Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZNF675 Gene

Aliases for ZNF675 Gene

  • Zinc Finger Protein 675 2 3 5
  • TRAF6-Inhibitory Zinc Finger Protein 3 4
  • TRAF6-Binding Zinc Finger Protein 3 4
  • TRAF6 Inhibitory Zinc Finger 2 3
  • TIZ 3 4
  • TBZF 3

External Ids for ZNF675 Gene

Previous GeneCards Identifiers for ZNF675 Gene

  • GC19M023628
  • GC19M023835
  • GC19M023379
  • GC19M023711

Summaries for ZNF675 Gene

GeneCards Summary for ZNF675 Gene

ZNF675 (Zinc Finger Protein 675) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and ubiquitin protein ligase binding. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot for ZNF675 Gene

  • May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF675 Gene

Genomics for ZNF675 Gene

Regulatory Elements for ZNF675 Gene

Enhancers for ZNF675 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F023685 1 ENCODE 15.2 +0.6 575 3.1 PKNOX1 ATF1 ZFP64 ARID4B SIN3A ZNF48 YY1 GTF3C2 CBX5 ZNF207 ENSG00000233836 ZNF254 ZNF675 ZNF91 ENSG00000268362 GC19P023634
GH19F023724 0.8 Ensembl ENCODE 12.9 -37.4 -37362 0.8 ATF3 IKZF1 RAD21 YY1 ENSG00000233836 ZNF675 ZNF681 GC19M023721 GC19P023736
GH19F023798 0.6 ENCODE 4.3 -112.7 -112741 2.4 DPF2 GATA3 CTBP1 ATF3 POLR2A SMARCA4 CUX1 FOS ENSG00000233836 ZNF681 ENSG00000268362 ENSG00000269397 ZNF726 ZNF675 ZNF91 BNIP3P39 GC19P023828
GH19F023786 0.4 ENCODE 5.5 -100.2 -100187 1.7 FOS ENSG00000268362 ZNF675 IPO5P1 BNIP3P39 GC19M023775
GH19F023810 0.4 ENCODE 5.5 -123.8 -123767 0.7 FOS ENSG00000233836 ZNF675 BNIP3P39 GC19P023828
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF675 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF675 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000141525 720 2201 PKNOX1 ATF1 ZFP64 ARID4B SIN3A ZNF48 YY1 GTF3C2 CBX5 ZNF207

Genomic Location for ZNF675 Gene

Chromosome:
19
Start:
23,525,631 bp from pter
End:
23,687,220 bp from pter
Size:
161,590 bases
Orientation:
Minus strand

Genomic View for ZNF675 Gene

Genes around ZNF675 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF675 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF675 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF675 Gene

Proteins for ZNF675 Gene

  • Protein details for ZNF675 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD23-ZN675_HUMAN
    Recommended name:
    Zinc finger protein 675
    Protein Accession:
    Q8TD23
    Secondary Accessions:
    • Q8N211

    Protein attributes for ZNF675 Gene

    Size:
    568 amino acids
    Molecular mass:
    66299 Da
    Quaternary structure:
    • Interacts with TRAF6.

neXtProt entry for ZNF675 Gene

Post-translational modifications for ZNF675 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF675 Gene

Domains & Families for ZNF675 Gene

Gene Families for ZNF675 Gene

Protein Domains for ZNF675 Gene

Suggested Antigen Peptide Sequences for ZNF675 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TD23

UniProtKB/Swiss-Prot:

ZN675_HUMAN :
  • Contains 1 KRAB domain.
  • Contains 15 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Similarity:
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF675: view

Function for ZNF675 Gene

Molecular function for ZNF675 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.

Gene Ontology (GO) - Molecular Function for ZNF675 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding NAS 11751921
GO:0005515 protein binding IPI 11751921
GO:0008270 zinc ion binding NAS 11751921
genes like me logo Genes that share ontologies with ZNF675: view

Phenotypes for ZNF675 Gene

GenomeRNAi human phenotypes for ZNF675:
genes like me logo Genes that share phenotypes with ZNF675: view

Animal Model Products

Targeted motifs for ZNF675 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF675
  • Consensus sequence: ARGAGGMCAAAATGW Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF675 Gene

Localization for ZNF675 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF675 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF675 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF675 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 11751921
GO:0048471 perinuclear region of cytoplasm IDA 11751921
genes like me logo Genes that share ontologies with ZNF675: view

Pathways & Interactions for ZNF675 Gene

SuperPathways for ZNF675 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF675: view

Pathways by source for ZNF675 Gene

2 Reactome pathways for ZNF675 Gene

Gene Ontology (GO) - Biological Process for ZNF675 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11751921
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007249 I-kappaB kinase/NF-kappaB signaling IDA 11751921
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IDA 11751921
genes like me logo Genes that share ontologies with ZNF675: view

No data available for SIGNOR curated interactions for ZNF675 Gene

Transcripts for ZNF675 Gene

Unigene Clusters for ZNF675 Gene

Zinc finger protein 675:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF675 Gene

No ASD Table

Relevant External Links for ZNF675 Gene

GeneLoc Exon Structure for
ZNF675
ECgene alternative splicing isoforms for
ZNF675

Expression for ZNF675 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF675 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF675 Gene:

ZNF675

SOURCE GeneReport for Unigene cluster for ZNF675 Gene:

Hs.264345
genes like me logo Genes that share expression patterns with ZNF675: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ZNF675 Gene

Orthologs for ZNF675 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF675 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF675 34 35
  • 99.53 (n)
mouse
(Mus musculus)
Mammalia Zfp493 35
  • 57 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 53 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 50 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 52 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
Species where no ortholog for ZNF675 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF675 Gene

ENSEMBL:
Gene Tree for ZNF675 (if available)
TreeFam:
Gene Tree for ZNF675 (if available)

Paralogs for ZNF675 Gene

(523) SIMAP similar genes for ZNF675 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF675 Gene

genes like me logo Genes that share paralogs with ZNF675: view

Variants for ZNF675 Gene

Sequence variations from dbSNP and Humsavar for ZNF675 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10402364 -- 23,660,363(+) AACAT(A/G)ACACT intron-variant, utr-variant-5-prime
rs10406844 -- 23,686,877(+) tctta(C/T)ggctg intron-variant
rs10410066 -- 23,661,208(+) aagca(C/G)tttct intron-variant
rs10411860 -- 23,661,461(+) CAAGG(C/T)AAGCA intron-variant
rs10415424 -- 23,683,243(+) cttct(A/G)ggagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF675 Gene

Variant ID Type Subtype PubMed ID
nsv963033 CNV duplication 23825009
nsv579051 CNV loss 21841781
nsv524183 CNV gain 19592680
nsv458528 CNV loss 19166990
nsv2447 CNV insertion 18451855
nsv1153393 OTHER inversion 26484159
nsv1134776 CNV deletion 24896259
nsv1078888 OTHER inversion 25765185
nsv1057420 CNV gain 25217958
esv3644010 CNV loss 21293372
esv3644009 CNV gain 21293372
esv3644008 CNV loss 21293372
esv3644007 CNV loss 21293372
esv3644006 CNV loss 21293372
esv3644005 CNV gain 21293372
esv3583313 CNV loss 25503493
esv2758750 CNV gain+loss 17122850
esv2751784 CNV gain 17911159
esv2676309 CNV deletion 23128226
esv2656649 CNV deletion 23128226
esv23608 CNV loss 19812545
dgv6344n54 CNV loss 21841781
dgv3481n100 CNV gain 25217958
dgv3479n100 CNV loss 25217958
dgv1741n106 OTHER inversion 24896259

Variation tolerance for ZNF675 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.72; 78.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF675 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF675

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF675 Gene

Disorders for ZNF675 Gene

Relevant External Links for ZNF675

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF675

No disorders were found for ZNF675 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF675 Gene

Publications for ZNF675 Gene

  1. A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6. (PMID: 11751921) Shin J.N. … Kim H.-H. (J. Biol. Chem. 2002) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for ZNF675 Gene

Sources for ZNF675 Gene

Content
Loading form....