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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF667 Gene

protein-coding   GIFtS: 54
GCID: GC19M056951

Zinc Finger Protein 667

  Search for ZNF667
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Zinc Finger Protein 6671 2
MIPU12 5
Myocardial Ischemic Preconditioning Upregulated 1 Ortholog2

External Ids:    HGNC: 288541   Entrez Gene: 639342   Ensembl: ENSG000001980467   OMIM: 6110245   UniProtKB: Q5HYK93   
ORGUL members:         
NONCODE14:n338959 n408896      

Export aliases for ZNF667 gene to outside databases

Previous GC identifers: GC19M061644 GC19M053259


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF667 Gene: 
ZNF667 (zinc finger protein 667) is a protein-coding gene, and is affiliated with the lncRNA class. Among its related super-pathways are Gene Expression. GO annotations related to this gene include DNA binding and zinc ion binding.

UniProtKB/Swiss-Prot: ZN667_HUMAN, Q5HYK9
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF667 gene promoter:
         PPAR-gamma1   GCNF-1   GCNF   PPAR-gamma2   GCNF-2   POU3F2   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF667 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF667

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF667


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

ZNF667 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF667 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M056951:  view genomic region     (about GC identifiers)

Start:
56,950,693 bp from pter      End:
56,989,434 bp from pter
Size:
38,742 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for ZNF667

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN667_HUMAN, Q5HYK9 (See protein sequence)
Recommended Name: Zinc finger protein 667  
Size: 610 amino acids; 70161 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH74898.2; Type=Erroneous initiation; Sequence=AAH74899.2; Type=Erroneous initiation;
Secondary accessions: B2RMS6 B9EK36 Q6B093 Q9H807

Explore the universe of human proteins at neXtProt for ZNF667: NX_Q5HYK9

Explore proteomics data for ZNF667 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5HYK9

  • ZNF667 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF667 Protein Expression
    REFSEQ proteins: NP_071386.3  
    ENSEMBL proteins: 
     ENSP00000468550   ENSP00000439402   ENSP00000292069   ENSP00000467627   ENSP00000468466  
     ENSP00000464708   ENSP00000344699  
    Reactome Protein details: Q5HYK9
    Human Recombinant Protein Products for ZNF667: 
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    Cloud-Clone Corp. Proteins for ZNF667 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF667 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR001909 Krueppel-associated_box
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q5HYK9

    ProtoNet protein and cluster: Q5HYK9

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN667_HUMAN, Q5HYK9
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 15 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF667 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN667_HUMAN, Q5HYK9
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF667 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidZNF667 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ZNF667 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Generic Transcription Pathway
    Generic Transcription Pathway0.47
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for ZNF667
        Generic Transcription Pathway
    Gene Expression



    ZNF667 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF667

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF667 (Q5HYK92, 3 ENSP000002920694) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC37Q165432, 3, ENSP000002220054MINT-8251054 I2D: score=2 STRING: ENSP00000222005
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF667 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF667 (ZN667)

    Search CenterWatch for drugs/clinical trials and news about ZNF667 / ZN667

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF667 gene: 
    NM_022103.3  

    Unigene Cluster for ZNF667:

    Zinc finger protein 667
    Hs.676605  [show with all ESTs]
    Unigene Representative Sequence: NR_030740
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591790 ENST00000504904(uc010etl.3 uc002qne.3) ENST00000292069(uc002qnd.3 uc010etm.3)
    ENST00000592189 ENST00000587555 ENST00000589946 ENST00000589652 ENST00000342634

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate ZNF667 (see all 12):
    hsa-miR-607 hsa-miR-3155 hsa-miR-455-3p hsa-miR-484 hsa-miR-9 hsa-miR-629* hsa-miR-3920 hsa-miR-29a*
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF667

    Additional mRNA sequence: 

    AK024073.1 AK056508.1 AK096513.1 AK126957.1 AK127426.1 BC074898.2 BC074899.2 BC136388.1 
    BC150593.1 BX647401.1 CR936605.1 NR_030740.1 

    10 DOTS entries:

    DT.86838648  DT.40214309  DT.100776896  DT.101963835  DT.101967259  DT.100776897  DT.100033642  DT.121433102 
    DT.86675503  DT.99937747 

    24/52 AceView cDNA sequences (see all 52):

    BX280032 BC074899 AL709810 N45689 CD108954 AI969366 AL040559 W01780 
    BX506784 BC074898 AI699607 AK127426 AI678781 AW451117 AW274693 AK056508 
    AI985791 BX642001 AK126957 AA020835 BX642000 AK096513 BG329738 BM479859 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF667 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d
    SP1:                          -     -           -                 -                                   -                           
    SP2:        -     -     -     -     -     -     -     -     -     -                                   -                           
    SP3:                          -     -     -     -     -     -     -                                   -                           
    SP4:                                                              -                                                               
    SP5:                          -     -     -     -     -     -     -           -     -                 -                           


    ECgene alternative splicing isoforms for ZNF667

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF667 expression in normal human tissues (normalized intensities)      ZNF667 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF667 Expression
    About this image


    ZNF667 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Limb (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod

    See ZNF667 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF667

    SOURCE GeneReport for Unigene cluster: Hs.676605
        SABiosciences Custom PCR Arrays for ZNF667
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF667 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6671 , 5 zinc finger protein 6671, 5 80.01(n)1
    74.79(a)1
      7 (3.64 cM)5
    3847631  NM_001024928.21  NP_001020099.11 
     62865795 


    ENSEMBL Gene Tree for ZNF667 (if available)
    TreeFam Gene Tree for ZNF667 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF667 gene
    18/503 SIMAP similar genes for ZNF667 using alignment to 7 protein entries:     ZN667_HUMAN (see all proteins) (see all similar genes):
    DKFZp686O111    ZFP41    ZNF78L1    kr-znf3    ZNF527    ZNF22
    ZNF818P    ZNF83    DKFZp666C237    ZKSCAN8    ZNF677    ZNF721
    DKFZp686M04222    ZFS-4    ZFS-5    ZNF232    ZNF702P    ZNF573

    ZNF667 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/733 SNPs in ZNF667 are shown (see all 733)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs730640541,2
    C,F--56950247(+) AGGAAA/GTTAGG 2 -- int14Minor allele frequency- G:0.15CSA WA NA EA 360
    rs1435282551,2
    --56950583(+) TAGGAA/TGACCT 2 -- int10--------
    rs1908012251,2
    --56950640(+) GGTATA/TCTCAA 2 -- int10--------
    rs3729422841,2
    C--56950706(+) AATTA-/AAAAAA 4 -- ut31 nc-transcript-variant0--------
    rs1381157171,2
    C--56950830(+) ACTCCA/GTATAT 2 -- ut31 nc-transcript-variant0--------
    rs1121990801,2
    C,F--56950892(+) ATTTAC/TTTCTC 2 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.50CSA 2
    rs1434907551,2
    --56950900(+) CTCACA/TGTTCT 2 -- ut31 nc-transcript-variant0--------
    rs743786621,2
    C--56950949(+) AGGTTC/TTCGTA 2 -- ut31 nc-transcript-variant0--------
    rs1471699701,2
    C--56951037(+) ATGTCC/TTTTTG 2 -- ut31 nc-transcript-variant0--------
    rs1138025311,2
    F--56951062(+) TCTGTC/TGCCCA 2 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for ZNF667 (56950693 - 56989434 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ZNF667:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2719038CNV Deletion23290073
    esv2719037CNV Deletion23290073
    esv1044797CNV Insertion17803354
    esv273931CNV Insertion20981092
    esv268963CNV Insertion20981092
    nsv912516CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF667 for disorders           About MalaCards
    OMIM gene information: 611024    OMIM disorders: --


    ZNF667 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ZNF667
    Human Genome Epidemiology (HuGE) Navigator: ZNF667 (1 document)

    Export disorders for ZNF667 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF667 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with ZNF667)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Protein phosphatase 1g isoforms linked interactions in the brain. (PubMed id 23080069)1 Esteves S.L....da Cruz e Silva E.F. (2013)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    7. Functional analysis of a novel KRAB/C2H2 zinc finger protein Mipu1. (PubMed id 17397802)1 Jiang L....Xiao X. (2007)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 63934 HGNC: 28854 AceView: FLJ14011 Ensembl:ENSG00000198046 euGenes: HUgn63934
    ECgene: ZNF667 H-InvDB: ZNF667

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF667 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF667 gene:
    Search GeneIP for patents involving ZNF667

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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