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Aliases for ZNF665 Gene

Aliases for ZNF665 Gene

  • Zinc Finger Protein 665 2 3 5
  • ZFP160L 3 4
  • Zinc Finger Protein 160-Like 4

External Ids for ZNF665 Gene

Previous GeneCards Identifiers for ZNF665 Gene

  • GC19M058358
  • GC19M053667
  • GC19M049990

Summaries for ZNF665 Gene

GeneCards Summary for ZNF665 Gene

ZNF665 (Zinc Finger Protein 665) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF160.

UniProtKB/Swiss-Prot for ZNF665 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF665 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF665 Gene

Genomics for ZNF665 Gene

Regulatory Elements for ZNF665 Gene

Enhancers for ZNF665 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H053977 1.3 Ensembl ENCODE 39.9 -786.6 -786566 5.8 HDGF PKNOX1 SIN3A FEZF1 ZNF2 ZNF766 ZNF143 SP3 NFYC REST PRPF31 ZNF525 LENG8-AS1 ZNF160 ZNF845 ZNF665 ZNF761 ZNF347 LENG8 ENSG00000235681
GH19H054186 1.4 ENCODE dbSUPER 32.4 -996.2 -996226 6.8 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 PRPF31 ZNF665 LENG8 LENG8-AS1 CNOT3 ZNF845 ZNF525 ZNF677 ENSG00000269001 ENSG00000269288
GH19H053864 1.8 FANTOM5 ENCODE dbSUPER 13.8 -675.5 -675519 9.8 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 FOS ENSG00000269001 ZNF845 ZNF765 ZNF816 LENG8 ENSG00000235681 ZNF813 TPM3P6 ZNF160 LENG8-AS1
GH19H053517 1.1 ENCODE 22 -326.2 -326219 4.8 PKNOX1 ARNT ARID4B SIN3A YY1 ZNF766 ZNF143 SP3 ZHX2 MXD4 ZNF137P LENG8-AS1 PRPF31 ZNF160 ZNF761 ZNF525 ZNF611 LENG8 ZNF665 ZNF677
GH19H053881 1.4 Ensembl ENCODE dbSUPER 14.8 -689.0 -689046 2.9 RB1 KLF17 SIN3A GLI4 BMI1 ZBTB40 RAD21 ZEB1 GLIS2 EGR1 ZNF845 ENSG00000235681 ENSG00000269001 ZNF665 LENG8-AS1 LENG8 ZNF347 ZNF160 PRPF31 ZNF761
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF665 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF665 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Transcription factor binding sites by QIAGEN in the ZNF665 gene promoter:

Genomic Locations for ZNF665 Gene

Genomic Locations for ZNF665 Gene
34,184 bases
Minus strand

Genomic View for ZNF665 Gene

Genes around ZNF665 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF665 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF665 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF665 Gene

Proteins for ZNF665 Gene

  • Protein details for ZNF665 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 665
    Protein Accession:
    Secondary Accessions:
    • A8K5T8

    Protein attributes for ZNF665 Gene

    613 amino acids
    Molecular mass:
    70223 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF665 Gene


neXtProt entry for ZNF665 Gene

Post-translational modifications for ZNF665 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF665 Gene

No data available for DME Specific Peptides for ZNF665 Gene

Domains & Families for ZNF665 Gene

Gene Families for ZNF665 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF665 Gene

Suggested Antigen Peptide Sequences for ZNF665 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF665: view

Function for ZNF665 Gene

Molecular function for ZNF665 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF665 Gene

Gene Ontology (GO) - Molecular Function for ZNF665 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF665: view
genes like me logo Genes that share phenotypes with ZNF665: view

Animal Model Products

CRISPR Products

miRNA for ZNF665 Gene

miRTarBase miRNAs that target ZNF665

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF665 Gene

Localization for ZNF665 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF665 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF665 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF665 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF665: view

Pathways & Interactions for ZNF665 Gene

SuperPathways for ZNF665 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF665: view

Pathways by source for ZNF665 Gene

2 Reactome pathways for ZNF665 Gene

Interacting Proteins for ZNF665 Gene

Gene Ontology (GO) - Biological Process for ZNF665 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF665: view

No data available for SIGNOR curated interactions for ZNF665 Gene

Drugs & Compounds for ZNF665 Gene

No Compound Related Data Available

Transcripts for ZNF665 Gene

Unigene Clusters for ZNF665 Gene

Zinc finger protein 665:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF665 Gene

No ASD Table

Relevant External Links for ZNF665 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF665 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF665 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF665 Gene

Protein tissue co-expression partners for ZNF665 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF665 Gene:


SOURCE GeneReport for Unigene cluster for ZNF665 Gene:


Evidence on tissue expression from TISSUES for ZNF665 Gene

  • Thyroid gland(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF665: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF665 Gene

Orthologs for ZNF665 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF665 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF665 33 34
  • 98.92 (n)
(Rattus norvegicus)
Mammalia LOC100365363 33
  • 72.65 (n)
(Mus musculus)
Mammalia Zfp160 33 16 34
  • 71.47 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
-- 34
  • 40 (a)
(Bos Taurus)
Mammalia -- 34
  • 50 (a)
Species where no ortholog for ZNF665 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF665 Gene

Gene Tree for ZNF665 (if available)
Gene Tree for ZNF665 (if available)

Paralogs for ZNF665 Gene

(538) SIMAP similar genes for ZNF665 Gene using alignment to 1 proteins: Pseudogenes for ZNF665 Gene

genes like me logo Genes that share paralogs with ZNF665: view

Variants for ZNF665 Gene

Sequence variations from dbSNP and Humsavar for ZNF665 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000268467 -- 53,191,708(+) GTGTG(A/G)TGGTG intron-variant
rs1000301168 -- 53,191,462(+) AATTA(C/T)AAAAT intron-variant
rs1000315901 -- 53,179,561(+) GCATA(C/T)CCAGG intron-variant
rs1000355836 -- 53,192,965(+) CTAAC(A/G)CTCCA intron-variant
rs1000477979 -- 53,171,184(+) TTTCA(C/G)CATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF665 Gene

Variant ID Type Subtype PubMed ID
nsv960867 CNV duplication 23825009
nsv956581 CNV deletion 24416366
nsv580078 CNV gain 21841781
nsv580077 CNV loss 21841781
nsv512592 CNV loss 21212237
nsv435701 CNV deletion 17901297
nsv1146588 CNV deletion 26484159
nsv1141887 OTHER inversion 24896259
nsv1078889 OTHER inversion 25765185
nsv1071945 CNV deletion 25765185
esv3893240 CNV loss 25118596
esv3644743 CNV loss 21293372
esv3644742 CNV gain 21293372
esv3644741 CNV gain 21293372
esv3644740 CNV gain 21293372
esv3574753 CNV gain 25503493
esv3556584 CNV deletion 23714750
esv2762999 CNV gain 21179565
esv2718813 CNV deletion 23290073
esv2718812 CNV deletion 23290073
esv2718787 CNV deletion 23290073
esv2611703 CNV deletion 19546169
esv1301232 CNV deletion 17803354
esv1006343 CNV deletion 20482838
dgv430n27 CNV gain 19166990
dgv3644n100 CNV gain 25217958
dgv1812n106 CNV deletion 24896259

Variation tolerance for ZNF665 Gene

Residual Variation Intolerance Score: 98.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF665 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF665 Gene

Disorders for ZNF665 Gene

Relevant External Links for ZNF665

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF665 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF665 Gene

Publications for ZNF665 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Genome-wide association study to identify genetic determinants of severe asthma. (PMID: 22561531) Wan YI … Hall IP (Thorax 2012) 3 60
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 60

Products for ZNF665 Gene

Sources for ZNF665 Gene

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