) ENST00000476563 ENST00000470847 ENST00000447137(uc003ttb.2)
    ENST00000473601
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF680

    Additional mRNA sequence: 

    AK074911.1 AK094476.1 AK122937.1 AK131240.1 BC030700.1 

    10 DOTS entries:

    DT.205500  DT.99929838  DT.100684886  DT.121053060  DT.121053248  DT.121053037  DT.121053235  DT.97859198 
    DT.121053122  DT.121496408 

    Selected AceView cDNA sequences (see all 50):

    AK131240 CR617028 AW263436 BM456797 CN479281 AI858613 AA766138 AI648400 
    BX282558 AK074911 BC030700 AW194212 BX955740 AI963028 CD356088 BX955731 
    BU690047 BE618517 BG260987 AW994868 BX483304 BI548509 NM_178558 BG773545 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF680 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
    SP1:                                            -     -     -           -                                                         
    SP2:                                            -     -     -           -           -     -                                       
    SP3:                                            -     -     -           -           -     -     -                                 
    SP4:                                            -     -     -     -     -     -                 -                                 
    SP5:                                            -     -     -     -     -     -                 -                                 


    ECgene alternative splicing isoforms for ZNF680

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF680 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF680 Expression
    About this image

    ZNF680 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF680 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520886
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF680 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 8)
    Uncharacterized protein
    (see all 8)
    48(a)
    38(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    AAWZ02037240(11818-13836)
    GL343434.1(292314-296903)
            Species with no ortholog for ZNF680

    ENSEMBL Gene Tree for ZNF680 (if available)
    TreeFam Gene Tree for ZNF680 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF680 gene
    ZNF852  ZNF4862  ZNF1952  ZNF922  ZNF1002  ZNF7322  ZNF6752  ZNF1382  
    ZNF5062  ZNF662  ZNF2732  ZNF6952  ZNF6262  ZNF4792  ZNF2532  ZNF932  
    ZNF6822  ZNF4922  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF6792  ZNF2572  
    ZNF2542  ZNF7372  ZNF724P2  ZNF982  ZNF7162  ZNF7142  ZNF4292  ZNF5192  
    ZNF4302  ZNF7302  ZNF7082  ZNF1172  ZNF4312  ZNF902  ZNF7262  ZNF7282  
    Selected SIMAP similar genes for ZNF680 using alignment to 1 protein entry:     ZN680_HUMAN(see all similar genes):
    MGC12518    ZNF273    ZNF738    ZNF78L1    ZFS-4    ZNF818P
    kr-znf3    ZFS-6    ZNF431    ZNF55    ZNF676    ZNF708
    ZNF728    ZNF98    smap-7    ZNF430    ZNF92    ZFS-1

    Find genes that share paralogs with ZNF680           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF680
    PGOHUM00000233359


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF680 (see all 921)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs784462191,2
    C,F--63979771(+) GTGAAT/GGTAAA 1 -- ds50012Minor allele frequency- G:0.25WA EA 238
    rs1462935981,2
    --63979786(+) CACCAC/TTATGA 1 -- ds50010--------
    rs1144797881,2
    C,F--63979862(+) TACTGG/CGTATC 1 -- ds50013Minor allele frequency- C:0.16WA NA EA 358
    rs802564241,2
    C,F--63979917(+) CACACG/ATTTAT 1 -- ds50011Minor allele frequency- A:0.37EA 120
    rs1176357251,2
    F--63980030(+) TTTCTC/GTTACT 1 -- ds50011Minor allele frequency- G:0.01EA 120
    rs731287601,2
    C,F--63980181(+) TCTTTT/CACCTC 1 -- ds50016Minor allele frequency- C:0.16NA CSA WA EA 364
    rs1890688111,2
    --63980202(+) TAAAGA/TGAAAA 1 -- ds50010--------
    rs47171951,2
    C,F,H--63980233(+) ATAACG/ACTTCA 1 -- ds500119Minor allele frequency- A:0.17NS EA NA WA CSA 2210
    rs1442764461,2
    --63980299(+) TTATAC/TATAAT 1 -- ut310--------
    rs1460991491,2
    --63980338(+) TAGCAC/TAAAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF680 (63980255 - 64023505 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ZNF680:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1147e201CNV Deletion23290073
    esv2422405CNV Duplication17116639
    nsv888255CNV Loss21882294
    nsv888272CNV Loss21882294
    nsv464518CNV Gain19166990
    dgv7308n71CNV Gain21882294
    dgv7307n71CNV Gain21882294
    nsv888259CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF680
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF680

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF680           About GenesLikeMe

    Genetic Association Database (GAD): ZNF680
    Human Genome Epidemiology (HuGE) Navigator: ZNF680 (4 documents)

    Export disorders for ZNF680 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF680 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF680)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 340252 HGNC: 26897 AceView: FLJ90430 Ensembl:ENSG00000173041 euGenes: HUgn340252
    ECgene: ZNF680 H-InvDB: ZNF680

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ZNF680 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF680 gene:
    Search GeneIP for patents involving ZNF680

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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