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ZNF664 Gene

protein-coding   GIFtS: 50
GCID: GC12P124457

Zinc Finger Protein 664

(Previous name: zinc finger protein 176)
(Previous symbol: ZNF176)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6641 2     ZFOC12 3
Zinc Finger Protein 1761 2 3     Zinc Finger Organ Of Corti 12
ZNF1761 2     ZNF1963
Zinc Finger Protein From Organ Of Corti2 3     

External Ids:    HGNC: 254061   Entrez Gene: 1443482   Ensembl: ENSG000001791957   UniProtKB: Q8N3J93   

Export aliases for ZNF664 gene to outside databases

Previous GC identifers: GC12P122983 GC12P121419


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF664 Gene:
ZNF664 (zinc finger protein 664) is a protein-coding gene. An important paralog of this gene is OSR2.

UniProtKB/Swiss-Prot: ZN664_HUMAN, Q8N3J9
Function: May be involved in transcriptional regulation

Gene Wiki entry for ZNF664 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF664 gene promoter:
         STAT5A   E4BP4   E47   c-Ets-1   Evi-1   Arnt   Hand1   Sox9   Pax-4a   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ZNF664 promoter sequence
   Search Chromatin IP Primers for ZNF664

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF664


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

ZNF664 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF664 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P124457:  view genomic region     (about GC identifiers)

Start:
124,456,392 bp from pter      End:
124,499,986 bp from pter
Size:
43,595 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN664_HUMAN, Q8N3J9 (See protein sequence)
Recommended Name: Zinc finger protein 664  
Size: 261 amino acids; 30284 Da
Secondary accessions: B3KP97 Q15914 Q3ZCQ7

Explore the universe of human proteins at neXtProt for ZNF664: NX_Q8N3J9

Explore proteomics data for ZNF664 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF664 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001191227.1  NP_689650.1  

    ENSEMBL proteins: 
     ENSP00000441405   ENSP00000376205   ENSP00000440645   ENSP00000337320  
    Reactome Protein details: Q8N3J9

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8N3J9

    ProtoNet protein and cluster: Q8N3J9

    UniProtKB/Swiss-Prot: ZN664_HUMAN, Q8N3J9
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 9 C2H2-type zinc fingers


    Find genes that share domains with ZNF664           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN664_HUMAN, Q8N3J9
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF664           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF664

    miRNA
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    miRTarBase miRNAs that target ZNF664:
    hsa-mir-484 (MIRT042057)

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    Selected qRT-PCR Assays for microRNAs that regulate ZNF664 (see all 73):
    hsa-miR-323-3p hsa-miR-3938 hsa-miR-4272 hsa-miR-371-5p hsa-miR-629 hsa-miR-3116 hsa-miR-192* hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidZNF664 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN664_HUMAN, Q8N3J9: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    Find genes that share ontologies with ZNF664           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF664 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF664           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF664
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF664
    Interactions:

        Search GeneGlobe Interaction Network for ZNF664

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF664 (ENSP000003373204) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0008150biological_process ND--

    Find genes that share ontologies with ZNF664           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF664 (ZN664)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF664 gene (2 alternative transcripts): 
    NM_001204298.1  NM_152437.2  

    Unigene Cluster for ZNF664:

    Zinc finger protein 664
    Hs.524828  [show with all ESTs]
    Unigene Representative Sequence: AL834266
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000537532 ENST00000539644 ENST00000392404 ENST00000541448 ENST00000538932(uc001ugb.3 uc001uga.3)
    ENST00000542820 ENST00000540009 ENST00000542493 ENST00000543017 ENST00000539257
    ENST00000337815 ENST00000546098 ENST00000539501 ENST00000540498
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ZNF664 (see all 73):
    hsa-miR-323-3p hsa-miR-3938 hsa-miR-4272 hsa-miR-371-5p hsa-miR-629 hsa-miR-3116 hsa-miR-192* hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidZNF664 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF664
      QuantiFast Probe-based Assays in human, mouse, rat ZNF664

    Additional mRNA sequence: 

    AF024695.1 AK023009.1 AK056034.1 AL834266.1 BC017960.1 BC033539.1 BC037793.2 BC051696.1 
    BC093848.1 BC101530.1 BX647762.1 L41669.1 

    17 DOTS entries:

    DT.100793214  DT.95216541  DT.97846813  DT.121181434  DT.101983814  DT.305261  DT.101957374  DT.95213857 
    DT.92444989  DT.100793210  DT.121181297  DT.121181305  DT.75149050  DT.121181286  DT.121310489  DT.91974188 
    DT.97811948 

    Selected AceView cDNA sequences (see all 341):

    BQ215765 BM672040 CA436978 AI026034 BX102549 CD673678 BC017960 CA436146 
    AI738872 BG236183 BM794717 AA948662 AI090041 BE079328 BU623986 AA378961 
    BE079517 AA632071 CA777619 AU131513 AI950614 AA336761 AL560889 AI269441 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ZNF664 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g
    SP1:              -           -           -     -     -     -     -           -                                                   
    SP2:        -     -           -           -     -     -     -     -     -     -                                                   
    SP3:              -           -           -     -     -     -     -     -     -                                                   
    SP4:              -           -           -     -     -     -     -     -     -                                                   
    SP5:                          -           -     -     -     -     -     -                                                         


    ECgene alternative splicing isoforms for ZNF664

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF664 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTTGCTGG
    ZNF664 Expression
    About this image

    ZNF664 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF664 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524828
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ZNF664 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6641 , 5 zinc finger protein 6641, 5 90.93(n)1
    100(a)1
      5 (63.86 cM)5
    2697041  NM_001081750.11  NP_001075219.11 
     1248626915 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    27(a)
    1 → many
    2(189037489-189042398)
    zebrafish
    (Danio rerio)
    Actinopterygii BX649556.26
    CR388052.26
    (see all 31)
    Uncharacterized protein
    (see all 31)
    54(a)
    44(a)
    (see all 31)
    many ↔ many
    many ↔ many
    (see all 31)
    Zv9_scaffold3530(37025-100672) ENSDARG00000088936
    4(55951578-55952441) ENSDARG00000088847
    fruit fly
    (Drosophila melanogaster)
    Insecta CG18326
    --
    18(a)
    1 → many
    2L(22165720-22169143)
    worm
    (Caenorhabditis elegans)
    Secernentea eor-16
    Protein EOR-1 (eor-1) mRNA, complete cds
    8(a)
    1 → many
    IV(4793202-4799356) WBGene00001324


    ENSEMBL Gene Tree for ZNF664 (if available)
    TreeFam Gene Tree for ZNF664 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF664 gene
    OSR22  OSR12  ZNF2392  
    Selected SIMAP similar genes for ZNF664 using alignment to 2 protein entries:     ZN664_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    ZNF239    ZNF214    ZFP37    ZFP2    ZNF383
    ZNF391    ZNF485    ZNF782    ZNF624    ZNF658    ZNF879
    ZNF35    ZNF397    ZNF79    DKFZp666C237    DKFZp761O1618    HZF36

    Find genes that share paralogs with ZNF664           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ZNF664:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746515CNV Deletion23290073
    nsv820508CNV Duplication20802225
    nsv819172CNV Loss19587683
    nsv899580CNV Loss21882294
    nsv819689CNV Loss19587683
    esv22500CNV Loss19812545
    nsv826535CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF664           About GenesLikeMe

    Genetic Association Database (GAD): ZNF664
    Human Genome Epidemiology (HuGE) Navigator: ZNF664 (2 documents)

    Export disorders for ZNF664 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF664 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ZNF664)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Biological, clinical and population relevance of 95 loci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (Nature 2010)
    2. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. (PubMed id 19936222)1, 4 Chasman D.I....Ridker P.M. (PLoS Genet. 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. A novel zinc finger gene preferentially expressed in the retina and the organ of Corti localizes to human chromosome 12q24.3. (PubMed id 8634327)1, 2 Rivolta M.N.... Wilcox E.R. (Biochim. Biophys. Acta 1996)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 144348 HGNC: 25406 AceView: DKFZp761B128 Ensembl:ENSG00000179195 euGenes: HUgn144348
    ECgene: ZNF664 H-InvDB: ZNF664

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF664 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF664 gene:
    Search GeneIP for patents involving ZNF664

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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