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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF667 Gene

protein-coding GIFtS: 54
GCID: GC19M056951

Zinc Finger Protein 667

Search for ZNF667
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 667¹ ²
MIPU1² ⁵
Myocardial Ischemic Preconditioning Upregulated 1 Ortholog²

External Ids:	HGNC: 28854¹	Entrez Gene: 63934²	Ensembl: ENSG00000198046⁷	OMIM: 611024⁵	UniProtKB: Q5HYK9³

ORGUL members:
	NONCODE¹⁴:n338959 n408896

Export aliases for ZNF667 gene to outside databases

Previous GC identifers: GC19M061644 GC19M053259

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF667 Gene:

ZNF667 (zinc finger protein 667) is a protein-coding gene, and is affiliated with the lncRNA class. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding.

UniProtKB/Swiss-Prot: ZN667_HUMAN, Q5HYK9

Function: May be involved in transcriptional regulation (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.2 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF667 gene promoter:
PPAR-gamma1 GCNF-1 GCNF PPAR-gamma2 GCNF-2 POU3F2 Evi-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF667 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF667

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF667

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43

ZNF667 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF667 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M056951: view genomic region (about GC identifiers)

Start:	56,950,693 bp from pter	End:	56,989,434 bp from pter
Size:	38,742 bases	Orientation:	minus strand

ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ZNF667

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN667_HUMAN, Q5HYK9 (See protein sequence)

Recommended Name: Zinc finger protein 667

Size: 610 amino acids; 70161 Da

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=AAH74898.2; Type=Erroneous initiation; Sequence=AAH74899.2; Type=Erroneous initiation;

Secondary accessions: B2RMS6 B9EK36 Q6B093 Q9H807

Explore the universe of human proteins at neXtProt for ZNF667: NX_Q5HYK9

Explore proteomics data for ZNF667 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q5HYK9

ZNF667 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_071386.3

ENSEMBL proteins:

ENSP00000468550 ENSP00000439402 ENSP00000292069 ENSP00000467627 ENSP00000468466

ENSP00000464708 ENSP00000344699

Reactome Protein details: Q5HYK9
Human Recombinant Protein Products for ZNF667:

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

ZNF667 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

ZNF: Zinc fingers, C2H2-type

4 InterPro protein domains:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q5HYK9

ProtoNet protein and cluster: Q5HYK9

1 Blocks protein domain: IPB001909 KRAB box

UniProtKB/Swiss-Prot: ZN667_HUMAN, Q5HYK9

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 15 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

ZNF667 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ZN667_HUMAN, Q5HYK9

Function: May be involved in transcriptional regulation (By similarity)

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	--	--
GO:0046872	metal ion binding	IEA	--

ZNF667 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
Products:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for ZNF667 About

See pathways by source

SuperPath

Contained pathways About

Generic Transcription Pathway

Generic Transcription Pathway

0.47

Gene Expression

0.47

Pathways by source See SuperPaths
Show all pathways

2 Reactome Pathways for ZNF667

	Generic Transcription Pathway
	Gene Expression

ZNF667 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF667

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ZNF667 (Q5HYK9^{2, 3} ENSP00000292069⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDC37	Q16543²^,³, ENSP00000222005⁴	MINT-8251054 I2D: score=2 STRING: ENSP00000222005

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF667 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ZNF667 (ZN667)

Search CenterWatch for drugs/clinical trials and news about ZNF667 / ZN667

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF667 gene:

NM_022103.3

Unigene Cluster for ZNF667:

Zinc finger protein 667

Hs.676605 [show with all ESTs]

Unigene Representative Sequence: NR_030740

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000591790 ENST00000504904(uc010etl.3 uc002qne.3) ENST00000292069(uc002qnd.3 uc010etm.3)

ENST00000592189 ENST00000587555 ENST00000589946 ENST00000589652 ENST00000342634

miRNA Products:
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		hsa-miR-607 hsa-miR-3155 hsa-miR-455-3p hsa-miR-484 hsa-miR-9 hsa-miR-629* hsa-miR-3920 hsa-miR-29a*

		SwitchGear 3'UTR luciferase reporter plasmid: ZNF667 3' UTR sequence

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Additional mRNA sequence:

AK024073.1 AK056508.1 AK096513.1 AK126957.1 AK127426.1 BC074898.2 BC074899.2 BC136388.1

BC150593.1 BX647401.1 CR936605.1 NR_030740.1

10 DOTS entries:

DT.86838648 DT.40214309 DT.100776896 DT.101963835 DT.101967259 DT.100776897 DT.100033642 DT.121433102

DT.86675503 DT.99937747

24/52 AceView cDNA sequences (see all 52):

BX280032 BC074899 AL709810 N45689 CD108954 AI969366 AL040559 W01780

BX506784 BC074898 AI699607 AK127426 AI678781 AW451117 AW274693 AK056508

AI985791 BX642001 AK126957 AA020835 BX642000 AK096513 BG329738 BM479859

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF667 (see all 9) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	^	8a	·	8b	^	9	^	10	^	11a	·	11b	·	11c	·	11d
SP1:									-		-				-						-												-
SP2:			-		-		-		-		-		-		-		-		-		-												-
SP3:									-		-		-		-		-		-		-												-
SP4:																					-
SP5:									-		-		-		-		-		-		-				-		-						-

ECgene alternative splicing isoforms for ZNF667

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF667 expression in normal human tissues (normalized intensities) ZNF667 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

ZNF667 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/3 selected tissues (see all 3) fully expand


Limb (Muscoskeletal System)
Prechondrocytic Mesenchymal Cells Zeugopod

Bone (Muscoskeletal System)
Prechondrocytic Mesenchymal Cells Zeugopod

Cartilage (Muscoskeletal System)
Prechondrocytic Mesenchymal Cells Zeugopod

See ZNF667 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF667

SOURCE GeneReport for Unigene cluster: Hs.676605

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for ZNF667 gene from 1/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Zfp667^{1 , 5}	zinc finger protein 667^{1, 5}	80.01(n)¹ 74.79(a)¹		7 (3.64 cM)⁵ 384763¹ NM_001024928.2¹ NP_001020099.1¹ 6286579⁵

ENSEMBL Gene Tree for ZNF667 (if available)
TreeFam Gene Tree for ZNF667 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF667 gene

18/503 SIMAP similar genes for ZNF667 using alignment to 7 protein entries: ZN667_HUMAN (see all proteins) (see all similar genes):

DKFZp686O111 ZFP41 ZNF78L1 kr-znf3 ZNF527 ZNF22

ZNF818P ZNF83 DKFZp666C237 ZKSCAN8 ZNF677 ZNF721

DKFZp686M04222 ZFS-4 ZFS-5 ZNF232 ZNF702P ZNF573

ZNF667 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73064054^1,2	C,F	--	56950247(+)	`AGGAAA/GTTAGG`	2	--	int¹		4		CSA WA NA EA	360
rs143528255^1,2		--	56950583(+)	`TAGGAA/TGACCT`	2	--	int¹		0	--	--	--	--
rs190801225^1,2		--	56950640(+)	`GGTATA/TCTCAA`	2	--	int¹		0	--	--	--	--
rs372942284^1,2	C	--	56950706(+)	`AATTA-/AAAAAA`	4	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs138115717^1,2	C	--	56950830(+)	`ACTCCA/GTATAT`	2	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs112199080^1,2	C,F	--	56950892(+)	`ATTTAC/TTTCTC`	2	--	ut3¹ nc-transcript-variant		1		CSA	2
rs143490755^1,2		--	56950900(+)	`CTCACA/TGTTCT`	2	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs74378662^1,2	C	--	56950949(+)	`AGGTTC/TTCGTA`	2	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs147169970^1,2	C	--	56951037(+)	`ATGTCC/TTTTTG`	2	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs113802531^1,2	F	--	56951062(+)	`TCTGTC/TGCCCA`	2	--	ut3¹ nc-transcript-variant		1		CSA	2

HapMap Linkage Disequilibrium report for ZNF667 (56950693 - 56989434 bp)

Structural Variations
Database of Genomic Variants (DGV) 6 variations for ZNF667: About this table

Variant ID	Type	Subtype	PubMed ID
esv2719038	CNV	Deletion	23290073
esv2719037	CNV	Deletion	23290073
esv1044797	CNV	Insertion	17803354
esv273931	CNV	Insertion	20981092
esv268963	CNV	Insertion	20981092
nsv912516	CNV	Gain	21882294

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF667 for disorders About MalaCards

ZNF667 for disorders About GeneDecksing

OMIM gene information: 611024 OMIM disorders: --

Genetic Association Database (GAD): ZNF667
Human Genome Epidemiology (HuGE) Navigator: ZNF667 (1 document)

Export disorders for ZNF667 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF667 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ZNF667)

Utopia: connect your pdf to the dynamic
world of online information

Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Protein phosphatase 1g isoforms linked interactions in the brain. (PubMed id 23080069)¹ Esteves S.L....da Cruz e Silva E.F. (2013)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (2011)
Functional analysis of a novel KRAB/C2H2 zinc finger protein Mipu1. (PubMed id 17397802)¹ Jiang L....Xiao X. (2007)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 63934	HGNC: 28854	AceView: FLJ14011	Ensembl:ENSG00000198046	euGenes: HUgn63934
ECgene: ZNF667	H-InvDB: ZNF667

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF667	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF667 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ZNF667 gene:
Search GeneIP for patents involving ZNF667

GeneCards and IP:
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Zinc Finger Protein 667

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ZNF667 Gene

Zinc Finger Protein 667

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