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ZNF667 Gene(Protein Coding)

Zinc Finger Protein 667

GCID:
GC19M056439
GIFtS:
51
Genes Participants
UDN Logo

Aliases for ZNF667 Gene

Aliases for ZNF667 Gene

  • Zinc Finger Protein 667 2 3 5
  • Myocardial Ischemic Preconditioning Upregulated 1 Ortholog 3
  • MIPU1 3

External Ids for ZNF667 Gene

Previous GeneCards Identifiers for ZNF667 Gene

  • GC19M061644
  • GC19M056951
  • GC19M053259

Summaries for ZNF667 Gene

GeneCards Summary for ZNF667 Gene

ZNF667 (Zinc Finger Protein 667) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription cofactor activity. An important paralog of this gene is ENSG00000256566.

UniProtKB/Swiss-Prot for ZNF667 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF667 Gene

Genomics for ZNF667 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ZNF667 Gene

Enhancers for ZNF667 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G055503 1.3 Ensembl ENCODE 59.5 +974.1 974097 1.6 PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 CBX5 ZNF416 FIZ1 ZNF667 ZNF667-AS1 ZNF582-AS1 NAT14 ZNF542P ZNF583 U2AF2 LOC729999 ZNF580
GH19G055519 1.6 FANTOM5 Ensembl ENCODE 43 +957.9 957856 1.0 HDGF ATF1 ZNF493 ZNF133 YBX1 GLI4 ZNF416 FOS ZNF548 SP3 FIZ1 ZNF471 NAT14 ZNF580 ZNF667 ZNF582-AS1 ZNF667-AS1 ZNF542P U2AF2 ZNF583
GH19G056594 1 ENCODE 50.6 -117.4 -117376 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A FEZF1 YBX1 GLI4 ZNF48 YY1 ZNF17 ENSG00000269696 ZNF549 ZNF773 ZNF543 U2AF2 ZFP28 ZNF667 ZNF470 FIZ1
GH19G057388 1.1 ENCODE 18.5 -911.9 -911935 2.2 PKNOX1 FOXA2 WRNIP1 SIN3A DMAP1 YY1 ZNF143 FOS SP3 CEBPZ ZSCAN18 ENSG00000269696 LOC100128398 ZNF470 ZNF582-AS1 ZNF583 ZNF304 ZNF264 ZNF667 ZNF667-AS1
GH19G055671 1.4 ENCODE dbSUPER 13.4 +801.6 801563 10.0 HDGF PKNOX1 ARNT CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF471 ZNF583 ZNF470 ZNF582-AS1 ENSG00000269696 ZNF542P ZNF667-AS1 ENSG00000267224 ZFP28 ZNF667
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF667 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF667 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111756 165 2600 SIN3A ZNF76 RAD21 YY1 ETS1 FOS KLF7 ZNF548 EGR2 SP3

Transcription factor binding sites by QIAGEN in the ZNF667 gene promoter:

Genomic Location for ZNF667 Gene

Chromosome:
19
Start:
56,438,512 bp from pter
End:
56,478,065 bp from pter
Size:
39,554 bases
Orientation:
Minus strand

Genomic View for ZNF667 Gene

Genes around ZNF667 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF667 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF667 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF667 Gene

Proteins for ZNF667 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ZNF667 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HYK9-ZN667_HUMAN
    Recommended name:
    Zinc finger protein 667
    Protein Accession:
    Q5HYK9
    Secondary Accessions:
    • B2RMS6
    • B9EK36
    • Q6B093
    • Q9H807

    Protein attributes for ZNF667 Gene

    Size:
    610 amino acids
    Molecular mass:
    70161 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH74898.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH74899.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF667 Gene

Protein Expression for ZNF667 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF667 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF667 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ZNF667

No data available for DME Specific Peptides for ZNF667 Gene

Domains & Families for ZNF667 Gene

Gene Families for ZNF667 Gene

HGNC:

Protein Domains for ZNF667 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF667 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5HYK9

UniProtKB/Swiss-Prot:

ZN667_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF667: view

Function for ZNF667 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ZNF667 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF667 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF667: view

Phenotypes for ZNF667 Gene

GenomeRNAi human phenotypes for ZNF667:
genes like me logo Genes that share phenotypes with ZNF667: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF667 Gene

Localization for ZNF667 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF667 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF667 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF667 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF667: view

Pathways & Interactions for ZNF667 Gene

SuperPathways for ZNF667 Gene

PathCards logo More details on SuperPathways for ZNF667
SuperPathway Contained pathways
1 Gene Expression
Gene Expression
.48
Generic Transcription Pathway
.48
genes like me logo Genes that share pathways with ZNF667: view

Pathways by source for ZNF667 Gene

2 Reactome pathways for ZNF667 Gene

Interacting Proteins for ZNF667 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000292069%0d%0a9606.ENSP00000253024%0d%0a9606.ENSP00000353622%0d%0a9606.ENSP00000369131%0d%0a9606.ENSP00000362768%0d%0a9606.ENSP00000267163%0d%0a
Selected Interacting proteins: Q5HYK9-ZN667_HUMAN ENSP00000292069 for ZNF667 Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for ZNF667 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF667: view

No data available for SIGNOR curated interactions for ZNF667 Gene

Drugs & Compounds for ZNF667 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ZNF667 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ZNF667 Gene

(5) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(52) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF667 Gene

Zinc finger protein 667:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF667 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d
SP1: - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - -
SP4: -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: -
SP9: - - - -

Relevant External Links for ZNF667 Gene

GeneLoc Exon Structure for
ZNF667
ECgene alternative splicing isoforms for
ZNF667

Expression for ZNF667 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF667 Gene

mRNA expression in normal human tissues for ZNF667 Gene
mRNA expression by BioGPS for ZNF667 GenemRNA expression by GTEx for ZNF667 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF667 Gene

This gene is overexpressed in Pituitary (x5.1).

Protein differential expression in normal tissues from HIPED for ZNF667 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF667 Gene



Protein tissue co-expression partners for ZNF667 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF667 Gene:

ZNF667

SOURCE GeneReport for Unigene cluster for ZNF667 Gene:

Hs.676605

Evidence on tissue expression from TISSUES for ZNF667 Gene

  • Lung(4.2)
  • Heart(2.1)
  • Muscle(2)
genes like me logo Genes that share expression patterns with ZNF667: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF667 Gene

Orthologs for ZNF667 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF667 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ZNF667 34 35
  • 99.67 (n)
cow
(Bos Taurus)
 Mammalia ZNF667 34 35
  • 88.42 (n)
dog
(Canis familiaris)
 Mammalia ZNF667 34 35
  • 88.42 (n)
rat
(Rattus norvegicus)
 Mammalia Zfp667 34
  • 80.8 (n)
mouse
(Mus musculus)
 Mammalia Zfp667 34 16 35
  • 80.01 (n)
Species where no ortholog for ZNF667 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF667 Gene

ENSEMBL:
Gene Tree for ZNF667 (if available)
TreeFam:
Gene Tree for ZNF667 (if available)

Paralogs for ZNF667 Gene

Paralogs for ZNF667 Gene

(504) SIMAP similar genes for ZNF667 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF667: view

Variants for ZNF667 Gene

Sequence variations from dbSNP and Humsavar for ZNF667 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000034281 -- 56,477,642(+) TCAGG(A/C)GATCA upstream-variant-2KB
rs1000115909 -- 56,446,837(+) AGTCA(C/T)ATCAG intron-variant
rs1000136988 -- 56,466,522(+) TCTCT(C/G)GTGCT intron-variant
rs1000188556 -- 56,474,402(+) GAGGC(C/G)AGGGA intron-variant, utr-variant-5-prime
rs1000254031 -- 56,472,527(+) CGGCT(C/T)CTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF667 Gene

Variant ID Type Subtype PubMed ID
dgv6591n54 CNV loss 21841781
esv1044797 CNV insertion 17803354
esv2719037 CNV deletion 23290073
esv2719038 CNV deletion 23290073
esv3304685 CNV mobile element insertion 20981092
esv3309659 CNV mobile element insertion 20981092
esv3324616 CNV insertion 20981092
esv3424509 CNV insertion 20981092
esv3440809 CNV insertion 20981092
nsv1055357 CNV gain 25217958

Variation tolerance for ZNF667 Gene

Residual Variation Intolerance Score: 66.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.97; 79.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF667 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF667

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF667 Gene

Disorders for ZNF667 Gene

Relevant External Links for ZNF667

Genetic Association Database (GAD)
ZNF667
Human Genome Epidemiology (HuGE) Navigator
ZNF667
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF667

No disorders were found for ZNF667 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF667 Gene

Publications for ZNF667 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Mipu1 protects H9c2 myogenic cells from hydrogen peroxide-induced apoptosis through inhibition of the expression of the death receptor Fas. (PMID: 25310648) Wang G. … Xiao X. (Int J Mol Sci 2014) 3 64
  5. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PMID: 23080069) Esteves S.L. … da Cruz e Silva E.F. (J. Mol. Neurosci. 2013) 3 64

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