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Aliases for ZNF678 Gene

Aliases for ZNF678 Gene

  • Zinc Finger Protein 678 2 3 5
  • Hypothetical Protein MGC42493 2

External Ids for ZNF678 Gene

Previous GeneCards Identifiers for ZNF678 Gene

  • GC01P224141
  • GC01P225817
  • GC01P227751
  • GC01P198267

Summaries for ZNF678 Gene

GeneCards Summary for ZNF678 Gene

ZNF678 (Zinc Finger Protein 678) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF724.

UniProtKB/Swiss-Prot for ZNF678 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF678 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF678 Gene

Genomics for ZNF678 Gene

Regulatory Elements for ZNF678 Gene

Enhancers for ZNF678 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H227733 1.4 ENCODE dbSUPER 93.6 +171.6 171574 2.8 MLX ZFP64 FEZF1 DMAP1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 NFYC CICP26 ZNF678 C1orf35 ENSG00000269890 CDC42BPA HIST3H3 PRSS38 JMJD4 LOC100126822 SNAP47
GH01H227431 1.6 Ensembl ENCODE dbSUPER 80 -131.5 -131472 1.5 PKNOX1 FOXA2 ARNT ZNF2 ZNF766 ZNF416 FOS MCM3 REST ZNF662 CICP26 ZNF678 C1orf35 ENSG00000269890 CDC42BPA HIST3H3 JMJD4 PSEN2 LINC01641 RPS18P3
GH01H227933 1.4 Ensembl ENCODE dbSUPER 52.4 +371.5 371480 2.6 ZNF473 INSM2 KLF17 ZEB1 ZNF391 FOS SP3 ZNF280D ZNF174 TSHZ1 ZNF678 CICP26 OBSCN OBSCN-AS1 C1orf35 JMJD4 CDC42BPA HIST3H3 MIR5008 PRSS38
GH01H226651 1.9 FANTOM5 Ensembl ENCODE dbSUPER 38.1 -903.6 -903563 16.5 HDGF PKNOX1 SIN3A FEZF1 YBX1 ETS1 GLIS2 ZNF143 FOS ATF7 ZNF678 ITPKB ACBD3 CDC42BPA STUM PSEN2 ITPKB-AS1 GC01P226605
GH01H226708 1.9 FANTOM5 Ensembl ENCODE dbSUPER 33.9 -851.9 -851907 6.6 PKNOX1 FOXA2 ZNF133 FEZF1 GLI4 ZNF2 YY1 ZNF121 ZNF302 ZNF143 ZNF678 ACBD3 CDC42BPA ITPKB ITPKB-AS1 LINC01703 ENSG00000272562 LOC105373117 GC01M226732
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF678 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF678 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for ZNF678 Gene

Genomic Locations for ZNF678 Gene
113,925 bases
Plus strand

Genomic View for ZNF678 Gene

Genes around ZNF678 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF678 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF678 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF678 Gene

Proteins for ZNF678 Gene

  • Protein details for ZNF678 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 678
    Protein Accession:
    Secondary Accessions:
    • Q8IVQ9

    Protein attributes for ZNF678 Gene

    525 amino acids
    Molecular mass:
    61411 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF678 Gene

Post-translational modifications for ZNF678 Gene

  • Ubiquitination at Lys68
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF678 Gene

No data available for DME Specific Peptides for ZNF678 Gene

Domains & Families for ZNF678 Gene

Gene Families for ZNF678 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF678 Gene


Suggested Antigen Peptide Sequences for ZNF678 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF678: view

Function for ZNF678 Gene

Molecular function for ZNF678 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF678 Gene

Gene Ontology (GO) - Molecular Function for ZNF678 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF678: view
genes like me logo Genes that share phenotypes with ZNF678: view

miRNA for ZNF678 Gene

miRTarBase miRNAs that target ZNF678

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF678 Gene

Localization for ZNF678 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF678 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF678 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF678 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF678: view

Pathways & Interactions for ZNF678 Gene

SuperPathways for ZNF678 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF678: view

Pathways by source for ZNF678 Gene

2 Reactome pathways for ZNF678 Gene

Interacting Proteins for ZNF678 Gene

Gene Ontology (GO) - Biological Process for ZNF678 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF678: view

No data available for SIGNOR curated interactions for ZNF678 Gene

Drugs & Compounds for ZNF678 Gene

No Compound Related Data Available

Transcripts for ZNF678 Gene

Unigene Clusters for ZNF678 Gene

Zinc finger protein 678:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF678 Gene

No ASD Table

Relevant External Links for ZNF678 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF678 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF678 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF678 Gene:


SOURCE GeneReport for Unigene cluster for ZNF678 Gene:

genes like me logo Genes that share expression patterns with ZNF678: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF678 Gene

Orthologs for ZNF678 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF678 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF678 34
  • 97 (a)
(Bos Taurus)
Mammalia LOC101904664 33
  • 72.58 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 60 (a)
-- 34
  • 60 (a)
-- 34
  • 57 (a)
-- 34
  • 50 (a)
-- 34
  • 43 (a)
-- 34
  • 42 (a)
-- 34
  • 35 (a)
-- 34
  • 33 (a)
(Mus musculus)
Mammalia Zfp72 34
  • 56 (a)
(Canis familiaris)
Mammalia -- 34
  • 55 (a)
(Gallus gallus)
Aves -- 34
  • 46 (a)
Species where no ortholog for ZNF678 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF678 Gene

Gene Tree for ZNF678 (if available)
Gene Tree for ZNF678 (if available)

Paralogs for ZNF678 Gene

(540) SIMAP similar genes for ZNF678 Gene using alignment to 4 proteins: Pseudogenes for ZNF678 Gene

genes like me logo Genes that share paralogs with ZNF678: view

Variants for ZNF678 Gene

Sequence variations from dbSNP and Humsavar for ZNF678 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000005703 -- 227,657,618(+) GGCCT(G/T)TAAAA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000040083 -- 227,580,696(+) AGGCC(A/G)AGGCA intron-variant
rs1000041603 -- 227,562,068(+) AGCCC(A/G)AGCAC upstream-variant-2KB
rs1000128127 -- 227,628,080(+) TAGCA(A/G)TGAGT intron-variant
rs1000157889 -- 227,604,294(+) TTTAT(C/T)AGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF678 Gene

Variant ID Type Subtype PubMed ID
nsv945343 CNV duplication 23825009
nsv945342 CNV duplication 23825009
nsv945341 CNV duplication 23825009
nsv945340 CNV duplication 23825009
nsv475962 CNV novel sequence insertion 20440878
nsv1007479 CNV gain 25217958
esv3589038 CNV loss 21293372
esv3589037 CNV loss 21293372
esv3589036 CNV loss 21293372
esv3547766 CNV deletion 23714750
esv3407161 CNV insertion 20981092
esv2724206 CNV deletion 23290073
esv2724195 CNV deletion 23290073
esv2668154 CNV deletion 23128226
esv2662269 CNV deletion 23128226

Variation tolerance for ZNF678 Gene

Gene Damage Index Score: 3.46; 54.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF678 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF678 Gene

Disorders for ZNF678 Gene

Relevant External Links for ZNF678

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF678 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF678 Gene

Publications for ZNF678 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 45 60
  3. Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. (PMID: 20846217) Lee JJ … Hirschhorn J (Annals of human genetics 2010) 3 45 60
  4. Genome-wide association analysis identifies 20 loci that influence adult height. (PMID: 18391952) Weedon MN … Frayling TM (Nature genetics 2008) 3 45 60
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60

Products for ZNF678 Gene

Sources for ZNF678 Gene

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