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ZNF66 Gene

protein-coding   GIFtS: 29
GCID: GC19P020944

Zinc Finger Protein 66

(Previous names: zinc finger protein 66, pseudogene)
(Previous symbol: ZNF66P)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 661 2
ZNF66P1 2 3
Zinc Finger Protein 66, Pseudogene1
Zinc Finger Protein 66 Pseudogene3
MIPU15
ZNF6675

External Ids:    HGNC: 131351   Entrez Gene: 76172   Ensembl: ENSG000001602297   OMIM: 6110245   UniProtKB: Q6ZN083   

Export aliases for ZNF66 gene to outside databases

Previous GC identifers: GC19U990108 GC19M020521 GC19P020751


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF66 Gene:
ZNF66 (zinc finger protein 66) is a protein-coding gene. An important paralog of this gene is ZNF85.

UniProtKB/Swiss-Prot: ZNF66_HUMAN, Q6ZN08
Function: May be involved in transcriptional regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF66
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF66 promoter sequence
   Search Chromatin IP Primers for ZNF66

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF66


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p12   HGNC cytogenetic band: 19p12

ZNF66 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF66 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P020944:  view genomic region     (about GC identifiers)

Start:
20,959,076 bp from pter      End:
21,020,282 bp from pter
Size:
61,207 bases      Orientation:
plus strand

1 alternative location:
Chr19+,NW_003315962 113,130-180,684     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZNF66_HUMAN, Q6ZN08 (See protein sequence)
Recommended Name: Putative zinc finger protein 66  
Size: 573 amino acids; 65874 Da
Caution: Could be the product of a pseudogene
Secondary accessions: I3L4P5 Q15939

Explore the universe of human proteins at neXtProt for ZNF66: NX_Q6ZN08

Explore proteomics data for ZNF66 at MOPED


See ZNF66 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000459415   ENSP00000469543   ENSP00000461425   ENSP00000459573  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR001909 Krueppel-associated_box
 IPR015880 Znf_C2H2-like
 IPR013087 Znf_C2H2/integrase_DNA-bd
 IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q6ZN08

ProtoNet protein and cluster: Q6ZN08

1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

UniProtKB/Swiss-Prot: ZNF66_HUMAN, Q6ZN08
Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
Similarity: Contains 15 C2H2-type zinc fingers
Similarity: Contains 1 KRAB domain


Find genes that share domains with ZNF66           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZNF66_HUMAN, Q6ZN08
Function: May be involved in transcriptional regulation (By similarity)

     Genatlas biochemistry entry for ZNF66:
zinc finger protein 66 (C2H2 type,Kruppel-like)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with ZNF66           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZNF66_HUMAN, Q6ZN08: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005634nucleus IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for ZNF66

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--

Find genes that share ontologies with ZNF66           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ZNF66 gene: 
NM_001009883.1  

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000360204(uc002npe.3) ENST00000594534 ENST00000344519 ENST00000425625

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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

ZNF66 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ZNF66 Protein Expression
    Custom PCR Arrays for ZNF66
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ZNF66 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 8)
Uncharacterized protein
(see all 8)
55(a)
44(a)
(see all 8)
many ↔ many
many ↔ many
(see all 8)
AAWZ02037240(11818-13836)
GL343434.1(292314-296903)
        Species with no ortholog for ZNF66

ENSEMBL Gene Tree for ZNF66 (if available)
TreeFam Gene Tree for ZNF66 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ZNF66 gene
ZNF852  ZNF4862  ZNF1952  ZNF922  ZNF1002  ZNF7322  ZNF6752  ZNF1382  
ZNF5062  ZNF2732  ZNF6952  ZNF6262  ZNF6802  ZNF4792  ZNF2532  ZNF932  
ZNF6822  ZNF4922  ZNF6762  ZNF6812  ZNF1412  ZNF7362  ZNF6792  ZNF2572  
ZNF2542  ZNF7372  ZNF724P2  ZNF982  ZNF7162  ZNF7142  ZNF4292  ZNF5192  
ZNF4302  ZNF7302  ZNF7082  ZNF1172  ZNF4312  ZNF902  ZNF7262  ZNF7282  
Selected SIMAP similar genes for ZNF66 using alignment to 5 protein entries:     ZNF66_HUMAN (see all proteins) (see all similar genes):
ARL6IP5    ZNF506    TGM4    ZNF93    MGC12518    ZNF90
C14orf23    ZNF624    ZNF98    C1orf143    NLN    ZNF273
ZNF724P    ADCK1    C12orf76    TNNT1    ZNF257    ZNF253

Find genes that share paralogs with ZNF66           About GenesLikeMe


3 Pseudogenes.org Pseudogenes for ZNF66
PGOHUM00000261271 PGOHUM00000234560 PGOHUM00000262510


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ZNF66
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611024    OMIM disorders: --


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Genetic Association Database (GAD): ZNF66
Human Genome Epidemiology (HuGE) Navigator: ZNF66 (1 document)

Export disorders for ZNF66 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ZNF66 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ZNF66)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  2. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PubMed id 1505991)1, 3 Lichter P.... Ward D.C. (Genomics 1992)
  3. Characterization and mapping of human genes encoding zinc finger proteins. (PubMed id 1946370)1, 2 Bray P.L.... Dawid I.B. (Proc. Natl. Acad. Sci. U.S.A. 1991)
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7617 HGNC: 13135 Ensembl:ENSG00000160229 euGenes: HUgn7617 ECgene: ZNF66
H-InvDB: ZNF66

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ZNF66 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ZNF66 gene:
Search GeneIP for patents involving ZNF66

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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