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Aliases for ZNF658 Gene

Aliases for ZNF658 Gene

  • Zinc Finger Protein 658 2 3 5

External Ids for ZNF658 Gene

Previous GeneCards Identifiers for ZNF658 Gene

  • GC09M040501
  • GC09M040750

Summaries for ZNF658 Gene

GeneCards Summary for ZNF658 Gene

ZNF658 (Zinc Finger Protein 658) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF850.

UniProtKB/Swiss-Prot for ZNF658 Gene

  • Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) (5-C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3) found in the promoter region. May play a role in the control of ribosome biogenesis, regulating predominantly rRNA levels, as well as those of several ribosomal proteins, thus coordinating this highly zinc-demanding process with the available zinc supply.

Additional gene information for ZNF658 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF658 Gene

Genomics for ZNF658 Gene

Genomic Location for ZNF658 Gene

Chromosome:
9
Start:
66,856,426 bp from pter
End:
66,932,141 bp from pter
Size:
75,716 bases
Orientation:
Plus strand

Genomic View for ZNF658 Gene

Genes around ZNF658 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF658 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF658 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF658 Gene

No data available for Regulatory Elements for ZNF658 Gene

Proteins for ZNF658 Gene

  • Protein details for ZNF658 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TYW1-ZN658_HUMAN
    Recommended name:
    Zinc finger protein 658
    Protein Accession:
    Q5TYW1
    Secondary Accessions:
    • Q6PIP3
    • Q96M55
    • Q9H9S6
    • Q9UG02

    Protein attributes for ZNF658 Gene

    Size:
    1059 amino acids
    Molecular mass:
    122274 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31626.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14145.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB53677.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF658 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF658 Gene

Post-translational modifications for ZNF658 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF658 Gene

Domains & Families for ZNF658 Gene

Gene Families for ZNF658 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF658 Gene

Suggested Antigen Peptide Sequences for ZNF658 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TYW1

UniProtKB/Swiss-Prot:

ZN658_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF658: view

Function for ZNF658 Gene

Molecular function for ZNF658 Gene

UniProtKB/Swiss-Prot Function:
Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) (5-C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3) found in the promoter region. May play a role in the control of ribosome biogenesis, regulating predominantly rRNA levels, as well as those of several ribosomal proteins, thus coordinating this highly zinc-demanding process with the available zinc supply.

Gene Ontology (GO) - Molecular Function for ZNF658 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 25582195
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF658: view
genes like me logo Genes that share phenotypes with ZNF658: view

Animal Model Products

CRISPR Products

miRNA for ZNF658 Gene

miRTarBase miRNAs that target ZNF658

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF658
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF658 Gene

Localization for ZNF658 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF658 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF658 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF658 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF658: view

Pathways & Interactions for ZNF658 Gene

SuperPathways for ZNF658 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF658: view

Pathways by source for ZNF658 Gene

2 Reactome pathways for ZNF658 Gene

Interacting Proteins for ZNF658 Gene

Gene Ontology (GO) - Biological Process for ZNF658 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0042254 ribosome biogenesis IMP 25582195
GO:0045892 negative regulation of transcription, DNA-templated IMP 25582195
GO:0071294 cellular response to zinc ion IMP 25582195
genes like me logo Genes that share ontologies with ZNF658: view

No data available for SIGNOR curated interactions for ZNF658 Gene

Drugs & Compounds for ZNF658 Gene

No Compound Related Data Available

Transcripts for ZNF658 Gene

mRNA/cDNA for ZNF658 Gene

Unigene Clusters for ZNF658 Gene

Zinc finger protein 658:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ZNF658
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF658 Gene

No ASD Table

Relevant External Links for ZNF658 Gene

GeneLoc Exon Structure for
ZNF658
ECgene alternative splicing isoforms for
ZNF658

Expression for ZNF658 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF658 Gene

Protein differential expression in normal tissues from HIPED for ZNF658 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF658 Gene



Protein tissue co-expression partners for ZNF658 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF658 Gene:

ZNF658

SOURCE GeneReport for Unigene cluster for ZNF658 Gene:

Hs.522147

Evidence on tissue expression from TISSUES for ZNF658 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF658: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF658 Gene

Orthologs for ZNF658 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF658 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF658 33
  • 99.31 (n)
dog
(Canis familiaris)
Mammalia ZNF658 33
  • 82.36 (n)
mouse
(Mus musculus)
Mammalia Gm7145 33
  • 66.86 (n)
Zfp735 16
rat
(Rattus norvegicus)
Mammalia LOC102553026 33
  • 60.45 (n)
Species where no ortholog for ZNF658 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF658 Gene

ENSEMBL:
Gene Tree for ZNF658 (if available)
TreeFam:
Gene Tree for ZNF658 (if available)

Paralogs for ZNF658 Gene

(523) SIMAP similar genes for ZNF658 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF658 Gene

genes like me logo Genes that share paralogs with ZNF658: view

Variants for ZNF658 Gene

Sequence variations from dbSNP and Humsavar for ZNF658 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000002444 -- 66,900,679(-) GGCGC(A/G)TTAAC upstream-variant-2KB
rs1000141849 -- 66,905,299(-) CAAGA(G/T)TTCAA intron-variant
rs1000217611 -- 66,922,428(-) GCGTG(A/C)GTGAC intron-variant
rs1000422865 -- 66,916,213(-) ACAGA(A/G)ATAAA intron-variant
rs1000515112 -- 66,905,640(-) TGAAC(A/G)GGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF658 Gene

Variant ID Type Subtype PubMed ID
dgv1218n67 CNV gain 20364138
esv27810 CNV gain 19812545
esv3620457 CNV loss 21293372
esv3620458 CNV gain 21293372
nsv1132686 CNV duplication 24896259
nsv469605 CNV gain 16826518
nsv614322 CNV loss 21841781
nsv614323 CNV gain+loss 21841781
nsv614324 CNV gain 21841781
nsv831560 CNV gain 17160897
nsv831561 CNV loss 17160897

Variation tolerance for ZNF658 Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.73; 73.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF658 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF658

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF658 Gene

Disorders for ZNF658 Gene

Relevant External Links for ZNF658

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF658

No disorders were found for ZNF658 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF658 Gene

Publications for ZNF658 Gene

  1. The zinc finger protein ZNF658 regulates the transcription of genes involved in zinc homeostasis and affects ribosome biogenesis through the zinc transcriptional regulatory element. (PMID: 25582195) Ogo OA … Ford D (Molecular and cellular biology 2015) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60

Products for ZNF658 Gene

Sources for ZNF658 Gene

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