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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF667 Gene

protein-coding   GIFtS: 50
GCID: GC19M056951

zinc finger protein 667

  Search for ZNF667
in our new
 Human Malady Compendium 
Biological research products
for ZNF667
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 6671 2
MIPU12 5
FLJ140111
Myocardial Ischemic Preconditioning Upregulated 1 Ortholog2

External Ids:    HGNC: 288541   Entrez Gene: 639342   Ensembl: ENSG000001980467   OMIM: 6110245   UniProtKB: Q5HYK93   
ORGUL members:         
NONCODE:n408896    

Export aliases for ZNF667 gene to outside databases

Previous GC identifers: GC19M061644 GC19M053259


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN667_HUMAN, Q5HYK9
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF667 gene promoter:
         PPAR-gamma1   GCNF-1   GCNF   PPAR-gamma2   GCNF-2   POU3F2   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF667 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF667

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF667


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF667 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF667 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M056951:  view genomic region     (about GC identifiers)

Start:
56,950,693 bp from pter      End:
56,989,434 bp from pter
Size:
38,742 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN667_HUMAN, Q5HYK9 (See protein sequence)
Recommended Name: Zinc finger protein 667  
Size: 610 amino acids; 70161 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH74898.2; Type=Erroneous initiation; Sequence=AAH74899.2; Type=Erroneous initiation;
Secondary accessions: B2RMS6 B9EK36 Q6B093 Q9H807

Explore the universe of human proteins at neXtProt for ZNF667: NX_Q5HYK9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5HYK9

  • ZNF667 Protein expression data from MOPED and PaxDb:    About this image 
    ZNF667 Protein Expression
    REFSEQ proteins: NP_071386.3  
    ENSEMBL proteins: 
     ENSP00000468550   ENSP00000439402   ENSP00000292069   ENSP00000467627   ENSP00000468466  
     ENSP00000464708   ENSP00000344699  
    Reactome Protein details: Q5HYK9
    Human Recombinant Protein Products for ZNF667: 
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    OriGene Protein Over-expression Lysate: ZNF667
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    Novus Biologicals ZNF667 Protein
    Novus Biologicals ZNF667 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ZNF667

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF667 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ZNF667


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ZNF667 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q5HYK9

    ProtoNet protein and cluster: Q5HYK9

    1 Blocks protein family: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN667_HUMAN, Q5HYK9
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 15 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN667_HUMAN, Q5HYK9
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding IEA--
         
    ZNF667 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ZNF667 

    miRNA
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    hsa-miR-607 hsa-miR-3155 hsa-miR-455-3p hsa-miR-484 hsa-miR-9 hsa-miR-629* hsa-miR-3920 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidZNF667 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF667 (see all 7)
    OriGene shRNA RFP: ZNF667
    OriGene siRNA: ZNF667
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF667


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for ZNF667
        Generic Transcription Pathway
    Gene Expression



    ZNF667 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF667

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF667 (Q5HYK92, 3 ENSP000002920694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC37Q165432, 3, ENSP000002220054MINT-8251054 I2D: score=2 STRING: ENSP00000222005
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF667 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF667
    Search CenterWatch for drugs/clinical trials and news about ZNF667 / ZN667 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF667 gene: 
    NM_022103.3  

    Unigene Cluster for ZNF667:

    Zinc finger protein 667
    Hs.676605  [show with all ESTs]
    Unigene Representative Sequence: NR_030740
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591790 ENST00000504904(uc010etl.3 uc002qne.3) ENST00000292069(uc002qnd.3 uc010etm.3)
    ENST00000592189 ENST00000587555 ENST00000589946 ENST00000589652 ENST00000342634


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ZNF667
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF667 (see all 12):
    hsa-miR-607 hsa-miR-3155 hsa-miR-455-3p hsa-miR-484 hsa-miR-9 hsa-miR-629* hsa-miR-3920 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidZNF667 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    OriGene shRNA RFP: ZNF667
    OriGene siRNA: ZNF667
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    Sirion Biotech Custom design and validation of potent shRNA sequences against ZNF667 
    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF667
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF667

    Additional cDNA sequence: 

    AK024073.1 AK056508.1 AK096513.1 AK126957.1 AK127426.1 BC074898.2 BC074899.2 BC136388.1 
    BC150593.1 BX647401.1 CR936605.1 NR_030740.1 

    10 DOTS entries:

    DT.86838648  DT.40214309  DT.100776896  DT.101963835  DT.101967259  DT.100776897  DT.100033642  DT.121433102 
    DT.86675503  DT.99937747 

    24/52 AceView cDNA sequences (see all 52):

    AW274693 BX280032 CD108954 AK056508 N45689 BX506784 BX642001 AI969366 
    AI678781 BC074898 AI699607 AI985791 BC074899 AL040559 W01780 AL709810 
    AW451117 AK127426 AU143773 BM479859 AK096513 BX642000 NM_022103 AK024073 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF667 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d
    SP1:                          -     -           -                 -                                   -                           
    SP2:        -     -     -     -     -     -     -     -     -     -                                   -                           
    SP3:                          -     -     -     -     -     -     -                                   -                           
    SP4:                                                              -                                                               
    SP5:                          -     -     -     -     -     -     -           -     -                 -                           


    ECgene alternative splicing isoforms for ZNF667

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF667 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    ZNF667 Expression
    About this image
    See ZNF667 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF667

    SOURCE GeneReport for Unigene cluster: Hs.676605
        SABiosciences Custom PCR Arrays for ZNF667

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF667

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF667 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6671 , 5 zinc finger protein 6671, 5 80.01(n)1
    74.79(a)1
      7 (3.64 cM)5
    3847631  NM_001024928.21  NP_001020099.11 
     62865795 


    ENSEMBL Gene Tree for ZNF667 (if available)
    TreeFam Gene Tree for ZNF667 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/661 NCBI SNPs in ZNF667 are shown (see all 661    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs730640541,2
    C--56950247(+) AGGAAA/GTTAGG 2 -- int14Minor allele frequency- G:0.15CSA WA NA EA 360
    rs1435282551,2
    --56950583(+) TAGGAA/TGACCT 2 -- int10--------
    rs1908012251,2
    --56950640(+) GGTATA/TCTCAA 2 -- int10--------
    rs1381157171,2
    --56950830(+) ACTCCA/GTATAT 2 -- nc-transcript-variantut310--------
    rs1121990801,2
    --56950892(+) ATTTAC/TTTCTC 2 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.50CSA 2
    rs1434907551,2
    --56950900(+) CTCACA/TGTTCT 2 -- nc-transcript-variantut310--------
    rs743786621,2
    C--56950949(+) AGGTTC/TTCGTA 2 -- ut31 nc-transcript-variant0--------
    rs1471699701,2
    --56951037(+) ATGTCC/TTTTTG 2 -- ut31 nc-transcript-variant0--------
    rs1138025311,2
    --56951062(+) TCTGTC/TGCCCA 2 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.50CSA 2
    rs1865639321,2
    --56951213(+) CAGTGC/GAGACG 2 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for ZNF667 (56950693 - 56989434 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ZNF667: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF667
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF667

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF667 for disorders           About MalaCards

    ZNF667 for disorders           About GeneDecksing

    OMIM gene information: 611024    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: ZNF667 (1 document)

    Export disorders for ZNF667 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF667 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF667)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    4. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. Functional analysis of a novel KRAB/C2H2 zinc finger protein Mipu1. (PubMed id 17397802)1 Jiang L....Xiao X. (2007)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 63934 HGNC: 28854 AceView: FLJ14011 Ensembl:ENSG00000198046 euGenes: HUgn63934
    ECgene: ZNF667 H-InvDB: ZNF667

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF667 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF667 gene:
    Search GeneIP for patents involving ZNF667

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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