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ZNF669 Gene

protein-coding   GIFtS: 49
GCID: GC01M247261

Zinc Finger Protein 669

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6691 2

External Ids:    HGNC: 257361   Entrez Gene: 798622   Ensembl: ENSG000001882957   UniProtKB: Q96BR63   

Export aliases for ZNF669 gene to outside databases

Previous GC identifers: GC01M243590 GC01M245327 GC01M217657


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF669 Gene:
ZNF669 (zinc finger protein 669) is a protein-coding gene. An important paralog of this gene is ZNF564.

UniProtKB/Swiss-Prot: ZN669_HUMAN, Q96BR6
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_167186.2  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF669 gene promoter:
         MZF-1   POU2F1   POU2F1a   Meis-1a   NF-Y   E47   CBF(2)   Meis-1b   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF669 promoter sequence
   Search Chromatin IP Primers for ZNF669

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF669


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q44   HGNC cytogenetic band: 1q44

ZNF669 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF669 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M247261:  view genomic region     (about GC identifiers)

Start:
247,263,264 bp from pter      End:
247,267,674 bp from pter
Size:
4,411 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN669_HUMAN, Q96BR6 (See protein sequence)
Recommended Name: Zinc finger protein 669  
Size: 464 amino acids; 52597 Da
Secondary accessions: B3KP94 Q5VT39 Q9H9Q6
Alternative splicing: 2 isoforms:  Q96BR6-1   Q96BR6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF669: NX_Q96BR6

Explore proteomics data for ZNF669 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF669 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136044.1  NP_079080.2  

    ENSEMBL proteins: 
     ENSP00000404370   ENSP00000342818   ENSP00000355457   ENSP00000355456   ENSP00000429550  
     ENSP00000351636  
    Reactome Protein details: Q96BR6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96BR6

    ProtoNet protein and cluster: Q96BR6

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN669_HUMAN, Q96BR6
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 9 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF669           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN669_HUMAN, Q96BR6
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF669           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF669:
     Decreased viability with pacli  Increased HPV18 LCR reporter a 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF669

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN669_HUMAN, Q96BR6: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF669           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF669 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF669           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF669
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF669
    Interactions:

        Search GeneGlobe Interaction Network for ZNF669

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ZNF669 (ENSP000003428184) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000228605ENSP000004012724STRING: ENSP00000401272
    INADLENSP000003602004STRING: ENSP00000360200
    PRPF38BENSP000003590424STRING: ENSP00000359042
    TNFRSF25ENSP000003670134STRING: ENSP00000367013
    --ENSP000003929404STRING: ENSP00000392940
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF669           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF669 (ZN669)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF669 gene (2 alternative transcripts): 
    NM_001142572.1  NM_024804.2  

    Unigene Cluster for ZNF669:

    Zinc finger protein 669
    Hs.163754  [show with all ESTs]
    Unigene Representative Sequence: NM_024804
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448299(uc001icf.2) ENST00000343381(uc001ice.2) ENST00000366501
    ENST00000366500 ENST00000476158 ENST00000358785
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF669
      QuantiFast Probe-based Assays in human, mouse, rat ZNF669

    Additional mRNA sequence: 

    AK022668.1 AK056020.1 BC015312.1 

    3 DOTS entries:

    DT.99981089  DT.40232823  DT.75106378 

    23 AceView cDNA sequences:

    CA447495 AK056020 BG613859 AU125372 AK022668 AW571489 NM_024804 BX114930 
    BQ184036 AA587784 BU683924 BP367165 BG289442 BC015312 AI632205 BU902972 
    BU171359 AW360859 AA665316 AU149045 AI739165 BG035125 AA209205 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF669    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e
    SP1:                                -                                             
    SP2:                                                                              
    SP3:                                -                                             
    SP4:                                            -                                 
    SP5:                                -           -                                 


    ECgene alternative splicing isoforms for ZNF669

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF669 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGCATTCA
    ZNF669 Expression
    About this image

    ZNF669 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF669 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.163754
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF669 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp9631 zinc finger protein 963 66.01(n)
    50(a)
      620419  NM_001200023.1  NP_001186952.1 


    ENSEMBL Gene Tree for ZNF669 (if available)
    TreeFam Gene Tree for ZNF669 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF669 gene
    ZNF5642  ZNF4902  ZNF4412  ZNF625-ZNF202  ZNF8782  ENSG000002671792  ZNF142  ENSG000002697552  
    ENSG000001968262  ZNF7002  ZNF692  ZNF4402  ZNF4432  ZNF670-ZNF6952  ZNF442  ZNF4392  
    ZNF8232  ENSG000001884742  ZNF4912  ZNF5552  ENSG000002688702  ZNF7092  ZNF6252  ZNF7992  
    ZNF202  ZNF7882  ZNF1012  ZNF7912  ZNF4422  ZNF4332  ZNF572  ZNF6272  
    ZNF5632  ENSG000002573552  ZNF1362  ZNF5562  ZNF7632  ENSG000002687442  ZNF8442  ZNF772  
    Selected SIMAP similar genes for ZNF669 using alignment to 5 protein entries:     ZN669_HUMAN (see all proteins) (see all similar genes):
    ZNF625-ZNF20    ZNF433    ZNF625    ZFP57    ZNF114    ZNF177
    ZNF627    ZNF878    ZNF14    ZNF124    ZNF559    ZNF20
    AVGR4    ZNF844    ZNF614    ZNF778    ZNF415    ZNF302

    Find genes that share paralogs with ZNF669           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF669
    PGOHUM00000240641


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF669 (see all 218)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs121199181,2
    C,F,A--247262843(+) TTTCAG/CCATGT 2 -- int14Minor allele frequency- C:0.29NA CSA 7
    rs1842994381,2
    --247262895(+) ACCTCA/GGCCTC 2 -- int10--------
    rs1892937961,2
    --247262923(+) CAGGCA/GTGAGC 2 -- int10--------
    rs727703171,2
    C,F--247262942(+) CCAGCC/TGCATA 2 -- int11Minor allele frequency- T:0.04NA 120
    rs107545361,2
    C,F,A,H--247262943(+) CAGCCG/ACATAG 2 -- int113Minor allele frequency- A:0.22NS EA NA WA CSA 780
    rs1427940041,2
    --247262977(+) CTCTGC/TCACCA 2 -- int10--------
    rs1923322351,2
    --247263009(+) TCTCAA/GCTAAC 2 -- int10--------
    rs108024681,2
    C,F,A--247263032(+) CTCCCT/CGGTTC 2 -- int15Minor allele frequency- C:0.44NA WA CSA 9
    rs108024691,2
    C,F,A--247263044(+) AACGAT/CTCTCC 2 -- int15Minor allele frequency- C:0.40NA WA 10
    rs1845943471,2
    --247263074(+) GCTGGC/GATTAC 2 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF669 (247263264 - 247267674 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZNF669:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509779CNV Insertion20534489
    nsv873428CNV Loss21882294
    dgv562n71CNV Loss21882294
    nsv873424CNV Gain21882294
    esv33129CNV Gain+Loss17666407

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF669 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF669)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79862 HGNC: 25736 AceView: FLJ12606 Ensembl:ENSG00000188295 euGenes: HUgn79862
    ECgene: ZNF669 H-InvDB: ZNF669

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF669 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF669 gene:
    Search GeneIP for patents involving ZNF669

    GeneCards and IP:
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