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ZNF664-FAM101A Gene

protein-coding   GIFtS: 16
GCID: GC12P124459

Protein FAM101A


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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein FAM101A2
ZNF664-FAM101A Readthrough2

External Ids:    Entrez Gene: 1005331832   

Export aliases for ZNF664-FAM101A gene to outside databases

Previous GC identifer: GC12U901544


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ZNF664-FAM101A Gene:
This locus represents naturally occurring read-through transcription between the neighboring zinc finger protein
664 (GeneID 144348) and hypothetical protein LOC144347 (GeneID 144347) genes on chromosome 12. The read-through
transcript produces a protein that shares sequence identity with the downstream hypothetical protein LOC144347
locus. (provided by RefSeq, Feb 2011)

GeneCards Summary for ZNF664-FAM101A Gene:
ZNF664-FAM101A is a protein-coding gene. An important paralog of this gene is FAM101A.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF664-FAM101A
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF664-FAM101A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   

ZNF664-FAM101A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF664-FAM101A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P124459:  view genomic region     (about GC identifiers)

Start:
124,457,762 bp from pter      End:
124,800,570 bp from pter
Size:
342,809 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB: --
REFSEQ proteins: NP_001191228.1  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZNF664-FAM101A gene: 
NM_001204299.1  

Unigene Cluster for ZNF664-FAM101A:

Protein FAM101A
Hs.432901  [show with all ESTs]
Unigene Representative Sequence: NM_001204299
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Additional mRNA sequence: 

AK074545.1 AK126577.1 BC026875.1 BC042102.1 BC067283.1 BC085606.1 BC141805.1 

6 DOTS entries:

DT.99964166  DT.312376  DT.101981274  DT.100780729  DT.100780730  DT.100728229 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --


ZNF664-FAM101A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 9) fully expand
 
 Gonad
         Primordial Germ Cells Allantois
         Primordial germ cell-like cells
 
 Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
         Epiblast Stem Cell line 5
 
 Bone (Muscoskeletal System)
         Zeugopod Growth Plate
 
 Somite (Muscoskeletal System)
         Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
 
 Germ Cells (Reproductive System)
         Primordial germ cell-like cells
ZNF664-FAM101A Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.432901
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for ZNF664-FAM101A gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Fam101a1 , 5 family with sequence similarity 101, member A1, 5 80.74(n)1
75.56(a)1
  5 (63.95 cM)5
731211  NM_028443.21  NP_082719.11 
 1250034475 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF664-FAM101A gene
FAM101A  

Find genes that share paralogs with ZNF664-FAM101A           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ZNF664-FAM101A (see all 5772)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1116992111,2
C--121564778(+) ATTTAGTGTGTG 
 TGTGT
/-
GTGTG
1 -- int11Minor allele frequency- -:0.50CSA 2
rs1426215861,2
C--124500561(+) TGTGCC/TGCAGT 1 -- int10--------
rs73015471,2
C,F,A--124500676(+) GTGGGG/AGGTGG 1 -- int14Minor allele frequency- A:0.35NA WA 124
rs106061851,2
C--124500723(+) TGGTG-/AATCTGC 1 -- int11Minor allele frequency- AA:0.00CSA 2
rs1815496861,2
--124500885(+) GGGCAC/GAGCTC 1 -- int10--------
rs1505864861,2
--124500909(+) AGAAAC/TTGAAG 1 -- int10--------
rs761275171,2
C,F--124500911(+) AAATTG/AAAGAG 1 -- int11Minor allele frequency- A:0.02WA 118
rs1862059991,2
--124500953(+) GATTCC/TTTCCA 1 -- int10--------
rs123104081,2
C,F,H--124500994(+) AAAATT/GTTTGA 1 -- int16Minor allele frequency- G:0.05NS EA WA 474
rs734094281,2
C,F--124501144(+) ACAGGG/TCAAGA 1 -- int13Minor allele frequency- T:0.38WA 122

HapMap Linkage Disequilibrium report for ZNF664-FAM101A (124457762 - 124707762 bp, first 250kb of ZNF664-FAM101A)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for ZNF664-FAM101A (see all 31):    About this table    
Variant IDTypeSubtypePubMed ID
esv2675611CNV Deletion23128226
esv2746517CNV Deletion23290073
esv995708CNV Deletion20482838
esv2746515CNV Deletion23290073
esv2746520CNV Deletion23290073
esv2746518CNV Deletion23290073
esv2746516CNV Deletion23290073
esv2746521CNV Deletion23290073
esv2669580CNV Deletion23128226
esv2672400CNV Deletion23128226

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF664-FAM101A gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF664-FAM101A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network. (PubMed id 23149075)1 Aslibekyan S....Arnett D.K. (Nutr Metab Cardiovasc Dis 2013)
  2. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)
  4. Biological, clinical and population relevance of 95 loci for blood lipids. (PubMed id 20686565)1 Teslovich T.M....Kathiresan S. (Nature 2010)
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  6. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1 Scherer S.E.... Gibbs R.A. (Nature 2006)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100533183 euGenes: HUgn100533183

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF664-FAM101A gene:
Search GeneIP for patents involving ZNF664-FAM101A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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