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Aliases for ZNF654 Gene

Aliases for ZNF654 Gene

  • Zinc Finger Protein 654 2 3 5
  • Melanoma-Associated Antigen 4

External Ids for ZNF654 Gene

Previous GeneCards Identifiers for ZNF654 Gene

  • GC03P088271
  • GC03P088188
  • GC03P088059

Summaries for ZNF654 Gene

GeneCards Summary for ZNF654 Gene

ZNF654 (Zinc Finger Protein 654) is a Protein Coding gene. Diseases associated with ZNF654 include malignant choroid melanoma and cell type cancer. An important paralog of this gene is RLF.

UniProtKB/Swiss-Prot for ZNF654 Gene

  • May be involved in transcriptional regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF654 Gene

Genomics for ZNF654 Gene

Regulatory Elements for ZNF654 Gene

Genomic Location for ZNF654 Gene

Chromosome:
3
Start:
88,139,104 bp from pter
End:
88,144,665 bp from pter
Size:
5,562 bases
Orientation:
Plus strand

Genomic View for ZNF654 Gene

Genes around ZNF654 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF654 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF654 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF654 Gene

Proteins for ZNF654 Gene

  • Protein details for ZNF654 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZM8-ZN654_HUMAN
    Recommended name:
    Zinc finger protein 654
    Protein Accession:
    Q8IZM8
    Secondary Accessions:
    • Q9H791
    • Q9NV14

    Protein attributes for ZNF654 Gene

    Size:
    581 amino acids
    Molecular mass:
    65854 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAN40504.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA91946.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15007.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF654 Gene

Proteomics data for ZNF654 Gene at MOPED

Post-translational modifications for ZNF654 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF654 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ZNF654 Gene

Domains & Families for ZNF654 Gene

Protein Domains for ZNF654 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF654 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZM8

UniProtKB/Swiss-Prot:

ZN654_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF654: view

No data available for Gene Families for ZNF654 Gene

Function for ZNF654 Gene

Molecular function for ZNF654 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with ZNF654: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF654 Gene

Localization for ZNF654 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF654 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF654 Gene COMPARTMENTS Subcellular localization image for ZNF654 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
lysosome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ZNF654 Gene

Pathways & Interactions for ZNF654 Gene

SuperPathways for ZNF654 Gene

No Data Available

Interacting Proteins for ZNF654 Gene

Gene Ontology (GO) - Biological Process for ZNF654 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF654: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF654 Gene

Drugs & Compounds for ZNF654 Gene

No Compound Related Data Available

Transcripts for ZNF654 Gene

mRNA/cDNA for ZNF654 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(65) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF654 Gene

Zinc finger protein 654:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF654 Gene

No ASD Table

Relevant External Links for ZNF654 Gene

GeneLoc Exon Structure for
ZNF654
ECgene alternative splicing isoforms for
ZNF654

Expression for ZNF654 Gene

mRNA expression in normal human tissues for ZNF654 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF654 Gene

This gene is overexpressed in Prostate (45.1) and CD8 Tcells (23.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF654 Gene



SOURCE GeneReport for Unigene cluster for ZNF654 Gene Hs.591650

genes like me logo Genes that share expression patterns with ZNF654: view

Protein tissue co-expression partners for ZNF654 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ZNF654 Gene

Orthologs for ZNF654 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF654 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF654 35
  • 92.47 (n)
  • 90.86 (a)
dog
(Canis familiaris)
Mammalia ZNF654 35
  • 93.57 (n)
  • 92.6 (a)
mouse
(Mus musculus)
Mammalia Zfp654 35
  • 87.84 (n)
  • 85.96 (a)
Zfp654 16
Zfp654 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp654 35
  • 87.89 (n)
  • 84.56 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 26 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF654 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF654 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF654 35
  • 68.44 (n)
  • 58.08 (a)
-- 36
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 21 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia znf654 35
  • 56.02 (n)
  • 46.5 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100536880 35
  • 46.03 (n)
  • 35.24 (a)
znf654 36
  • 4 (a)
OneToMany
Species with no ortholog for ZNF654:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF654 Gene

ENSEMBL:
Gene Tree for ZNF654 (if available)
TreeFam:
Gene Tree for ZNF654 (if available)

Paralogs for ZNF654 Gene

Paralogs for ZNF654 Gene

(1) SIMAP similar genes for ZNF654 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ZNF654 Gene

genes like me logo Genes that share paralogs with ZNF654: view

Variants for ZNF654 Gene

Variation tolerance for ZNF654 Gene

Residual Variation Intolerance Score: 67.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF654 Gene

HapMap Linkage Disequilibrium report
ZNF654

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for ZNF654 Gene

Disorders for ZNF654 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF654 Gene - From: DISEASES

Disorder Aliases PubMed IDs
malignant choroid melanoma
  • malignant melanoma of choroid
cell type cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF654

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF654
genes like me logo Genes that share disorders with ZNF654: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF654 Gene

Publications for ZNF654 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry J.R. … Ong K.K. (Nature 2014) 3

Products for ZNF654 Gene

Sources for ZNF654 Gene

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