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Aliases for ZNF678 Gene

Aliases for ZNF678 Gene

  • Zinc Finger Protein 678 2 3 5
  • Hypothetical Protein MGC42493 2

External Ids for ZNF678 Gene

Previous GeneCards Identifiers for ZNF678 Gene

  • GC01P224141
  • GC01P225817
  • GC01P227751
  • GC01P198267

Summaries for ZNF678 Gene

GeneCards Summary for ZNF678 Gene

ZNF678 (Zinc Finger Protein 678) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF718.

UniProtKB/Swiss-Prot for ZNF678 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF678 Gene

Genomics for ZNF678 Gene

Regulatory Elements for ZNF678 Gene

Enhancers for ZNF678 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF678 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF678 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF678 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF678 Gene

227,563,519 bp from pter
227,677,443 bp from pter
113,925 bases
Plus strand

Genomic View for ZNF678 Gene

Genes around ZNF678 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF678 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF678 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF678 Gene

Proteins for ZNF678 Gene

  • Protein details for ZNF678 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 678
    Protein Accession:
    Secondary Accessions:
    • Q8IVQ9

    Protein attributes for ZNF678 Gene

    525 amino acids
    Molecular mass:
    61411 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF678 Gene

Proteomics data for ZNF678 Gene at MOPED

Post-translational modifications for ZNF678 Gene

  • Ubiquitination at Lys 68
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF678 Gene

No data available for DME Specific Peptides for ZNF678 Gene

Domains & Families for ZNF678 Gene

Gene Families for ZNF678 Gene

Protein Domains for ZNF678 Gene

Suggested Antigen Peptide Sequences for ZNF678 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF678: view

Function for ZNF678 Gene

Molecular function for ZNF678 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF678: view

Animal Model Products

miRNA for ZNF678 Gene

miRTarBase miRNAs that target ZNF678

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF678 Gene

Localization for ZNF678 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF678 Gene

Subcellular locations from

Jensen Localization Image for ZNF678 Gene COMPARTMENTS Subcellular localization image for ZNF678 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF678 Gene

Pathways & Interactions for ZNF678 Gene

SuperPathways for ZNF678 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF678: view

Pathways by source for ZNF678 Gene

2 Reactome pathways for ZNF678 Gene

Interacting Proteins for ZNF678 Gene

Gene Ontology (GO) - Biological Process for ZNF678 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF678: view

No data available for SIGNOR curated interactions for ZNF678 Gene

Drugs & Compounds for ZNF678 Gene

No Compound Related Data Available

Transcripts for ZNF678 Gene

Unigene Clusters for ZNF678 Gene

Zinc finger protein 678:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF678 Gene

No ASD Table

Relevant External Links for ZNF678 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF678 Gene

mRNA expression in normal human tissues for ZNF678 Gene

SOURCE GeneReport for Unigene cluster for ZNF678 Gene Hs.30323

genes like me logo Genes that share expression patterns with ZNF678: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF678 Gene

Orthologs for ZNF678 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF678 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC101904664 35
  • 72.58 (n)
  • 62.41 (a)
(Canis familiaris)
Mammalia -- 36
  • 55 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
-- 36
  • 42 (a)
-- 36
  • 33 (a)
-- 36
  • 57 (a)
-- 36
  • 35 (a)
-- 36
  • 50 (a)
-- 36
  • 60 (a)
-- 36
  • 43 (a)
(Mus musculus)
Mammalia Zfp72 36
  • 56 (a)
(Pan troglodytes)
Mammalia ZNF678 36
  • 97 (a)
(Gallus gallus)
Aves -- 36
  • 46 (a)
Species with no ortholog for ZNF678:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF678 Gene

Gene Tree for ZNF678 (if available)
Gene Tree for ZNF678 (if available)

Paralogs for ZNF678 Gene

(540) SIMAP similar genes for ZNF678 Gene using alignment to 4 proteins: Pseudogenes for ZNF678 Gene

genes like me logo Genes that share paralogs with ZNF678: view

Variants for ZNF678 Gene

Sequence variations from dbSNP and Humsavar for ZNF678 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17854209 - 227,654,680(+) AACAT(A/G)AAAGA intron-variant, nc-transcript-variant, reference, missense
rs12118505 - 227,654,840(+) ACTAA(C/T)TAGCC intron-variant, nc-transcript-variant, reference, missense
rs61283390 - 227,654,704(+) AGAAA(A/C)CCTAC intron-variant, nc-transcript-variant, reference, missense
rs965942 -- 227,585,273(-) TCCAA(C/T)AGTTT intron-variant
rs903685 -- 227,603,720(+) GTCTG(G/T)TGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF678 Gene

Variant ID Type Subtype PubMed ID
nsv873246 CNV Gain 21882294
nsv873248 CNV Gain 21882294
esv2724195 CNV Deletion 23290073
esv2662269 CNV Deletion 23128226
esv2668154 CNV Deletion 23128226
esv2724206 CNV Deletion 23290073

Variation tolerance for ZNF678 Gene

Gene Damage Index Score: 3.46; 54.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF678 Gene

Disorders for ZNF678 Gene

Relevant External Links for ZNF678

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF678 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF678 Gene

Publications for ZNF678 Gene

  1. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. (PMID: 20846217) Lee J.J. … Hirschhorn J. (Ann. Hum. Genet. 2010) 3
  5. Genome-wide association analysis identifies 20 loci that influence adult height. (PMID: 18391952) Weedon M.N. … Frayling T.M. (Nat. Genet. 2008) 3

Products for ZNF678 Gene

Sources for ZNF678 Gene