ZNF664 Gene
protein-coding GIFtS: 50
GCID: GC12P124457
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zinc finger protein 664(Previous name: zinc finger protein 176 ) (Previous symbol: ZNF176)
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Aliases for ZNF664 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6641 2 | | Zinc Finger Protein From Organ Of Corti2 3 | | Zinc Finger Protein 1761 2 3 | | DKFZp761B1281 | | ZFOC11 2 3 | | Zinc Finger Organ Of Corti 12 | | ZNF1761 2 | | ZNF1963 |
Export aliases for ZNF664 gene to outside databasesPrevious GC identifers: GC12P122983 GC12P121419 |
Summaries for ZNF664 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: ZN664_HUMAN, Q8N3J9Function: May be involved in transcriptional regulation Gene Wiki entry for ZNF664
|
Genomic Views for ZNF664 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009755.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ZNF664 gene promoter: STAT5A E4BP4 E47 c-Ets-1 Evi-1 Arnt Hand1 Sox9 Pax-4a ATF Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF664
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF664 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24ZNF664 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P124457: view genomic region
(about GC identifiers)
Start:
|
124,456,392 bp from pter |
End:
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124,499,974 bp from pter |
Size:
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43,583 bases |
Orientation:
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plus strand |
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Proteins for ZNF664 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ZN664_HUMAN, Q8N3J9 (See
protein sequence)Recommended Name: Zinc finger protein 664 Size: 261 amino acids; 30284 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B3KP97 Q15914 Q3ZCQ7Explore the universe of human proteins at neXtProt for ZNF664: NX_Q8N3J9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N3J9 ZNF664 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001191227.1 NP_689650.1 ENSEMBL proteins: ENSP00000441405 ENSP00000376205 ENSP00000440645 ENSP00000337320 Reactome Protein details: Q8N3J9 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IDA | -- |
ZNF664 for ontologies About GeneDecksing
ZNF664 Antibody Products: Assay Products for ZNF664: |
Protein
Domains / Families for ZNF664 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF664 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N3J9ProtoNet protein and cluster: Q8N3J9 UniProtKB/Swiss-Prot: ZN664_HUMAN, Q8N3J9Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 9 C2H2-type zinc fingers |
Function for ZNF664 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ZN664_HUMAN, Q8N3J9Function: May be involved in transcriptional regulation
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF664 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF664 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF664 (NM_152437) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF664 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF664  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF664 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
ZNF664 for ontologies About GeneDecksing
|
Pathways & Interactions for ZNF664 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
2
Reactome Pathways for ZNF664
ZNF664 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF664
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 1 Interacting protein for ZNF664 (ENSP000003373204) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
ZNF664 for ontologies About GeneDecksing
|
Drugs & Compounds for ZNF664 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for ZNF664 Search CenterWatch for drugs/clinical trials and news about ZNF664 / ZN664 
|
Transcripts for ZNF664 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ZNF664 gene (2 alternative transcripts): NM_001204298.1 NM_152437.2 Unigene Cluster for ZNF664: Zinc finger protein 664 Hs.524828 [show with all ESTs]Unigene Representative Sequence: AL83426614 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000537532 ENST00000539644 ENST00000392404 ENST00000541448 ENST00000538932(uc001ugb.3 uc001uga.3) ENST00000542820 ENST00000540009 ENST00000542493 ENST00000543017 ENST00000539257 ENST00000337815 ENST00000546098 ENST00000539501 ENST00000540498
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF664 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF664 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF664 (NM_152437) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF664 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF664  |
Additional cDNA sequence: AF024695.1 AK023009.1 AK056034.1 AL834266.1 BC017960.1 BC033539.1 BC037793.2 BC051696.1 BC093848.1 BC101530.1 BX647762.1 L41669.1 16 DOTS entries: DT.100793214 DT.95216541 DT.97846813 DT.121181434 DT.101983814 DT.305261 DT.101957374 DT.95213857 DT.100793210 DT.121181297 DT.121181305 DT.75149050 DT.121181286 DT.121310489 DT.91974188 DT.97811948 24/341 AceView cDNA sequences (see all 341): BM978639 W05082 H89004 AI261831 BE765379 BM724166 BE765371 AI279001 BC037793 AA972508 AV727330 BQ028564 BP872679 CB854801 CR607556 AI499971 AL582225 BM720118 AU134529 BI496822 AI222714 BQ188022 BU689997 AA487934 GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF664 (see all 12) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | · | 12e | · | 12f | · | 12g | |
| SP1: | |   | |   | - |   | |   | - |   | |   | - |   | - |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | - |   | - |   | |   | - |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | |   | - |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | |   | - |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for ZNF664
|
Expression for ZNF664 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF664 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CTGTTGCTGG
About this image See ZNF664 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ZNF664
SOURCE GeneReport for Unigene cluster: Hs.524828 SABiosciences Custom PCR Arrays for ZNF664
Primer Products: |  | Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF664 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF664 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF664 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF664 |
Orthologs for ZNF664 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ZNF664 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for ZNF664 (if available) TreeFam Gene Tree for ZNF664 (if available)  |
Paralogs for ZNF664 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ZNF664 gene
- ZNF2292 ZNF2232 ZNF2302 ENSG000000623702 ZNF1552 ZNF2272 ZNF2392 ZNF2342
- ZNF2242 ZNF2252 ZNF2262 ZNF2142 ZNF2222 ZNF2842 ENSG000002671732 ZNF452
- ZNF2352 ZNF2212 ZNF2852 ENSG000002670222 ZNF2332
18/580 SIMAP similar genes for ZNF664 using alignment to 2 protein entries: ZN664_HUMAN (see all proteins)
(see all similar genes):ZNF78L1 ZNF239 ZNF214 ZFP37 ZFP2 ZNF383 ZNF391 ZNF485 ZNF782 ZNF624 ZNF658 ZNF879 ZNF35 ZNF397 ZNF79 DKFZp666C237 DKFZp761O1618 HZF36
ZNF664 for paralogs About GeneDecksing
|
Genomic Variants for ZNF664 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 12 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF664 (124456392 - 124499974 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 5 variations for ZNF664 3 CNVs: 66352 76170 58555 2 Indels: 58554 76171  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF664 |
|
Disorders
/ Diseases for ZNF664 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF664 for disorders About GeneDecksing
4 diseases for ZNF664: About MalaCardsautosomal dominant nonsyndromic deafness nonsyndromic deafness gastric cancer cholesterol Human Genome Epidemiology (HuGE) Navigator: ZNF664 (2 documents) Export disorders for ZNF664 gene to outside databases
|
Publications for ZNF664 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF664 gene, integrated from 9 sources (see all 17): (articles sorted by number of sources associating them with ZNF664) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A novel zinc finger gene preferentially expressed in the retina and the organ of Corti localizes to human chromosome 12q24.3. (PubMed id 8634327)1, 2 Rivolta M.N.... Wilcox E.R. (1996)
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
- Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1 Teslovich T.M....Kathiresan S. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Forty-three loci associated with plasma lipoprotein s ize, concentration, and cholesterol content in genome-wide analysis. (PubMed id 19936222)1 Chasman D.I....Ridker P.M. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
|
External Searches for ZNF664 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ZNF664 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF664 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF664 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ZNF664 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF664 gene: Search GeneIP for patents involving ZNF664
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ZNF664 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF664 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF664 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF664 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF664 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF664 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF664 |
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| | | Search Tocris compounds for ZNF664 |
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 | | ZNF664 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF664 |
|  |  |  | | | ThermoFisher Antibodies for ZNF664 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF664 |
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