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Aliases for ZNF680 Gene

Aliases for ZNF680 Gene

  • Zinc Finger Protein 680 2 3 5
  • Hypothetical Protein FLJ90430 2

External Ids for ZNF680 Gene

Previous GeneCards Identifiers for ZNF680 Gene

  • GC07M063427
  • GC07M063617
  • GC07M063980
  • GC07M060361

Summaries for ZNF680 Gene

GeneCards Summary for ZNF680 Gene

ZNF680 (Zinc Finger Protein 680) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF718.

UniProtKB/Swiss-Prot for ZNF680 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF680 Gene

Genomics for ZNF680 Gene

Regulatory Elements for ZNF680 Gene

Enhancers for ZNF680 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF680 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF680 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF680 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF680 Gene

64,501,290 bp from pter
64,563,127 bp from pter
61,838 bases
Minus strand

Genomic View for ZNF680 Gene

Genes around ZNF680 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF680 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF680 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF680 Gene

Proteins for ZNF680 Gene

  • Protein details for ZNF680 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 680
    Protein Accession:
    Secondary Accessions:
    • B3KVJ4
    • Q6ZNF3
    • Q8NC79

    Protein attributes for ZNF680 Gene

    530 amino acids
    Molecular mass:
    61798 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11286.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF680 Gene


neXtProt entry for ZNF680 Gene

Proteomics data for ZNF680 Gene at MOPED

Post-translational modifications for ZNF680 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF680 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF680 Gene

Domains & Families for ZNF680 Gene

Gene Families for ZNF680 Gene

Protein Domains for ZNF680 Gene

Suggested Antigen Peptide Sequences for ZNF680 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 12 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF680: view

Function for ZNF680 Gene

Molecular function for ZNF680 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF680: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF680 Gene

Localization for ZNF680 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF680 Gene

Subcellular locations from

Jensen Localization Image for ZNF680 Gene COMPARTMENTS Subcellular localization image for ZNF680 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF680 Gene

Pathways & Interactions for ZNF680 Gene

SuperPathways for ZNF680 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF680: view

Pathways by source for ZNF680 Gene

2 Reactome pathways for ZNF680 Gene

Interacting Proteins for ZNF680 Gene

Gene Ontology (GO) - Biological Process for ZNF680 Gene


No data available for SIGNOR curated interactions for ZNF680 Gene

Drugs & Compounds for ZNF680 Gene

No Compound Related Data Available

Transcripts for ZNF680 Gene

Unigene Clusters for ZNF680 Gene

Zinc finger protein 680:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF680 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - -

Relevant External Links for ZNF680 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF680 Gene

mRNA expression in normal human tissues for ZNF680 Gene

SOURCE GeneReport for Unigene cluster for ZNF680 Gene Hs.520886

genes like me logo Genes that share expression patterns with ZNF680: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF680 Gene

Orthologs for ZNF680 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF680 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF680 35
  • 99.43 (n)
  • 98.87 (a)
ZNF680 36
  • 99 (a)
(Bos Taurus)
Mammalia -- 36
  • 52 (a)
(Canis familiaris)
Mammalia -- 36
  • 38 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 35 (a)
-- 36
  • 48 (a)
(Mus musculus)
Mammalia Zfp953 36
  • 52 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
-- 36
  • 31 (a)
-- 36
  • 38 (a)
-- 36
  • 35 (a)
-- 36
  • 29 (a)
-- 36
  • 29 (a)
-- 36
  • 28 (a)
-- 36
  • 28 (a)
Species with no ortholog for ZNF680:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF680 Gene

Gene Tree for ZNF680 (if available)
Gene Tree for ZNF680 (if available)

Paralogs for ZNF680 Gene

(491) SIMAP similar genes for ZNF680 Gene using alignment to 1 proteins: Pseudogenes for ZNF680 Gene

genes like me logo Genes that share paralogs with ZNF680: view

Variants for ZNF680 Gene

Sequence variations from dbSNP and Humsavar for ZNF680 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs11768951 - 64,522,359(+) CCTTA(A/G)ACTCA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs17856885 - 64,521,765(+) TAAAG(C/T)CTTTG nc-transcript-variant, reference, missense
rs17852813 - 64,521,181(+) ATTAT(C/T)GTCAC nc-transcript-variant, reference, missense
rs6952263 -- 64,534,207(+) aggaa(C/T)agtca intron-variant
rs6952579 -- 64,555,713(+) cagga(A/G)ttaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF680 Gene

Variant ID Type Subtype PubMed ID
nsv888255 CNV Loss 21882294
dgv1147e201 CNV Deletion 23290073
nsv888259 CNV Gain 21882294
esv2422405 CNV Duplication 17116639
nsv464518 CNV Gain 19166990
dgv7307n71 CNV Gain 21882294
nsv888272 CNV Loss 21882294
dgv7308n71 CNV Gain 21882294

Variation tolerance for ZNF680 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF680 Gene

Disorders for ZNF680 Gene

Relevant External Links for ZNF680

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF680 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF680 Gene

Publications for ZNF680 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for ZNF680 Gene

Sources for ZNF680 Gene