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Aliases for ZNF669 Gene

Aliases for ZNF669 Gene

  • Zinc Finger Protein 669 2 3

External Ids for ZNF669 Gene

Previous GeneCards Identifiers for ZNF669 Gene

  • GC01M243590
  • GC01M245327
  • GC01M247261
  • GC01M217657

Summaries for ZNF669 Gene

GeneCards Summary for ZNF669 Gene

ZNF669 (Zinc Finger Protein 669) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF709.

UniProtKB/Swiss-Prot for ZNF669 Gene

  • May be involved in transcriptional regulation

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF669 Gene

Genomics for ZNF669 Gene

Regulatory Elements for ZNF669 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF669 Gene

Chromosome:
1
Start:
247,099,962 bp from pter
End:
247,104,400 bp from pter
Size:
4,439 bases
Orientation:
Minus strand

Genomic View for ZNF669 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF669 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF669 Gene

Proteins for ZNF669 Gene

  • Protein details for ZNF669 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BR6-ZN669_HUMAN
    Recommended name:
    Zinc finger protein 669
    Protein Accession:
    Q96BR6
    Secondary Accessions:
    • B3KP94
    • Q5VT39
    • Q9H9Q6

    Protein attributes for ZNF669 Gene

    Size:
    464 amino acids
    Molecular mass:
    52597 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF669 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF669 Gene

Proteomics data for ZNF669 Gene at MOPED

Post-translational modifications for ZNF669 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF669 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF669

No data available for DME Specific Peptides for ZNF669 Gene

Domains & Families for ZNF669 Gene

Gene Families for ZNF669 Gene

Protein Domains for ZNF669 Gene

Graphical View of Domain Structure for InterPro Entry

Q96BR6

UniProtKB/Swiss-Prot:

ZN669_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF669: view

Function for ZNF669 Gene

Molecular function for ZNF669 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for ZNF669 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF669: view
genes like me logo Genes that share phenotypes with ZNF669: view

Animal Model Products

CRISPR Products

miRNA for ZNF669 Gene

miRTarBase miRNAs that target ZNF669

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF669

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF669 Gene

Localization for ZNF669 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF669 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF669 Gene COMPARTMENTS Subcellular localization image for ZNF669 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF669 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF669: view

Pathways & Interactions for ZNF669 Gene

SuperPathways for ZNF669 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF669: view

Pathways by source for ZNF669 Gene

2 Reactome pathways for ZNF669 Gene

Interacting Proteins for ZNF669 Gene

Gene Ontology (GO) - Biological Process for ZNF669 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF669: view

No data available for SIGNOR curated interactions for ZNF669 Gene

Drugs & Compounds for ZNF669 Gene

No Compound Related Data Available

Transcripts for ZNF669 Gene

Unigene Clusters for ZNF669 Gene

Zinc finger protein 669:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF669

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF669 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e
SP1: -
SP2:
SP3: -
SP4: -
SP5: - -

Relevant External Links for ZNF669 Gene

GeneLoc Exon Structure for
ZNF669
ECgene alternative splicing isoforms for
ZNF669

Expression for ZNF669 Gene

mRNA expression in normal human tissues for ZNF669 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF669 Gene



SOURCE GeneReport for Unigene cluster for ZNF669 Gene Hs.163754

genes like me logo Genes that share expression patterns with ZNF669: view

Protein tissue co-expression partners for ZNF669 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF669 Gene

Orthologs for ZNF669 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF669 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Zfp964 36
  • 36 (a)
ManyToMany
Zfp963 36
  • 44 (a)
ManyToMany
Zfp869 36
  • 32 (a)
ManyToMany
Zfp868 36
  • 35 (a)
ManyToMany
Zfp866 36
  • 35 (a)
ManyToMany
Zfp963 35
  • 66.01 (n)
  • 50 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 44 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ZNF669 35
  • 98.94 (n)
  • 98.41 (a)
Species with no ortholog for ZNF669:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF669 Gene

ENSEMBL:
Gene Tree for ZNF669 (if available)
TreeFam:
Gene Tree for ZNF669 (if available)

Paralogs for ZNF669 Gene

(469) SIMAP similar genes for ZNF669 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZNF669 Gene

genes like me logo Genes that share paralogs with ZNF669: view

Variants for ZNF669 Gene

Sequence variations from dbSNP and Humsavar for ZNF669 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2270616 -- 247,104,366(+) caacc(G/T)ccagg utr-variant-5-prime
rs3736325 -- 247,101,560(+) AAACT(C/G)TTTTG intron-variant
rs4925692 - 247,103,972(+) caggg(A/C)tccgg intron-variant, reference, missense, utr-variant-5-prime
rs6668480 -- 247,104,229(+) cgtca(A/G)ctagg utr-variant-5-prime
rs7533935 - 247,100,391(+) cacgc(C/T)ttggc missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ZNF669 Gene

Variant ID Type Subtype PubMed ID
nsv873424 CNV Gain 21882294
esv33129 CNV Gain+Loss 17666407
nsv873428 CNV Loss 21882294
dgv562n71 CNV Loss 21882294
nsv509779 CNV Insertion 20534489

Variation tolerance for ZNF669 Gene

Residual Variation Intolerance Score: 97.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.03; 80.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF669 Gene

HapMap Linkage Disequilibrium report
ZNF669

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF669 Gene

Disorders for ZNF669 Gene

Relevant External Links for ZNF669

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF669
genes like me logo Genes that share disorders with ZNF669: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF669 Gene

Publications for ZNF669 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 67
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for ZNF669 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ZNF669
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF669
    • Block miRNA regulation of ZNF669 using miScript Target Protectors

    Sources for ZNF669 Gene

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