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Aliases for ZNF667 Gene

Aliases for ZNF667 Gene

  • Zinc Finger Protein 667 2 3 5
  • Myocardial Ischemic Preconditioning Upregulated 1 Ortholog 3
  • MIPU1 3

External Ids for ZNF667 Gene

Previous GeneCards Identifiers for ZNF667 Gene

  • GC19M061644
  • GC19M056951
  • GC19M053259

Summaries for ZNF667 Gene

GeneCards Summary for ZNF667 Gene

ZNF667 (Zinc Finger Protein 667) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription cofactor activity. An important paralog of this gene is ENSG00000256566.

UniProtKB/Swiss-Prot for ZNF667 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF667 Gene

Genomics for ZNF667 Gene

Regulatory Elements for ZNF667 Gene

Enhancers for ZNF667 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F055519 1 FANTOM5 Ensembl ENCODE 19.6 +957.9 957856 1.0 HDGF ATF1 ZNF493 ZNF133 GLI4 YBX1 ZNF416 ZNF548 FOS MCM3 FIZ1 ZNF580 NAT14 U2AF2 SHISA7 ZNF667 ZNF667-AS1 SSC5D SBK3 LOC100506374
GH19F055503 1.1 Ensembl ENCODE 19.6 +974.1 974097 1.6 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF416 ZNF143 ZNF548 U2AF2 ZNF667 FIZ1 ZNF667-AS1 NAT14 LOC100506374 ZNF580 ZNF582-AS1 ENSG00000267523 KMT5C
GH19F056507 1 FANTOM5 ENCODE 14.7 -30.1 -30109 2.1 ZNF76 SIN3A YY1 ZNF121 GLIS2 ZNF366 KLF7 ZNF391 EGR2 ZNF280D ENSG00000269696 ZNF667 ZNF471 ZNF583 ZNF835 ZNF470 ZFP28 ZNF71 SMIM17 ZNF582
GH19F056476 0.2 ENCODE 14.2 +0.6 608 2.8 ZNF76 SIN3A ETS1 YY1 GLIS2 FOS KLF7 ZNF548 EGR2 ZNF280D ZNF667-AS1 ZNF667 ZNF264 U2AF2 ZNF543 ENSG00000267523 ZNF582-AS1 ZNF805 ZNF17 ZNF460
GH19F055671 1.1 ENCODE 13.4 +801.6 801563 10.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF583 ZNF470 ZNF582-AS1 ENSG00000269696 ZNF542P ZNF667-AS1 ENSG00000267224 ZFP28 ZNF667 LOC729999
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ZNF667 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF667 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000349133 65 2800 ZFP64 ZNF76 SIN3A ETS1 YY1 FOS KLF7 ZNF548 EGR2 ZNF280D

Genomic Location for ZNF667 Gene

Chromosome:
19
Start:
56,438,512 bp from pter
End:
56,478,065 bp from pter
Size:
39,554 bases
Orientation:
Minus strand

Genomic View for ZNF667 Gene

Genes around ZNF667 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF667 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF667 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF667 Gene

Proteins for ZNF667 Gene

  • Protein details for ZNF667 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HYK9-ZN667_HUMAN
    Recommended name:
    Zinc finger protein 667
    Protein Accession:
    Q5HYK9
    Secondary Accessions:
    • B2RMS6
    • B9EK36
    • Q6B093
    • Q9H807

    Protein attributes for ZNF667 Gene

    Size:
    610 amino acids
    Molecular mass:
    70161 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH74898.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH74899.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF667 Gene

Post-translational modifications for ZNF667 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF667 Gene

Domains & Families for ZNF667 Gene

Gene Families for ZNF667 Gene

Protein Domains for ZNF667 Gene

Suggested Antigen Peptide Sequences for ZNF667 Gene

Graphical View of Domain Structure for InterPro Entry

Q5HYK9

UniProtKB/Swiss-Prot:

ZN667_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 15 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 15 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF667: view

Function for ZNF667 Gene

Molecular function for ZNF667 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF667 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003712 transcription cofactor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF667: view

Phenotypes for ZNF667 Gene

genes like me logo Genes that share phenotypes with ZNF667: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF667 Gene

Localization for ZNF667 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF667 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF667 Gene COMPARTMENTS Subcellular localization image for ZNF667 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF667 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IBA --
genes like me logo Genes that share ontologies with ZNF667: view

Pathways & Interactions for ZNF667 Gene

SuperPathways for ZNF667 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF667: view

Pathways by source for ZNF667 Gene

2 Reactome pathways for ZNF667 Gene

Gene Ontology (GO) - Biological Process for ZNF667 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ZNF667: view

No data available for SIGNOR curated interactions for ZNF667 Gene

Transcripts for ZNF667 Gene

Unigene Clusters for ZNF667 Gene

Zinc finger protein 667:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF667 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d
SP1: - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - -
SP4: -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: -
SP9: - - - -

Relevant External Links for ZNF667 Gene

GeneLoc Exon Structure for
ZNF667
ECgene alternative splicing isoforms for
ZNF667

Expression for ZNF667 Gene

mRNA expression in normal human tissues for ZNF667 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF667 Gene

This gene is overexpressed in Pituitary (x5.1).

Protein differential expression in normal tissues from HIPED for ZNF667 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF667 Gene



Protein tissue co-expression partners for ZNF667 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF667 Gene:

ZNF667

SOURCE GeneReport for Unigene cluster for ZNF667 Gene:

Hs.676605
genes like me logo Genes that share expression patterns with ZNF667: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ZNF667 Gene

Orthologs for ZNF667 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF667 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF667 34 35
  • 99.67 (n)
cow
(Bos Taurus)
Mammalia ZNF667 34 35
  • 88.42 (n)
dog
(Canis familiaris)
Mammalia ZNF667 34 35
  • 88.42 (n)
rat
(Rattus norvegicus)
Mammalia Zfp667 34
  • 80.8 (n)
mouse
(Mus musculus)
Mammalia Zfp667 34 16 35
  • 80.01 (n)
Species where no ortholog for ZNF667 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF667 Gene

ENSEMBL:
Gene Tree for ZNF667 (if available)
TreeFam:
Gene Tree for ZNF667 (if available)

Paralogs for ZNF667 Gene

Paralogs for ZNF667 Gene

(504) SIMAP similar genes for ZNF667 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ZNF667: view

Variants for ZNF667 Gene

Sequence variations from dbSNP and Humsavar for ZNF667 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10404523 -- 56,475,361(+) ACTAT(C/G)CTTTT intron-variant, utr-variant-5-prime
rs10408270 -- 56,449,440(+) ggagg(C/T)caagg intron-variant
rs10408272 -- 56,450,636(+) aaaga(C/T)ggact intron-variant
rs10408604 -- 56,449,374(+) tcaga(A/G)aattc intron-variant
rs10408921 -- 56,472,359(+) TCTTC(A/G)GTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF667 Gene

Variant ID Type Subtype PubMed ID
dgv6591n54 CNV loss 21841781
esv1044797 CNV insertion 17803354
esv2719037 CNV deletion 23290073
esv2719038 CNV deletion 23290073
esv3304685 CNV mobile element insertion 20981092
esv3309659 CNV mobile element insertion 20981092
esv3324616 CNV insertion 20981092
esv3424509 CNV insertion 20981092
esv3440809 CNV insertion 20981092
nsv1055357 CNV gain 25217958

Variation tolerance for ZNF667 Gene

Residual Variation Intolerance Score: 66.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.97; 79.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF667 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF667

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF667 Gene

Disorders for ZNF667 Gene

Relevant External Links for ZNF667

Genetic Association Database (GAD)
ZNF667
Human Genome Epidemiology (HuGE) Navigator
ZNF667
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF667

No disorders were found for ZNF667 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF667 Gene

Publications for ZNF667 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Mipu1 protects H9c2 myogenic cells from hydrogen peroxide-induced apoptosis through inhibition of the expression of the death receptor Fas. (PMID: 25310648) Wang G. … Xiao X. (Int J Mol Sci 2014) 3 64
  5. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PMID: 23080069) Esteves S.L. … da Cruz e Silva E.F. (J. Mol. Neurosci. 2013) 3 64

Products for ZNF667 Gene

Sources for ZNF667 Gene

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