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Aliases for ZNF675 Gene

Aliases for ZNF675 Gene

  • Zinc Finger Protein 675 2 3
  • TRAF6-Inhibitory Zinc Finger Protein 3 4
  • TRAF6-Binding Zinc Finger Protein 3 4
  • TRAF6 Inhibitory Zinc Finger 2 3
  • TIZ 3 4
  • TBZF 3

External Ids for ZNF675 Gene

Previous GeneCards Identifiers for ZNF675 Gene

  • GC19M023628
  • GC19M023835
  • GC19M023379
  • GC19M023711

Summaries for ZNF675 Gene

GeneCards Summary for ZNF675 Gene

ZNF675 (Zinc Finger Protein 675) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression. GO annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is ZNF253.

UniProtKB/Swiss-Prot for ZNF675 Gene

  • May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF675 Gene

Genomics for ZNF675 Gene

Genomic Location for ZNF675 Gene

23,525,631 bp from pter
23,687,234 bp from pter
161,604 bases
Minus strand

Genomic View for ZNF675 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF675 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF675 Gene

No data available for Regulatory Elements for ZNF675 Gene

Proteins for ZNF675 Gene

  • Protein details for ZNF675 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 675
    Protein Accession:
    Secondary Accessions:
    • Q8N211

    Protein attributes for ZNF675 Gene

    568 amino acids
    Molecular mass:
    66299 Da
    Quaternary structure:
    • Interacts with TRAF6.

neXtProt entry for ZNF675 Gene

Proteomics data for ZNF675 Gene at MOPED

Post-translational modifications for ZNF675 Gene

  • Ubiquitination at Lys285
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF675 Gene

No data available for DME Specific Peptides for ZNF675 Gene

Domains for ZNF675 Gene

Gene Families for ZNF675 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF675 Gene

Suggested Antigen Peptide Sequences for ZNF675 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8TD23
  • Contains 1 KRAB domain.
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF675: view

Function for ZNF675 Gene

Molecular function for ZNF675 Gene

UniProtKB/Swiss-Prot Function: May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity

Gene Ontology (GO) - Molecular Function for ZNF675 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding NAS 11751921
GO:0005515 protein binding IPI 11751921
GO:0008270 zinc ion binding NAS 11751921
GO:0031625 ubiquitin protein ligase binding IPI 11751921
genes like me logo Genes that share ontologies with ZNF675: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF675 Gene

Localization for ZNF675 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF675 Gene

Subcellular locations from

Jensen Localization Image for ZNF675 Gene COMPARTMENTS Subcellular localization image for ZNF675 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ZNF675 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 11751921
GO:0048471 perinuclear region of cytoplasm IDA 11751921
genes like me logo Genes that share ontologies with ZNF675: view

Pathways for ZNF675 Gene

SuperPathways for ZNF675 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF675: view

Pathways by source for ZNF675 Gene

2 Reactome pathways for ZNF675 Gene

Gene Ontology (GO) - Biological Process for ZNF675 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11751921
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007249 I-kappaB kinase/NF-kappaB signaling IDA 11751921
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IDA 11751921
genes like me logo Genes that share ontologies with ZNF675: view

Transcripts for ZNF675 Gene

Unigene Clusters for ZNF675 Gene

Zinc finger protein 675:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF675 Gene

No ASD Table

Relevant External Links for ZNF675 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF675 Gene

mRNA expression in normal human tissues for ZNF675 Gene

SOURCE GeneReport for Unigene cluster for ZNF675 Gene Hs.264345

genes like me logo Genes that share expressions with ZNF675: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for ZNF675 Gene

Orthologs for ZNF675 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF675 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF675 35
  • 99.53 (n)
  • 99.29 (a)
ZNF675 36
  • 99 (a)
(Bos Taurus)
Mammalia -- 36
  • 53 (a)
(Canis familiaris)
Mammalia -- 36
  • 40 (a)
(Mus musculus)
Mammalia Zfp493 36
  • 57 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 41 (a)
-- 36
  • 50 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
-- 36
  • 36 (a)
-- 36
  • 42 (a)
-- 36
  • 39 (a)
-- 36
  • 33 (a)
-- 36
  • 32 (a)
-- 36
  • 32 (a)
-- 36
  • 30 (a)
Species with no ortholog for ZNF675:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF675 Gene

Gene Tree for ZNF675 (if available)
Gene Tree for ZNF675 (if available)

Paralogs for ZNF675 Gene

Selected SIMAP similar genes for ZNF675 Gene using alignment to 8 proteins: Pseudogenes for ZNF675 Gene

genes like me logo Genes that share paralogs with ZNF675: view

Variants for ZNF675 Gene

Sequence variations from dbSNP and Humsavar for ZNF675 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1063327 -- 23,653,879(-) ACCGA(C/T)CCTCA missense, reference
rs1852437 -- 23,681,580(-) tgctt(G/T)gtgtt intron-variant
rs1968020 -- 23,686,119(-) CTTGA(C/T)TTGTA intron-variant
rs1968021 -- 23,685,910(-) ACAGG(A/G)GACTG intron-variant
rs2364618 -- 23,663,552(+) CCAGG(C/T)GTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF675 Gene

Variant ID Type Subtype PubMed ID
esv731 CNV CNV 17122850
esv2751784 CNV Gain 17911159
essv17031 CNV CNV 17122850
dgv3819n71 CNV Loss 21882294
nsv911466 CNV Gain 21882294
nsv524183 CNV Gain 19592680
nsv458528 CNV Loss 19166990
nsv2447 CNV Insertion 18451855
esv2656649 CNV Deletion 23128226
esv2676309 CNV Deletion 23128226
esv23608 CNV Loss 19812545

Relevant External Links for ZNF675 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF675 Gene

Disorders for ZNF675 Gene

No disorders were found for ZNF675 Gene.

No data available for UniProtKB/Swiss-Prot for ZNF675 Gene

Publications for ZNF675 Gene

  1. A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6. (PMID: 11751921) Shin J.N. … Kim H.-H. (J. Biol. Chem. 2002) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3
  4. A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers. (PMID: 15576338) Rosas-Acosta G. … Wilson V.G. (Mol. Cell Proteomics 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ZNF675 Gene

Sources for ZNF675 Gene

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