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Aliases for ZNF658 Gene

Aliases for ZNF658 Gene

  • Zinc Finger Protein 658 2 3 5

External Ids for ZNF658 Gene

Previous GeneCards Identifiers for ZNF658 Gene

  • GC09M040501
  • GC09M040750

Summaries for ZNF658 Gene

GeneCards Summary for ZNF658 Gene

ZNF658 (Zinc Finger Protein 658) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is ZNF729.

UniProtKB/Swiss-Prot for ZNF658 Gene

  • Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) (5-C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3) found in the promoter region. May play a role in the control of ribosome biogenesis, regulating predominantly rRNA levels, as well as those of several ribosomal proteins, thus coordinating this highly zinc-demanding process with the available zinc supply.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF658 Gene

Genomics for ZNF658 Gene

Genomic Location for ZNF658 Gene

Chromosome:
9
Start:
66,856,426 bp from pter
End:
66,932,141 bp from pter
Size:
75,716 bases
Orientation:
Plus strand

Genomic View for ZNF658 Gene

Genes around ZNF658 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF658 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF658 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF658 Gene

No data available for Regulatory Elements for ZNF658 Gene

Proteins for ZNF658 Gene

  • Protein details for ZNF658 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TYW1-ZN658_HUMAN
    Recommended name:
    Zinc finger protein 658
    Protein Accession:
    Q5TYW1
    Secondary Accessions:
    • Q6PIP3
    • Q96M55
    • Q9H9S6
    • Q9UG02

    Protein attributes for ZNF658 Gene

    Size:
    1059 amino acids
    Molecular mass:
    122274 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31626.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14145.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB53677.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF658 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF658 Gene

Proteomics data for ZNF658 Gene at MOPED

Post-translational modifications for ZNF658 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF658 Gene

Domains & Families for ZNF658 Gene

Gene Families for ZNF658 Gene

Protein Domains for ZNF658 Gene

Suggested Antigen Peptide Sequences for ZNF658 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TYW1

UniProtKB/Swiss-Prot:

ZN658_HUMAN :
  • Contains 1 KRAB domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 24 C2H2-type zinc fingers.
Domain:
  • Contains 1 KRAB domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 24 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF658: view

Function for ZNF658 Gene

Molecular function for ZNF658 Gene

UniProtKB/Swiss-Prot Function:
Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) (5-C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3) found in the promoter region. May play a role in the control of ribosome biogenesis, regulating predominantly rRNA levels, as well as those of several ribosomal proteins, thus coordinating this highly zinc-demanding process with the available zinc supply.

Gene Ontology (GO) - Molecular Function for ZNF658 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with ZNF658: view
genes like me logo Genes that share phenotypes with ZNF658: view

Animal Model Products

CRISPR Products

miRNA for ZNF658 Gene

miRTarBase miRNAs that target ZNF658

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF658 Gene

Localization for ZNF658 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF658 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF658 Gene COMPARTMENTS Subcellular localization image for ZNF658 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF658 Gene

Pathways & Interactions for ZNF658 Gene

SuperPathways for ZNF658 Gene

Superpath Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF658: view

Pathways by source for ZNF658 Gene

2 Reactome pathways for ZNF658 Gene

Interacting Proteins for ZNF658 Gene

Gene Ontology (GO) - Biological Process for ZNF658 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042254 ribosome biogenesis IMP 25582195
GO:0045892 negative regulation of transcription, DNA-templated IMP 25582195
GO:0071294 cellular response to zinc ion IMP 25582195
genes like me logo Genes that share ontologies with ZNF658: view

No data available for SIGNOR curated interactions for ZNF658 Gene

Drugs & Compounds for ZNF658 Gene

No Compound Related Data Available

Transcripts for ZNF658 Gene

mRNA/cDNA for ZNF658 Gene

Unigene Clusters for ZNF658 Gene

Zinc finger protein 658:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF658 Gene

No ASD Table

Relevant External Links for ZNF658 Gene

GeneLoc Exon Structure for
ZNF658
ECgene alternative splicing isoforms for
ZNF658

Expression for ZNF658 Gene

mRNA expression in normal human tissues for ZNF658 Gene

Protein differential expression in normal tissues from HIPED for ZNF658 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ZNF658 Gene



SOURCE GeneReport for Unigene cluster for ZNF658 Gene Hs.522147

genes like me logo Genes that share expression patterns with ZNF658: view

Protein tissue co-expression partners for ZNF658 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF658 Gene

Orthologs for ZNF658 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF658 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF658 35
  • 99.31 (n)
  • 98.58 (a)
dog
(Canis familiaris)
Mammalia ZNF658 35
  • 82.36 (n)
  • 72.22 (a)
mouse
(Mus musculus)
Mammalia Gm7145 35
  • 66.86 (n)
  • 58.51 (a)
Zfp735 16
rat
(Rattus norvegicus)
Mammalia LOC102553026 35
  • 60.45 (n)
  • 48.94 (a)
Species with no ortholog for ZNF658:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF658 Gene

ENSEMBL:
Gene Tree for ZNF658 (if available)
TreeFam:
Gene Tree for ZNF658 (if available)

Paralogs for ZNF658 Gene

(523) SIMAP similar genes for ZNF658 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ZNF658: view

Variants for ZNF658 Gene

Sequence variations from dbSNP and Humsavar for ZNF658 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2065444 - 66,908,699(+) ATGGT(A/C)TTTAG reference, missense
rs1060552 -- 66,920,774(+) AACAC(A/G)TAGTG utr-variant-3-prime
rs2259423 -- 66,921,042(+) CCATA(A/G)AGCAC utr-variant-3-prime
rs2259426 -- 66,920,985(+) CATAA(G/T)ATGGA utr-variant-3-prime
rs2259428 -- 66,920,931(+) TTTAC(C/T)CTTGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ZNF658 Gene

Variant ID Type Subtype PubMed ID
dgv8179n71 CNV Gain 21882294
essv9712 CNV CNV 17122850
dgv8183n71 CNV Gain 21882294
nsv893129 CNV Gain 21882294
nsv831560 CNV Gain 17160897
nsv893132 CNV Gain 21882294
nsv893133 CNV Gain+Loss 21882294
nsv893135 CNV Gain 21882294
dgv8185n71 CNV Gain 21882294
nsv831561 CNV Loss 17160897
dgv8186n71 CNV Gain 21882294
dgv8187n71 CNV Gain 21882294
nsv893142 CNV Loss 21882294
dgv8189n71 CNV Gain 21882294
nsv893154 CNV Gain 21882294
esv27810 CNV Gain 19812545
dgv1218n67 CNV Gain 20364138

Variation tolerance for ZNF658 Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.73; 73.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF658 Gene

HapMap Linkage Disequilibrium report
ZNF658

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF658 Gene

Disorders for ZNF658 Gene

Relevant External Links for ZNF658

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF658

No disorders were found for ZNF658 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF658 Gene

Publications for ZNF658 Gene

  1. The zinc finger protein ZNF658 regulates the transcription of genes involved in zinc homeostasis and affects ribosome biogenesis through the zinc transcriptional regulatory element. (PMID: 25582195) Ogo O.A. … Ford D. (Mol. Cell. Biol. 2015) 3 4 67
  2. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3

Products for ZNF658 Gene

Sources for ZNF658 Gene

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