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Aliases for ZNF668 Gene

Aliases for ZNF668 Gene

  • Zinc Finger Protein 668 2 3

External Ids for ZNF668 Gene

Previous GeneCards Identifiers for ZNF668 Gene

  • GC16M030980
  • GC16M028633

Summaries for ZNF668 Gene

GeneCards Summary for ZNF668 Gene

ZNF668 (Zinc Finger Protein 668) is a Protein Coding gene. Among its related pathways are Gene Expression and Gene Expression.

UniProtKB/Swiss-Prot for ZNF668 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF668 Gene

Genomics for ZNF668 Gene

Regulatory Elements for ZNF668 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ZNF668 Gene

31,060,843 bp from pter
31,074,320 bp from pter
13,478 bases
Minus strand

Genomic View for ZNF668 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZNF668 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF668 Gene

Proteins for ZNF668 Gene

  • Protein details for ZNF668 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 668
    Protein Accession:
    Secondary Accessions:
    • C9JHH8
    • F5H7E7
    • Q59EV1
    • Q8N669
    • Q9H8L4

    Protein attributes for ZNF668 Gene

    619 amino acids
    Molecular mass:
    67890 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14602.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD92947.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF668 Gene


neXtProt entry for ZNF668 Gene

Proteomics data for ZNF668 Gene at MOPED

Post-translational modifications for ZNF668 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ZNF668 Gene

Domains for ZNF668 Gene

Gene Families for ZNF668 Gene

  • ZNF :Zinc fingers, C2H2-type

Protein Domains for ZNF668 Gene

Suggested Antigen Peptide Sequences for ZNF668 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96K58
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF668: view

Function for ZNF668 Gene

Molecular function for ZNF668 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF668 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF668: view

Animal Model Products

CRISPR Products

miRNA for ZNF668 Gene

miRTarBase miRNAs that target ZNF668

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF668

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZNF668 Gene

Localization for ZNF668 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF668 Gene

Subcellular locations from

Jensen Localization Image for ZNF668 Gene COMPARTMENTS Subcellular localization image for ZNF668 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF668 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF668: view

Pathways for ZNF668 Gene

SuperPathways for ZNF668 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF668: view

Pathways by source for ZNF668 Gene

2 Reactome pathways for ZNF668 Gene

Gene Ontology (GO) - Biological Process for ZNF668 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF668: view

Transcripts for ZNF668 Gene

Unigene Clusters for ZNF668 Gene

Zinc finger protein 668:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ZNF668

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF668 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for ZNF668 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF668 Gene

mRNA expression in normal human tissues for ZNF668 Gene

Protein differential expression in normal tissues for ZNF668 Gene

This gene is overexpressed in Monocytes (28.0), Neutrophil (14.6), Blymphocyte (10.7), and Tlymphocyte (10.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF668 Gene

SOURCE GeneReport for Unigene cluster for ZNF668 Gene Hs.102928

genes like me logo Genes that share expressions with ZNF668: view

Expression partners for ZNF668 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF668 Gene

Orthologs for ZNF668 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF668 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF668 35
  • 88.26 (n)
  • 94.16 (a)
ZNF668 36
  • 95 (a)
(Canis familiaris)
Mammalia ZNF668 35
  • 89.07 (n)
  • 95.64 (a)
ZNF668 36
  • 95 (a)
(Mus musculus)
Mammalia Zfp668 35
  • 83.68 (n)
  • 92.08 (a)
Zfp668 16
Zfp668 36
  • 92 (a)
(Pan troglodytes)
Mammalia ZNF668 35
  • 99.63 (n)
  • 100 (a)
ZNF668 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zfp668 35
  • 83.25 (n)
  • 91.76 (a)
(Monodelphis domestica)
Mammalia ZNF668 36
  • 78 (a)
(Gallus gallus)
Aves ZNF668 36
  • 35 (a)
(Anolis carolinensis)
Reptilia ZNF668 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76080 35
znf668 35
  • 67.83 (n)
  • 70 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1627 35
(Danio rerio)
Actinopterygii znf668 35
  • 56.63 (n)
  • 58.55 (a)
znf668 36
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17612 36
  • 11 (a)
Species with no ortholog for ZNF668:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF668 Gene

Gene Tree for ZNF668 (if available)
Gene Tree for ZNF668 (if available)

Paralogs for ZNF668 Gene

Selected SIMAP similar genes for ZNF668 Gene using alignment to 5 proteins: Pseudogenes for ZNF668 Gene

genes like me logo Genes that share paralogs with ZNF668: view

No data available for Paralogs for ZNF668 Gene

Variants for ZNF668 Gene

Sequence variations from dbSNP and Humsavar for ZNF668 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs881929 -- 31,068,050(+) CTCTG(G/T)GTCTC intron-variant, upstream-variant-2KB
rs2005563 -- 31,068,857(-) tgcgg(G/T)gggag intron-variant
rs2032917 - 31,064,387(-) AGTGC(C/G)TGTCC reference, missense
rs2288003 -- 31,061,887(-) GTGGC(A/G)TCCTG synonymous-codon, reference
rs2303223 -- 31,063,854(-) TGCGG(C/T)AAAGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ZNF668 Gene

Variant ID Type Subtype PubMed ID
nsv905729 CNV Loss 21882294
dgv2670n71 CNV Loss 21882294
nsv457483 CNV Loss 19166990
nsv833193 CNV Gain+Loss 17160897
dgv2672n71 CNV Loss 21882294

Relevant External Links for ZNF668 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF668 Gene

Disorders for ZNF668 Gene

No disorders were found for ZNF668 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ZNF668 Gene

Publications for ZNF668 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer. (PMID: 21852383) Hu R. … Lin S.Y. (Cancer Res. 2011) 2 3
  4. Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage. (PMID: 23777805) Hu R. … Lin S.Y. (Cell Cycle 2013) 2 3
  5. A COFRADIC protocol to study protein ubiquitination. (PMID: 24816145) Stes E. … Gevaert K. (J. Proteome Res. 2014) 3

Products for ZNF668 Gene

Sources for ZNF668 Gene

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