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Aliases for ZNF668 Gene

Aliases for ZNF668 Gene

  • Zinc Finger Protein 668 2 3 5

External Ids for ZNF668 Gene

Previous GeneCards Identifiers for ZNF668 Gene

  • GC16M030980
  • GC16M028633

Summaries for ZNF668 Gene

GeneCards Summary for ZNF668 Gene

ZNF668 (Zinc Finger Protein 668) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding.

UniProtKB/Swiss-Prot for ZNF668 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF668 Gene

Genomics for ZNF668 Gene

Regulatory Elements for ZNF668 Gene

Enhancers for ZNF668 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF668 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF668 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF668 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF668 Gene

31,060,843 bp from pter
31,074,320 bp from pter
13,478 bases
Minus strand

Genomic View for ZNF668 Gene

Genes around ZNF668 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF668 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF668 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF668 Gene

Proteins for ZNF668 Gene

  • Protein details for ZNF668 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 668
    Protein Accession:
    Secondary Accessions:
    • C9JHH8
    • F5H7E7
    • Q59EV1
    • Q8N669
    • Q9H8L4

    Protein attributes for ZNF668 Gene

    619 amino acids
    Molecular mass:
    67890 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14602.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD92947.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF668 Gene


neXtProt entry for ZNF668 Gene

Proteomics data for ZNF668 Gene at MOPED

Post-translational modifications for ZNF668 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF668 Gene

Domains & Families for ZNF668 Gene

Gene Families for ZNF668 Gene

Protein Domains for ZNF668 Gene

Suggested Antigen Peptide Sequences for ZNF668 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 16 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF668: view

Function for ZNF668 Gene

Molecular function for ZNF668 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF668: view

Animal Model Products

CRISPR Products

miRNA for ZNF668 Gene

miRTarBase miRNAs that target ZNF668

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF668 Gene

Localization for ZNF668 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF668 Gene

Subcellular locations from

Jensen Localization Image for ZNF668 Gene COMPARTMENTS Subcellular localization image for ZNF668 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF668 Gene

Pathways & Interactions for ZNF668 Gene

SuperPathways for ZNF668 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF668: view

Pathways by source for ZNF668 Gene

2 Reactome pathways for ZNF668 Gene

Gene Ontology (GO) - Biological Process for ZNF668 Gene


No data available for SIGNOR curated interactions for ZNF668 Gene

Drugs & Compounds for ZNF668 Gene

No Compound Related Data Available

Transcripts for ZNF668 Gene

Unigene Clusters for ZNF668 Gene

Zinc finger protein 668:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF668 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for ZNF668 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF668 Gene

mRNA expression in normal human tissues for ZNF668 Gene

Protein differential expression in normal tissues from HIPED for ZNF668 Gene

This gene is overexpressed in Monocytes (28.0), Neutrophil (14.6), Blymphocyte (10.7), and Tlymphocyte (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF668 Gene

SOURCE GeneReport for Unigene cluster for ZNF668 Gene Hs.102928

genes like me logo Genes that share expression patterns with ZNF668: view

Protein tissue co-expression partners for ZNF668 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF668 Gene

Orthologs for ZNF668 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF668 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF668 35
  • 88.26 (n)
  • 94.16 (a)
ZNF668 36
  • 95 (a)
(Canis familiaris)
Mammalia ZNF668 35
  • 89.07 (n)
  • 95.64 (a)
ZNF668 36
  • 95 (a)
(Mus musculus)
Mammalia Zfp668 35
  • 83.68 (n)
  • 92.08 (a)
Zfp668 16
Zfp668 36
  • 92 (a)
(Pan troglodytes)
Mammalia ZNF668 35
  • 99.63 (n)
  • 100 (a)
ZNF668 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Zfp668 35
  • 83.25 (n)
  • 91.76 (a)
(Monodelphis domestica)
Mammalia ZNF668 36
  • 78 (a)
(Gallus gallus)
Aves ZNF668 36
  • 35 (a)
(Anolis carolinensis)
Reptilia ZNF668 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76080 35
znf668 35
  • 67.83 (n)
  • 70 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1627 35
(Danio rerio)
Actinopterygii znf668 35
  • 56.63 (n)
  • 58.55 (a)
znf668 36
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17612 36
  • 11 (a)
Species with no ortholog for ZNF668:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF668 Gene

Gene Tree for ZNF668 (if available)
Gene Tree for ZNF668 (if available)

Paralogs for ZNF668 Gene

(448) SIMAP similar genes for ZNF668 Gene using alignment to 5 proteins: Pseudogenes for ZNF668 Gene

genes like me logo Genes that share paralogs with ZNF668: view

No data available for Paralogs for ZNF668 Gene

Variants for ZNF668 Gene

Sequence variations from dbSNP and Humsavar for ZNF668 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs2032917 - 31,064,387(-) AGTGC(C/G/T)TGTCC reference, missense
rs17851949 - 31,062,017(+) TCACC(C/T)CTTCA reference, missense
rs8046978 - 31,061,588(+) CTGCT(A/G)CCGGG reference, missense
VAR_035595 A breast cancer sample
VAR_035596 A breast cancer sample

Structural Variations from Database of Genomic Variants (DGV) for ZNF668 Gene

Variant ID Type Subtype PubMed ID
nsv905729 CNV Loss 21882294
dgv2670n71 CNV Loss 21882294
nsv457483 CNV Loss 19166990
nsv833193 CNV Gain+Loss 17160897
dgv2672n71 CNV Loss 21882294

Variation tolerance for ZNF668 Gene

Residual Variation Intolerance Score: 7.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF668 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF668 Gene

Disorders for ZNF668 Gene

Relevant External Links for ZNF668

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF668 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF668 Gene

Publications for ZNF668 Gene

  1. Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage. (PMID: 23777805) Hu R. … Lin S.Y. (Cell Cycle 2013) 2 3 67
  2. ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer. (PMID: 21852383) Hu R. … Lin S.Y. (Cancer Res. 2011) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for ZNF668 Gene

Sources for ZNF668 Gene