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ZNF677 Gene

protein-coding   GIFtS: 44
GCID: GC19M053731

Zinc Finger Protein 677

  Search for ZNF677
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6771 2
Hypothetical Protein MGC486251 2

External Ids:    HGNC: 287301   Entrez Gene: 3429262   Ensembl: ENSG000001979287   UniProtKB: Q86XU03   

Export aliases for ZNF677 gene to outside databases

Previous GC identifers: GC19M058431 GC19M050059


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF677 Gene:
ZNF677 (zinc finger protein 677) is a protein-coding gene. An important paralog of this gene is ZNF534.

UniProtKB/Swiss-Prot: ZN677_HUMAN, Q86XU0
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF677 gene promoter:
         Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF677 promoter sequence
   Search Chromatin IP Primers for ZNF677

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF677


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

ZNF677 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF677 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M053731:  view genomic region     (about GC identifiers)

Start:
53,731,577 bp from pter      End:
53,758,151 bp from pter
Size:
26,575 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN677_HUMAN, Q86XU0 (See protein sequence)
Recommended Name: Zinc finger protein 677  
Size: 584 amino acids; 67996 Da

Explore the universe of human proteins at neXtProt for ZNF677: NX_Q86XU0

Explore proteomics data for ZNF677 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF677 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_872415.1  
    ENSEMBL proteins: 
     ENSP00000469391   ENSP00000472416   ENSP00000469701   ENSP00000472132   ENSP00000471071  
     ENSP00000471266   ENSP00000472783   ENSP00000334394  
    Reactome Protein details: Q86XU0

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q86XU0

    ProtoNet protein and cluster: Q86XU0

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN677_HUMAN, Q86XU0
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 10 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF677           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN677_HUMAN, Q86XU0
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF677           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN677_HUMAN, Q86XU0: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF677           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF677 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF677           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF677
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF677
    Interactions:

        Search GeneGlobe Interaction Network for ZNF677

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ZNF677 (ENSP000003343944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WFDC1ENSP000002194544STRING: ENSP00000219454
    --ENSP000003886134STRING: ENSP00000388613
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    Find genes that share ontologies with ZNF677           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF677 (ZN677)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF677 gene: 
    NM_182609.2  

    Unigene Cluster for ZNF677:

    Zinc finger protein 677
    Hs.20506  [show with all ESTs]
    Unigene Representative Sequence: BX648243
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000598513 ENST00000594517 ENST00000599328 ENST00000599012 ENST00000594681
    ENST00000598806 ENST00000593539 ENST00000601828 ENST00000601413 ENST00000595293
    ENST00000333952(uc002qbf.1 uc002qbg.1 uc002qbh.3)
    miRNA
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF677

    Additional mRNA sequence: 

    AK026366.1 AK308120.1 BC029855.1 BC050038.1 BX648243.1 

    16 DOTS entries:

    DT.97808761  DT.102843496  DT.100739154  DT.91651498  DT.121462291  DT.91651496  DT.110798  DT.121462240 
    DT.310269  DT.430119  DT.75119762  DT.121610623  DT.40239265  DT.92061037  DT.40130940  DT.75127217 

    Selected AceView cDNA sequences (see all 65):

    AI867202 AK026366 CK820333 BC050038 BC029855 BE503439 BM725805 CR597217 
    NM_182609 AL698929 AW161454 AA994202 AA021609 AW163626 AW273403 BM874164 
    AI637736 AI887676 BX095276 AA813323 AA843090 AA359799 CK125988 AI337612 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF677 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCACTGTT
    ZNF677 Expression
    About this image

    ZNF677 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF677 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.20506
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for ZNF677 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF6776
    zinc finger protein 677
    62(a)
    1 ↔ 1
    1(104785454-104809069)


    ENSEMBL Gene Tree for ZNF677 (if available)
    TreeFam Gene Tree for ZNF677 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF677 gene
    ZNF5342  ZNF321P2  ZNF4682  ZNF5782  ZNF8802  ZNF7662  ZNF3202  ZNF5252  
    ZNF8602  ZNF4152  ZNF6002  ZNF282  ZNF5282  ZNF6112  ZNF832  ZNF6102  
    ZNF8162  ZNF7012  ZNF7652  ZNF4802  ZNF8132  
    Selected SIMAP similar genes for ZNF677 using alignment to 7 protein entries:     ZN677_HUMAN (see all proteins) (see all similar genes):
    ZNF534    ZNF761    ZNF528    ZNF525    ZNF320    ZNF616
    ZNF766    ZNF83    ZNF480    ZNF195    ZNF28    ZNF415
    ZNF880    ZNF684    ZNF595    ZNF283    ZNF431    ZNF519

    Find genes that share paralogs with ZNF677           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ZNF677
    PGOHUM00000240256 PGOHUM00000240717


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF677 (see all 531)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1845529871,2
    --53738219(+) TATTAC/TTTCAG 1 -- int10--------
    rs1163742881,2
    C,F--53738228(+) AGAAAT/CTTCAT 1 -- int11Minor allele frequency- C:0.02WA 118
    rs1874255671,2
    --53738252(+) TCATAC/TGCTTA 1 -- int10--------
    rs1467419941,2
    --53738253(+) CATATA/GCTTAC 1 -- int10--------
    rs1918420691,2
    --53738291(+) GCATGC/TAGAAA 1 -- int10--------
    rs756513201,2
    F--53738529(+) TGTTAT/AAGATG 1 -- int11Minor allele frequency- A:0.03NA 120
    rs2008475741,2
    C--53738573(+) AGTGT-/TTGATA
            
    TTAAG
    1 -- int10--------
    rs1841117661,2
    --53738587(+) AGTGTC/TCCAAT 1 -- int10--------
    rs1394593201,2
    --53738634(+) ATTCAC/TTCAGG 1 -- int10--------
    rs1892966171,2
    --53738656(+) TGATTA/GTATTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ZNF677 (53731577 - 53758151 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF677:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718787CNV Deletion23290073
    esv2718812CNV Deletion23290073
    nsv912342CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF677 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF677)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    4. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 342926 HGNC: 28730 AceView: MGC48625 Ensembl:ENSG00000197928 euGenes: HUgn342926
    ECgene: ZNF677 H-InvDB: ZNF677

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF677 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF677 gene:
    Search GeneIP for patents involving ZNF677

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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