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Aliases for ZNF676 Gene

Aliases for ZNF676 Gene

  • Zinc Finger Protein 676 2 3 5

External Ids for ZNF676 Gene

Previous GeneCards Identifiers for ZNF676 Gene

  • GC19M022361
  • GC19M021899

Summaries for ZNF676 Gene

GeneCards Summary for ZNF676 Gene

ZNF676 (Zinc Finger Protein 676) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF718.

UniProtKB/Swiss-Prot for ZNF676 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF676 Gene

Genomics for ZNF676 Gene

Regulatory Elements for ZNF676 Gene

Enhancers for ZNF676 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF676 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF676 Gene

Chromosome:
19
Start:
22,178,936 bp from pter
End:
22,248,018 bp from pter
Size:
69,083 bases
Orientation:
Minus strand

Genomic View for ZNF676 Gene

Genes around ZNF676 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF676 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF676 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF676 Gene

Proteins for ZNF676 Gene

  • Protein details for ZNF676 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7Q3-ZN676_HUMAN
    Recommended name:
    Zinc finger protein 676
    Protein Accession:
    Q8N7Q3
    Secondary Accessions:
    • A8MVX5

    Protein attributes for ZNF676 Gene

    Size:
    588 amino acids
    Molecular mass:
    67624 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF676 Gene

Proteomics data for ZNF676 Gene at MOPED

Post-translational modifications for ZNF676 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF676 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF676

No data available for DME Specific Peptides for ZNF676 Gene

Domains & Families for ZNF676 Gene

Gene Families for ZNF676 Gene

Protein Domains for ZNF676 Gene

Suggested Antigen Peptide Sequences for ZNF676 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N7Q3

UniProtKB/Swiss-Prot:

ZN676_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF676: view

Function for ZNF676 Gene

Molecular function for ZNF676 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF676: view

Animal Model Products

CRISPR Products

miRNA for ZNF676 Gene

miRTarBase miRNAs that target ZNF676

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF676 Gene

Localization for ZNF676 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF676 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF676 Gene COMPARTMENTS Subcellular localization image for ZNF676 gene
Compartment Confidence
nucleus 5
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ZNF676 Gene

Pathways & Interactions for ZNF676 Gene

SuperPathways for ZNF676 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF676: view

Pathways by source for ZNF676 Gene

2 Reactome pathways for ZNF676 Gene

Interacting Proteins for ZNF676 Gene

Gene Ontology (GO) - Biological Process for ZNF676 Gene

None

No data available for SIGNOR curated interactions for ZNF676 Gene

Drugs & Compounds for ZNF676 Gene

No Compound Related Data Available

Transcripts for ZNF676 Gene

mRNA/cDNA for ZNF676 Gene

(19) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF676 Gene

Zinc finger protein 676:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF676 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4: - -
SP5:
SP6: -
SP7: - - -
SP8: -
SP9: -

Relevant External Links for ZNF676 Gene

GeneLoc Exon Structure for
ZNF676
ECgene alternative splicing isoforms for
ZNF676

Expression for ZNF676 Gene

mRNA expression in normal human tissues for ZNF676 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF676 Gene

This gene is overexpressed in Thyroid (x4.4) and Testis (x4.3).

Protein differential expression in normal tissues from HIPED for ZNF676 Gene

This gene is overexpressed in Tlymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF676 Gene



SOURCE GeneReport for Unigene cluster for ZNF676 Gene Hs.55452

genes like me logo Genes that share expression patterns with ZNF676: view

Protein tissue co-expression partners for ZNF676 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF676 Gene

Orthologs for ZNF676 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF676 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Zfp273 35
  • 72.22 (n)
  • 63.15 (a)
Zfp273 16
Zfp493 36
  • 54 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ZNF208 35
  • 95 (n)
  • 91.96 (a)
ZNF676 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC501406 35
  • 72.38 (n)
  • 63.1 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 52 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 38 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 42 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
Species with no ortholog for ZNF676:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF676 Gene

ENSEMBL:
Gene Tree for ZNF676 (if available)
TreeFam:
Gene Tree for ZNF676 (if available)

Paralogs for ZNF676 Gene

(504) SIMAP similar genes for ZNF676 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF676: view

Variants for ZNF676 Gene

Sequence variations from dbSNP and Humsavar for ZNF676 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_047437 -
VAR_047438 -
VAR_047439 -
rs63204863 -- 22,230,669(+) TATAT(A/T)TTTTT intron-variant
rs71924274 -- 22,214,599(+) GTCTC(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF676 Gene

Variant ID Type Subtype PubMed ID
esv4924 CNV Complex 18987735
esv2718335 CNV Deletion 23290073
dgv552e201 CNV Deletion 23290073
dgv3808n71 CNV Gain 21882294
dgv1066e1 CNV Complex 17122850
esv731 CNV CNV 17122850
esv34340 CNV Loss 17911159
dgv553e201 CNV Deletion 23290073
dgv633e199 CNV Deletion 23128226
nsv436853 CNV Insertion 17901297
dgv554e201 CNV Deletion 23290073
nsv436253 CNV Deletion 17901297
nsv911434 CNV Gain 21882294
nsv436857 CNV Insertion 17901297
nsv525240 CNV Gain 19592680
dgv3812n71 CNV Loss 21882294
dgv3813n71 CNV Gain 21882294
dgv3814n71 CNV Gain 21882294
nsv833786 CNV Gain 17160897
dgv3n43 CNV Gain 19587683
nsv911441 CNV Gain 21882294
nsv469671 CNV Complex 16826518
nsv2440 CNV Insertion 18451855
esv1004381 CNV Deletion 20482838
esv1536549 CNV Insertion 17803354

Variation tolerance for ZNF676 Gene

Residual Variation Intolerance Score: 94.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.32; 92.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF676 Gene

HapMap Linkage Disequilibrium report
ZNF676

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF676 Gene

Disorders for ZNF676 Gene

Relevant External Links for ZNF676

Genetic Association Database (GAD)
ZNF676
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF676

No disorders were found for ZNF676 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF676 Gene

Publications for ZNF676 Gene

  1. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. (PMID: 20421499) Levy D. … Aviv A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 48 67
  2. Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. (PMID: 23001564) Mangino M. … Aviv A. (Hum. Mol. Genet. 2012) 3
  3. Identification of DeltaNp63alpha protein interactions by mass spectrometry. (PMID: 20085233) Amoresano A. … CalabrA^ V. (J. Proteome Res. 2010) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ZNF676 Gene

Sources for ZNF676 Gene

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