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Aliases for ZNF664 Gene

Aliases for ZNF664 Gene

  • Zinc Finger Protein 664 2 3 5
  • Zinc Finger Protein 176 2 3 4
  • Zinc Finger Protein From Organ Of Corti 3 4
  • ZFOC1 3 4
  • Zinc Finger, Organ Of Corti 1 2
  • Zinc Finger Organ Of Corti 1 3
  • ZNF176 3
  • ZNF196 4

External Ids for ZNF664 Gene

Previous HGNC Symbols for ZNF664 Gene

  • ZNF176

Previous GeneCards Identifiers for ZNF664 Gene

  • GC12P122983
  • GC12P124457
  • GC12P121419

Summaries for ZNF664 Gene

GeneCards Summary for ZNF664 Gene

ZNF664 (Zinc Finger Protein 664) is a Protein Coding gene. Diseases associated with ZNF664 include Deafness, Autosomal Dominant 41 and Deafness, Autosomal Dominant 25. Among its related pathways are Gene Expression. An important paralog of this gene is ZNF214.

UniProtKB/Swiss-Prot for ZNF664 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF664 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF664 Gene

Genomics for ZNF664 Gene

Regulatory Elements for ZNF664 Gene

Enhancers for ZNF664 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G123907 0.8 Ensembl 19.8 -63.7 -63745 0.6 PKNOX1 KLF17 SIN3A RAD21 ZNF48 ZNF366 ZHX1 EGR2 ZNF263 ZNF202 DNAH10 ZNF664 DNAH10OS CCDC92 RFLNA GC12P123897 ENSG00000270028
GH12G124005 1.4 Ensembl ENCODE dbSUPER 11.2 +34.9 34866 1.7 HDAC1 ATF1 CBX3 RB1 NFXL1 RAD21 TCF12 GATA2 ZNF366 KLF13 DNAH10 DNAH10OS ZNF664 CCDC92 RFLNA PIR55353 ENSG00000275389
GH12G124029 1.4 Ensembl ENCODE dbSUPER 11.1 +58.9 58919 1.8 PKNOX1 ZSCAN4 SIN3A ZBTB40 GATA2 EGR1 SCRT2 FOS OVOL3 USF2 CCDC92 RFLNA ZNF664 GTF2H3 DNAH10OS PIR55353 ENSG00000275389
GH12G123900 0.7 ENCODE 19.4 -70.6 -70587 0.7 USF1 JUN MAX SIN3A RBBP5 ZFHX2 POLR2A EGR1 NFYB SCRT2 ZNF664 DNAH10OS CCDC92 GC12P123897 ENSG00000270028
GH12G123937 1.3 Ensembl ENCODE 10.3 -33.7 -33651 2.0 HDGF PKNOX1 CREB3L1 SIN3A ZNF2 ZBTB7B YY1 GLIS2 ZNF766 KLF7 CCDC92 DNAH10OS ZNF664 PIR47036 PIR34615
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF664 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF664 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058798 -215 3201 HDGF ARID4B SIN3A YY1 ZNF207 ZNF143 ZNF263 SP3 MXD4 REST

Genomic Location for ZNF664 Gene

Chromosome:
12
Start:
123,971,845 bp from pter
End:
124,015,439 bp from pter
Size:
43,595 bases
Orientation:
Plus strand

Genomic View for ZNF664 Gene

Genes around ZNF664 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF664 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF664 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF664 Gene

Proteins for ZNF664 Gene

  • Protein details for ZNF664 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3J9-ZN664_HUMAN
    Recommended name:
    Zinc finger protein 664
    Protein Accession:
    Q8N3J9
    Secondary Accessions:
    • B3KP97
    • Q15914
    • Q3ZCQ7

    Protein attributes for ZNF664 Gene

    Size:
    261 amino acids
    Molecular mass:
    30284 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF664 Gene

Post-translational modifications for ZNF664 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF664 Gene

No data available for DME Specific Peptides for ZNF664 Gene

Domains & Families for ZNF664 Gene

Gene Families for ZNF664 Gene

Protein Domains for ZNF664 Gene

Suggested Antigen Peptide Sequences for ZNF664 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N3J9

UniProtKB/Swiss-Prot:

ZN664_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF664: view

Function for ZNF664 Gene

Molecular function for ZNF664 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF664 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF664: view
genes like me logo Genes that share phenotypes with ZNF664: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF664 Gene

Localization for ZNF664 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF664 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF664 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF664 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with ZNF664: view

Pathways & Interactions for ZNF664 Gene

SuperPathways for ZNF664 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF664: view

Pathways by source for ZNF664 Gene

2 Reactome pathways for ZNF664 Gene

Gene Ontology (GO) - Biological Process for ZNF664 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ZNF664: view

No data available for SIGNOR curated interactions for ZNF664 Gene

Drugs & Compounds for ZNF664 Gene

No Compound Related Data Available

Transcripts for ZNF664 Gene

Unigene Clusters for ZNF664 Gene

Zinc finger protein 664:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF664 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g
SP1: - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: - - - -
SP9: - - - - - - - - -
SP10: - - - - -
SP11:
SP12:

Relevant External Links for ZNF664 Gene

GeneLoc Exon Structure for
ZNF664
ECgene alternative splicing isoforms for
ZNF664

Expression for ZNF664 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF664 Gene

Protein differential expression in normal tissues from HIPED for ZNF664 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF664 Gene



Protein tissue co-expression partners for ZNF664 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF664 Gene:

ZNF664

SOURCE GeneReport for Unigene cluster for ZNF664 Gene:

Hs.524828

Evidence on tissue expression from TISSUES for ZNF664 Gene

  • Nervous system(4.8)
  • Eye(4.2)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with ZNF664: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF664 Gene

Orthologs for ZNF664 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF664 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF664 34 35
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia ZNF664 34 35
  • 95.15 (n)
cow
(Bos Taurus)
Mammalia ZNF664 34 35
  • 93.1 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911699 34
  • 91.53 (n)
mouse
(Mus musculus)
Mammalia Zfp664 34 16 35
  • 90.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 21 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 27 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii BX649556.2 35
  • 54 (a)
ManyToMany
CR388052.2 35
  • 44 (a)
ManyToMany
si:ch211-178j18.2 35
  • 43 (a)
ManyToMany
si:dkey-146c18.5 35
  • 41 (a)
ManyToMany
BX324003.4 35
  • 40 (a)
ManyToMany
BX511066.4 35
  • 40 (a)
ManyToMany
BX548067.3 35
  • 40 (a)
ManyToMany
BX901892.1 35
  • 40 (a)
ManyToMany
BX927193.1 35
  • 40 (a)
ManyToMany
BX950868.2 35
  • 40 (a)
ManyToMany
si:ch211-208f21.2 35
  • 40 (a)
ManyToMany
si:ch211-231i17.4 35
  • 40 (a)
ManyToMany
si:dkey-3p4.8 35
  • 40 (a)
ManyToMany
zgc:173619 35 35
  • 40 (a)
ManyToMany
BX276122.1 35
  • 39 (a)
ManyToMany
BX537137.1 35
  • 39 (a)
ManyToMany
CABZ01001466.1 35
  • 39 (a)
ManyToMany
CABZ01028403.3 35
  • 39 (a)
ManyToMany
CR759907.4 35
  • 39 (a)
ManyToMany
si:ch211-209j12.3 35
  • 39 (a)
ManyToMany
zgc:173620 35
  • 39 (a)
ManyToMany
si:dkey-156j15.1 35
  • 38 (a)
ManyToMany
si:dkey-7j22.4 35
  • 38 (a)
ManyToMany
BX842593.1 35
  • 37 (a)
ManyToMany
si:dkey-285e18.6 35
  • 37 (a)
ManyToMany
si:dkey-28i19.1 35
  • 37 (a)
ManyToMany
CABZ01017733.1 35
  • 33 (a)
ManyToMany
CU138542.1 35
  • 33 (a)
ManyToMany
si:dkey-264f17.4 35
  • 31 (a)
ManyToMany
si:ch211-79k12.2 35
  • 18 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1832 35
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea eor-1 35
  • 8 (a)
OneToMany
Species where no ortholog for ZNF664 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ZNF664 Gene

ENSEMBL:
Gene Tree for ZNF664 (if available)
TreeFam:
Gene Tree for ZNF664 (if available)

Paralogs for ZNF664 Gene

(583) SIMAP similar genes for ZNF664 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF664: view

Variants for ZNF664 Gene

Sequence variations from dbSNP and Humsavar for ZNF664 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000005912 -- 123,978,645(+) GGACA(C/G)TAGAT intron-variant
rs1000106696 -- 123,978,301(+) GGTTA(C/T)AGGAT intron-variant
rs1000145084 -- 124,013,947(+) TATTA(A/G)TCCAT intron-variant, utr-variant-3-prime
rs1000227671 -- 123,990,088(+) CATTC(A/G)TGGAG intron-variant
rs1000317136 -- 123,977,860(+) ATGAA(A/G)TCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF664 Gene

Variant ID Type Subtype PubMed ID
dgv2934n54 CNV gain 21841781
esv22500 CNV loss 19812545
esv2746515 CNV deletion 23290073
esv3631000 CNV gain 21293372
nsv819172 CNV loss 19587683
nsv819689 CNV loss 19587683
nsv820508 CNV duplication 20802225
nsv826535 CNV gain 20364138
nsv975536 CNV duplication 23825009

Variation tolerance for ZNF664 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF664 Gene

Human Gene Mutation Database (HGMD)
ZNF664
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF664

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF664 Gene

Disorders for ZNF664 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF664 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal dominant 41
  • autosomal dominant nonsyndromic deafness 41
deafness, autosomal dominant 25
  • autosomal dominant nonsyndromic deafness 25
clubfoot
  • congenital clubfoot
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF664

Genetic Association Database (GAD)
ZNF664
Human Genome Epidemiology (HuGE) Navigator
ZNF664
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF664
genes like me logo Genes that share disorders with ZNF664: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF664 Gene

Publications for ZNF664 Gene

  1. Exome sequencing identifies ZNF644 mutations in high myopia. (PMID: 21695231) Shi Y. … Yang Z. (PLoS Genet. 2011) 2 3 64
  2. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 46 64
  3. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. (PMID: 19936222) Chasman D.I. … Ridker P.M. (PLoS Genet. 2009) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. A novel zinc finger gene preferentially expressed in the retina and the organ of Corti localizes to human chromosome 12q24.3. (PMID: 8634327) Rivolta M.N. … Wilcox E.R. (Biochim. Biophys. Acta 1996) 3 4 64

Products for ZNF664 Gene

Sources for ZNF664 Gene

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