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ZNF668 Gene

protein-coding   GIFtS: 50
GCID: GC16M031072

Zinc Finger Protein 668

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6681 2

External Ids:    HGNC: 258211   Entrez Gene: 797592   Ensembl: ENSG000001673947   UniProtKB: Q96K583   

Export aliases for ZNF668 gene to outside databases

Previous GC identifers: GC16M030980 GC16M028633


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF668 Gene:
ZNF668 (zinc finger protein 668) is a protein-coding gene.

UniProtKB/Swiss-Prot: ZN668_HUMAN, Q96K58
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF668 gene promoter:
         Sp1   Pbx1a   Pax-5   AP-4   GATA-2   AREB6   Egr-2   Max   SEF-1 (1)   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF668 promoter sequence
   Search Chromatin IP Primers for ZNF668

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF668


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

ZNF668 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF668 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M031072:  view genomic region     (about GC identifiers)

Start:
31,072,164 bp from pter      End:
31,085,641 bp from pter
Size:
13,478 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZN668_HUMAN, Q96K58 (See protein sequence)
Recommended Name: Zinc finger protein 668  
Size: 619 amino acids; 67890 Da
Sequence caution: Sequence=BAB14602.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAD92947.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: C9JHH8 F5H7E7 Q59EV1 Q8N669 Q9H8L4
Alternative splicing: 2 isoforms:  Q96K58-1   Q96K58-2   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ZNF668: NX_Q96K58

Explore proteomics data for ZNF668 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF668 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001166139.1  NP_001166140.1  NP_001166141.1  NP_078982.3  

    ENSEMBL proteins: 
     ENSP00000403975   ENSP00000378434   ENSP00000300849   ENSP00000442573   ENSP00000412340  
     ENSP00000416853   ENSP00000390671   ENSP00000441349   ENSP00000440149  
    Reactome Protein details: Q96K58

    ZNF668 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96K58

    ProtoNet protein and cluster: Q96K58

    UniProtKB/Swiss-Prot: ZN668_HUMAN, Q96K58
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 16 C2H2-type zinc fingers


    Find genes that share domains with ZNF668           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN668_HUMAN, Q96K58
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF668           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF668
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    miRNA
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    miRTarBase miRNAs that target ZNF668:
    hsa-mir-30c-5p (MIRT047905)

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    hsa-miR-3659 hsa-miR-122 hsa-miR-4294
    SwitchGear 3'UTR luciferase reporter plasmidZNF668 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN668_HUMAN, Q96K58: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF668           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF668 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF668           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF668
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF668
    Interactions:

        Search GeneGlobe Interaction Network for ZNF668

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ZNF668 (Q96K583 ENSP000003008494) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    NPM1P067483, ENSP000002969304I2D: score=1 STRING: ENSP00000296930
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    Find genes that share ontologies with ZNF668           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF668 (ZN668)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF668 gene (4 alternative transcripts): 
    NM_001172668.1  NM_001172669.1  NM_001172670.1  NM_024706.4  

    Unigene Cluster for ZNF668:

    Zinc finger protein 668
    Hs.102928  [show with all ESTs]
    Unigene Representative Sequence: NM_001172668
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426488 ENST00000394983 ENST00000300849(uc002eao.3) ENST00000539836(uc021tgt.1)
    ENST00000414399 ENST00000442862 ENST00000417935 ENST00000564456 ENST00000535577(uc010cag.2)
    ENST00000538906(uc010caf.3)
    miRNA
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    hsa-miR-3659 hsa-miR-122 hsa-miR-4294
    SwitchGear 3'UTR luciferase reporter plasmidZNF668 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF668
      QuantiTect SYBR Green Assays in human, mouse, rat ZNF668
      QuantiFast Probe-based Assays in human, mouse, rat ZNF668

    Additional mRNA sequence: 

    AB209710.2 AK023541.1 AK027398.1 AK289899.1 AK308239.1 AK315623.1 BC021997.2 

    11 DOTS entries:

    DT.452699  DT.101977976  DT.75102955  DT.120680786  DT.120680790  DT.100779047  DT.70103289  DT.120680785 
    DT.120680789  DT.75150915  DT.95134506 

    Selected AceView cDNA sequences (see all 106):

    C00063 BG683193 AI826653 BU632177 AA465604 CA421463 NM_024706 BM806981 
    AI918190 AI823353 AI598235 AI655877 BC021997 AI621218 BG760515 AI394731 
    BF111720 AW007717 CA430741 AI057087 CB131369 BE274233 AI310072 AI280963 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF668    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6
    SP1:                                                      
    SP2:        -     -     -                                 
    SP3:                    -                                 
    SP4:              -     -                                 


    ECgene alternative splicing isoforms for ZNF668

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF668 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCCCCAGC
    ZNF668 Expression
    About this image

    ZNF668 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF668 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.102928
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF668 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6681 , 5 zinc finger protein 6681, 5 83.68(n)1
    92.08(a)1
      7 (69.79 cM)5
    2442191  NM_146259.31  NP_666371.11 
     1278651705 
    chicken
    (Gallus gallus)
    Aves ZNF6686
    zinc finger protein 668
    35(a)
    1 ↔ 1
    8(5662437-5667101)
    lizard
    (Anolis carolinensis)
    Reptilia ZNF6686
    zinc finger protein 668
    62(a)
    1 ↔ 1
    GL343220.1(2093986-2095764)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.16272 Xenopus laevis transcribed sequence with weak similarity more 74.87(n)    BX844034.1 
    zebrafish
    (Danio rerio)
    Actinopterygii znf6681 zinc finger protein 668 56.63(n)
    58.55(a)
      797423  NM_001012489.1  NP_001012507.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG176126
    --
    11(a)
    1 ↔ 1
    2L(4380722-4382735)


    ENSEMBL Gene Tree for ZNF668 (if available)
    TreeFam Gene Tree for ZNF668 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF668 gene
    Selected SIMAP similar genes for ZNF668 using alignment to 5 protein entries:     ZN668_HUMAN (see all proteins) (see all similar genes):
    ZFS-4    ZNF826P    HZF36    ZNF818P    DKFZp666M039    ZNF22
    ZNF391    ZNF684    ZNF718    DKFZp313M0722    ZNF383    ZNF619
    ZSCAN31    DKFZp686N14223    ZFP2    ZNF167    ZNF26    ZNF32

    Find genes that share paralogs with ZNF668           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ZNF668
    PGOHUM00000235189


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF668 (see all 317)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355954
    A breast cancer sample4--see VAR_0355952 A T mis40--------
    VAR_0355974
    A breast cancer sample4--see VAR_0355972 T R mis40--------
    VAR_0355964
    A breast cancer sample4--see VAR_0355962 G S mis40--------
    VAR_0355984
    A breast cancer sample4--see VAR_0355982 R Q mis40--------
    rs1448184881,2
    C--31071816(+) AATGAA/C/GCAATA 4 -- ds50010--------
    rs1863741401,2
    C--31072008(+) TGCCCA/GTGAAA 4 -- ds50010--------
    rs1386777791,2
    C--31072046(+) TACTTC/TGGGAA 4 -- ds50010--------
    rs1901419851,2
    --31072060(+) GCATCC/GAAAGA 4 -- ds50010--------
    rs1818515781,2
    --31072137(+) ACCCAC/TTCACT 4 -- ds50010--------
    rs745380491,2
    C,F--31072158(+) ACACAG/CAAGAT 4 -- ds50011Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for ZNF668 (31072164 - 31085641 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ZNF668:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv905729CNV Loss21882294
    dgv2670n71CNV Loss21882294
    nsv457483CNV Loss19166990
    dgv2672n71CNV Loss21882294
    nsv833193CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): ZNF668
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF668
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF668

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF668           About GenesLikeMe


    Export disorders for ZNF668 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF668 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF668)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage. (PubMed id 23777805)1 Hu R....Lin S.Y. (Cell Cycle 2013)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer. (PubMed id 21852383)1 Hu R....Lin S.Y. (Cancer Res. 2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79759 HGNC: 25821 AceView: FLJ13479 Ensembl:ENSG00000167394 euGenes: HUgn79759
    ECgene: ZNF668 H-InvDB: ZNF668

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF668 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for ZNF668 gene:
    Search GeneIP for patents involving ZNF668

    GeneCards and IP:
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