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Aliases for ZNF674 Gene

Aliases for ZNF674 Gene

  • Zinc Finger Protein 674 2 3
  • Zinc Finger Family Member 674 3
  • ZNF673B 3
  • MRX92 3

External Ids for ZNF674 Gene

Previous HGNC Symbols for ZNF674 Gene

  • MRX92

Previous GeneCards Identifiers for ZNF674 Gene

  • GC00U921661
  • GC0XM046243
  • GC0XM046358
  • GC0XM044070

Summaries for ZNF674 Gene

Entrez Gene Summary for ZNF674 Gene

  • This gene encodes a zinc finger protein with an N-terminal Kruppel-associated box-containing (KRAB) domain and 11 Kruppel-type C2H2 zinc finger domains. Like other zinc finger proteins, this gene may function as a transcription factor. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked mental retardation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

GeneCards Summary for ZNF674 Gene

ZNF674 (Zinc Finger Protein 674) is a Protein Coding gene. Diseases associated with ZNF674 include znf674-related x-linked mental retardation and xp11.3 deletion syndrome. An important paralog of this gene is ZNF182.

UniProtKB/Swiss-Prot for ZNF674 Gene

  • May be involved in transcriptional regulation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF674 Gene

Genomics for ZNF674 Gene

Regulatory Elements for ZNF674 Gene

Genomic Location for ZNF674 Gene

46,497,725 bp from pter
46,545,457 bp from pter
47,733 bases
Minus strand

Genomic View for ZNF674 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF674 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF674 Gene

Proteins for ZNF674 Gene

  • Protein details for ZNF674 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 674
    Protein Accession:
    Secondary Accessions:
    • B4DHE2
    • E9PHQ4

    Protein attributes for ZNF674 Gene

    581 amino acids
    Molecular mass:
    67199 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF674 Gene


neXtProt entry for ZNF674 Gene

Proteomics data for ZNF674 Gene at MOPED

Post-translational modifications for ZNF674 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF674 Gene

No data available for DME Specific Peptides for ZNF674 Gene

Domains for ZNF674 Gene

Gene Families for ZNF674 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF674 Gene

Suggested Antigen Peptide Sequences for ZNF674 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q2M3X9
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 11 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF674: view

Function for ZNF674 Gene

Molecular function for ZNF674 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF674 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF674: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ZNF674 Gene

Localization for ZNF674 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF674 Gene

Subcellular locations from

Jensen Localization Image for ZNF674 Gene COMPARTMENTS Subcellular localization image for ZNF674 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF674 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF674: view

Pathways for ZNF674 Gene

SuperPathways for ZNF674 Gene

No Data Available

Interacting Proteins for ZNF674 Gene

Gene Ontology (GO) - Biological Process for ZNF674 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF674: view

No data available for Pathways by source for ZNF674 Gene

Transcripts for ZNF674 Gene

mRNA/cDNA for ZNF674 Gene

(9) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF674 Gene

Zinc finger protein 674:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF674

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF674 Gene

No ASD Table

Relevant External Links for ZNF674 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF674 Gene

mRNA expression in normal human tissues for ZNF674 Gene

Protein differential expression in normal tissues for ZNF674 Gene

This gene is overexpressed in Gallbladder (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZNF674 Gene

SOURCE GeneReport for Unigene cluster for ZNF674 Gene Hs.636105

mRNA Expression by UniProt/SwissProt for ZNF674 Gene

Tissue specificity: Expressed in testis.
genes like me logo Genes that share expressions with ZNF674: view

Expression partners for ZNF674 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF674 Gene

Orthologs for ZNF674 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF674 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF674 35
  • 87.94 (n)
  • 79.83 (a)
ZNF674 36
  • 79 (a)
(Canis familiaris)
Mammalia LOC491850 35
  • 86.32 (n)
  • 80 (a)
(Pan troglodytes)
Mammalia ZNF674 35
  • 99.36 (n)
  • 98.44 (a)
ZNF674 36
  • 98 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
-- 36
  • 50 (a)
-- 36
  • 43 (a)
-- 36
  • 43 (a)
-- 36
  • 43 (a)
-- 36
  • 42 (a)
-- 36
  • 41 (a)
-- 36
  • 38 (a)
-- 36
  • 44 (a)
-- 36
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
Species with no ortholog for ZNF674:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF674 Gene

Gene Tree for ZNF674 (if available)
Gene Tree for ZNF674 (if available)

Paralogs for ZNF674 Gene

Selected SIMAP similar genes for ZNF674 Gene using alignment to 2 proteins: Pseudogenes for ZNF674 Gene

genes like me logo Genes that share paralogs with ZNF674: view

Variants for ZNF674 Gene

Sequence variations from dbSNP and Humsavar for ZNF674 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1569481 -- 46,532,588(+) GCCTT(C/T)ACAAA intron-variant
rs1737367 - 46,501,045(+) ATGGA(A/G)GCATA reference, missense
rs1737368 -- 46,501,064(+) TATGC(C/T)TTACA synonymous-codon, reference
rs1810454 -- 46,530,370(+) ACTGC(G/T)GAGTG intron-variant
rs1963142 -- 46,541,312(+) gccga(G/T)atcgc intron-variant

Relevant External Links for ZNF674 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF674 Gene

Disorders for ZNF674 Gene

(1) University of Copenhagen DISEASES for ZNF674 Gene

genes like me logo Genes that share disorders with ZNF674: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for ZNF674 Gene

Publications for ZNF674 Gene

  1. ZNF674: a new Kruppel-associated box-containing zinc-finger gene involved in nonsyndromic X-linked mental retardation. (PMID: 16385466) Lugtenberg D. … van Bokhoven H. (Am. J. Hum. Genet. 2006) 2 3 4
  2. Intellectual disability associated with retinal dystrophy in the Xp11.3 deletion syndrome: ZNF674 on trial. Guilty or innocent? (PMID: 22126752) Delphin N. … Rozet J.M. (Eur. J. Hum. Genet. 2012) 3
  3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4

Products for ZNF674 Gene

Sources for ZNF674 Gene

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