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Aliases for ZNF675 Gene

Aliases for ZNF675 Gene

  • Zinc Finger Protein 675 2 3 5
  • TRAF6-Inhibitory Zinc Finger Protein 3 4
  • TRAF6-Binding Zinc Finger Protein 3 4
  • TRAF6 Inhibitory Zinc Finger 2 3
  • TIZ 3 4
  • TBZF 3

External Ids for ZNF675 Gene

Previous GeneCards Identifiers for ZNF675 Gene

  • GC19M023628
  • GC19M023835
  • GC19M023379
  • GC19M023711

Summaries for ZNF675 Gene

GeneCards Summary for ZNF675 Gene

ZNF675 (Zinc Finger Protein 675) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and ubiquitin protein ligase binding. An important paralog of this gene is ZNF718.

UniProtKB/Swiss-Prot for ZNF675 Gene

  • May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF675 Gene

Genomics for ZNF675 Gene

Regulatory Elements for ZNF675 Gene

Promoters for ZNF675 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF675 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF675 Gene

Chromosome:
19
Start:
23,525,631 bp from pter
End:
23,687,220 bp from pter
Size:
161,590 bases
Orientation:
Minus strand

Genomic View for ZNF675 Gene

Genes around ZNF675 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF675 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF675 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF675 Gene

Proteins for ZNF675 Gene

  • Protein details for ZNF675 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD23-ZN675_HUMAN
    Recommended name:
    Zinc finger protein 675
    Protein Accession:
    Q8TD23
    Secondary Accessions:
    • Q8N211

    Protein attributes for ZNF675 Gene

    Size:
    568 amino acids
    Molecular mass:
    66299 Da
    Quaternary structure:
    • Interacts with TRAF6.

neXtProt entry for ZNF675 Gene

Proteomics data for ZNF675 Gene at MOPED

Post-translational modifications for ZNF675 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF675 Gene

Domains & Families for ZNF675 Gene

Gene Families for ZNF675 Gene

Protein Domains for ZNF675 Gene

Suggested Antigen Peptide Sequences for ZNF675 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TD23

UniProtKB/Swiss-Prot:

ZN675_HUMAN :
  • Contains 1 KRAB domain.
  • Contains 15 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Similarity:
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF675: view

Function for ZNF675 Gene

Molecular function for ZNF675 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.

Gene Ontology (GO) - Molecular Function for ZNF675 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF675: view

Phenotypes for ZNF675 Gene

GenomeRNAi human phenotypes for ZNF675:
genes like me logo Genes that share phenotypes with ZNF675: view

Animal Model Products

CRISPR Products

Targeted motifs for ZNF675 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF675
  • Consensus sequence: ARGAGGMCAAAATGW Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF675 Gene

Localization for ZNF675 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF675 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF675 Gene COMPARTMENTS Subcellular localization image for ZNF675 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ZNF675 Gene

Pathways & Interactions for ZNF675 Gene

SuperPathways for ZNF675 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF675: view

Pathways by source for ZNF675 Gene

2 Reactome pathways for ZNF675 Gene

Gene Ontology (GO) - Biological Process for ZNF675 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11751921
GO:0019221 cytokine-mediated signaling pathway IDA 11751921
GO:0043508 negative regulation of JUN kinase activity IDA 11751921
GO:0045671 negative regulation of osteoclast differentiation IDA 11751921
GO:0046329 negative regulation of JNK cascade IDA 11751921
genes like me logo Genes that share ontologies with ZNF675: view

No data available for SIGNOR curated interactions for ZNF675 Gene

Drugs & Compounds for ZNF675 Gene

No Compound Related Data Available

Transcripts for ZNF675 Gene

Unigene Clusters for ZNF675 Gene

Zinc finger protein 675:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF675 Gene

No ASD Table

Relevant External Links for ZNF675 Gene

GeneLoc Exon Structure for
ZNF675
ECgene alternative splicing isoforms for
ZNF675

Expression for ZNF675 Gene

mRNA expression in normal human tissues for ZNF675 Gene

SOURCE GeneReport for Unigene cluster for ZNF675 Gene Hs.264345

genes like me logo Genes that share expression patterns with ZNF675: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ZNF675 Gene

Orthologs for ZNF675 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF675 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF675 35
  • 99.53 (n)
  • 99.29 (a)
ZNF675 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 53 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 40 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Zfp493 36
  • 57 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for ZNF675:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF675 Gene

ENSEMBL:
Gene Tree for ZNF675 (if available)
TreeFam:
Gene Tree for ZNF675 (if available)

Paralogs for ZNF675 Gene

(523) SIMAP similar genes for ZNF675 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF675 Gene

genes like me logo Genes that share paralogs with ZNF675: view

Variants for ZNF675 Gene

Sequence variations from dbSNP and Humsavar for ZNF675 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11671053 - 23,654,343(+) AATTC(A/G)CCTTG reference, missense
rs4380159 - 23,654,563(+) GTGCA(A/C)CTTAC reference, missense
rs73029758 - 23,653,705(+) AAGGG(A/C/T)TGAGG reference, missense
rs1063327 -- 23,653,879(-) ACCGA(C/T)CCTCA reference, missense
rs1852437 -- 23,681,580(-) tgctt(G/T)gtgtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF675 Gene

Variant ID Type Subtype PubMed ID
esv731 CNV CNV 17122850
esv2751784 CNV Gain 17911159
essv17031 CNV CNV 17122850
dgv3819n71 CNV Loss 21882294
nsv911466 CNV Gain 21882294
nsv524183 CNV Gain 19592680
nsv458528 CNV Loss 19166990
nsv2447 CNV Insertion 18451855
esv2656649 CNV Deletion 23128226
esv2676309 CNV Deletion 23128226
esv23608 CNV Loss 19812545

Variation tolerance for ZNF675 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.72; 78.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF675 Gene

HapMap Linkage Disequilibrium report
ZNF675

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF675 Gene

Disorders for ZNF675 Gene

Relevant External Links for ZNF675

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF675

No disorders were found for ZNF675 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF675 Gene

Publications for ZNF675 Gene

  1. A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6. (PMID: 11751921) Shin J.N. … Kim H.-H. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3
  5. Recognition specificity of self-incompatibility maintained after the divergence of Brassica oleracea and Brassica rapa. (PMID: 11851921) Kimura R. … Nishio T. (Plant J. 2002) 3

Products for ZNF675 Gene

Sources for ZNF675 Gene

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