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ZNF658 Gene

protein-coding   GIFtS: 46
GCID: GC09M040750

Zinc Finger Protein 658

  Search for ZNF658
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Zinc Finger Protein 6581 2

External Ids:    HGNC: 252261   Entrez Gene: 261492   Ensembl: ENSG000001964097   UniProtKB: Q5TYW13   

Export aliases for ZNF658 gene to outside databases

Previous GC identifer: GC09M040501


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ZNF658 Gene:
ZNF658 (zinc finger protein 658) is a protein-coding gene. An important paralog of this gene is ZNF616.

UniProtKB/Swiss-Prot: ZN658_HUMAN, Q5TYW1
Function: May be involved in transcriptional regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_187214.1  NC_018920.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ZNF658
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF658 promoter sequence
   Search Chromatin IP Primers for ZNF658

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ZNF658


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.1   Ensembl cytogenetic band:  9p13.1   HGNC cytogenetic band: 9p13.1

ZNF658 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF658 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M040750:  view genomic region     (about GC identifiers)

Start:
40,760,700 bp from pter      End:
40,836,415 bp from pter
Size:
75,716 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZN658_HUMAN, Q5TYW1 (See protein sequence)
Recommended Name: Zinc finger protein 658  
Size: 1059 amino acids; 122274 Da
Sequence caution: Sequence=AAH31626.1; Type=Erroneous initiation; Sequence=BAB14145.1; Type=Erroneous initiation;
Sequence=CAB53677.2; Type=Erroneous initiation;
Secondary accessions: Q6PIP3 Q96M55 Q9H9S6 Q9UG02
Alternative splicing: 2 isoforms:  Q5TYW1-1   Q5TYW1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ZNF658: NX_Q5TYW1

Explore proteomics data for ZNF658 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ZNF658 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149350.3  
    ENSEMBL proteins: 
     ENSP00000434029   ENSP00000473484   ENSP00000366853   ENSP00000408462  
    Reactome Protein details: Q5TYW1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR001909 Krueppel-associated_box
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q5TYW1

    ProtoNet protein and cluster: Q5TYW1

    1 Blocks protein domain: IPB001909 KRAB box

    UniProtKB/Swiss-Prot: ZN658_HUMAN, Q5TYW1
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 24 C2H2-type zinc fingers
    Similarity: Contains 1 KRAB domain


    ZNF658 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN658_HUMAN, Q5TYW1
    Function: May be involved in transcriptional regulation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IBA--
    GO:0046872metal ion binding IEA--
         
    ZNF658 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ZNF658:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ZNF658
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    miRTarBase miRNAs that target ZNF658:
    hsa-mir-122-5p (MIRT023238)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZN658_HUMAN, Q5TYW1: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ZNF658 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ZNF658 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ZNF658
        Generic Transcription Pathway



    ZNF658 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ZNF658
    Interactions:

        Search GeneGlobe Interaction Network for ZNF658

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IBA--

    ZNF658 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ZNF658 (ZN658)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ZNF658 gene: 
    NM_033160.5  

    Unigene Cluster for ZNF658:

    Zinc finger protein 658
    Hs.522147  [show with all ESTs]
    Unigene Representative Sequence: NM_033160
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479710(uc010mmm.2) ENST00000602553 ENST00000377626(uc004abs.2 uc010mmn.1)
    ENST00000441795
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat ZNF658

    Additional mRNA sequence: 

    AK022636.1 AK024222.1 AK057375.1 AK292150.1 AL110217.1 BC031626.1 

    5 DOTS entries:

    DT.121185725  DT.100748857  DT.316263  DT.40247560  DT.416386 

    11 AceView cDNA sequences:

    AK095694 AI400091 BU685875 AV724641 BM981059 AW874634 BV200308 AI919585 
    BM710714 AV721950 BU687037 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ZNF658 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ZNF658 Expression
    About this image

    ZNF658 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ZNF658 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522147
        Custom PCR Arrays for ZNF658
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF658

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ZNF658 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm71451 predicted gene 7145 66.86(n)
    58.51(a)
      634762  XM_006530013.1  XP_006530076.1 


    ENSEMBL Gene Tree for ZNF658 (if available)
    TreeFam Gene Tree for ZNF658 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ZNF658 gene
    ZNF6162  ZNF4732  ZNF1602  ZNF4932  ZNF5462  ZNF992  ZNF8362  ZNF7212  
    ZNF5942  ZFP622  ZNF8412  ZNF432  ZNF780B2  ZNF1972  ZNF1072  ZNF585A2  
    ZNF8082  ZNF3472  ZNF8452  ZNF585B2  ZNF6292  ZNF6242  ZNF2682  ZNF8142  
    Selected SIMAP similar genes for ZNF658 using alignment to 3 protein entries:     ZN658_HUMAN (see all proteins) (see all similar genes):
    ZNF658B    ZFS-5    ZNF78L1    kr-znf3    ZNF702P    DKFZp686B16128
    ZNF558    ZFS-1    ZKSCAN7    DKFZp434J0650    DKFZp666M039    ZKSCAN8
    ZNF167    ZNF300P1    ZNF436    ZNF485    ZNF664    ZSCAN16

    ZNF658 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ZNF658
    PGOHUM00000261941 PGOHUM00000236052 PGOHUM00000250496


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ZNF658 (see all 328)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112615251,2
    C--40770943(+) GCAGAC/TTTAAA 1 -- ds50010--------
    rs1816361401,2
    --40770959(+) CTGTCC/TGACAG 1 -- ds50010--------
    rs1479998241,2
    --40770994(+) CAGTAA/TGGAGC 1 -- ds50010--------
    rs625612271,2
    C--40771345(+) TTCTAA/GGTGAA 1 -- ds50010--------
    rs625612281,2
    C--40771356(+) TATTTC/TATCTC 1 -- ds50010--------
    rs1859717471,2
    --40771559(+) GTGACA/GTCTCT 1 -- ut310--------
    rs1395637991,2
    --40771765(+) TGTTCA/GTTTTT 1 -- ut310--------
    rs1895582651,2
    --40771793(+) GACCTC/TGTGCT 1 -- ut310--------
    rs1497307021,2
    --40771798(+) TGTGCG/TCTATG 1 -- ut310--------
    rs1180982111,2
    C,F--40771803(+) TCTATG/AGTTTT 1 -- ut311Minor allele frequency- A:0.12EA 120

    HapMap Linkage Disequilibrium report for ZNF658 (40760700 - 40836415 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ZNF658 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893142CNV Loss21882294
    nsv831561CNV Loss17160897
    dgv8179n71CNV Gain21882294
    dgv8189n71CNV Gain21882294
    nsv893154CNV Gain21882294
    dgv8185n71CNV Gain21882294
    esv27810CNV Gain19812545
    nsv893129CNV Gain21882294
    nsv831560CNV Gain17160897
    dgv8183n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ZNF658 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ZNF658)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26149 HGNC: 25226 AceView: LOC401509 Ensembl:ENSG00000196409 euGenes: HUgn26149
    ECgene: ZNF658 H-InvDB: ZNF658

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ZNF658 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ZNF658 gene:
    Search GeneIP for patents involving ZNF658

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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