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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF675 Gene

protein-coding   GIFtS: 48
GCID: GC19M023711

Zinc Finger Protein 675

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 6751 2
TRAF6 Inhibitory Zinc Finger1 2
TIZ2 3
TRAF6-Binding Zinc Finger Protein2 3
TRAF6-Inhibitory Zinc Finger Protein2 3
TBZF2

External Ids:    HGNC: 307681   Entrez Gene: 1713922   Ensembl: ENSG000001973727   UniProtKB: Q8TD233   

Export aliases for ZNF675 gene to outside databases

Previous GC identifers: GC19M023628 GC19M023835 GC19M023379


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF675 Gene: 
ZNF675 (zinc finger protein 675) is a protein-coding gene. Diseases associated with ZNF675 include neonatal abstinence syndrome, and among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and ubiquitin protein ligase binding. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot: ZN675_HUMAN, Q8TD23
Function: May be involved in transcriptional regulation. May play a role during osteoclast differentiation by
modulating TRAF6 signaling activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ZNF675
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF675 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF675

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF675


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF675 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF675 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M023711:  view genomic region     (about GC identifiers)

Start:
23,708,433 bp from pter      End:
23,870,022 bp from pter
Size:
161,590 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN675_HUMAN, Q8TD23 (See protein sequence)
Recommended Name: Zinc finger protein 675  
Size: 568 amino acids; 66299 Da
Subunit: Interacts with TRAF6
Subcellular location: Nucleus (Probable)
Secondary accessions: Q8N211

Explore the universe of human proteins at neXtProt for ZNF675: NX_Q8TD23

Explore proteomics data for ZNF675 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TD23

  • ZNF675 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF675 Protein Expression
    REFSEQ proteins: NP_612203.2  
    ENSEMBL proteins: 
     ENSP00000469379   ENSP00000472170   ENSP00000473217   ENSP00000352836   ENSP00000473035  
     ENSP00000472142   ENSP00000473168   ENSP00000469271  
    Reactome Protein details: Q8TD23
    Human Recombinant Protein Products for ZNF675: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA11751921
    GO:0048471perinuclear region of cytoplasm IDA11751921

    ZNF675 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8TD23

    ProtoNet protein and cluster: Q8TD23

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN675_HUMAN, Q8TD23
    Similarity: Contains 15 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF675 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN675_HUMAN, Q8TD23
    Function: May be involved in transcriptional regulation. May play a role during osteoclast differentiation by
    modulating TRAF6 signaling activity

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding NAS11751921
    GO:0005515protein binding IPI11751921
    GO:0008270zinc ion binding NAS11751921
    GO:0031625ubiquitin protein ligase binding IPI11751921
         
    ZNF675 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF675 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF675
        Generic Transcription Pathway
    Gene Expression



    ZNF675 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF675

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for ZNF675 (Q8TD231, 2, 3 ENSP000003528364) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LMO4P619682, 3MINT-60899 I2D: score=3 
    TRAF6Q9Y4K31, 3EBI-528190,EBI-359276 I2D: score=3 
    IL1BP015843, ENSP000002633414I2D: score=1 STRING: ENSP00000263341
    TNFSF11O147883, ENSP000002398494I2D: score=1 STRING: ENSP00000239849
    --ENSP000003168404STRING: ENSP00000316840
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA11751921
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007249I-kappaB kinase/NF-kappaB cascade IDA11751921
    GO:0010804negative regulation of tumor necrosis factor-mediated signaling pathway IDA11751921

    ZNF675 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF675 (ZN675)

    Search CenterWatch for drugs/clinical trials and news about ZNF675 / ZN675

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF675 gene: 
    NM_138330.2  

    Unigene Cluster for ZNF675:

    Zinc finger protein 675
    Hs.264345  [show with all ESTs]
    Unigene Representative Sequence: AB209601
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000601935 ENST00000600313 ENST00000596211 ENST00000359788(uc002nri.3)
    ENST00000600299 ENST00000599535 ENST00000597074 ENST00000601010 ENST00000599168

    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF675

    Additional mRNA sequence: 

    AB209601.1 AK093669.1 AK307845.1 AY044432.1 BC032394.1 D70835.1 

    8 DOTS entries:

    DT.100813026  DT.92417186  DT.121501717  DT.95088170  DT.121501584  DT.121501614  DT.121501754  DT.121501611 

    24/31 AceView cDNA sequences (see all 31):

    BF308250 BC032394 BI756041 BX480242 BX482517 NM_138330 AY044432 BX109308 
    AW272732 AU098870 AI017910 BF204032 AA172313 BU509894 AK093669 AX748253 
    BF343330 BU853392 BE694257 BE694276 BE694240 CD689130 BX463489 AI679204 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF675 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAAATTA
    ZNF675 Expression
    About this image


    See ZNF675 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF675

    SOURCE GeneReport for Unigene cluster: Hs.264345
        SABiosciences Custom PCR Arrays for ZNF675
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF675

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF675 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    26(a)
    1 → many
    GL343733.1(125230-159240)
            Species with no ortholog for ZNF675

    ENSEMBL Gene Tree for ZNF675 (if available)
    TreeFam Gene Tree for ZNF675 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF675 gene
    ZNF852  ZNF4862  ZNF1952  ZNF7272  ZNF922  ZNF1002  ZNF7322  ZNF1382  
    ZNF5062  ZNF662  ZNF2732  ZNF6952  ZNF6262  ZNF6802  ZNF4792  ZNF2532  
    ZNF6822  ZNF4922  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF6792  ZNF2572  
    ZNF2672  ZNF2542  ZNF7372  ZNF982  ZNF7162  ZNF7142  ZNF5192  ZNF4302  
    ZNF7302  ZNF7082  ZNF1172  ZNF4312  ZNF902  ZNF7262  ZNF7282  
    18/521 SIMAP similar genes for ZNF675 using alignment to 8 protein entries:     ZN675_HUMAN (see all proteins) (see all similar genes):
    ZNF818P    ZNF98    ZNF78L1    MGC12518    ZNF726    ZNF724P
    ZNF431    ZNF506    ZNF43    ZNF254    ZNF701    ZNF430
    ZNF257    ZNF320    ZFS-5    ZNF730    ZNF273    ZNF90

    ZNF675 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ZNF675
    PGOHUM00000234620


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/985 SNPs in ZNF675 are shown (see all 985)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs129719871,2
    C,F,A--23835401(+) ACTGCG/ACCCAG 1 -- ds50017Minor allele frequency- A:0.34NA WA CSA 248
    rs730297501,2
    C,F--23835475(+) ATGTGT/GTTTTC 1 -- ds50011Minor allele frequency- G:0.04NA 120
    rs1419332151,2
    --23835511(+) TTCTCC/GCATAC 1 -- ds50010--------
    rs45600381,2
    C,F,H--23835582(+) ATGTAT/CATGAT 1 -- ds500111Minor allele frequency- C:0.05NA WA CSA EA 373
    rs45600391,2
    C,F,A,H--23835601(+) TGATAA/CCAGTA 1 -- ds500118Minor allele frequency- C:0.03NS EA NA WA CSA 659
    rs44026881,2
    C,H--23835693(+) TTAAAA/GTCTTT 1 -- ds500113Minor allele frequency- G:0.01NA WA CSA EA 376
    rs730297571,2
    --23835807(+) TTTTTA/CTTAAG 1 -- ut310--------
    rs1833640771,2
    C--23835996(+) ATATTG/TAGAAA 1 -- ut310--------
    rs1999441131,2
    C--23836014(+) GGTGTT/CGTCAA 1 -- ut311Minor allele frequency- C:0.00EU 1201
    rs1440331031,2
    C--23836070(+) ATTTTT/GTTATG 2 /K /N mis11Minor allele frequency- G:0.00NA 4524

    HapMap Linkage Disequilibrium report for ZNF675 (23708433 - 23870022 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for ZNF675 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676309CNV Deletion23128226
    esv2656649CNV Deletion23128226
    nsv2447CNV Insertion18451855
    nsv458528CNV Loss19166990
    dgv3819n71CNV Loss21882294
    esv23608CNV Loss19812545
    nsv524183CNV Gain19592680
    esv2751784CNV Gain17911159
    nsv911466CNV Gain21882294
    esv731CNV CNV17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ZNF675:    About MalaCards
    neonatal abstinence syndrome    


    ZNF675 for disorders           About GeneDecksing


    Export disorders for ZNF675 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF675 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF675)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6. (PubMed id 11751921)1, 2, 3, 9 Shin J.N.... Kim H.-H. (2002)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    5. A universal strategy for proteomic studies of SUMO an d other ubiquitin-like modifiers. (PubMed id 15576338)1 Rosas-Acosta G....Wilson V.G. (2005)
    6. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    8. Recognition specificity of self-incompatibility maintained after the divergence of Brassica oleracea and Brassica rapa. (PubMed id 11851921)1 Kimura R....Nishio T. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 171392 HGNC: 30768 AceView: TIZ Ensembl:ENSG00000197372 euGenes: HUgn171392
    ECgene: ZNF675 H-InvDB: ZNF675

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF675 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF675 gene:
    Search GeneIP for patents involving ZNF675

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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