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ZNF672 Gene

protein-coding   GIFtS: 44
GCID: GC01P249132

Zinc Finger Protein 672

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 6721 2
Hypothetical Protein FLJ223011

External Ids:    HGNC: 261791   Entrez Gene: 798942   Ensembl: ENSG000001711617   UniProtKB: Q499Z43   
ORGUL members:         

Export aliases for ZNF672 gene to outside databases

Previous GC identifers: GC01P245343 GC01P247099 GC01P219373


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF672 Gene:
ZNF672 (zinc finger protein 672) is a protein-coding gene. Diseases associated with ZNF672 include microcephaly.

UniProtKB/Swiss-Prot: ZN672_HUMAN, Q499Z4
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_167186.2  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF672 gene promoter:
         HEN1   Sox5   AML1a   deltaCREB   STAT3   Olf-1   C/EBPalpha   RSRFC4   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF672 promoter sequence
   Search Chromatin IP Primers for ZNF672

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF672


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

ZNF672 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF672 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P249132:  view genomic region     (about GC identifiers)

Start:
249,132,409 bp from pter      End:
249,143,716 bp from pter
Size:
11,308 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN672_HUMAN, Q499Z4 (See protein sequence)
Recommended Name: Zinc finger protein 672  
Size: 452 amino acids; 50224 Da
Secondary accessions: Q96H65 Q96IM3 Q9H6G5
Alternative splicing: 2 isoforms:  Q499Z4-1   Q499Z4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF672: NX_Q499Z4

Explore proteomics data for ZNF672 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF672 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079112.1  
    ENSEMBL proteins: 
     ENSP00000421915   ENSP00000422534   ENSP00000427021   ENSP00000426199  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q499Z4

    ProtoNet protein and cluster: Q499Z4

    UniProtKB/Swiss-Prot: ZN672_HUMAN, Q499Z4
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 14 C2H2-type zinc fingers


    ZNF672 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN672_HUMAN, Q499Z4
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    ZNF672 for ontologies           About GeneDecksing


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    hsa-mir-26b-5p (MIRT029240)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN672_HUMAN, Q499Z4: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF672 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF672
    Interactions:

        Search GeneGlobe Interaction Network for ZNF672

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    ZNF672 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ZNF672 (ZN672)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF672 gene: 
    NM_024836.1  

    Unigene Cluster for ZNF672:

    Zinc finger protein 672
    Hs.521151  [show with all ESTs]
    Unigene Representative Sequence: BC035140
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510904 ENST00000306562(uc001iex.3) ENST00000505503 ENST00000428515
    ENST00000502697 ENST00000515369 ENST00000423362
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ZNF672:
    hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidZNF672 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ZNF672
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF672
      QuantiFast Probe-based Assays in human, mouse, rat ZNF672

    Additional mRNA sequence: 

    AK025954.1 AK027476.1 AK027679.1 AK298016.1 BC007385.2 BC008872.1 BC029310.1 BC035140.1 
    BC050348.1 BC068506.1 

    19 DOTS entries:

    DT.100760993  DT.448777  DT.101979769  DT.100814734  DT.100814730  DT.121352101  DT.100814733  DT.121352065 
    DT.70104370  DT.121352141  DT.92441029  DT.97792462  DT.121351972  DT.121352018  DT.121352156  DT.121352170 
    DT.86998566  DT.121351959  DT.99983397 

    Selected AceView cDNA sequences (see all 288):

    BX418393 AW408734 BM126938 BM695991 AW168450 BM928376 BC068506 BM547482 
    BC029310 AI479851 BM042189 AI292062 BM554110 BE645885 AI091689 AA363203 
    AA378980 BE251535 BF507542 AI479998 BQ576357 BQ229762 BQ880907 BM717390 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF672 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
    SP1:                          -     -     -     -     -     -     -     -                 -                           
    SP2:                                -     -     -     -     -     -                       -                           
    SP3:                                -     -     -     -     -     -                       -     -                     
    SP4:                                                  -     -     -                       -                           
    SP5:                                                              -                       -                           


    ECgene alternative splicing isoforms for ZNF672

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF672 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTAGTGAAA
    ZNF672 Expression
    About this image

    ZNF672 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF672 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.521151
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF672 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6721 , 5 zinc finger protein 6721, 5 75.09(n)1
    77.61(a)1
      11 (36.19 cM)5
    3194751  NM_001256520.11  NP_001243449.11 
     583151245 


    ENSEMBL Gene Tree for ZNF672 (if available)
    TreeFam Gene Tree for ZNF672 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF672 gene
    Selected SIMAP similar genes for ZNF672 using alignment to 3 protein entries:     ZN672_HUMAN (see all proteins) (see all similar genes):
    ZNF696    DKFZp666C237    ZSCAN29    ZKSCAN1    ZNF    ZNF324
    ZNF554    ZNF850    ZNF391    ZNF500    ZNF514    ZNF679
    ZNF78L1    ZNF891    ZNF84    ZNF263    ZNF418    ZNF589

    ZNF672 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF672 (see all 255)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112054201,2
    F--249130602(+) TTCCAT/CAAACA 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1147754331,2
    C,F--249130666(+) GTAGAG/TAAATA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs66921531,2
    C,F,H--249130698(+) TTTAAT/CTGACA 1 -- us2k1 tfbs310Minor allele frequency- C:0.09NS EA NA WA 1210
    rs670058931,2
    C--249130730(+) TTGAA-/CTTT  
            
    CTTTC
    1 -- us2k10--------
    rs1883818361,2
    --249130798(+) AACATA/TGGAAA 1 -- us2k10--------
    rs1930254891,2
    --249130914(+) TTAGAA/GTTTGT 1 -- us2k10--------
    rs802370381,2
    F--249131211(+) TCAAGA/CGCATT 1 -- us2k10--------
    rs1417800211,2
    C--249131232(+) CTCTCA/GATGTT 1 -- us2k10--------
    rs1884481641,2
    --249131355(+) GCGGGC/TCAGCA 1 -- us2k10--------
    rs1140165391,2
    C,F--249131386(+) GGCGTG/ACTGGC 1 -- us2k11Minor allele frequency- A:0.07WA 118

    HapMap Linkage Disequilibrium report for ZNF672 (249132409 - 249143716 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ZNF672:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5398CNV Insertion18451855
    esv2750835CNV Gain17911159
    esv2750832CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for ZNF672:    
    About MalaCards
    microcephaly


    ZNF672 for disorders           About GeneDecksing


    Export disorders for ZNF672 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF672 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF672)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79894 HGNC: 26179 AceView: FLJ22301 Ensembl:ENSG00000171161 euGenes: HUgn79894
    ECgene: ZNF672 H-InvDB: ZNF672

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF672 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF672 gene:
    Search GeneIP for patents involving ZNF672

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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