ZNF670 Gene
protein-coding GIFtS: 48
GCID: GC01M247111
|
|
zinc finger protein 670
| |
Aliases
for ZNF670 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Zinc Finger Protein 6701 2 | | MGC124661 |
| External Ids: | HGNC: 281671 | Entrez Gene: 934742 | Ensembl: ENSG000001357477 | UniProtKB: Q9BS343 | | ORGUL members: | |
|---|
| NONCODE:n410652 n410650 | |
Export aliases for ZNF670 gene to outside databasesPrevious GC identifers: GC01M243527 GC01M245266 GC01M247200 GC01M217593
|---|
Summaries
for ZNF670 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN670_HUMAN, Q9BS34Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF670 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF670 gene promoter:
AREB6 RFX1 Pax-5 Zic1 ZIC2/Zic2 Tal-1beta ITF-2 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF670
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF670 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44ZNF670 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M247111: view genomic region
(about GC identifiers)
Start:
|
247,108,849 bp from pter |
End:
|
247,242,115 bp from pter |
Size:
|
133,267 bases |
Orientation:
|
minus strand |
ORGUL member locations:
Legend (see complete legend)
247108848 247175482 247242115 chr1
|
Proteins
for ZNF670 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN670_HUMAN, Q9BS34 (See
protein sequence)Recommended Name: Zinc finger protein 670 Size: 389 amino acids; 44603 Da
Subcellular location: Nucleus (Probable)Explore the universe of human proteins at neXtProt for ZNF670: NX_Q9BS34
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BS34
ZNF670 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001191149.1 NP_149990.1
ENSEMBL proteins: ENSP00000428213 ENSP00000428036 ENSP00000355459 Reactome Protein details: Q9BS34
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF670 for ontologies About GeneDecksing
ZNF670 Antibody Products:
Assay Products for ZNF670: |
Protein
Domains /
Families
for ZNF670 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF670 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BS34ProtoNet protein and cluster: Q9BS34 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN670_HUMAN, Q9BS34Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 9 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF670 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZN670_HUMAN, Q9BS34Function: May be involved in transcriptional regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF670
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF670
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF670 (NM_033213) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF670 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF670 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF670 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF670 for ontologies About GeneDecksing
|
Pathways & Interactions
for ZNF670 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF670
ZNF670 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF670
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for ZNF670 (Q9BS342, 3 ENSP000003554594) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF670 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF670 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF670
Search CenterWatch for drugs/clinical trials and news about ZNF670 / ZN670
|
Transcripts
for ZNF670 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF670 gene (2 alternative transcripts): NM_001204220.1 NM_033213.4 Unigene Cluster for ZNF670: Zinc finger protein 670 Hs.732305 [show with all ESTs]Unigene Representative Sequence: NM_0332133 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000465049(uc001ica.3) ENST00000474541(uc001icb.2) ENST00000366503(uc001icd.2 uc021plz.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF670
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF670
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF670 (NM_033213) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF670 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF670 |
Additional cDNA sequence: AK027325.1 AK074774.1 BC005360.1 NR_037894.1 3 DOTS entries: DT.97809858 DT.121463198 DT.101980512 24/40 AceView cDNA sequences (see all 40): CR597038 BU178715 BQ897766 BU165067 BU158458 BM069899 BG532425 BX283936 AL603505 AL524527 BC041082 AK074774 AI861830 BQ226925 BG288840 BC055096 BC023527 BX475993 BF683074 BM463812 NM_033213 AK126366 BX099966 NM_020394
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF670 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | | |
| SP3: | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF670
|
Expression
for ZNF670 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF670 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF670 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF670
SOURCE GeneReport for Unigene cluster: Hs.732305
SABiosciences Custom PCR Arrays for ZNF670
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF670
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ZNF670 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF670 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF670 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF670 |
Orthologs
for ZNF670 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ZNF670 (if available)
TreeFam Gene Tree for ZNF670 (if available) |
Paralogs
for ZNF670 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF670 gene
- ZNF6692 ZNF4902 ZNF5642 ZNF4412 ZNF8782 ENSG000002671792 ZNF142 ENSG000001968262
- ZNF7002 ZNF692 ZNF4402 ZNF4432 ZNF442 ZNF4392 ZNF8232 ZNF4912
- ENSG000001884742 ZNF5552 ZNF7092 ZNF6252 ZNF7992 ZNF202 ZNF1012 ZNF7912
- ZNF4422 ZNF4332 ZNF572 ZNF5632 ZNF6272 ENSG000002573552 ZNF1362 ZNF5562
- ZNF7632 ZNF1242 ZNF6992 ZNF8442 ZNF772
18/504 SIMAP similar genes for ZNF670 using alignment to 3 protein entries: ZN670_HUMAN (see all proteins)
(see all similar genes):ZNF519 KIAA1651 BNC2 APCDD1 OK/SW-cl.41 ZNF726
ZNF761 ZNF66 DNAPTP3 ZNF695 ZNF267 ZNF525
ZNF554 MGC12518 PKN1 TMEM135 ZCCHC10 ZNF816
ZNF670 for paralogs About GeneDecksing
5/7 Pseudogenes.org Pseudogenes for ZNF670 (see all 7)
PGOHUM00000248866 PGOHUM00000234146 PGOHUM00000239051 PGOHUM00000240489 PGOHUM00000235868
|
Genomic Variants
for ZNF670 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF670 (247108849 - 247242115 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ZNF670
1 CNV: 6816
1 Indel: 71708 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ZNF670 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF670 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF670 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF670) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
|
External Searches for ZNF670 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF670 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF670 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF670 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF670 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF670 gene:
Search GeneIP for patents involving ZNF670
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF670 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF670 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF670 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF670 | | | OriGene Protein Over-expression Lysate for ZNF670 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF670 | | OriGene 3'-UTR Clone for ZNF670 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF670 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF670 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF670 | | OriGene Custom Protein Services for ZNF670 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF670 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF670 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF670 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF670 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF670 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF670 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZNF670 |
| |  |  |  |  | | | | |
 |
 |
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 | | | ZNF670 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF670 |
|  |  |  | | | | Search ThermoFisher Antibodies for ZNF670 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF670 |
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