ZNF667 Gene

Aliases
for ZNF667 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC19M061644 GC19M053259

Summaries
for ZNF667 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for ZNF667 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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SwitchGear Promoter luciferase reporter plasmid: ZNF667 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF667

ZNF667 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M056951:  view genomic region     (about GC identifiers)

Proteins
for ZNF667 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for ZNF667: NX_Q5HYK9

Explore proteomics data for ZNF667 at MOPED

Post-translational modifications: 

ZNF667 Human Recombinant Protein Products:

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	antibodies-online peptides for ZNF667

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	antibodies-online kits for ZNF667 (6 products)

Domains /
Families
for ZNF667 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q5HYK9

Find genes that share domains with ZNF667           About GenesLikeMe

Function
for ZNF667 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for ZNF667

miRNA Products:		miRTarBase miRNAs that target ZNF667: hsa-mir-345-5p (MIRT042727), hsa-mir-21-5p (MIRT030883)
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		Selected qRT-PCR Assays for microRNAs that regulate ZNF667 (see all 12):
		hsa-miR-607 hsa-miR-3155 hsa-miR-455-3p hsa-miR-484 hsa-miR-9 hsa-miR-629* hsa-miR-3920 hsa-miR-29a*
		SwitchGear 3'UTR luciferase reporter plasmid: ZNF667 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ZNF667
		Predesigned siRNA for gene silencing in human, mouse, rat ZNF667

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ZNF667

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF667

Localization
for ZNF667 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	4
cytosol	2

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for ZNF667 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for ZNF667 About     See pathways by source

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	SuperPath	Contained pathways About
1	Gene Expression	Generic Transcription Pathway 0.40 Gene Expression 0.40

1 Reactome Pathway for ZNF667

Generic Transcription Pathway

Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for ZNF667 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for ZNF667 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for ZNF667 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ZNF667 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Limb (Muscoskeletal System)
Prechondrocytic Mesenchymal Cells Zeugopod
Bone (Muscoskeletal System)
Prechondrocytic Mesenchymal Cells Zeugopod
Cartilage (Muscoskeletal System)
Prechondrocytic Mesenchymal Cells Zeugopod

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for ZNF667
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ZNF667
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		QuantiFast Probe-based Assays in human, mouse, rat ZNF667

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF667

Orthologs
for ZNF667 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for ZNF667 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for ZNF667 gene

Selected SIMAP similar genes for ZNF667 using alignment to 7 protein entries:     ZN667_HUMAN (see all proteins) (see all similar genes):

DKFZp686O111    ZFP41    ZNF78L1    kr-znf3    ZNF527    ZNF22

ZNF818P    ZNF83    DKFZp666C237    ZKSCAN8    ZNF677    DKFZp686M04222

ZFS-4    ZFS-5    ZNF232    ZNF702P    ZNF721    ZNF573

Find genes that share paralogs with ZNF667           About GenesLikeMe

Genomic Variants
for ZNF667 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF667 (see all 733)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs730640541,2	C,F	--	56950247(+)	AGGAAA/GTTAGG	2	--	int1		4		CSA WA NA EA	360
rs1435282551,2		--	56950583(+)	TAGGAA/TGACCT	2	--	int1		0	--	--	--	--
rs1908012251,2		--	56950640(+)	GGTATA/TCTCAA	2	--	int1		0	--	--	--	--
rs3729422841,2	C	--	56950706(+)	AATTA-/AAAAAA	4	--	ut31 nc-transcript-variant		0	--	--	--	--
rs1381157171,2	C	--	56950830(+)	ACTCCA/GTATAT	2	--	ut31 nc-transcript-variant		0	--	--	--	--
rs1121990801,2	C,F	--	56950892(+)	ATTTAC/TTTCTC	2	--	ut31 nc-transcript-variant		1		CSA	2
rs1434907551,2		--	56950900(+)	CTCACA/TGTTCT	2	--	ut31 nc-transcript-variant		0	--	--	--	--
rs743786621,2	C	--	56950949(+)	AGGTTC/TTCGTA	2	--	ut31 nc-transcript-variant		0	--	--	--	--
rs1471699701,2	C	--	56951037(+)	ATGTCC/TTTTTG	2	--	ut31 nc-transcript-variant		0	--	--	--	--
rs1138025311,2	F	--	56951062(+)	TCTGTC/TGCCCA	2	--	ut31 nc-transcript-variant		1		CSA	2

HapMap Linkage Disequilibrium report for ZNF667 (56950693 - 56989434 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for ZNF667:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2719038	CNV	Deletion	23290073
esv2719037	CNV	Deletion	23290073
esv1044797	CNV	Insertion	17803354
esv273931	CNV	Insertion	20981092
esv268963	CNV	Insertion	20981092
nsv912516	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ZNF667

DNA2.0 Custom Variant and Variant Library Synthesis for ZNF667

Disorders / Diseases
for ZNF667 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for ZNF667 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
4. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PubMed id 23080069)¹ Esteves S.L....da Cruz e Silva E.F. (J. Mol. Neurosci. 2013)
5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)¹ Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (amp 2011)
7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)¹ Vinayagam A....Wanker E.E. (Sci Signal 2011)
8. Functional analysis of a novel KRAB/C2H2 zinc finger protein Mipu1. (PubMed id 17397802)¹ Jiang L....Xiao X. (Biochem. Biophys. Res. Commun. 2007)
9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (BMC Genomics 2007)
10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)

External Searches for ZNF667 gene

Genome Databases showing ZNF667 gene

Other Databases showing ZNF667 gene

Specialized Databases showing ZNF667 gene

Products
for ZNF667 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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