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Aliases for ZNF677 Gene

Aliases for ZNF677 Gene

  • Zinc Finger Protein 677 2 3 5
  • Hypothetical Protein MGC48625 2

External Ids for ZNF677 Gene

Previous GeneCards Identifiers for ZNF677 Gene

  • GC19M058431
  • GC19M053731
  • GC19M050059

Summaries for ZNF677 Gene

GeneCards Summary for ZNF677 Gene

ZNF677 (Zinc Finger Protein 677) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF813.

UniProtKB/Swiss-Prot for ZNF677 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF677 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF677 Gene

Genomics for ZNF677 Gene

Regulatory Elements for ZNF677 Gene

Enhancers for ZNF677 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H054199 1.9 FANTOM5 ENCODE dbSUPER 20.2 -950.8 -950813 12.1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D PRPF31 CNOT3 LENG8 LENG8-AS1 ZNF525 LILRB5 ZNF845 ZNF765 ENSG00000235681 RPS9
GH19H054186 1.4 ENCODE dbSUPER 19.7 -934.7 -934724 6.8 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 PRPF31 ZNF665 LENG8 LENG8-AS1 CNOT3 ZNF845 ZNF525 ZNF677 ENSG00000269001 ENSG00000269288
GH19H053517 1.1 ENCODE 21.5 -264.7 -264717 4.8 PKNOX1 ARNT ARID4B SIN3A YY1 ZNF766 ZNF143 SP3 ZHX2 MXD4 ZNF137P LENG8-AS1 PRPF31 ZNF160 ZNF761 ZNF525 ZNF611 LENG8 ZNF665 ZNF677
GH19H052941 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10 +310.4 310406 6.1 HDGF PKNOX1 ATF1 FOXA2 MLX ARID4B DMAP1 ETS1 GLIS2 ATF7 ZNF816 ZNF160 VN1R2 ZNF677 ZNF665 ZNF761 ZNF347 ZNF415 ZNF83 ZNF701
GH19H053977 1.3 Ensembl ENCODE 11.1 -725.1 -725064 5.8 HDGF PKNOX1 SIN3A FEZF1 ZNF2 ZNF766 ZNF143 SP3 NFYC REST PRPF31 ZNF525 LENG8-AS1 ZNF160 ZNF845 ZNF665 ZNF761 ZNF347 LENG8 ENSG00000235681
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF677 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF677 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111361 -2 1800 MXI1 ZBTB40 YY1 ETS1 HIC1 POLR2A ZSCAN29 KLF8 MAZ SP3

Transcription factor binding sites by QIAGEN in the ZNF677 gene promoter:

Genomic Locations for ZNF677 Gene

Genomic Locations for ZNF677 Gene
19,518 bases
Minus strand

Genomic View for ZNF677 Gene

Genes around ZNF677 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF677 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF677 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF677 Gene

Proteins for ZNF677 Gene

  • Protein details for ZNF677 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 677
    Protein Accession:

    Protein attributes for ZNF677 Gene

    584 amino acids
    Molecular mass:
    67996 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF677 Gene

Post-translational modifications for ZNF677 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF677 Gene

Domains & Families for ZNF677 Gene

Gene Families for ZNF677 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF677 Gene

Suggested Antigen Peptide Sequences for ZNF677 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF677: view

Function for ZNF677 Gene

Molecular function for ZNF677 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF677 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF677: view
genes like me logo Genes that share phenotypes with ZNF677: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF677 Gene

Localization for ZNF677 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF677 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF677 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF677 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF677: view

Pathways & Interactions for ZNF677 Gene

SuperPathways for ZNF677 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF677: view

Pathways by source for ZNF677 Gene

2 Reactome pathways for ZNF677 Gene

Interacting Proteins for ZNF677 Gene

Gene Ontology (GO) - Biological Process for ZNF677 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF677: view

No data available for SIGNOR curated interactions for ZNF677 Gene

Drugs & Compounds for ZNF677 Gene

No Compound Related Data Available

Transcripts for ZNF677 Gene

Unigene Clusters for ZNF677 Gene

Zinc finger protein 677:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF677 Gene

No ASD Table

Relevant External Links for ZNF677 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF677 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF677 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF677 Gene

This gene is overexpressed in Testis (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of ZNF677 Gene:


SOURCE GeneReport for Unigene cluster for ZNF677 Gene:

genes like me logo Genes that share expression patterns with ZNF677: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF677 Gene

Orthologs for ZNF677 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF677 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF677 33 34
  • 98.97 (n)
(Bos Taurus)
Mammalia ZNF677 33 34
  • 74.81 (n)
(Canis familiaris)
Mammalia ZNF677 34
  • 62 (a)
Species where no ortholog for ZNF677 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF677 Gene

Gene Tree for ZNF677 (if available)
Gene Tree for ZNF677 (if available)

Paralogs for ZNF677 Gene

(466) SIMAP similar genes for ZNF677 Gene using alignment to 7 proteins: Pseudogenes for ZNF677 Gene

genes like me logo Genes that share paralogs with ZNF677: view

Variants for ZNF677 Gene

Sequence variations from dbSNP and Humsavar for ZNF677 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000062047 -- 53,246,575(+) AAATC(A/C)TATTT intron-variant
rs1000125975 -- 53,242,432(+) TGCAA(A/G)GTGAG intron-variant
rs1000263130 -- 53,242,431(+) CTGCA(A/T)GGTGA intron-variant
rs1000367625 -- 53,247,739(+) CTCTG(C/G)TATCA intron-variant
rs1000753206 -- 53,236,530(+) CTTAG(G/T)TCCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF677 Gene

Variant ID Type Subtype PubMed ID
nsv580079 CNV loss 21841781
nsv1141887 OTHER inversion 24896259
nsv1078889 OTHER inversion 25765185
nsv1064604 CNV loss 25217958
nsv1055236 CNV gain 25217958
esv3644741 CNV gain 21293372
esv2718812 CNV deletion 23290073
esv2718787 CNV deletion 23290073
dgv3645n100 CNV gain 25217958

Variation tolerance for ZNF677 Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF677 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF677 Gene

Disorders for ZNF677 Gene

Relevant External Links for ZNF677

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF677 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF677 Gene

Publications for ZNF677 Gene

  1. DNA methylation transcriptionally regulates the putative tumor cell growth suppressor ZNF677 in non-small cell lung cancers. (PMID: 25504438) Heller G … Zöchbauer-Müller S (Oncotarget 2015) 2 3 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 60
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for ZNF677 Gene

Sources for ZNF677 Gene

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