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Aliases for ZNF669 Gene

Aliases for ZNF669 Gene

  • Zinc Finger Protein 669 2 3 5

External Ids for ZNF669 Gene

Previous GeneCards Identifiers for ZNF669 Gene

  • GC01M243590
  • GC01M245327
  • GC01M247261
  • GC01M217657

Summaries for ZNF669 Gene

GeneCards Summary for ZNF669 Gene

ZNF669 (Zinc Finger Protein 669) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF670.

UniProtKB/Swiss-Prot for ZNF669 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF669 Gene

Genomics for ZNF669 Gene

Regulatory Elements for ZNF669 Gene

Enhancers for ZNF669 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G247103 1.1 ENCODE 30.4 +0.1 92 2.2 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF766 CBX5 ZNF207 ZNF669 ENSG00000228982
GH01G247077 1.1 ENCODE 21.9 +25.7 25671 3.0 PKNOX1 FOXA2 MLX CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF669 ZNF496 ZNF670-ZNF695 AHCTF1 ZNF695 ZNF670 LOC100420880
GH01G246959 1.4 FANTOM5 Ensembl ENCODE 10.7 +144.2 144206 1.2 HDAC1 ATF1 CREB3L1 RAD21 RELB IKZF2 CREM CEBPB TBX21 CREB3 AHCTF1 ZNF669 KIF28P LINC01341 ZNF496 NLRP3 ZNF695
GH01G246575 2 FANTOM5 Ensembl ENCODE dbSUPER 6.4 +523.4 523378 10.2 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B FEZF1 DMAP1 YY1 ZNF766 CNST SMYD3 ENSG00000225300 ZNF669 TFB2M
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF669 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF669 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000023181 299 2199 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF766 CBX5 ZNF207

Genomic Location for ZNF669 Gene

247,099,962 bp from pter
247,104,400 bp from pter
4,439 bases
Minus strand

Genomic View for ZNF669 Gene

Genes around ZNF669 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF669 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF669 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF669 Gene

Proteins for ZNF669 Gene

  • Protein details for ZNF669 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 669
    Protein Accession:
    Secondary Accessions:
    • B3KP94
    • Q5VT39
    • Q9H9Q6

    Protein attributes for ZNF669 Gene

    464 amino acids
    Molecular mass:
    52597 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF669 Gene


neXtProt entry for ZNF669 Gene

Post-translational modifications for ZNF669 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF669 Gene

No data available for DME Specific Peptides for ZNF669 Gene

Domains & Families for ZNF669 Gene

Gene Families for ZNF669 Gene

Protein Domains for ZNF669 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF669: view

Function for ZNF669 Gene

Molecular function for ZNF669 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF669 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF669: view
genes like me logo Genes that share phenotypes with ZNF669: view

Animal Model Products

CRISPR Products

miRNA for ZNF669 Gene

miRTarBase miRNAs that target ZNF669
Targeted motifs for ZNF669 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF669
  • Consensus sequence: GARTGGTCATCGCCC Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF669 Gene

Localization for ZNF669 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF669 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF669 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF669 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF669: view

Pathways & Interactions for ZNF669 Gene

SuperPathways for ZNF669 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF669: view

Pathways by source for ZNF669 Gene

2 Reactome pathways for ZNF669 Gene

Interacting Proteins for ZNF669 Gene

Gene Ontology (GO) - Biological Process for ZNF669 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF669: view

No data available for SIGNOR curated interactions for ZNF669 Gene

Drugs & Compounds for ZNF669 Gene

No Compound Related Data Available

Transcripts for ZNF669 Gene

Unigene Clusters for ZNF669 Gene

Zinc finger protein 669:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF669 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e
SP1: -
SP3: -
SP4: -
SP5: - -

Relevant External Links for ZNF669 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF669 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF669 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF669 Gene

Protein tissue co-expression partners for ZNF669 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF669 Gene:


SOURCE GeneReport for Unigene cluster for ZNF669 Gene:


Evidence on tissue expression from TISSUES for ZNF669 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with ZNF669: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF669 Gene

Orthologs for ZNF669 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF669 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF669 34
  • 98.94 (n)
(Mus musculus)
Mammalia Zfp963 34 16 35
  • 66.01 (n)
Zfp964 35
  • 36 (a)
Zfp866 35
  • 35 (a)
Zfp868 35
  • 35 (a)
Zfp869 35
  • 32 (a)
(Bos Taurus)
Mammalia -- 35
  • 44 (a)
Species where no ortholog for ZNF669 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF669 Gene

Gene Tree for ZNF669 (if available)
Gene Tree for ZNF669 (if available)

Paralogs for ZNF669 Gene

(469) SIMAP similar genes for ZNF669 Gene using alignment to 5 proteins: Pseudogenes for ZNF669 Gene

genes like me logo Genes that share paralogs with ZNF669: view

Variants for ZNF669 Gene

Sequence variations from dbSNP and Humsavar for ZNF669 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000921480 -- 247,104,544(+) CCTAG(A/C/T)GGTTT upstream-variant-2KB
rs1001066025 -- 247,105,581(+) GATCC(A/G)GGACA upstream-variant-2KB
rs1001920160 -- 247,105,784(+) CCAGA(C/T)TGACT upstream-variant-2KB
rs1001975491 -- 247,105,570(+) AACAC(A/T)GGTTT upstream-variant-2KB
rs1002067517 -- 247,100,264(+) CAGGC(A/G)TAAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF669 Gene

Variant ID Type Subtype PubMed ID
esv33129 CNV gain+loss 17666407
esv3589499 CNV loss 21293372
esv3589503 CNV loss 21293372
esv3589507 CNV loss 21293372
esv3891392 CNV loss 25118596
nsv1014012 CNV loss 25217958
nsv509779 CNV insertion 20534489
nsv549547 CNV loss 21841781
nsv999879 CNV gain 25217958

Variation tolerance for ZNF669 Gene

Residual Variation Intolerance Score: 97.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.03; 80.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF669 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF669 Gene

Disorders for ZNF669 Gene

Relevant External Links for ZNF669

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF669 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF669 Gene

Publications for ZNF669 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for ZNF669 Gene

Sources for ZNF669 Gene

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