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Aliases for ZNF670-ZNF695 Gene

Subcategory (RNA class) for ZNF670-ZNF695 Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for ZNF670-ZNF695 Gene

  • ZNF670-ZNF695 Readthrough (NMD Candidate) 2 3 5

External Ids for ZNF670-ZNF695 Gene

Previous GeneCards Identifiers for ZNF670-ZNF695 Gene

  • GC01U903219
  • GC01M247112

Summaries for ZNF670-ZNF695 Gene

Entrez Gene Summary for ZNF670-ZNF695 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring zinc finger protein 670 (ZNF670) and zinc finger protein 695 (ZNF695) genes on chromosome 1. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is thus unlikely to produce a protein product. [provided by RefSeq, Feb 2011]

GeneCards Summary for ZNF670-ZNF695 Gene

ZNF670-ZNF695 (ZNF670-ZNF695 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF534.

Additional gene information for ZNF670-ZNF695 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF670-ZNF695 Gene

Genomics for ZNF670-ZNF695 Gene

Regulatory Elements for ZNF670-ZNF695 Gene

Enhancers for ZNF670-ZNF695 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H246564 1.7 FANTOM5 ENCODE dbSUPER 41.3 +509.3 509251 9 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF670-ZNF695 ZNF669 AHCTF1 CNST ZNF496 ZNF124 ENSG00000227671 SMYD3 LINC01341 ENSG00000225300
GH01H247330 1.3 ENCODE dbSUPER 23.9 -253.1 -253139 3 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 YY1 ETS1 ZNF766 ZNF496 ZNF669 AHCTF1 ZNF670-ZNF695 ZNF124 ENSG00000202079
GH01H246138 1.5 Ensembl ENCODE dbSUPER 20.2 +937.8 937750 4 PKNOX1 ATF1 ARNT SIN3A TCF12 GATA2 ELK1 FOS ATF7 CAVIN1 LOC101928089 ZNF670-ZNF695 ZNF669 RNU6-1283P ENSG00000235096 AHCTF1 ENSG00000232192 CHCHD4P5
GH01H247077 1.1 ENCODE 26.1 +0.1 84 3 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 CBX5 ZNF143 ZNF669 AHCTF1 ZNF670-ZNF695 ZNF124 ZNF496 ZNF695 ZNF670 LOC100420880
GH01H246213 1.3 Ensembl ENCODE 20.2 +864.1 864107 2 PKNOX1 ATF1 ARNT YY1 TCF12 ZNF766 GATA2 ELK1 FOS ATF7 ZNF670-ZNF695 ZNF669 RNU6-1283P AHCTF1 GC01M246190 SMYD3-IT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF670-ZNF695 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF670-ZNF695 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000023179 213 2001 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZBTB7B YY1 CBX5 ZNF143 SP3

Genomic Location for ZNF670-ZNF695 Gene

Chromosome:
1
Start:
246,945,547 bp from pter
End:
247,078,813 bp from pter
Size:
133,267 bases
Orientation:
Minus strand

Genomic View for ZNF670-ZNF695 Gene

Genes around ZNF670-ZNF695 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF670-ZNF695 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF670-ZNF695 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF670-ZNF695 Gene

Proteins for ZNF670-ZNF695 Gene

  • Protein details for ZNF670-ZNF695 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    E7EVQ0
    Recommended name:
    ZNF670-ZNF695 readthrough (NMD candidate)
    Protein Accession:
    E7EVQ0

    Protein attributes for ZNF670-ZNF695 Gene

    Size:
    118 amino acids
    Molecular mass:
    13151 Da
    Quaternary structure:
    No Data Available
  • Protein details for ZNF670-ZNF695 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    F2Z2N8
    Recommended name:
    ZNF670-ZNF695 readthrough (NMD candidate)
    Protein Accession:
    F2Z2N8

    Protein attributes for ZNF670-ZNF695 Gene

    Size:
    137 amino acids
    Molecular mass:
    16018 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF670-ZNF695 Gene

Protein Expression for ZNF670-ZNF695 Gene

Post-translational modifications for ZNF670-ZNF695 Gene

No Post-translational modifications

Other Protein References for ZNF670-ZNF695 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for ZNF670-ZNF695 Gene

Domains & Families for ZNF670-ZNF695 Gene

Protein Domains for ZNF670-ZNF695 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF670-ZNF695: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ZNF670-ZNF695 Gene

Function for ZNF670-ZNF695 Gene

Phenotypes From GWAS Catalog for ZNF670-ZNF695 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF670-ZNF695 Gene

Localization for ZNF670-ZNF695 Gene

Gene Ontology (GO) - Cellular Components for ZNF670-ZNF695 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with ZNF670-ZNF695: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for ZNF670-ZNF695 Gene

Pathways & Interactions for ZNF670-ZNF695 Gene

SuperPathways for ZNF670-ZNF695 Gene

No Data Available

Interacting Proteins for ZNF670-ZNF695 Gene

Gene Ontology (GO) - Biological Process for ZNF670-ZNF695 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF670-ZNF695: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF670-ZNF695 Gene

Drugs & Compounds for ZNF670-ZNF695 Gene

No Compound Related Data Available

Transcripts for ZNF670-ZNF695 Gene

mRNA/cDNA for ZNF670-ZNF695 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF670-ZNF695 Gene

No ASD Table

Relevant External Links for ZNF670-ZNF695 Gene

GeneLoc Exon Structure for
ZNF670-ZNF695
ECgene alternative splicing isoforms for
ZNF670-ZNF695

Expression for ZNF670-ZNF695 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF670-ZNF695 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for ZNF670-ZNF695 Gene



genes like me logo Genes that share expression patterns with ZNF670-ZNF695: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF670-ZNF695 Gene

Orthologs for ZNF670-ZNF695 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF670-ZNF695 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF670 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 49 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Zfp963 34
  • 45 (a)
ManyToMany
Zfp964 34
  • 40 (a)
ManyToMany
Zfp866 34
  • 39 (a)
ManyToMany
Zfp868 34
  • 36 (a)
ManyToMany
Zfp869 34
  • 34 (a)
ManyToMany
Species where no ortholog for ZNF670-ZNF695 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF670-ZNF695 Gene

ENSEMBL:
Gene Tree for ZNF670-ZNF695 (if available)
TreeFam:
Gene Tree for ZNF670-ZNF695 (if available)

Paralogs for ZNF670-ZNF695 Gene

genes like me logo Genes that share paralogs with ZNF670-ZNF695: view

Variants for ZNF670-ZNF695 Gene

Sequence variations from dbSNP and Humsavar for ZNF670-ZNF695 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000020620 -- 246,992,688(+) ACAAA(A/T)TTTTT intron-variant
rs1000024522 -- 247,036,897(+) ACACA(A/C)ACACA intron-variant, utr-variant-3-prime
rs1000025141 -- 247,073,649(+) TGTGG(A/T)CTTTG intron-variant
rs1000027617 -- 246,974,943(+) AAGGT(C/G)TTTGT intron-variant
rs1000083209 -- 247,041,219(+) GGACA(G/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF670-ZNF695 Gene

Variant ID Type Subtype PubMed ID
esv2487818 CNV deletion 19546169
esv2668869 CNV deletion 23128226
esv2672680 CNV deletion 23128226
esv2673254 CNV deletion 23128226
esv29446 CNV loss 19812545
esv33129 CNV gain+loss 17666407
esv3589499 CNV loss 21293372
esv3589500 CNV loss 21293372
esv3589501 CNV loss 21293372
esv3589502 CNV loss 21293372
esv3589503 CNV loss 21293372
esv3589504 CNV loss 21293372
esv3589505 CNV loss 21293372
esv3891381 CNV loss 25118596
nsv1014012 CNV loss 25217958
nsv1141906 OTHER inversion 24896259
nsv524007 CNV gain 19592680
nsv549546 CNV loss 21841781
nsv549547 CNV loss 21841781
nsv945436 CNV duplication 23825009
nsv999879 CNV gain 25217958

Relevant External Links for ZNF670-ZNF695 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF670-ZNF695

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ZNF670-ZNF695 Gene

Disorders for ZNF670-ZNF695 Gene

Relevant External Links for ZNF670-ZNF695

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF670-ZNF695

No disorders were found for ZNF670-ZNF695 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF670-ZNF695 Gene

Publications for ZNF670-ZNF695 Gene

  1. Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study. (PMID: 23006423) Niu N … Wang L (BMC cancer 2012) 3 60
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 60

Products for ZNF670-ZNF695 Gene

Sources for ZNF670-ZNF695 Gene

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