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Aliases for ZNF652 Gene

Aliases for ZNF652 Gene

  • Zinc Finger Protein 652 2 3 5
  • KIAA0924 4

External Ids for ZNF652 Gene

Previous GeneCards Identifiers for ZNF652 Gene

  • GC17M044728
  • GC17M047366
  • GC17M042731

Summaries for ZNF652 Gene

GeneCards Summary for ZNF652 Gene

ZNF652 (Zinc Finger Protein 652) is a Protein Coding gene. Diseases associated with ZNF652 include vulva cancer. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZBTB47.

UniProtKB/Swiss-Prot for ZNF652 Gene

  • Functions as a transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF652 Gene

Genomics for ZNF652 Gene

Regulatory Elements for ZNF652 Gene

Promoters for ZNF652 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF652 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF652 Gene

Chromosome:
17
Start:
49,289,206 bp from pter
End:
49,362,473 bp from pter
Size:
73,268 bases
Orientation:
Minus strand

Genomic View for ZNF652 Gene

Genes around ZNF652 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF652 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF652 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF652 Gene

Proteins for ZNF652 Gene

  • Protein details for ZNF652 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2D9-ZN652_HUMAN
    Recommended name:
    Zinc finger protein 652
    Protein Accession:
    Q9Y2D9
    Secondary Accessions:
    • A4QPD9
    • Q5H9Q0

    Protein attributes for ZNF652 Gene

    Size:
    606 amino acids
    Molecular mass:
    69744 Da
    Quaternary structure:
    • Interacts with CBFA2T3.
    SequenceCaution:
    • Sequence=BAA76768.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF652 Gene

Proteomics data for ZNF652 Gene at MOPED

Post-translational modifications for ZNF652 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF652 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for ZNF652

No data available for DME Specific Peptides for ZNF652 Gene

Domains & Families for ZNF652 Gene

Gene Families for ZNF652 Gene

Protein Domains for ZNF652 Gene

Suggested Antigen Peptide Sequences for ZNF652 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2D9

UniProtKB/Swiss-Prot:

ZN652_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF652: view

Function for ZNF652 Gene

Molecular function for ZNF652 Gene

UniProtKB/Swiss-Prot Function:
Functions as a transcriptional repressor.

Phenotypes for ZNF652 Gene

GenomeRNAi human phenotypes for ZNF652:
genes like me logo Genes that share phenotypes with ZNF652: view

Animal Model Products

CRISPR Products

miRNA for ZNF652 Gene

miRTarBase miRNAs that target ZNF652

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF652 Gene

Localization for ZNF652 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF652 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZNF652 Gene COMPARTMENTS Subcellular localization image for ZNF652 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ZNF652 Gene

Pathways & Interactions for ZNF652 Gene

SuperPathways for ZNF652 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF652 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF652 Gene

Drugs & Compounds for ZNF652 Gene

No Compound Related Data Available

Transcripts for ZNF652 Gene

Unigene Clusters for ZNF652 Gene

Zinc finger protein 652:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF652 Gene

No ASD Table

Relevant External Links for ZNF652 Gene

GeneLoc Exon Structure for
ZNF652
ECgene alternative splicing isoforms for
ZNF652

Expression for ZNF652 Gene

mRNA expression in normal human tissues for ZNF652 Gene

Protein differential expression in normal tissues from HIPED for ZNF652 Gene

This gene is overexpressed in Plasma (32.7), Peripheral blood mononuclear cells (16.3), CD8 Tcells (9.0), and NK cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF652 Gene



SOURCE GeneReport for Unigene cluster for ZNF652 Gene Hs.463375

mRNA Expression by UniProt/SwissProt for ZNF652 Gene

Q9Y2D9-ZN652_HUMAN
Tissue specificity: Widely expressed with higher expression in breast, prostate, vulva and pancreas.
genes like me logo Genes that share expression patterns with ZNF652: view

Protein tissue co-expression partners for ZNF652 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF652 Gene

Orthologs for ZNF652 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF652 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF652 35
  • 99.78 (n)
  • 99.83 (a)
ZNF652 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF652 36
  • 96 (a)
OneToOne
ZNF652 35
  • 94.44 (n)
  • 96.7 (a)
dog
(Canis familiaris)
Mammalia ZNF652 35
  • 94.22 (n)
  • 96.86 (a)
ZNF652 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp652 16
Zfp652 36
  • 91 (a)
OneToOne
Zfp652 35
  • 88.21 (n)
  • 91.07 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF652 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF652 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp652 35
  • 89.04 (n)
  • 91.74 (a)
chicken
(Gallus gallus)
Aves ZNF652 35
  • 85.75 (n)
  • 92.57 (a)
ZNF652 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF652 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14592 35
zebrafish
(Danio rerio)
Actinopterygii znf652 36
  • 59 (a)
OneToOne
znf652 35
  • 62.76 (n)
  • 63.2 (a)
Species with no ortholog for ZNF652:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF652 Gene

ENSEMBL:
Gene Tree for ZNF652 (if available)
TreeFam:
Gene Tree for ZNF652 (if available)

Paralogs for ZNF652 Gene

Paralogs for ZNF652 Gene

Pseudogenes.org Pseudogenes for ZNF652 Gene

genes like me logo Genes that share paralogs with ZNF652: view

Variants for ZNF652 Gene

Sequence variations from dbSNP and Humsavar for ZNF652 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs747039 -- 49,329,551(-) CCATA(A/C/T)AAAAT intron-variant
rs2040860 -- 49,307,977(-) ATGTT(A/G)GGTCT intron-variant
rs2072153 -- 49,312,652(-) TTGTT(C/G/T)TTCTG intron-variant
rs2072154 -- 49,312,484(-) ACATT(A/G)CTGTT intron-variant
rs2189785 -- 49,308,182(-) AAACC(A/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF652 Gene

Variant ID Type Subtype PubMed ID
esv271977 CNV Insertion 20981092
nsv526307 CNV Gain 19592680
nsv2075 CNV Loss 18451855

Variation tolerance for ZNF652 Gene

Residual Variation Intolerance Score: 17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 49.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF652 Gene

HapMap Linkage Disequilibrium report
ZNF652

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF652 Gene

Disorders for ZNF652 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF652 Gene - From: DISEASES

Disorder Aliases PubMed IDs
vulva cancer
  • ca vulva
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF652

Genetic Association Database (GAD)
ZNF652
Human Genome Epidemiology (HuGE) Navigator
ZNF652
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF652
genes like me logo Genes that share disorders with ZNF652: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF652 Gene

Publications for ZNF652 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. Fine-mapping the 2q37 and 17q11.2-q22 loci for novel genes and sequence variants associated with a genetic predisposition to prostate cancer. (PMID: 25335771) Laitinen V.H. … Schleutker J. (Int. J. Cancer 2015) 3
  3. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3
  4. A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation. (PMID: 22829776) Coviello A.D. … Perry J.R. (PLoS Genet. 2012) 3
  5. Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans. (PMID: 20852445) Liu C. … Lin X. (J. Hypertens. 2011) 3

Products for ZNF652 Gene

Sources for ZNF652 Gene

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