Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF677 Gene

Aliases for ZNF677 Gene

  • Zinc Finger Protein 677 2 3 5
  • Hypothetical Protein MGC48625 2

External Ids for ZNF677 Gene

Previous GeneCards Identifiers for ZNF677 Gene

  • GC19M058431
  • GC19M053731
  • GC19M050059

Summaries for ZNF677 Gene

GeneCards Summary for ZNF677 Gene

ZNF677 (Zinc Finger Protein 677) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF860.

UniProtKB/Swiss-Prot for ZNF677 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF677 Gene

Genomics for ZNF677 Gene

Regulatory Elements for ZNF677 Gene

Enhancers for ZNF677 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF677 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF677 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF677 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ZNF677 gene promoter:

Genomic Location for ZNF677 Gene

53,235,381 bp from pter
53,254,898 bp from pter
19,518 bases
Minus strand

Genomic View for ZNF677 Gene

Genes around ZNF677 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF677 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF677 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF677 Gene

Proteins for ZNF677 Gene

  • Protein details for ZNF677 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 677
    Protein Accession:

    Protein attributes for ZNF677 Gene

    584 amino acids
    Molecular mass:
    67996 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF677 Gene

Proteomics data for ZNF677 Gene at MOPED

Post-translational modifications for ZNF677 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF677 Gene

Domains & Families for ZNF677 Gene

Gene Families for ZNF677 Gene

Protein Domains for ZNF677 Gene

Suggested Antigen Peptide Sequences for ZNF677 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 10 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF677: view

Function for ZNF677 Gene

Molecular function for ZNF677 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes for ZNF677 Gene

genes like me logo Genes that share phenotypes with ZNF677: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF677 Gene

Localization for ZNF677 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF677 Gene

Subcellular locations from

Jensen Localization Image for ZNF677 Gene COMPARTMENTS Subcellular localization image for ZNF677 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF677 Gene

Pathways & Interactions for ZNF677 Gene

SuperPathways for ZNF677 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF677: view

Pathways by source for ZNF677 Gene

2 Reactome pathways for ZNF677 Gene

Interacting Proteins for ZNF677 Gene

Gene Ontology (GO) - Biological Process for ZNF677 Gene


No data available for SIGNOR curated interactions for ZNF677 Gene

Drugs & Compounds for ZNF677 Gene

No Compound Related Data Available

Transcripts for ZNF677 Gene

Unigene Clusters for ZNF677 Gene

Zinc finger protein 677:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF677 Gene

No ASD Table

Relevant External Links for ZNF677 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF677 Gene

mRNA expression in normal human tissues for ZNF677 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF677 Gene

This gene is overexpressed in Testis (x5.0).

SOURCE GeneReport for Unigene cluster for ZNF677 Gene Hs.20506

genes like me logo Genes that share expression patterns with ZNF677: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF677 Gene

Orthologs for ZNF677 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF677 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF677 35
  • 74.81 (n)
  • 59.83 (a)
ZNF677 36
  • 60 (a)
(Pan troglodytes)
Mammalia ZNF677 35
  • 98.97 (n)
  • 98.97 (a)
ZNF677 36
  • 99 (a)
(Canis familiaris)
Mammalia ZNF677 36
  • 62 (a)
Species with no ortholog for ZNF677:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF677 Gene

Gene Tree for ZNF677 (if available)
Gene Tree for ZNF677 (if available)

Paralogs for ZNF677 Gene

(466) SIMAP similar genes for ZNF677 Gene using alignment to 7 proteins: Pseudogenes for ZNF677 Gene

genes like me logo Genes that share paralogs with ZNF677: view

Variants for ZNF677 Gene

Sequence variations from dbSNP and Humsavar for ZNF677 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11881131 - 53,243,747(+) ACCAT(C/T)TTCTG reference, synonymous-codon, missense
rs10425706 - 53,237,966(+) TTCTC(C/T)CATAC reference, missense
rs7259373 -- 53,252,058(+) TATAA(C/T)GCCAG intron-variant
rs7260260 -- 53,239,645(+) TAATG(A/C)AGGCA intron-variant
rs7260595 -- 53,239,864(+) AGCAC(A/G)TCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF677 Gene

Variant ID Type Subtype PubMed ID
esv2718787 CNV Deletion 23290073
nsv912342 CNV Gain 21882294
esv2718812 CNV Deletion 23290073

Variation tolerance for ZNF677 Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF677 Gene

Disorders for ZNF677 Gene

Relevant External Links for ZNF677

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF677 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF677 Gene

Publications for ZNF677 Gene

  1. DNA methylation transcriptionally regulates the putative tumor cell growth suppressor ZNF677 in non-small cell lung cancers. (PMID: 25504438) Heller G. … ZAPchbauer-MA1ller S. (Oncotarget 2015) 2 3 67
  2. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ZNF677 Gene

Sources for ZNF677 Gene