ZNF675 Gene
protein-coding GIFtS: 48
GCID: GC19M023835
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zinc finger protein 675
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Aliases
for ZNF675 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6751 2 | | TIZ1 2 3 | | TBZF1 2 | | TRAF6-Binding Zinc Finger Protein2 3 | | TRAF6-Inhibitory Zinc Finger Protein2 3 | | TRAF6 Inhibitory Zinc Finger2 |
Export aliases for ZNF675 gene to outside databasesPrevious GC identifers: GC19M023628 GC19M023379 |
Summaries
for ZNF675 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN675_HUMAN, Q8TD23Function: May be involved in transcriptional regulation. May play a role during osteoclast differentiation bymodulating TRAF6 signaling activity
|
Genomic Views
for ZNF675 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZNF675
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF675
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF675 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p12 Ensembl cytogenetic band: 19p12 HGNC cytogenetic band: 19p12ZNF675 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M023835: view genomic region
(about GC identifiers)
Start:
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23,835,708 bp from pter |
End:
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23,870,017 bp from pter |
Size:
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34,310 bases |
Orientation:
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minus strand |
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Proteins
for ZNF675 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN675_HUMAN, Q8TD23 (See
protein sequence)Recommended Name: Zinc finger protein 675 Size: 568 amino acids; 66299 Da
Subunit: Interacts with TRAF6
Subcellular location: Nucleus (Probable)
Secondary accessions: Q8N211Explore the universe of human proteins at neXtProt for ZNF675: NX_Q8TD23
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TD23
ZNF675 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612203.2
ENSEMBL proteins: ENSP00000352836 Reactome Protein details: Q8TD23
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF675 for ontologies About GeneDecksing
ZNF675 Antibody Products:
Assay Products for ZNF675: |
Protein
Domains /
Families
for ZNF675 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF675 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TD23ProtoNet protein and cluster: Q8TD23 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN675_HUMAN, Q8TD23Similarity: Contains 15 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF675 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN675_HUMAN, Q8TD23Function: May be involved in transcriptional regulation. May play a role during osteoclast differentiation bymodulating TRAF6 signaling activity
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF675
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF675
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZNF675 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF675 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF675
ZNF675 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF675
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5 Interacting proteins for ZNF675 (Q8TD231, 2, 3 ENSP000003528364) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
ZNF675 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF675 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF675
Search CenterWatch for drugs/clinical trials and news about ZNF675 / ZN675
|
Transcripts
for ZNF675 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF675 gene: NM_138330.2 Unigene Cluster for ZNF675: Zinc finger protein 675 Hs.264345 [show with all ESTs]Unigene Representative Sequence: AB2096011 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000359788(uc002nri.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF675
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF675
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF675 (NM_138330) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF675 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF675 |
Additional cDNA sequence: AB209601.1 AK093669.1 AK307845.1 AY044432.1 BC032394.1 D70835.1 8 DOTS entries: DT.100813026 DT.92417186 DT.121501717 DT.95088170 DT.121501584 DT.121501614 DT.121501754 DT.121501611 24/31 AceView cDNA sequences (see all 31): NM_138330 AY044432 AA172313 BF308250 BI756041 AX748253 AK093669 AI017910 AW272732 AU098870 BX109308 BX480242 BU509894 BX482517 BF204032 BF343330 BC032394 BE694257 BU853392 CD689130 BE694276 BE694240 BE694258 BX463489
GeneLoc Exon Structure
|
Expression
for ZNF675 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF675 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGAAATTA
About this image
See ZNF675 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF675
SOURCE GeneReport for Unigene cluster: Hs.264345
SABiosciences Custom PCR Arrays for ZNF675
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF675
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF675 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF675 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF675 |
Orthologs
for ZNF675 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF675 gene from 1/4 species (see all 4) About this table
ENSEMBL Gene Tree for ZNF675 (if available)
TreeFam Gene Tree for ZNF675 (if available) |
Paralogs
for ZNF675 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF675 gene
- ZNF852 ZNF4932 ZNF4862 ZNF1002 ZNF922 ZNF7322 ZNF1382 ZNF5062
- ZNF2732 ZNF66P2 ZNF6952 ZNF6262 ZNF6802 ZNF2532 ZNF4792 ZNF932
- ZNF4922 ZNF6822 ZNF6762 ZNF1412 ZNF6812 ZNF6792 ZNF2572 ZNF2542
- ZNF7372 ZNF724P2 ZNF982 ZNF849P2 ZNF7162 ZNF7142 ZNF4292 ZNF4302
- ZNF7302 ZNF6782 ZNF1172 ZNF7082 ZNF1072 ZNF4312 ZNF902
18/511 SIMAP similar genes for ZNF675 using alignment to 8 protein entries: ZN675_HUMAN (see all proteins)
(see all similar genes):ZNF818P ZNF78L1 MGC12518 ZFS-5 ZFS-1 kr-znf3
DKFZp762K012 HZF30 ZNF254 ZNF724P ZNF737 ZNF738
ZNF85 ZNF98 ZNF273 ZNF107 ZNF492 ZNF506
ZNF675 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF675
PGOHUM00000234620
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Genomic Variants
for ZNF675 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF675 (23835708 - 23870017 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for ZNF675
6 CNVs: 89176 4072 89177 67506 89175 8869 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF675 |
|
Disorders
/ Diseases
for ZNF675 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF675 for disorders About GeneDecksing
1  disease for ZNF675: About MalaCardsneonatal abstinence syndrome
Export disorders for ZNF675 gene to outside databases
|
Publications
for ZNF675 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF675 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF675) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6. (PubMed id 11751921)1, 2, 3, 9 Shin J.N.... Kim H.-H. (2002)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- A universal strategy for proteomic studies of SUMO an d other ubiquitin-like modifiers. (PubMed id 15576338)1 Rosas-Acosta G....Wilson V.G. (2005)
- Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Recognition specificity of self-incompatibility maintained after the divergence of Brassica oleracea and Brassica rapa. (PubMed id 11851921)1 Kimura R....Nishio T. (2002)
|
External Searches for ZNF675 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF675 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF675 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF675 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF675 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF675 gene:
Search GeneIP for patents involving ZNF675
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF675 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF675 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF675 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF675 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF675 | | OriGene 3'-UTR Clone for ZNF675 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF675 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF675 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | ZNF675 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for ZNF675 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF675 |
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