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Aliases for ZNF653 Gene

Aliases for ZNF653 Gene

  • Zinc Finger Protein 653 2 3 5
  • 67 KDa Zinc Finger Protein 3 4
  • Zinc Finger Protein Zip67 3 4
  • ZIP67 3 4
  • E430039K05Rik 3

External Ids for ZNF653 Gene

Previous GeneCards Identifiers for ZNF653 Gene

  • GC19M011457
  • GC19M011594
  • GC19M011168

Summaries for ZNF653 Gene

GeneCards Summary for ZNF653 Gene

ZNF653 (Zinc Finger Protein 653) is a Protein Coding gene. An important paralog of this gene is ZFP91.

UniProtKB/Swiss-Prot for ZNF653 Gene

  • Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF653 Gene

Genomics for ZNF653 Gene

Regulatory Elements for ZNF653 Gene

Enhancers for ZNF653 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZNF653 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF653 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF653 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF653 Gene

11,483,427 bp from pter
11,505,923 bp from pter
22,497 bases
Minus strand

Genomic View for ZNF653 Gene

Genes around ZNF653 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF653 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF653 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF653 Gene

Proteins for ZNF653 Gene

  • Protein details for ZNF653 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 653
    Protein Accession:
    Secondary Accessions:
    • Q96AS7

    Protein attributes for ZNF653 Gene

    615 amino acids
    Molecular mass:
    67235 Da
    Quaternary structure:
    • Interacts with NR5A1.

neXtProt entry for ZNF653 Gene

Proteomics data for ZNF653 Gene at MOPED

Post-translational modifications for ZNF653 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF653 Gene

No data available for DME Specific Peptides for ZNF653 Gene

Domains & Families for ZNF653 Gene

Gene Families for ZNF653 Gene

Protein Domains for ZNF653 Gene

Suggested Antigen Peptide Sequences for ZNF653 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF653: view

Function for ZNF653 Gene

Molecular function for ZNF653 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity.
genes like me logo Genes that share phenotypes with ZNF653: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF653 Gene

Localization for ZNF653 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF653 Gene

Subcellular locations from

Jensen Localization Image for ZNF653 Gene COMPARTMENTS Subcellular localization image for ZNF653 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ZNF653 Gene

Pathways & Interactions for ZNF653 Gene

SuperPathways for ZNF653 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF653 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF653: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF653 Gene

Drugs & Compounds for ZNF653 Gene

No Compound Related Data Available

Transcripts for ZNF653 Gene

Unigene Clusters for ZNF653 Gene

Zinc finger protein 653:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF653 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - - - -
SP2: - - - - - - - - -
SP4: - -
SP5: -

Relevant External Links for ZNF653 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF653 Gene

mRNA expression in normal human tissues for ZNF653 Gene

Protein differential expression in normal tissues from HIPED for ZNF653 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF653 Gene

SOURCE GeneReport for Unigene cluster for ZNF653 Gene Hs.465928

mRNA Expression by UniProt/SwissProt for ZNF653 Gene

Tissue specificity: Highly expressed in testis, cerebellum, temporal lobe, hippocampus and the adrenal gland. Moderately expressed in spleen, uterus, thymus, pancreas, kidney, stomach and rectum.
genes like me logo Genes that share expression patterns with ZNF653: view

Protein tissue co-expression partners for ZNF653 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF653 Gene

Orthologs for ZNF653 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF653 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ZNF653 35
  • 90.97 (n)
  • 94.34 (a)
ZNF653 36
  • 94 (a)
(Canis familiaris)
Mammalia ZNF653 35
  • 91.69 (n)
  • 94.95 (a)
ZNF653 36
  • 94 (a)
(Mus musculus)
Mammalia Zfp653 35
  • 87.73 (n)
  • 92.98 (a)
Zfp653 16
Zfp653 36
  • 93 (a)
(Pan troglodytes)
Mammalia ZNF653 35
  • 97.95 (n)
  • 97.78 (a)
ZNF653 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Zfp653 35
  • 87.08 (n)
  • 92.8 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486237 35
  • 58.65 (n)
  • 55.63 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15416 35
(Danio rerio)
Actinopterygii znf653 36
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
Species with no ortholog for ZNF653:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF653 Gene

Gene Tree for ZNF653 (if available)
Gene Tree for ZNF653 (if available)

Paralogs for ZNF653 Gene

Paralogs for ZNF653 Gene

genes like me logo Genes that share paralogs with ZNF653: view

Variants for ZNF653 Gene

Sequence variations from dbSNP and Humsavar for ZNF653 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_028076 -
rs35556595 - 11,487,478(+) GAGAG(C/T)GTCGT reference, missense
rs7256655 -- 11,499,672(+) gttag(C/G)aggtt intron-variant
rs7508166 -- 11,494,241(+) tgctt(C/G)aacct intron-variant
rs62131158 -- 11,485,834(+) TGGGG(A/G)GAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF653 Gene

Variant ID Type Subtype PubMed ID
nsv519802 CNV Loss 19592680
nsv911062 CNV Loss 21882294
nsv911065 CNV Loss 21882294
nsv911066 CNV Loss 21882294

Variation tolerance for ZNF653 Gene

Residual Variation Intolerance Score: 24.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ZNF653 Gene

Disorders for ZNF653 Gene

Relevant External Links for ZNF653

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ZNF653 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF653 Gene

Publications for ZNF653 Gene

  1. Cloning and characterization of a novel zinc finger protein that modulates the transcriptional activity of nuclear receptors. (PMID: 12920234) Borud B. … Bakke M. (Mol. Endocrinol. 2003) 3 4 23 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for ZNF653 Gene

Sources for ZNF653 Gene