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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ZNF653 Gene

protein-coding   GIFtS: 46
GCID: GC19M011594

Zinc Finger Protein 653

  Search for ZNF653
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Zinc Finger Protein 6531 2
Zinc Finger Protein Zip672 3
67 KDa Zinc Finger Protein2 3
ZIP672 3
E430039K05Rik2

External Ids:    HGNC: 251961   Entrez Gene: 1159502   Ensembl: ENSG000001619147   OMIM: 6113715   UniProtKB: Q96CK03   

Export aliases for ZNF653 gene to outside databases

Previous GC identifers: GC19M011457 GC19M011168


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ZNF653 Gene: 
ZNF653 (zinc finger protein 653) is a protein-coding gene. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is ZNF692.

UniProtKB/Swiss-Prot: ZN653_HUMAN, Q96CK0
Function: Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional
activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ZNF653 gene promoter:
         Elk-1   AML1a   FOXO3   IRF-1   FOXO3b   Max   MZF-1   FOXO3a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidZNF653 promoter sequence
   Search SABiosciences Chromatin IP Primers for ZNF653

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF653


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ZNF653 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF653 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M011594:  view genomic region     (about GC identifiers)

Start:
11,594,242 bp from pter      End:
11,616,738 bp from pter
Size:
22,497 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZN653_HUMAN, Q96CK0 (See protein sequence)
Recommended Name: Zinc finger protein 653  
Size: 615 amino acids; 67235 Da
Subunit: Interacts with NR5A1
Subcellular location: Nucleus (Probable)
Secondary accessions: Q96AS7

Explore the universe of human proteins at neXtProt for ZNF653: NX_Q96CK0

Explore proteomics data for ZNF653 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96CK0

  • ZNF653 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ZNF653 Protein Expression
    REFSEQ proteins: NP_620138.2  
    ENSEMBL proteins: 
     ENSP00000465166   ENSP00000293771   ENSP00000465955   ENSP00000467069   ENSP00000465674  

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    Cloud-Clone Corp. Proteins for ZNF653 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    ZNF653 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR017956 AT_hook_DNA-bd_motif
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q96CK0

    ProtoNet protein and cluster: Q96CK0

    UniProtKB/Swiss-Prot: ZN653_HUMAN, Q96CK0
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 5 C2H2-type zinc fingers


    ZNF653 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZN653_HUMAN, Q96CK0
    Function: Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional
    activity

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    ZNF653 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ZNF653:
     Decreased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ZNF653 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ZNF653

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ZNF653 (Q96CK03 ENSP000002937714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR5A1Q132853, ENSP000003626904I2D: score=1 STRING: ENSP00000362690
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    ZNF653 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ZNF653 (ZN653)

    Search CenterWatch for drugs/clinical trials and news about ZNF653 / ZN653

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ZNF653 gene: 
    NM_138783.3  

    Unigene Cluster for ZNF653:

    Zinc finger protein 653
    Hs.465928  [show with all ESTs]
    Unigene Representative Sequence: NM_138783
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000590296 ENST00000293771(uc002mrz.2) ENST00000589051 ENST00000590548
    ENST00000592756 ENST00000588541 ENST00000593191
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK131037.1 AY072704.1 BC014187.2 BC016816.1 

    7 DOTS entries:

    DT.100883838  DT.101980316  DT.91724807  DT.92023168  DT.95157537  DT.91698825  DT.121505214 

    24/409 AceView cDNA sequences (see all 409):

    CR614297 BM467897 BI833479 BI756058 BC000193 BQ279023 BC008279 BM662700 
    BM801779 BE295484 BM977074 BQ065912 BQ643039 AI783500 CR608548 CR625388 
    BM921622 AI091320 BU193120 BE408896 BE042513 BU186092 AI475087 BM686156 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF653 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b
    SP1:        -     -     -                 -                                                           -               
    SP2:        -     -     -                 -                 -     -     -     -                       -               
    SP3:                                                                                                                  
    SP4:                                                                                            -     -               
    SP5:                                      -                                                                           


    ECgene alternative splicing isoforms for ZNF653

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ZNF653 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAAGCACA
    ZNF653 Expression
    About this image


    See ZNF653 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ZNF653

    SOURCE GeneReport for Unigene cluster: Hs.465928

    UniProtKB/Swiss-Prot: ZN653_HUMAN, Q96CK0
    Tissue specificity: Highly expressed in testis, cerebellum, temporal lobe, hippocampus and the adrenal gland.
    Moderately expressed in spleen, uterus, thymus, pancreas, kidney, stomach and rectum

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ZNF653 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Zfp6531 , 5 zinc finger protein 6531, 5 87.58(n)1
    92.97(a)1
      9 (8.18 cM)5
    3196011  NM_177318.21  NP_796292.11 
     220554605 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    74(a)
    1 → many
    2(78629099-78643213)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.154162 Xenopus laevis transcribed sequence with weak similarity more 74.97(n)    BX853915.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003297421 zinc finger protein 653-like 58.17(n)
    54.63(a)
      100329742  XM_002661114.2  XP_002661160.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG153366
    --
    17(a)
    possible ortholog
    X(8041982-8042529)


    ENSEMBL Gene Tree for ZNF653 (if available)
    TreeFam Gene Tree for ZNF653 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ZNF653 gene
    ZNF6922  ZFP912  ENSG000002674772  ZFP91-CNTF2  ZNF2762  
    18/27 SIMAP similar genes for ZNF653 using alignment to 5 protein entries:     ZN653_HUMAN (see all proteins) (see all similar genes):
    WT1    ZNF692    OVOL3    ZEB1    kr-znf3    ZNF263
    ZFS-6    HZF16    ZNF600    ZNF628    KLF1    ZNF410
    ZNF    KLF13    ZNF72    ZNF785    DKFZp686N0199    DKFZp434J0650

    ZNF653 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/548 SNPs in ZNF653 are shown (see all 548)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0280764
    ----see VAR_0280762 K R mis40--------
    rs788955811,2
    C,F--11593858(+) AGAGGC/TCCTCC 1 -- int11Minor allele frequency- T:0.17NA 120
    rs118788491,2
    C,F,H--11594045(+) GAAATT/CAGGGT 1 -- int117Minor allele frequency- C:0.10NS EA NA WA 2338
    rs1116443341,2
    C,F--11594136(+) GCTGGG/CCCCAG 1 -- int12Minor allele frequency- C:0.07CSA WA 120
    rs1442197841,2
    --11594225(+) ATTCAC/GGCCTA 1 -- int10--------
    rs1465539961,2
    --11594431(+) CCAGGC/TCCCGG 1 -- ut310--------
    rs2010983851,2
    C,F--11594490(+) TGGTCA/GGGTGG 1 -- ut311Minor allele frequency- G:0.01EU 955
    rs1511651161,2
    C--11594548(+) ACGCTG/CTCCAG 2 /D /E mis11Minor allele frequency- C:0.00NA 4542
    rs2019493841,2
    --11594661(+) GTAGCC/TACAGA 2 S G mis10--------
    rs2013858781,2
    --11594970(+) GGTGGA/GGACCG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ZNF653 (11594242 - 11616738 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ZNF653:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911066CNV Loss21882294
    nsv911062CNV Loss21882294
    nsv911065CNV Loss21882294
    nsv519802CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ZNF653 for disorders           About MalaCards
    OMIM gene information: 611371    OMIM disorders: --


    ZNF653 for disorders           About GeneDecksing


    Export disorders for ZNF653 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ZNF653 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ZNF653)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel zinc finger protein that modulates the transcriptional activity of nuclear receptors. (PubMed id 12920234)1, 2, 9 Borud B.... Bakke M. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115950 HGNC: 25196 AceView: SITPECandZIP67 Ensembl:ENSG00000161914 euGenes: HUgn115950
    ECgene: ZNF653 H-InvDB: ZNF653

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ZNF653 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ZNF653 gene:
    Search GeneIP for patents involving ZNF653

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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