ZNF677 Gene
protein-coding GIFtS: 44
GCID: GC19M053731
|
|
zinc finger protein 677
| |
Aliases
for ZNF677 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6771 2 | | MGC486251 | | Hypothetical Protein MGC486252 |
Export aliases for ZNF677 gene to outside databasesPrevious GC identifers: GC19M058431 GC19M050059 |
Summaries
for ZNF677 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN677_HUMAN, Q86XU0Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF677 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF677 gene promoter:
Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF677
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF677 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.42ZNF677 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M053731: view genomic region
(about GC identifiers)
Start:
|
53,731,577 bp from pter |
End:
|
53,758,126 bp from pter |
Size:
|
26,550 bases |
Orientation:
|
minus strand |
|
Proteins
for ZNF677 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN677_HUMAN, Q86XU0 (See
protein sequence)Recommended Name: Zinc finger protein 677 Size: 584 amino acids; 67996 Da
Subcellular location: Nucleus (Probable)Explore the universe of human proteins at neXtProt for ZNF677: NX_Q86XU0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86XU0
ZNF677 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_872415.1
ENSEMBL proteins: ENSP00000334394 Reactome Protein details: Q86XU0
Human Recombinant Protein Products for ZNF677:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF677 for ontologies About GeneDecksing
ZNF677 Antibody Products:
Assay Products for ZNF677: |
Protein
Domains /
Families
for ZNF677 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF677 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86XU0ProtoNet protein and cluster: Q86XU0 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN677_HUMAN, Q86XU0Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 10 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF677 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN677_HUMAN, Q86XU0Function: May be involved in transcriptional regulation Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF677 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF677
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF677
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF677 (NM_182609) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF677 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF677 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF677 |
|
Pathways & Interactions
for ZNF677 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF677
ZNF677 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF677
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for ZNF677 (ENSP000003343944) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF677 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF677 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF677
Search CenterWatch for drugs/clinical trials and news about ZNF677 / ZN677
|
Transcripts
for ZNF677 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF677 gene: NM_182609.2 Unigene Cluster for ZNF677: Zinc finger protein 677 Hs.20506 [show with all ESTs]Unigene Representative Sequence: BX6482431 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000333952(uc002qbf.1 uc002qbg.1 uc002qbh.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF677
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF677
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF677 (NM_182609) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF677 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF677 |
Additional cDNA sequence: AK026366.1 AK308120.1 BC029855.1 BC050038.1 BX648243.1 16 DOTS entries: DT.97808761 DT.102843496 DT.100739154 DT.91651498 DT.121462291 DT.91651496 DT.110798 DT.121462240 DT.310269 DT.430119 DT.75119762 DT.121610623 DT.40239265 DT.92061037 DT.40130940 DT.75127217 24/65 AceView cDNA sequences (see all 65): BC050038 CK820333 BC029855 CR597217 BE503439 AI867202 NM_182609 AL698929 BM725805 AK026366 BM873707 BI827411 CK820334 AV706846 BG426130 AW273403 CD642527 BQ549975 AA133891 AA994202 AA359799 AK124227 CK125988 BM874164
GeneLoc Exon Structure
|
Expression
for ZNF677 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF677 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCACTGTT
About this image
See ZNF677 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF677
SOURCE GeneReport for Unigene cluster: Hs.20506
SABiosciences Custom PCR Arrays for ZNF677
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF677
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF677 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF677 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF677 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF677 |
Orthologs
for ZNF677 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF677 gene from 3/10 species (see all 10) About this table
Species with no ortholog for ZNF677
ENSEMBL Gene Tree for ZNF677 (if available)
TreeFam Gene Tree for ZNF677 (if available) |
Paralogs
for ZNF677 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF677 gene
- ZNF5342 ZNF321P2 ZNF4682 ZNF5782 ZNF8802 ZNF7662 ZNF3202 ZNF5252
- ZNF8602 ZNF4152 ZNF6002 ZNF282 ZNF5282 ZNF6112 ZNF832 ZNF8162
- ZNF6102 ZNF7012 ZNF7652 ZNF4802 ZNF8132
18/446 SIMAP similar genes for ZNF677 using alignment to 7 protein entries: ZN677_HUMAN (see all proteins)
(see all similar genes):ZNF534 MGC12518 ZNF684 ZNF761 ZNF702P HZF30
ZNF283 DKFZp686N14223 DKFZp762K012 ZNF146 ZNF3 ZNF485
ZSCAN21 DKFZp666M039 ZNF501 ZNF525 ZNF528 DKFZp434G1930
ZNF677 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for ZNF677
PGOHUM00000240256 PGOHUM00000240717
|
Genomic Variants
for ZNF677 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF677 (53731577 - 53758126 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF677: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF677 |
|
Disorders
/ Diseases
for ZNF677 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF677 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF677 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF677) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
|
External Searches for ZNF677 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF677 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF677 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF677 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF677 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF677 gene:
Search GeneIP for patents involving ZNF677
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF677 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF677 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF677 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF677 | | | OriGene Protein Over-expression Lysate for ZNF677 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF677 | | OriGene 3'-UTR Clone for ZNF677 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF677 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF677 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF677 | | OriGene Custom Protein Services for ZNF677 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF677 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF677 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF677 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF677 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF677 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF677 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZNF677 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZNF677 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF677 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ZNF677 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF677 |
| |  | |
|
|
|
