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ZNF662 Gene

protein-coding   GIFtS: 43
GCID: GC03P042947

Zinc Finger Protein 662

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6621 2

External Ids:    HGNC: 319301   Entrez Gene: 3891142   Ensembl: ENSG000001829837   UniProtKB: Q6ZS273   

Export aliases for ZNF662 gene to outside databases

Previous GC identifer: GC03P042923


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF662 Gene:
ZNF662 (zinc finger protein 662) is a protein-coding gene. An important paralog of this gene is ZNF621.

UniProtKB/Swiss-Prot: ZN662_HUMAN, Q6ZS27
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ZNF662 gene promoter:
         HEN1   ATF-2   Pax-2   Pax-2a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF662 promoter sequence
   Search Chromatin IP Primers for ZNF662

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF662


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.1   Ensembl cytogenetic band:  3p22.1   HGNC cytogenetic band: 3p22.1

ZNF662 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF662 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P042947:  view genomic region     (about GC identifiers)

Start:
42,947,223 bp from pter      End:
42,960,825 bp from pter
Size:
13,603 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZN662_HUMAN, Q6ZS27 (See protein sequence)
Recommended Name: Zinc finger protein 662  
Size: 426 amino acids; 48496 Da
Sequence caution: Sequence=AAI28086.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A1A4T9 F8W7S8 Q6ZNF8 Q6ZQW8
Alternative splicing: 3 isoforms:  Q6ZS27-1   Q6ZS27-2   Q6ZS27-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF662: NX_Q6ZS27

Explore proteomics data for ZNF662 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF662 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001128128.1  NP_997287.2  

    ENSEMBL proteins: 
     ENSP00000405047   ENSP00000329264   ENSP00000408945   ENSP00000446208  
    Reactome Protein details: Q6ZS27

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    antibodies-online antibodies for ZNF662 (12 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q6ZS27

    ProtoNet protein and cluster: Q6ZS27

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN662_HUMAN, Q6ZS27
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 8 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    Find genes that share domains with ZNF662           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN662_HUMAN, Q6ZS27
    Function: May be involved in transcriptional regulation (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ZNF662           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ZNF662

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    hsa-miR-429 hsa-miR-3133 hsa-miR-340 hsa-miR-1262 hsa-miR-200c hsa-miR-3920 hsa-miR-651 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidZNF662 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN662_HUMAN, Q6ZS27: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    Find genes that share ontologies with ZNF662           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF662 About    
    See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with ZNF662           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF662
        Generic Transcription Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF662
    Interactions:

        Search GeneGlobe Interaction Network for ZNF662

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with ZNF662           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF662 (ZN662)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ZNF662 gene (2 alternative transcripts): 
    NM_001134656.1  NM_207404.3  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000440367 ENST00000328199 ENST00000475386 ENST00000422021 ENST00000430067
    ENST00000541208(uc003cmi.2 uc003cmk.2 uc003cmj.2)
    miRNA
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    hsa-miR-429 hsa-miR-3133 hsa-miR-340 hsa-miR-1262 hsa-miR-200c hsa-miR-3920 hsa-miR-651 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidZNF662 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ZNF662
      QuantiFast Probe-based Assays in human, mouse, rat ZNF662

    Selected AceView cDNA sequences (see all 189):

    AI700588 AW771170 NM_001296 BC011631 CR610139 BM726888 BE466204 BM674860 
    BC018716 BC008816 BI056128 AI870497 W61299 BX116130 AI674985 AA610143 
    BE669583 AK054699 BF110494 AI570427 AI565258 AA758769 BQ013601 BU159134 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF662    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:              -                                       
    SP2:                                                      
    SP3:                                      -               


    ECgene alternative splicing isoforms for ZNF662

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF662 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAGGACTGA
    ZNF662 Expression
    About this image

    ZNF662 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF662 Protein Expression
        Custom PCR Arrays for ZNF662
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF662

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ZNF662 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ZNF6621 zinc finger protein 662 91(n)
    87.91(a)
      485620  XM_005634318.1  XP_005634375.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004964431 zinc finger protein 34-like 52.65(n)
    43.6(a)
      100496443  XM_002942730.2  XP_002942776.2 


    ENSEMBL Gene Tree for ZNF662 (if available)
    TreeFam Gene Tree for ZNF662 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF662 gene
    ZNF6212  ZNF192  ZNF6202  ZNF6192  ENSG000002616112  
    Selected SIMAP similar genes for ZNF662 using alignment to 2 protein entries:     ZN662_HUMAN (see all proteins) (see all similar genes):
    ZNF78L1    HZF36    ZNF154    ZNF232    ZNF211    ZNF286B
    ZNF345    ZNF420    DKFZp313M0722    DKFZp547L155    ZFP41    ZNF16
    ZNF286A    ZNF323    ZNF850    ZNF551    DKFZp686L0787    GLI4

    Find genes that share paralogs with ZNF662           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF662 (see all 356)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124909021,2
    C,F,H--42945460(+) CACTCT/AAGGAA 1 -- us2k18Minor allele frequency- A:0.16NS EA NA WA 648
    rs1403156031,2
    --42945532(+) AGCAAC/TTGACC 1 -- us2k10--------
    rs2004876191,2
    --42945571(+) TCCTT-/CCTC  
            
    CCTCC
    1 -- us2k10--------
    rs2017843111,2
    C--42945619(+) TTCCT-/CCTC  
            
    CTCCC
    1 -- us2k10--------
    rs130736981,2
    A--42945693(+) cttccC/Ttcctt 2 -- us2k10--------
    rs1114156971,2
    C--42945710(+) TCCCTT/CCCTTT 2 -- us2k12Minor allele frequency- C:0.03CSA WA 120
    rs2004520531,2
    --42945781(+) TTCTT-/TCTCTCT 2 -- us2k10--------
    rs76259591,2
    C,F,A,H--42946047(+) tctttA/Ctttct 2 -- us2k1 tfbs318Minor allele frequency- C:0.19NS EA NA WA CSA 1937
    rs1441599421,2
    C--42946051(+) TATTTA/CTTTCT 2 -- us2k10--------
    rs1859757531,2
    --42946178(+) TTCCCC/TCTACC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ZNF662 (42947223 - 42960825 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ZNF662:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3783CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ZNF662
    DNA2.0 Custom Variant and Variant Library Synthesis for ZNF662

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with ZNF662           About GenesLikeMe

    Genetic Association Database (GAD): ZNF662

    Export disorders for ZNF662 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF662 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF662)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Genome-wide association of sleep and circadian phenotypes. (PubMed id 17903308)4 Gottlieb D.J....Wilk J.B. (BMC Med. Genet. 2007)
    3. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 389114 HGNC: 31930 AceView: FLJ45880andDKFZP434B172andLOC339903 Ensembl:ENSG00000182983 euGenes: HUgn389114
    ECgene: ZNF662 H-InvDB: ZNF662

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF662 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF662 gene:
    Search GeneIP for patents involving ZNF662

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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