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Aliases for ZNF680 Gene

Aliases for ZNF680 Gene

  • Zinc Finger Protein 680 2 3
  • Hypothetical Protein FLJ90430 2

External Ids for ZNF680 Gene

Previous GeneCards Identifiers for ZNF680 Gene

  • GC07M063427
  • GC07M063617
  • GC07M063980
  • GC07M060361

Summaries for ZNF680 Gene

GeneCards Summary for ZNF680 Gene

ZNF680 (Zinc Finger Protein 680) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF680 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF680 Gene

Genomics for ZNF680 Gene

Regulatory Elements for ZNF680 Gene

Genomic Location for ZNF680 Gene

Start:
64,501,367 bp from pter
End:
64,563,127 bp from pter
Size:
61,761 bases
Orientation:
Minus strand

Genomic View for ZNF680 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF680 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF680 Gene

Proteins for ZNF680 Gene

  • Protein details for ZNF680 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEM1-ZN680_HUMAN
    Recommended name:
    Zinc finger protein 680
    Protein Accession:
    Q8NEM1
    Secondary Accessions:
    • B3KVJ4
    • Q6ZNF3
    • Q8NC79

    Protein attributes for ZNF680 Gene

    Size:
    530 amino acids
    Molecular mass:
    61798 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11286.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF680 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF680 Gene

Proteomics data for ZNF680 Gene at MOPED

Post-translational modifications for ZNF680 Gene

  • Ubiquitination at Lys106 and Lys497
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF680 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF680 Gene

Domains for ZNF680 Gene

Gene Families for ZNF680 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF680 Gene

Suggested Antigen Peptide Sequences for ZNF680 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEM1

UniProtKB/Swiss-Prot:

ZN680_HUMAN :
  • Q8NEM1
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF680: view

Function for ZNF680 Gene

Molecular function for ZNF680 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF680 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF680: view

Phenotypes for ZNF680 Gene

GenomeRNAi human phenotypes for ZNF680:
genes like me logo Genes that share phenotypes with ZNF680: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF680 Gene

Localization for ZNF680 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF680 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF680 Gene COMPARTMENTS Subcellular localization image for ZNF680 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF680 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF680: view

Pathways for ZNF680 Gene

SuperPathways for ZNF680 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF680: view

Pathways by source for ZNF680 Gene

2 Reactome pathways for ZNF680 Gene

Interacting Proteins for ZNF680 Gene

Gene Ontology (GO) - Biological Process for ZNF680 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF680: view

Transcripts for ZNF680 Gene

Unigene Clusters for ZNF680 Gene

Zinc finger protein 680:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF680 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - -
SP8:
SP9:

Relevant External Links for ZNF680 Gene

GeneLoc Exon Structure for
ZNF680
ECgene alternative splicing isoforms for
ZNF680

Expression for ZNF680 Gene

mRNA expression in normal human tissues for ZNF680 Gene

SOURCE GeneReport for Unigene cluster for ZNF680 Gene Hs.520886

genes like me logo Genes that share expressions with ZNF680: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for ZNF680 Gene

Orthologs for ZNF680 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF680 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF680 35
  • 99.43 (n)
  • 98.87 (a)
ZNF680 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 52 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 38 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp953 36
  • 52 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
ManyToMany
-- 36
  • 31 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
Species with no ortholog for ZNF680:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF680 Gene

ENSEMBL:
Gene Tree for ZNF680 (if available)
TreeFam:
Gene Tree for ZNF680 (if available)

Paralogs for ZNF680 Gene

Selected SIMAP similar genes for ZNF680 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF680 Gene

genes like me logo Genes that share paralogs with ZNF680: view

Variants for ZNF680 Gene

Sequence variations from dbSNP and Humsavar for ZNF680 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1323201 -- 64,509,989(+) GTATT(C/T)TAAAT intron-variant
rs1323202 -- 64,510,022(+) AAACT(C/T)TAAAA intron-variant
rs1596927 -- 64,545,828(-) GGATC(C/T)ATCTG intron-variant
rs1853410 -- 64,506,298(+) CCGGG(C/T)TCACG intron-variant
rs1885912 -- 64,502,585(+) TGTTA(A/C)GATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF680 Gene

Variant ID Type Subtype PubMed ID
nsv888255 CNV Loss 21882294
dgv1147e201 CNV Deletion 23290073
nsv888259 CNV Gain 21882294
esv2422405 CNV Duplication 17116639
nsv464518 CNV Gain 19166990
dgv7307n71 CNV Gain 21882294
nsv888272 CNV Loss 21882294
dgv7308n71 CNV Gain 21882294

Relevant External Links for ZNF680 Gene

HapMap Linkage Disequilibrium report
ZNF680

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF680 Gene

Disorders for ZNF680 Gene

Relevant External Links for ZNF680

Genetic Association Database (GAD)
ZNF680
Human Genome Epidemiology (HuGE) Navigator
ZNF680
genes like me logo Genes that share disorders with ZNF680: view

No data available for UniProtKB/Swiss-Prot for ZNF680 Gene

Publications for ZNF680 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for ZNF680 Gene

Sources for ZNF680 Gene

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