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Aliases for ZNF674 Gene

Aliases for ZNF674 Gene

  • Zinc Finger Protein 674 2 3 5
  • Zinc Finger Family Member 674 3
  • ZNF673B 3
  • MRX92 3

External Ids for ZNF674 Gene

Previous HGNC Symbols for ZNF674 Gene

  • MRX92

Previous GeneCards Identifiers for ZNF674 Gene

  • GC00U921661
  • GC0XM046243
  • GC0XM046358
  • GC0XM044070

Summaries for ZNF674 Gene

Entrez Gene Summary for ZNF674 Gene

  • This gene encodes a zinc finger protein with an N-terminal Kruppel-associated box-containing (KRAB) domain and 11 Kruppel-type C2H2 zinc finger domains. Like other zinc finger proteins, this gene may function as a transcription factor. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked cognitive disabilities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]

GeneCards Summary for ZNF674 Gene

ZNF674 (Zinc Finger Protein 674) is a Protein Coding gene. Diseases associated with ZNF674 include Fundus Dystrophy. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF300.

UniProtKB/Swiss-Prot for ZNF674 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF674 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF674 Gene

Genomics for ZNF674 Gene

GeneHancer (GH) Regulatory Elements for ZNF674 Gene

Promoters and enhancers for ZNF674 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI046544 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -1.0 -1017 4.6 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF674-AS1 ZNF674 LOC100113397 LINC01560 INE1 SLC9A7 NUS1P1 ZNF41 KRBOX4 ENSG00000277721
GH0XI047216 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12 -673.1 -673060 5 HDGF PKNOX1 CLOCK ARNT SIN3A FEZF1 ZNF2 IRF4 YY1 POLR2B LOC105373194 CDK16 ZNF81 LOC100113397 INE1 ZNF182 ZNF674-AS1 LINC01560 USP11 ZNF674
GH0XI046572 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 5.3 -29.2 -29167 5.2 HDGF PKNOX1 ARID4B SIN3A GLIS2 ZNF143 ATF7 SP3 REST GLIS1 CHST7 SLC9A7 RP2 ZNF674 PIR58897
GH0XI046625 Enhancer 1.3 FANTOM5 Ensembl ENCODE 8.6 -82.6 -82589 4.5 PKNOX1 FEZF1 BATF IRF4 SCRT2 ATF7 ETV6 FOS BCLAF1 IKZF2 CHST7 SLC9A7 RP2 ZNF674 PGAM1P7 PIR58897
GH0XI046791 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 5 -247.3 -247336 3.4 BATF BRCA1 YY1 FOS IKZF2 RUNX3 SMARCC1 JUNB CEBPB ZEB2 RP2 CHST7 SLC9A7 ZNF674
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF674 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF674 gene promoter:

Genomic Locations for ZNF674 Gene

Genomic Locations for ZNF674 Gene
chrX:46,497,725-46,545,459
(GRCh38/hg38)
Size:
47,735 bases
Orientation:
Minus strand
chrX:46,357,160-46,404,892
(GRCh37/hg19)

Genomic View for ZNF674 Gene

Genes around ZNF674 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF674 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF674 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF674 Gene

Proteins for ZNF674 Gene

  • Protein details for ZNF674 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M3X9-ZN674_HUMAN
    Recommended name:
    Zinc finger protein 674
    Protein Accession:
    Q2M3X9
    Secondary Accessions:
    • B4DHE2
    • E9PHQ4

    Protein attributes for ZNF674 Gene

    Size:
    581 amino acids
    Molecular mass:
    67199 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF674 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF674 Gene

Post-translational modifications for ZNF674 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF674 Gene

Domains & Families for ZNF674 Gene

Gene Families for ZNF674 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF674 Gene

Suggested Antigen Peptide Sequences for ZNF674 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2M3X9

UniProtKB/Swiss-Prot:

ZN674_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF674: view

Function for ZNF674 Gene

Molecular function for ZNF674 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF674 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF674: view

Phenotypes for ZNF674 Gene

GenomeRNAi human phenotypes for ZNF674:
genes like me logo Genes that share phenotypes with ZNF674: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF674 Gene

Localization for ZNF674 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF674 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF674 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF674 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF674: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF674 Gene

Pathways & Interactions for ZNF674 Gene

SuperPathways for ZNF674 Gene

No Data Available

Interacting Proteins for ZNF674 Gene

Gene Ontology (GO) - Biological Process for ZNF674 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF674: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF674 Gene

Drugs & Compounds for ZNF674 Gene

No Compound Related Data Available

Transcripts for ZNF674 Gene

mRNA/cDNA for ZNF674 Gene

(13) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF674 Gene

Zinc finger protein 674:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF674 Gene

No ASD Table

Relevant External Links for ZNF674 Gene

GeneLoc Exon Structure for
ZNF674
ECgene alternative splicing isoforms for
ZNF674

Expression for ZNF674 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF674 Gene

Protein differential expression in normal tissues from HIPED for ZNF674 Gene

This gene is overexpressed in Gallbladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF674 Gene



Protein tissue co-expression partners for ZNF674 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF674 Gene:

ZNF674

SOURCE GeneReport for Unigene cluster for ZNF674 Gene:

Hs.636105

mRNA Expression by UniProt/SwissProt for ZNF674 Gene:

Q2M3X9-ZN674_HUMAN
Tissue specificity: Expressed in testis.

Evidence on tissue expression from TISSUES for ZNF674 Gene

  • Nervous system(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF674 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cerebellum
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • outer ear
  • salivary gland
  • skull
  • tooth
Thorax:
  • lung
  • rib
  • rib cage
Pelvis:
  • pelvis
  • testicle
  • urinary bladder
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with ZNF674: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF674 Gene

Orthologs for ZNF674 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF674 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF674 33 34
  • 99.36 (n)
cow
(Bos Taurus)
Mammalia ZNF674 33 34
  • 87.94 (n)
dog
(Canis familiaris)
Mammalia LOC491850 33
  • 86.32 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 50 (a)
ManyToMany
-- 34
  • 47 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
-- 34
  • 44 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 43 (a)
ManyToMany
-- 34
  • 42 (a)
ManyToMany
-- 34
  • 41 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 39 (a)
OneToMany
Species where no ortholog for ZNF674 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF674 Gene

ENSEMBL:
Gene Tree for ZNF674 (if available)
TreeFam:
Gene Tree for ZNF674 (if available)

Paralogs for ZNF674 Gene

(490) SIMAP similar genes for ZNF674 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ZNF674 Gene

genes like me logo Genes that share paralogs with ZNF674: view

Variants for ZNF674 Gene

Sequence variations from dbSNP and Humsavar for ZNF674 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs10156987 benign, Non-syndromic X-linked intellectual disability 46,499,154(-) A/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1057515887 uncertain-significance, Non-syndromic X-linked intellectual disability 46,498,281(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1057515888 uncertain-significance, Non-syndromic X-linked intellectual disability 46,498,722(-) TA/ 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1057515889 uncertain-significance, Non-syndromic X-linked intellectual disability 46,544,572(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant
rs12687128 benign, Non-syndromic X-linked intellectual disability 46,499,376(-) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF674 Gene

Variant ID Type Subtype PubMed ID
esv3576853 CNV gain 25503493

Variation tolerance for ZNF674 Gene

Residual Variation Intolerance Score: 96.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.45; 28.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF674 Gene

Human Gene Mutation Database (HGMD)
ZNF674
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF674

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF674 Gene

Disorders for ZNF674 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF674 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fundus dystrophy
  • retinal dystrophy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF674

genes like me logo Genes that share disorders with ZNF674: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF674 Gene

Publications for ZNF674 Gene

  1. ZNF674: a new kruppel-associated box-containing zinc-finger gene involved in nonsyndromic X-linked mental retardation. (PMID: 16385466) Lugtenberg D … van Bokhoven H (American journal of human genetics 2006) 2 3 4 58
  2. XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing. (PMID: 23871722) Piton A … Mandel JL (American journal of human genetics 2013) 4 58
  3. Intellectual disability associated with retinal dystrophy in the Xp11.3 deletion syndrome: ZNF674 on trial. Guilty or innocent? (PMID: 22126752) Delphin N … Rozet JM (European journal of human genetics : EJHG 2012) 3 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 58

Products for ZNF674 Gene

Sources for ZNF674 Gene

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