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Aliases for ZNF680 Gene

Aliases for ZNF680 Gene

  • Zinc Finger Protein 680 2 3 5
  • Hypothetical Protein FLJ90430 2

External Ids for ZNF680 Gene

Previous GeneCards Identifiers for ZNF680 Gene

  • GC07M063427
  • GC07M063617
  • GC07M063980
  • GC07M060361

Summaries for ZNF680 Gene

GeneCards Summary for ZNF680 Gene

ZNF680 (Zinc Finger Protein 680) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF273.

UniProtKB/Swiss-Prot for ZNF680 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF680 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF680 Gene

Genomics for ZNF680 Gene

Regulatory Elements for ZNF680 Gene

Enhancers for ZNF680 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H064305 1.2 FANTOM5 ENCODE 9 +255.9 255897 2.6 HDGF ATF1 ZNF2 YY1 ETS1 ZNF143 ATF7 RUNX3 SP3 REST GUSBP6 ZNF680 YWHAEP1 ZNF680P1 TRIM60P18 SEPHS1P1 CCT6P3 ZNF107 ZNF736 LOC105375323
GH07H064995 1.7 Ensembl ENCODE dbSUPER 4.3 -438.8 -438758 11.8 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 GTF2IP14 CCT6P3 ERV3-1 INTS4P1 ZNF117 CCT6P1 VKORC1L1 ZNF736 ENSG00000227113 EEF1DP4
GH07H064894 0.8 dbSUPER 4.2 -328.9 -328893 0.2 HDAC1 PKNOX1 RB1 ARNT CHAMP1 TCF12 ZNF766 CEBPB NCOA1 ZEB2 EEF1DP4 ZNF680 LOC441239 VN1R42P
GH07H064875 0.3 FANTOM5 4.2 -312.0 -311979 0.1 EEF1DP4 ZNF117 ZNF680 ZNF273 LOC441239
GH07H064835 0.5 FANTOM5 1.5 -272.3 -272301 0.2 MAFG ZBTB33 EMSY CHAMP1 LOC101929322 ZNF680 PIR39219 ENSG00000234338
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF680 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF680 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000212814 226 1799 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 YY1 ELK1 ZNF143 ATF7

Genomic Locations for ZNF680 Gene

Genomic Locations for ZNF680 Gene
61,838 bases
Minus strand

Genomic View for ZNF680 Gene

Genes around ZNF680 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF680 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF680 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF680 Gene

Proteins for ZNF680 Gene

  • Protein details for ZNF680 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 680
    Protein Accession:
    Secondary Accessions:
    • B3KVJ4
    • Q6ZNF3
    • Q8NC79

    Protein attributes for ZNF680 Gene

    530 amino acids
    Molecular mass:
    61798 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11286.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF680 Gene


neXtProt entry for ZNF680 Gene

Post-translational modifications for ZNF680 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF680 Gene

No data available for DME Specific Peptides for ZNF680 Gene

Domains & Families for ZNF680 Gene

Gene Families for ZNF680 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF680 Gene

Suggested Antigen Peptide Sequences for ZNF680 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF680: view

Function for ZNF680 Gene

Molecular function for ZNF680 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF680 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF680: view
genes like me logo Genes that share phenotypes with ZNF680: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF680 Gene

Localization for ZNF680 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF680 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF680 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF680 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF680: view

Pathways & Interactions for ZNF680 Gene

SuperPathways for ZNF680 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF680: view

Pathways by source for ZNF680 Gene

2 Reactome pathways for ZNF680 Gene

Interacting Proteins for ZNF680 Gene

Gene Ontology (GO) - Biological Process for ZNF680 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF680: view

No data available for SIGNOR curated interactions for ZNF680 Gene

Drugs & Compounds for ZNF680 Gene

No Compound Related Data Available

Transcripts for ZNF680 Gene

Unigene Clusters for ZNF680 Gene

Zinc finger protein 680:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF680 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - -

Relevant External Links for ZNF680 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF680 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF680 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF680 Gene:


SOURCE GeneReport for Unigene cluster for ZNF680 Gene:


Evidence on tissue expression from TISSUES for ZNF680 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF680: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF680 Gene

Orthologs for ZNF680 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF680 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF680 33 34
  • 99.43 (n)
(Bos Taurus)
Mammalia -- 34
  • 52 (a)
(Mus musculus)
Mammalia Zfp953 34
  • 52 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 48 (a)
-- 34
  • 35 (a)
(Canis familiaris)
Mammalia -- 34
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
-- 34
  • 38 (a)
-- 34
  • 35 (a)
-- 34
  • 31 (a)
-- 34
  • 29 (a)
-- 34
  • 29 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
Species where no ortholog for ZNF680 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF680 Gene

Gene Tree for ZNF680 (if available)
Gene Tree for ZNF680 (if available)

Paralogs for ZNF680 Gene

(491) SIMAP similar genes for ZNF680 Gene using alignment to 1 proteins: Pseudogenes for ZNF680 Gene

genes like me logo Genes that share paralogs with ZNF680: view

Variants for ZNF680 Gene

Sequence variations from dbSNP and Humsavar for ZNF680 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000003437 -- 64,534,038(+) TAAAT(A/G)TAAGA intron-variant
rs1000051732 -- 64,564,538(+) CCTCA(C/G)CCTCC upstream-variant-2KB
rs1000126260 -- 64,500,093(+) TAACT(C/G)GGCCA downstream-variant-500B
rs1000133875 -- 64,511,670(+) CATAA(A/T)TGTAA intron-variant
rs1000164570 -- 64,558,828(+) ATGTT(A/G)AGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF680 Gene

Variant ID Type Subtype PubMed ID
nsv970855 CNV duplication 23825009
nsv607312 CNV gain 21841781
nsv464518 CNV gain 19166990
nsv1018445 CNV gain 25217958
esv3891131 CNV gain+loss 25118596
esv2764000 CNV gain+loss 21179565
esv2422405 CNV duplication 17116639
dgv241n111 CNV duplication 26073780
dgv1099e201 CNV deletion 23290073

Variation tolerance for ZNF680 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF680 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF680 Gene

Disorders for ZNF680 Gene

Relevant External Links for ZNF680

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF680 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF680 Gene

Publications for ZNF680 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60

Products for ZNF680 Gene

Sources for ZNF680 Gene

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