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Aliases for ZNF662 Gene

Aliases for ZNF662 Gene

  • Zinc Finger Protein 662 2 3 5

External Ids for ZNF662 Gene

Previous GeneCards Identifiers for ZNF662 Gene

  • GC03P042923

Summaries for ZNF662 Gene

GeneCards Summary for ZNF662 Gene

ZNF662 (Zinc Finger Protein 662) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription cofactor activity. An important paralog of this gene is ZNF619.

UniProtKB/Swiss-Prot for ZNF662 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF662 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF662 Gene

Genomics for ZNF662 Gene

GeneHancer (GH) Regulatory Elements for ZNF662 Gene

Promoters and enhancers for ZNF662 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I042905 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 550.8 +0.6 610 1.2 L3MBTL2 NR4A1 ZFX MGA YY1 ZNF662 KRBOX1-AS1 KRBOX1 ENSG00000273291 ENSG00000273328
GH03I042802 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.3 -101.6 -101607 3.1 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ACKR2 ENSG00000280571 HIGD1A NKTR ZNF662 SNRK-AS1 CCDC13 LINC02158 GC03M042803 ENSG00000235288
GH03I042011 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 19.7 -891.3 -891325 5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A IRF4 YY1 POLR2B ZNF766 TRAK1 NKTR ULK4 CTNNB1 ZNF662 ENSG00000229339
GH03I042019 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.2 -882.4 -882419 8.6 ATF1 FOXA2 ARNT ARID4B YBX1 FEZF1 ZNF48 TCF12 ZNF213 ARID2 NKTR ULK4 ZNF662 CTNNB1 TRAK1 VIPR1 ENSG00000229339
GH03I042700 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 16.6 -203.5 -203520 2.5 ELF3 RB1 ARID4B KLF17 SIN3A RAD21 DNMT3B ZNF48 ZSCAN9 RARA HHATL HHATL-AS1 NKTR ZNF662 SNRK-AS1 KLHL40 CCDC13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF662 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF662 gene promoter:

Genomic Locations for ZNF662 Gene

Genomic Locations for ZNF662 Gene
chr3:42,905,731-42,919,333
(GRCh38/hg38)
Size:
13,603 bases
Orientation:
Plus strand
chr3:42,947,223-42,960,825
(GRCh37/hg19)

Genomic View for ZNF662 Gene

Genes around ZNF662 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF662 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF662 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF662 Gene

Proteins for ZNF662 Gene

  • Protein details for ZNF662 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZS27-ZN662_HUMAN
    Recommended name:
    Zinc finger protein 662
    Protein Accession:
    Q6ZS27
    Secondary Accessions:
    • A1A4T9
    • F8W7S8
    • Q6ZNF8
    • Q6ZQW8

    Protein attributes for ZNF662 Gene

    Size:
    426 amino acids
    Molecular mass:
    48496 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI28086.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF662 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF662 Gene

Post-translational modifications for ZNF662 Gene

No Post-translational modifications

Other Protein References for ZNF662 Gene

No data available for DME Specific Peptides for ZNF662 Gene

Domains & Families for ZNF662 Gene

Gene Families for ZNF662 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF662 Gene

Suggested Antigen Peptide Sequences for ZNF662 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZS27

UniProtKB/Swiss-Prot:

ZN662_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF662: view

Function for ZNF662 Gene

Molecular function for ZNF662 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF662 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF662: view
genes like me logo Genes that share phenotypes with ZNF662: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF662 Gene

Localization for ZNF662 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF662 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF662 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF662 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF662: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF662 Gene

Pathways & Interactions for ZNF662 Gene

SuperPathways for ZNF662 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF662: view

Pathways by source for ZNF662 Gene

2 Reactome pathways for ZNF662 Gene

Gene Ontology (GO) - Biological Process for ZNF662 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF662: view

No data available for SIGNOR curated interactions for ZNF662 Gene

Drugs & Compounds for ZNF662 Gene

No Compound Related Data Available

Transcripts for ZNF662 Gene

Unigene Clusters for ZNF662 Gene

Zinc finger protein 662:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF662 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: -
SP2:
SP3: -

Relevant External Links for ZNF662 Gene

GeneLoc Exon Structure for
ZNF662
ECgene alternative splicing isoforms for
ZNF662

Expression for ZNF662 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF662 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF662 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF662 Gene:

ZNF662

SOURCE GeneReport for Unigene cluster for ZNF662 Gene:

Hs.720173

Evidence on tissue expression from TISSUES for ZNF662 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF662: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF662 Gene

Orthologs for ZNF662 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF662 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF662 33 34
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia ZNF662 33 34
  • 91 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496443 33
  • 52.65 (n)
Species where no ortholog for ZNF662 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF662 Gene

ENSEMBL:
Gene Tree for ZNF662 (if available)
TreeFam:
Gene Tree for ZNF662 (if available)

Paralogs for ZNF662 Gene

Paralogs for ZNF662 Gene

(469) SIMAP similar genes for ZNF662 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF662: view

Variants for ZNF662 Gene

Sequence variations from dbSNP and Humsavar for ZNF662 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000008088 -- 42,909,835(+) C/T intron_variant
rs1000051805 -- 42,915,324(+) C/T coding_sequence_variant, synonymous_variant
rs1000292566 -- 42,909,200(+) G/A/C intron_variant
rs1000293316 -- 42,915,203(+) G/A coding_sequence_variant, missense_variant
rs1000627680 -- 42,913,547(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF662 Gene

Variant ID Type Subtype PubMed ID
nsv1074586 CNV deletion 25765185
nsv3783 CNV deletion 18451855

Variation tolerance for ZNF662 Gene

Residual Variation Intolerance Score: 72.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF662 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF662

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF662 Gene

Disorders for ZNF662 Gene

Additional Disease Information for ZNF662

No disorders were found for ZNF662 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF662 Gene

Publications for ZNF662 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein JI … Sullivan PF (Nature communications 2014) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for ZNF662 Gene

Sources for ZNF662 Gene

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