ZNF668 Gene
protein-coding GIFtS: 46
GCID: GC16M031072
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|
zinc finger protein 668
| |
Aliases
for ZNF668 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6681 2 | | FLJ134791 |
Export aliases for ZNF668 gene to outside databasesPrevious GC identifers: GC16M030980 GC16M028633 |
Summaries
for ZNF668 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN668_HUMAN, Q96K58Function: May be involved in transcriptional regulation (By similarity)
|
Genomic Views
for ZNF668 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF668 gene promoter:
Sp1 Pbx1a Pax-5 AP-4 GATA-2 AREB6 Egr-2 Max SEF-1 (1) c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF668
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF668 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2ZNF668 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M031072: view genomic region
(about GC identifiers)
Start:
|
31,072,164 bp from pter |
End:
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31,085,641 bp from pter |
Size:
|
13,478 bases |
Orientation:
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minus strand |
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Proteins
for ZNF668 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN668_HUMAN, Q96K58 (See
protein sequence)Recommended Name: Zinc finger protein 668 Size: 619 amino acids; 67890 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB14602.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAD92947.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q59EV1 Q8N669 Q9H8L4Explore the universe of human proteins at neXtProt for ZNF668: NX_Q96K58
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96K58
ZNF668 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001166139.1 NP_001166140.1 NP_001166141.1 NP_078982.3
ENSEMBL proteins: ENSP00000403975 ENSP00000378434 ENSP00000300849 ENSP00000442573 ENSP00000412340 ENSP00000416853 ENSP00000390671 ENSP00000441349 ENSP00000440149 Reactome Protein details: Q96K58
Human Recombinant Protein Products for ZNF668:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF668 for ontologies About GeneDecksing
ZNF668 Antibody Products:
Assay Products for ZNF668: |
Protein
Domains /
Families
for ZNF668 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF668 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96K58ProtoNet protein and cluster: Q96K58 UniProtKB/Swiss-Prot: ZN668_HUMAN, Q96K58Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 16 C2H2-type zinc fingers |
Function
for ZNF668 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN668_HUMAN, Q96K58Function: May be involved in transcriptional regulation (By similarity) Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF668 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF668 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF668 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): ZNF668 (NM_024706) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF668 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF668 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF668 |
|
Pathways & Interactions
for ZNF668 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF668
ZNF668 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF668
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for ZNF668 (Q96K583 ENSP000003008494) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF668 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF668 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF668
Search CenterWatch for drugs/clinical trials and news about ZNF668 / ZN668
|
Transcripts
for ZNF668 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF668 gene (4 alternative transcripts): NM_001172668.1 NM_001172669.1 NM_001172670.1 NM_024706.4 Unigene Cluster for ZNF668: Zinc finger protein 668 Hs.102928 [show with all ESTs]Unigene Representative Sequence: NM_00117266810 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000426488 ENST00000394983 ENST00000300849(uc002eao.3) ENST00000539836(uc021tgt.1)
ENST00000414399 ENST00000442862 ENST00000417935 ENST00000564456 ENST00000535577(uc010cag.2)
ENST00000538906(uc010caf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF668 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF668 (see all 4)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): ZNF668 (NM_024706) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF668 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF668 |
Additional cDNA sequence: AB209710.2 AK023541.1 AK027398.1 AK289899.1 AK308239.1 AK315623.1 BC021997.2 11 DOTS entries: DT.452699 DT.101977976 DT.75102955 DT.120680786 DT.120680790 DT.100779047 DT.70103289 DT.120680785 DT.120680789 DT.75150915 DT.95134506 24/106 AceView cDNA sequences (see all 106): AI826653 AI823353 BU632177 BC021997 AI918190 AA465604 BG683193 BM806981 AI655877 C00063 CA421463 NM_024706 AI598235 AW269921 BE266767 AU280368 CA430741 BI117125 BM544658 AW074440 BF062833 BE276202 BU625801 AW005230
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF668 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for ZNF668
|
Expression
for ZNF668 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF668 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCCCCCAGC
About this image
See ZNF668 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF668
SOURCE GeneReport for Unigene cluster: Hs.102928
SABiosciences Custom PCR Arrays for ZNF668
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF668
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF668 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF668 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF668 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF668 |
Orthologs
for ZNF668 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF668 gene from 4/11 species (see all 11) About this table
ENSEMBL Gene Tree for ZNF668 (if available)
TreeFam Gene Tree for ZNF668 (if available) |
Paralogs
for ZNF668 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF668 gene
- ZNF4082
18/482 SIMAP similar genes for ZNF668 using alignment to 6 protein entries: ZN668_HUMAN (see all proteins)
(see all similar genes):ZFS-4 ZNF826P HZF36 ZNF818P ZSCAN31 DKFZp666M039
ZNF22 ZNF391 ZNF684 ZNF718 ZNF78L1 ZNF436
DKFZp313M0722 ZNF383 ZNF619 ZNF55 ZNF DKFZp686N14223
ZNF668 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF668
PGOHUM00000235189
|
Genomic Variants
for ZNF668 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF668 (31072164 - 31085641 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF668: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF668 |
|
Disorders
/ Diseases
for ZNF668 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF668 for disorders About GeneDecksing
1  disease for ZNF668: About MalaCardsbreast cancer
Export disorders for ZNF668 gene to outside databases
|
Publications
for ZNF668 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF668 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF668) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer. (PubMed id 21852383)1 Hu R....Lin S.Y. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
|
External Searches for ZNF668 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF668 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF668 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF668 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF668 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF668 gene:
Search GeneIP for patents involving ZNF668
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF668 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ZNF668 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF668 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF668 | | | OriGene Protein Over-expression Lysate for ZNF668 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF668 | | OriGene 3'-UTR Clone for ZNF668 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF668 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF668 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF668 | | OriGene Custom Protein Services for ZNF668 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF668 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF668 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF668 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF668 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF668 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF668 |
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| | | | Search Tocris compounds for ZNF668 |
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 | | | ZNF668 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF668 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ZNF668 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF668 |
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