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Aliases for ZNF653 Gene

Aliases for ZNF653 Gene

  • Zinc Finger Protein 653 2 3 5
  • 67 KDa Zinc Finger Protein 3 4
  • Zinc Finger Protein Zip67 3 4
  • ZIP67 3 4
  • E430039K05Rik 3

External Ids for ZNF653 Gene

Previous GeneCards Identifiers for ZNF653 Gene

  • GC19M011457
  • GC19M011594
  • GC19M011168

Summaries for ZNF653 Gene

GeneCards Summary for ZNF653 Gene

ZNF653 (Zinc Finger Protein 653) is a Protein Coding gene. An important paralog of this gene is ENSG00000267477.

UniProtKB/Swiss-Prot for ZNF653 Gene

  • Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF653 Gene

Genomics for ZNF653 Gene

Regulatory Elements for ZNF653 Gene

Enhancers for ZNF653 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G011086 1.8 FANTOM5 ENCODE dbSUPER 10.7 +413.6 413553 11.0 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ZNF844 RAVER1 PRKCSH ZNF700 ZNF491 C19orf38 ZNF627 ZNF653 ZNF441 ZGLP1
GH19G010695 1.3 Ensembl ENCODE 10.7 +810.2 810214 1.4 MLX AGO1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 ZNF207 KLF13 ILF3-AS1 UBE2L4 ENSG00000267612 ZNF653 RPL18AP13 ZGLP1 QTRT1 ILF3
GH19G011478 1.8 FANTOM5 Ensembl ENCODE 2.3 +24.3 24298 5.4 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 ENSG00000242615 ZNF627 ZNF625 TIMM29 ZNF441 ZNF788 ZNF439 ZNF491 ZNF136 ILF3-AS1
GH19G011373 1.7 FANTOM5 ENCODE dbSUPER 2 +129.6 129604 6.2 HDGF PKNOX1 CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 TMEM205 CCDC159 RAB3D ZNF136 TIMM29 PLPPR2 ELAVL3 PRKCSH ZNF441 ZNF627
GH19G011530 1.5 FANTOM5 Ensembl ENCODE 1.8 -24.6 -24579 0.6 PKNOX1 MLX ARID4B SIN3A ZNF48 TCF12 SLC30A9 ZNF143 FOS ZNF263 ZNF439 CCDC151 ELAVL3 ZNF491 ZNF653 ZNF441 ECSIT GC19P011537
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF653 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF653 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107193 423 1401 HDGF AGO1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF207 KLF13 SP3

Genomic Location for ZNF653 Gene

Chromosome:
19
Start:
11,483,427 bp from pter
End:
11,505,923 bp from pter
Size:
22,497 bases
Orientation:
Minus strand

Genomic View for ZNF653 Gene

Genes around ZNF653 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF653 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF653 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF653 Gene

Proteins for ZNF653 Gene

  • Protein details for ZNF653 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CK0-ZN653_HUMAN
    Recommended name:
    Zinc finger protein 653
    Protein Accession:
    Q96CK0
    Secondary Accessions:
    • Q96AS7

    Protein attributes for ZNF653 Gene

    Size:
    615 amino acids
    Molecular mass:
    67235 Da
    Quaternary structure:
    • Interacts with NR5A1.

neXtProt entry for ZNF653 Gene

Post-translational modifications for ZNF653 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF653 Gene

No data available for DME Specific Peptides for ZNF653 Gene

Domains & Families for ZNF653 Gene

Gene Families for ZNF653 Gene

Protein Domains for ZNF653 Gene

Suggested Antigen Peptide Sequences for ZNF653 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96CK0

UniProtKB/Swiss-Prot:

ZN653_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF653: view

Function for ZNF653 Gene

Molecular function for ZNF653 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity.

Gene Ontology (GO) - Molecular Function for ZNF653 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF653: view
genes like me logo Genes that share phenotypes with ZNF653: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF653 Gene

Localization for ZNF653 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF653 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF653 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF653 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF653: view

Pathways & Interactions for ZNF653 Gene

SuperPathways for ZNF653 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF653 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF653: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF653 Gene

Transcripts for ZNF653 Gene

Unigene Clusters for ZNF653 Gene

Zinc finger protein 653:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF653 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - - - -
SP2: - - - - - - - - -
SP3:
SP4: - -
SP5: -
SP6:
SP7:

Relevant External Links for ZNF653 Gene

GeneLoc Exon Structure for
ZNF653
ECgene alternative splicing isoforms for
ZNF653

Expression for ZNF653 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF653 Gene

Protein differential expression in normal tissues from HIPED for ZNF653 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF653 Gene



Protein tissue co-expression partners for ZNF653 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF653 Gene:

ZNF653

SOURCE GeneReport for Unigene cluster for ZNF653 Gene:

Hs.465928

mRNA Expression by UniProt/SwissProt for ZNF653 Gene:

Q96CK0-ZN653_HUMAN
Tissue specificity: Highly expressed in testis, cerebellum, temporal lobe, hippocampus and the adrenal gland. Moderately expressed in spleen, uterus, thymus, pancreas, kidney, stomach and rectum.

Evidence on tissue expression from TISSUES for ZNF653 Gene

  • Nervous system(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with ZNF653: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF653 Gene

Orthologs for ZNF653 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF653 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF653 34 35
  • 97.95 (n)
dog
(Canis familiaris)
Mammalia ZNF653 34 35
  • 91.69 (n)
cow
(Bos Taurus)
Mammalia ZNF653 34 35
  • 90.97 (n)
mouse
(Mus musculus)
Mammalia Zfp653 34 16 35
  • 87.73 (n)
rat
(Rattus norvegicus)
Mammalia Zfp653 34
  • 87.08 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 74 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486237 34
  • 58.65 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15416 34
zebrafish
(Danio rerio)
Actinopterygii znf653 35
  • 52 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 17 (a)
OneToMany
Species where no ortholog for ZNF653 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF653 Gene

ENSEMBL:
Gene Tree for ZNF653 (if available)
TreeFam:
Gene Tree for ZNF653 (if available)

Paralogs for ZNF653 Gene

Variants for ZNF653 Gene

Sequence variations from dbSNP and Humsavar for ZNF653 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000018285 -- 11,494,860(+) GCCAT(A/G)GGGAA intron-variant
rs1000046368 -- 11,489,207(+) ATTTT(C/G)TTTTT intron-variant
rs1000294178 -- 11,505,625(+) TCGTA(-/CTT)CTTCC downstream-variant-500B, cds-indel
rs1000329578 -- 11,499,956(+) CTTCG(C/T)CATGG intron-variant
rs1000341825 -- 11,494,639(+) GCCGA(A/G)ATCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF653 Gene

Variant ID Type Subtype PubMed ID
nsv519802 CNV loss 19592680

Variation tolerance for ZNF653 Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF653 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF653

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF653 Gene

Disorders for ZNF653 Gene

Relevant External Links for ZNF653

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF653

No disorders were found for ZNF653 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF653 Gene

Publications for ZNF653 Gene

  1. Cloning and characterization of a novel zinc finger protein that modulates the transcriptional activity of nuclear receptors. (PMID: 12920234) Borud B. … Bakke M. (Mol. Endocrinol. 2003) 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 64

Products for ZNF653 Gene

Sources for ZNF653 Gene

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