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Aliases for ZNF678 Gene

Aliases for ZNF678 Gene

  • Zinc Finger Protein 678 2 3 5
  • Hypothetical Protein MGC42493 2

External Ids for ZNF678 Gene

Previous GeneCards Identifiers for ZNF678 Gene

  • GC01P224141
  • GC01P225817
  • GC01P227751
  • GC01P198267

Summaries for ZNF678 Gene

GeneCards Summary for ZNF678 Gene

ZNF678 (Zinc Finger Protein 678) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF676.

UniProtKB/Swiss-Prot for ZNF678 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF678 Gene

Genomics for ZNF678 Gene

Regulatory Elements for ZNF678 Gene

Enhancers for ZNF678 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G227545 0.7 ENCODE 8.6 -17.2 -17173 1.0 ZNF362 ZNF571 ZBTB11 ZNF837 SIN3A ZNF384 MNT ZNF311 PRDM2 HIC1 C1orf35 JMJD4 ZNF678 CDC42BPA SNAP47 GC01M227540 GC01P227562
GH01G227562 1.5 FANTOM5 ENCODE 3.6 +0.4 352 1.9 PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 C1orf35 CICP26 HIST3H3 CDC42BPA SNAP47 ZNF678 MRPL57P2
GH01G227586 0.4 ENCODE 11.3 +23.4 23416 0.2 TEAD4 ZNF678 RNA5SP77 SNAP47 LOC100421606 MRPL57P2
GH01G227792 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.9 +230.5 230528 2.6 CBX3 INSM2 KLF17 FEZF1 RAD21 GLIS2 ZNF366 EGR2 ZNF263 ZNF398 JMJD4 WNT9A C1orf35 SNAP47 COQ8A ZNF678 CDC42BPA LOC105373289 PRSS38
GH01G227748 1.5 FANTOM5 ENCODE dbSUPER 1.4 +185.5 185507 1.8 HDAC1 PKNOX1 ATF1 TBL1XR1 ZBTB40 ZNF766 RCOR1 CREM SMARCA5 ZBTB11 SNAP47 ZNF678 SNAP47-AS1 LOC105373289
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF678 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF678 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000021212 381 1401 PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207

Genomic Location for ZNF678 Gene

Chromosome:
1
Start:
227,563,519 bp from pter
End:
227,677,443 bp from pter
Size:
113,925 bases
Orientation:
Plus strand

Genomic View for ZNF678 Gene

Genes around ZNF678 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF678 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF678 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF678 Gene

Proteins for ZNF678 Gene

  • Protein details for ZNF678 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SXM1-ZN678_HUMAN
    Recommended name:
    Zinc finger protein 678
    Protein Accession:
    Q5SXM1
    Secondary Accessions:
    • Q8IVQ9

    Protein attributes for ZNF678 Gene

    Size:
    525 amino acids
    Molecular mass:
    61411 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF678 Gene

Post-translational modifications for ZNF678 Gene

  • Ubiquitination at posLast=6868
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF678 Gene

No data available for DME Specific Peptides for ZNF678 Gene

Domains & Families for ZNF678 Gene

Gene Families for ZNF678 Gene

Protein Domains for ZNF678 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF678 Gene

Graphical View of Domain Structure for InterPro Entry

Q5SXM1

UniProtKB/Swiss-Prot:

ZN678_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF678: view

Function for ZNF678 Gene

Molecular function for ZNF678 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF678 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF678: view
genes like me logo Genes that share phenotypes with ZNF678: view

Animal Model Products

miRNA for ZNF678 Gene

miRTarBase miRNAs that target ZNF678

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF678 Gene

Localization for ZNF678 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF678 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF678 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for ZNF678 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF678: view

Pathways & Interactions for ZNF678 Gene

SuperPathways for ZNF678 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF678: view

Pathways by source for ZNF678 Gene

2 Reactome pathways for ZNF678 Gene

Interacting Proteins for ZNF678 Gene

Gene Ontology (GO) - Biological Process for ZNF678 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF678: view

No data available for SIGNOR curated interactions for ZNF678 Gene

Drugs & Compounds for ZNF678 Gene

No Compound Related Data Available

Transcripts for ZNF678 Gene

Unigene Clusters for ZNF678 Gene

Zinc finger protein 678:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF678 Gene

No ASD Table

Relevant External Links for ZNF678 Gene

GeneLoc Exon Structure for
ZNF678
ECgene alternative splicing isoforms for
ZNF678

Expression for ZNF678 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF678 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF678 Gene:

ZNF678

SOURCE GeneReport for Unigene cluster for ZNF678 Gene:

Hs.30323
genes like me logo Genes that share expression patterns with ZNF678: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF678 Gene

Orthologs for ZNF678 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF678 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF678 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC101904664 34
  • 72.58 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 60 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 43 (a)
OneToMany
-- 35
  • 42 (a)
OneToMany
-- 35
  • 35 (a)
OneToMany
-- 35
  • 33 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp72 35
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 55 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 46 (a)
OneToMany
Species where no ortholog for ZNF678 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF678 Gene

ENSEMBL:
Gene Tree for ZNF678 (if available)
TreeFam:
Gene Tree for ZNF678 (if available)

Paralogs for ZNF678 Gene

Paralogs for ZNF678 Gene

(540) SIMAP similar genes for ZNF678 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ZNF678 Gene

genes like me logo Genes that share paralogs with ZNF678: view

Variants for ZNF678 Gene

Sequence variations from dbSNP and Humsavar for ZNF678 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000005703 -- 227,657,618(+) GGCCT(G/T)TAAAA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000040083 -- 227,580,696(+) AGGCC(A/G)AGGCA intron-variant
rs1000041603 -- 227,562,068(+) AGCCC(A/G)AGCAC upstream-variant-2KB
rs1000128127 -- 227,628,080(+) TAGCA(A/G)TGAGT intron-variant
rs1000157889 -- 227,604,294(+) TTTAT(C/T)AGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF678 Gene

Variant ID Type Subtype PubMed ID
esv2662269 CNV deletion 23128226
esv2668154 CNV deletion 23128226
esv2724195 CNV deletion 23290073
esv2724206 CNV deletion 23290073
esv3407161 CNV insertion 20981092
esv3547766 CNV deletion 23714750
esv3589036 CNV loss 21293372
esv3589037 CNV loss 21293372
esv3589038 CNV loss 21293372
nsv1007479 CNV gain 25217958
nsv475962 CNV novel sequence insertion 20440878
nsv945340 CNV duplication 23825009
nsv945341 CNV duplication 23825009
nsv945342 CNV duplication 23825009
nsv945343 CNV duplication 23825009

Variation tolerance for ZNF678 Gene

Gene Damage Index Score: 3.46; 54.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF678 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF678

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF678 Gene

Disorders for ZNF678 Gene

Relevant External Links for ZNF678

Genetic Association Database (GAD)
ZNF678
Human Genome Epidemiology (HuGE) Navigator
ZNF678
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF678

No disorders were found for ZNF678 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF678 Gene

Publications for ZNF678 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J. … Grant S.F. (BMC Med. Genet. 2010) 3 46 64
  3. Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. (PMID: 20846217) Lee J.J. … Hirschhorn J. (Ann. Hum. Genet. 2010) 3 46 64
  4. Genome-wide association analysis identifies 20 loci that influence adult height. (PMID: 18391952) Weedon M.N. … Frayling T.M. (Nat. Genet. 2008) 3 46 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

Products for ZNF678 Gene

Sources for ZNF678 Gene

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