ZNF658 Gene
protein-coding GIFtS: 44
GCID: GC09M040750
|
|
zinc finger protein 658
| |
Aliases
for ZNF658 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6581 2 | | DKFZp572C1631 | | FLJ328131 | | MGC352321 |
Export aliases for ZNF658 gene to outside databasesPrevious GC identifer: GC09M040501 |
Summaries
for ZNF658 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN658_HUMAN, Q5TYW1Function: May be involved in transcriptional regulation
|
Genomic Views
for ZNF658 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_078041.2
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ZNF658
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF658
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF658 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13.1 Ensembl cytogenetic band: 9p13.1 HGNC cytogenetic band: 9p13.1ZNF658 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M040750: view genomic region
(about GC identifiers)
Start:
|
40,760,700 bp from pter |
End:
|
40,836,415 bp from pter |
Size:
|
75,716 bases |
Orientation:
|
minus strand |
|
Proteins
for ZNF658 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN658_HUMAN, Q5TYW1 (See
protein sequence)Recommended Name: Zinc finger protein 658 Size: 1059 amino acids; 122274 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH31626.1; Type=Erroneous initiation; Sequence=BAB14145.1; Type=Erroneous initiation;Sequence=CAB53677.2; Type=Erroneous initiation;
Secondary accessions: Q6PIP3 Q96M55 Q9H9S6 Q9UG02Alternative splicing: 2 isoforms: Q5TYW1-1 Q5TYW1-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ZNF658: NX_Q5TYW1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5TYW1
ZNF658 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_149350.3
ENSEMBL proteins: ENSP00000434029 ENSP00000366853 ENSP00000408462 Reactome Protein details: Q5TYW1
Human Recombinant Protein Products for ZNF658:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
ZNF658 for ontologies About GeneDecksing
ZNF658 Antibody Products:
Assay Products for ZNF658: |
Protein
Domains /
Families
for ZNF658 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF658 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5TYW1ProtoNet protein and cluster: Q5TYW1 1 Blocks protein family: IPB001909 KRAB box
UniProtKB/Swiss-Prot: ZN658_HUMAN, Q5TYW1Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 24 C2H2-type zinc fingersSimilarity: Contains 1 KRAB domain |
Function
for ZNF658 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN658_HUMAN, Q5TYW1Function: May be involved in transcriptional regulation Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ZNF658 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for ZNF658:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF658
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF658
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ZNF658 (NM_033160) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF658 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF658 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF658 |
|
Pathways & Interactions
for ZNF658 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for ZNF658
ZNF658 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF658
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF658 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF658 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF658
Search CenterWatch for drugs/clinical trials and news about ZNF658 / ZN658
|
Transcripts
for ZNF658 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF658 gene: NM_033160.5 Unigene Cluster for ZNF658: Zinc finger protein 658 Hs.522147 [show with all ESTs]Unigene Representative Sequence: NM_0331603 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000479710(uc010mmm.2) ENST00000377626(uc004abs.2 uc010mmn.1)
ENST00000441795
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF658
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF658
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ZNF658 (NM_033160) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF658 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF658 |
Additional cDNA sequence: AK022636.1 AK024222.1 AK057375.1 AK292150.1 AL110217.1 BC031626.1 5 DOTS entries: DT.121185725 DT.100748857 DT.316263 DT.40247560 DT.416386 11 AceView cDNA sequences: BU685875 AK095694 AI400091 BV200308 BM710714 AI919585 AW874634 BM981059 AV724641 AV721950 BU687037
GeneLoc Exon Structure
|
Expression
for ZNF658 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF658 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF658 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF658
SOURCE GeneReport for Unigene cluster: Hs.522147
SABiosciences Custom PCR Arrays for ZNF658
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF658
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ZNF658 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF658 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF658 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF658 |
Orthologs
for ZNF658 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF658 gene from 3/16 species (see all 16) About this table
ENSEMBL Gene Tree for ZNF658 (if available)
TreeFam Gene Tree for ZNF658 (if available) |
Paralogs
for ZNF658 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF658 gene
- ZNF6162 ZNF1602 ZNF8502 ZNF992 ZNF5462 ZNF6652 ZNF7212 ZNF8362
- ZNF8412 ZNF912 ZNF432 ZNF780B2 ZNF1972 ZNF585A2 ZNF8082 ZNF7292
- ZNF3472 ZNF8452 ZNF1842 ZNF585B2 ZNF6242 ZNF2082
18/511 SIMAP similar genes for ZNF658 using alignment to 3 protein entries: ZN658_HUMAN (see all proteins)
(see all similar genes):ZNF658B ZFS-5 ZNF78L1 kr-znf3 ZNF702P DKFZp686B16128
ZNF558 ZFS-1 DKFZp434J0650 DKFZp666M039 ZNF167 ZNF300P1
ZNF485 ZNF664 ZSCAN16 ZNF DKFZp686K03205 DKFZp762K012
ZNF658 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for ZNF658
PGOHUM00000261941 PGOHUM00000236052 PGOHUM00000250496
|
Genomic Variants
for ZNF658 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF658 (40760700 - 40836415 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for ZNF658
6 CNVs: 70580 31477 33099 2817 4623 3769 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF658 |
|
Disorders
/ Diseases
for ZNF658 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ZNF658 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF658 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ZNF658) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
|
External Searches for ZNF658 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF658 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF658 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ZNF658 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF658 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF658 gene:
Search GeneIP for patents involving ZNF658
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF658 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ZNF658 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF658 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ZNF658 | | OriGene 3'-UTR Clone for ZNF658 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF658 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF658 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF658 | | OriGene Custom Protein Services for ZNF658 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF658 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF658 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF658 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF658 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF658 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF658 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ZNF658 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ZNF658 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF658 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ZNF658 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF658 |
| |  | |
|
|
|
