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Aliases for ZNF675 Gene

Aliases for ZNF675 Gene

  • Zinc Finger Protein 675 2 3 5
  • TRAF6-Inhibitory Zinc Finger Protein 3 4
  • TRAF6-Binding Zinc Finger Protein 3 4
  • TRAF6 Inhibitory Zinc Finger 2 3
  • TIZ 3 4
  • TBZF 3

External Ids for ZNF675 Gene

Previous GeneCards Identifiers for ZNF675 Gene

  • GC19M023628
  • GC19M023835
  • GC19M023379
  • GC19M023711

Summaries for ZNF675 Gene

GeneCards Summary for ZNF675 Gene

ZNF675 (Zinc Finger Protein 675) is a Protein Coding gene. Diseases associated with ZNF675 include Retinitis Pigmentosa 7 And Digenic and Polycystic Kidney Disease 4, With Or Without Hepatic Disease. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and ubiquitin protein ligase binding. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot for ZNF675 Gene

  • May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.

Additional gene information for ZNF675 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF675 Gene

Genomics for ZNF675 Gene

Regulatory Elements for ZNF675 Gene

Enhancers for ZNF675 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H023685 1 ENCODE 15.2 +0.6 575 3 PKNOX1 ATF1 ZFP64 ARID4B SIN3A YY1 GTF3C2 ZNF143 ZNF207 FOS ZNF91 ENSG00000233836 ENSG00000268362 ZNF254 ZNF675 GC19P023634
GH19H023724 0.4 ENCODE 12.9 -37.4 -37364 0 IKZF1 ENSG00000233836 ZNF675 ZNF681 GC19M023721 GC19P023736
GH19H023786 0.4 ENCODE 5.5 -100.2 -100187 1 FOS ENSG00000268362 ZNF675 IPO5P1 BNIP3P39 GC19M023775
GH19H023810 0.4 ENCODE 5.5 -123.8 -123767 0 FOS ENSG00000233836 ZNF675 BNIP3P39 GC19P023828
GH19H023547 0.4 ENCODE 5.2 +137.8 137776 3 GATA3 FOS ENSG00000233836 ZNF675 ENSG00000268362 LOC105372338 LOC105372337
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF675 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF675 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108377 620 2000 PKNOX1 ATF1 ZFP64 ARID4B SIN3A YY1 GTF3C2 ZNF143 ZNF207 FOS

Genomic Location for ZNF675 Gene

Chromosome:
19
Start:
23,525,631 bp from pter
End:
23,687,220 bp from pter
Size:
161,590 bases
Orientation:
Minus strand

Genomic View for ZNF675 Gene

Genes around ZNF675 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF675 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF675 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF675 Gene

Proteins for ZNF675 Gene

  • Protein details for ZNF675 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD23-ZN675_HUMAN
    Recommended name:
    Zinc finger protein 675
    Protein Accession:
    Q8TD23
    Secondary Accessions:
    • Q8N211

    Protein attributes for ZNF675 Gene

    Size:
    568 amino acids
    Molecular mass:
    66299 Da
    Quaternary structure:
    • Interacts with TRAF6.

neXtProt entry for ZNF675 Gene

Post-translational modifications for ZNF675 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF675 Gene

Domains & Families for ZNF675 Gene

Gene Families for ZNF675 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF675 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF675 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF675: view

No data available for UniProtKB/Swiss-Prot for ZNF675 Gene

Function for ZNF675 Gene

Molecular function for ZNF675 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.

Gene Ontology (GO) - Molecular Function for ZNF675 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding NAS 11751921
GO:0005515 protein binding IPI 11751921
GO:0008270 zinc ion binding NAS 11751921
GO:0031625 ubiquitin protein ligase binding IPI 11751921
genes like me logo Genes that share ontologies with ZNF675: view

Phenotypes for ZNF675 Gene

GenomeRNAi human phenotypes for ZNF675:
genes like me logo Genes that share phenotypes with ZNF675: view

Animal Model Products

CRISPR Products

Targeted motifs for ZNF675 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF675
  • Consensus sequence: ARGAGGMCAAAATGW Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF675
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF675 Gene

Localization for ZNF675 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF675 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF675 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF675 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA,IEA 11751921
GO:0048471 perinuclear region of cytoplasm IDA 11751921
genes like me logo Genes that share ontologies with ZNF675: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF675 Gene

Pathways & Interactions for ZNF675 Gene

SuperPathways for ZNF675 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF675: view

Pathways by source for ZNF675 Gene

2 Reactome pathways for ZNF675 Gene

Gene Ontology (GO) - Biological Process for ZNF675 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11751921
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007249 I-kappaB kinase/NF-kappaB signaling IDA 11751921
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IDA 11751921
genes like me logo Genes that share ontologies with ZNF675: view

No data available for SIGNOR curated interactions for ZNF675 Gene

Drugs & Compounds for ZNF675 Gene

No Compound Related Data Available

Transcripts for ZNF675 Gene

Unigene Clusters for ZNF675 Gene

Zinc finger protein 675:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF675
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF675 Gene

No ASD Table

Relevant External Links for ZNF675 Gene

GeneLoc Exon Structure for
ZNF675
ECgene alternative splicing isoforms for
ZNF675

Expression for ZNF675 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF675 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF675 Gene:

ZNF675

SOURCE GeneReport for Unigene cluster for ZNF675 Gene:

Hs.264345
genes like me logo Genes that share expression patterns with ZNF675: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF675 Gene

Orthologs for ZNF675 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF675 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF675 33 34
  • 99.53 (n)
mouse
(Mus musculus)
Mammalia Zfp493 34
  • 57 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 53 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 50 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 52 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
-- 34
  • 36 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
Species where no ortholog for ZNF675 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF675 Gene

ENSEMBL:
Gene Tree for ZNF675 (if available)
TreeFam:
Gene Tree for ZNF675 (if available)

Paralogs for ZNF675 Gene

(523) SIMAP similar genes for ZNF675 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF675 Gene

genes like me logo Genes that share paralogs with ZNF675: view

Variants for ZNF675 Gene

Sequence variations from dbSNP and Humsavar for ZNF675 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000139349 -- 23,686,264(+) CACTC(C/T)TTGAT intron-variant
rs1000172260 -- 23,686,510(+) TAGTA(C/G)AAACG intron-variant
rs1000247142 -- 23,666,509(+) CCTTA(A/G)GCCAT intron-variant
rs1000422710 -- 23,672,192(+) AAAAA(A/G)GGACA intron-variant
rs1000455222 -- 23,672,493(+) GTTGA(C/T)ATCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF675 Gene

Variant ID Type Subtype PubMed ID
dgv1741n106 OTHER inversion 24896259
dgv3479n100 CNV loss 25217958
dgv3481n100 CNV gain 25217958
dgv6344n54 CNV loss 21841781
esv23608 CNV loss 19812545
esv2656649 CNV deletion 23128226
esv2676309 CNV deletion 23128226
esv2751784 CNV gain 17911159
esv2758750 CNV gain+loss 17122850
esv3583313 CNV loss 25503493
esv3644005 CNV gain 21293372
esv3644006 CNV loss 21293372
esv3644007 CNV loss 21293372
esv3644008 CNV loss 21293372
esv3644009 CNV gain 21293372
esv3644010 CNV loss 21293372
nsv1057420 CNV gain 25217958
nsv1078888 OTHER inversion 25765185
nsv1134776 CNV deletion 24896259
nsv1153393 OTHER inversion 26484159
nsv2447 CNV insertion 18451855
nsv458528 CNV loss 19166990
nsv524183 CNV gain 19592680
nsv579051 CNV loss 21841781
nsv963033 CNV duplication 23825009

Variation tolerance for ZNF675 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.72; 78.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF675 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF675

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF675 Gene

Disorders for ZNF675 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF675 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 7 and digenic
  • leber congenital amaurosis 18
polycystic kidney disease 4, with or without hepatic disease
  • pkd3
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF675

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF675
genes like me logo Genes that share disorders with ZNF675: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF675 Gene

Publications for ZNF675 Gene

  1. A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6. (PMID: 11751921) Shin JN … Kim HH (The Journal of biological chemistry 2002) 2 3 4 22 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 60
  5. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F … Gauthier JM (Genome research 2004) 3 60

Products for ZNF675 Gene

Sources for ZNF675 Gene

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