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Aliases for ZNF676 Gene

Aliases for ZNF676 Gene

  • Zinc Finger Protein 676 2 3

External Ids for ZNF676 Gene

Previous GeneCards Identifiers for ZNF676 Gene

  • GC19M022361
  • GC19M021899

Summaries for ZNF676 Gene

GeneCards Summary for ZNF676 Gene

ZNF676 (Zinc Finger Protein 676) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF676 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF676 Gene

Genomics for ZNF676 Gene

Regulatory Elements for ZNF676 Gene

Genomic Location for ZNF676 Gene

22,179,091 bp from pter
22,196,951 bp from pter
17,861 bases
Minus strand

Genomic View for ZNF676 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF676 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF676 Gene

Proteins for ZNF676 Gene

  • Protein details for ZNF676 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 676
    Protein Accession:
    Secondary Accessions:
    • A8MVX5

    Protein attributes for ZNF676 Gene

    588 amino acids
    Molecular mass:
    67624 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF676 Gene

Proteomics data for ZNF676 Gene at MOPED

Post-translational modifications for ZNF676 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF676 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF676 Gene

Domains for ZNF676 Gene

Gene Families for ZNF676 Gene

  • ZNF :Zinc fingers, C2H2-type

Suggested Antigen Peptide Sequences for ZNF676 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8N7Q3
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF676: view

Function for ZNF676 Gene

Molecular function for ZNF676 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF676 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF676: view

Phenotypes for ZNF676 Gene

GenomeRNAi human phenotypes for ZNF676:
genes like me logo Genes that share phenotypes with ZNF676: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF676

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF676 Gene

Localization for ZNF676 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF676 Gene

Subcellular locations from

Jensen Localization Image for ZNF676 Gene COMPARTMENTS Subcellular localization image for ZNF676 gene
Compartment Confidence
nucleus 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZNF676 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF676: view

Pathways for ZNF676 Gene

SuperPathways for ZNF676 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF676: view

Pathways by source for ZNF676 Gene

2 Reactome pathways for ZNF676 Gene

Interacting Proteins for ZNF676 Gene

Gene Ontology (GO) - Biological Process for ZNF676 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF676: view

Transcripts for ZNF676 Gene

mRNA/cDNA for ZNF676 Gene

(19) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF676 Gene

Zinc finger protein 676:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF676

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF676 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP4: - -
SP6: -
SP7: - - -
SP8: -
SP9: -

Relevant External Links for ZNF676 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF676 Gene

mRNA expression in normal human tissues for ZNF676 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF676 Gene

This gene is overexpressed in Thyroid (4.4) and Testis (4.3).

Protein differential expression in normal tissues for ZNF676 Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF676 Gene

SOURCE GeneReport for Unigene cluster for ZNF676 Gene Hs.55452

genes like me logo Genes that share expressions with ZNF676: view

Expression partners for ZNF676 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF676 Gene

Orthologs for ZNF676 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF676 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Zfp273 35
  • 72.22 (n)
  • 63.15 (a)
Zfp595 16
Zfp493 36
  • 54 (a)
(Pan troglodytes)
Mammalia ZNF208 35
  • 95 (n)
  • 91.96 (a)
ZNF676 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC501406 35
  • 72.38 (n)
  • 63.1 (a)
(Bos Taurus)
Mammalia -- 36
  • 52 (a)
(Canis familiaris)
Mammalia -- 36
  • 38 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 42 (a)
-- 36
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
-- 36
  • 37 (a)
-- 36
  • 45 (a)
-- 36
  • 39 (a)
-- 36
  • 35 (a)
-- 36
  • 35 (a)
-- 36
  • 33 (a)
-- 36
  • 28 (a)
Species with no ortholog for ZNF676:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF676 Gene

Gene Tree for ZNF676 (if available)
Gene Tree for ZNF676 (if available)

Paralogs for ZNF676 Gene

Selected SIMAP similar genes for ZNF676 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF676: view

Variants for ZNF676 Gene

Sequence variations from dbSNP and Humsavar for ZNF676 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs281174 -- 22,209,618(-) acaaa(C/G)ctgca intron-variant
rs281175 -- 22,210,396(-) aaaaa(G/T)tgggg intron-variant
rs281176 -- 22,211,517(-) gctta(C/T)ctttt intron-variant
rs281177 -- 22,211,925(-) caggg(C/T)gcagt intron-variant
rs281178 -- 22,212,779(-) atcac(A/G)aggtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF676 Gene

Variant ID Type Subtype PubMed ID
esv4924 CNV Complex 18987735
esv2718335 CNV Deletion 23290073
dgv552e201 CNV Deletion 23290073
dgv3808n71 CNV Gain 21882294
dgv1066e1 CNV Complex 17122850
esv731 CNV CNV 17122850
esv34340 CNV Loss 17911159
dgv553e201 CNV Deletion 23290073
dgv633e199 CNV Deletion 23128226
nsv436853 CNV Insertion 17901297
dgv554e201 CNV Deletion 23290073
nsv436253 CNV Deletion 17901297
nsv911434 CNV Gain 21882294
nsv436857 CNV Insertion 17901297
nsv525240 CNV Gain 19592680
dgv3812n71 CNV Loss 21882294
dgv3813n71 CNV Gain 21882294
dgv3814n71 CNV Gain 21882294
nsv833786 CNV Gain 17160897
dgv3n43 CNV Gain 19587683
nsv911441 CNV Gain 21882294
nsv469671 CNV Complex 16826518
nsv2440 CNV Insertion 18451855
esv1004381 CNV Deletion 20482838
esv1536549 CNV Insertion 17803354

Relevant External Links for ZNF676 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF676 Gene

Disorders for ZNF676 Gene

Relevant External Links for ZNF676

Genetic Association Database (GAD)

No disorders were found for ZNF676 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ZNF676 Gene

Publications for ZNF676 Gene

  1. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. (PMID: 20421499) Levy D. … Aviv A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 48
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Identification of DeltaNp63alpha protein interactions by mass spectrometry. (PMID: 20085233) Amoresano A. … CalabrA^ V. (J. Proteome Res. 2010) 3
  4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  5. Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. (PMID: 23001564) Mangino M. … Aviv A. (Hum. Mol. Genet. 2012) 3

Products for ZNF676 Gene

Sources for ZNF676 Gene

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