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Aliases for ZNF652 Gene

Aliases for ZNF652 Gene

  • Zinc Finger Protein 652 2 3 5
  • KIAA0924 4

External Ids for ZNF652 Gene

Previous GeneCards Identifiers for ZNF652 Gene

  • GC17M044728
  • GC17M047366
  • GC17M042731

Summaries for ZNF652 Gene

GeneCards Summary for ZNF652 Gene

ZNF652 (Zinc Finger Protein 652) is a Protein Coding gene. Diseases associated with ZNF652 include Vulva Cancer. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZBTB47.

UniProtKB/Swiss-Prot for ZNF652 Gene

  • Functions as a transcriptional repressor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF652 Gene

Genomics for ZNF652 Gene

Regulatory Elements for ZNF652 Gene

Enhancers for ZNF652 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F049387 1.6 FANTOM5 Ensembl ENCODE 21 -27.3 -27328 5.2 PKNOX1 ATF1 ZNF133 FEZF1 DMAP1 GTF3C2 GATA2 FOS KAT8 HMBOX1 ZNF652 ENSG00000262837 LOC102724596 PHB ENSG00000207127 FLJ45513 ABI3 SNF8 PHOSPHO1 GNGT2
GH17F049337 1.1 Ensembl ENCODE 21.4 +20.8 20773 7.8 TBL1XR1 YBX1 BMI1 ZNF366 FOS CREM EGR2 ZNF362 CBFB USF2 ZNF652 RPL21P124 ENSG00000250186 PHB ABI3 GNGT2 FLJ40194 GC17M049339 PIR41840
GH17F049393 1.1 Ensembl ENCODE 16.7 -31.9 -31928 2.0 ELF3 WRNIP1 ARID4B SIN3A ZNF48 RAD21 RFX5 SCRT2 ZNF143 MIXL1 ZNF652 LOC102724596 ENSG00000207127 PHB ABI3 GNGT2 RPL21P124 ENSG00000250948
GH17F049333 0.7 Ensembl 20.2 +28.2 28172 1.0 BACH1 ZNF121 ZNF316 FOS NFE2 MAFK NFE2L2 MAFG ZBTB8A ARID1B ZNF652 LOC102724596 ENSG00000250186 RPL21P124 PHB ABI3 GNGT2 GC17M049326 GC17M049339
GH17F049259 1.5 FANTOM5 Ensembl ENCODE 6.7 +102.1 102054 2.0 TBP ZFP64 INSM2 ZNF76 KLF17 SIN3A ZNF2 ZEB1 ZNF391 FOS PHOSPHO1 ENSG00000250186 RPL21P124 PHB ZNF652 UBE2Z CALCOCO2 GC17P049267 FLJ40194
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF652 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF652 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001348439 873 3201 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 KLF13 SP3 SP5

Genomic Location for ZNF652 Gene

Chromosome:
17
Start:
49,289,206 bp from pter
End:
49,362,473 bp from pter
Size:
73,268 bases
Orientation:
Minus strand

Genomic View for ZNF652 Gene

Genes around ZNF652 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF652 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF652 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF652 Gene

Proteins for ZNF652 Gene

  • Protein details for ZNF652 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2D9-ZN652_HUMAN
    Recommended name:
    Zinc finger protein 652
    Protein Accession:
    Q9Y2D9
    Secondary Accessions:
    • A4QPD9
    • Q5H9Q0

    Protein attributes for ZNF652 Gene

    Size:
    606 amino acids
    Molecular mass:
    69744 Da
    Quaternary structure:
    • Interacts with CBFA2T3.
    SequenceCaution:
    • Sequence=BAA76768.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF652 Gene

Post-translational modifications for ZNF652 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF652 Gene

No data available for DME Specific Peptides for ZNF652 Gene

Domains & Families for ZNF652 Gene

Gene Families for ZNF652 Gene

Protein Domains for ZNF652 Gene

Suggested Antigen Peptide Sequences for ZNF652 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2D9

UniProtKB/Swiss-Prot:

ZN652_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 9 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with ZNF652: view

Function for ZNF652 Gene

Molecular function for ZNF652 Gene

UniProtKB/Swiss-Prot Function:
Functions as a transcriptional repressor.

Gene Ontology (GO) - Molecular Function for ZNF652 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16966434
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF652: view

Phenotypes for ZNF652 Gene

GenomeRNAi human phenotypes for ZNF652:
genes like me logo Genes that share phenotypes with ZNF652: view

Animal Model Products

miRNA for ZNF652 Gene

miRTarBase miRNAs that target ZNF652

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF652 Gene

Localization for ZNF652 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF652 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF652 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF652 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF652: view

Pathways & Interactions for ZNF652 Gene

SuperPathways for ZNF652 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF652 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF652: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF652 Gene

Transcripts for ZNF652 Gene

Unigene Clusters for ZNF652 Gene

Zinc finger protein 652:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF652 Gene

No ASD Table

Relevant External Links for ZNF652 Gene

GeneLoc Exon Structure for
ZNF652
ECgene alternative splicing isoforms for
ZNF652

Expression for ZNF652 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF652 Gene

Protein differential expression in normal tissues from HIPED for ZNF652 Gene

This gene is overexpressed in Plasma (32.7), Peripheral blood mononuclear cells (16.3), CD8 Tcells (9.0), and NK cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF652 Gene



Protein tissue co-expression partners for ZNF652 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF652 Gene:

ZNF652

SOURCE GeneReport for Unigene cluster for ZNF652 Gene:

Hs.463375

mRNA Expression by UniProt/SwissProt for ZNF652 Gene:

Q9Y2D9-ZN652_HUMAN
Tissue specificity: Widely expressed with higher expression in breast, prostate, vulva and pancreas.
genes like me logo Genes that share expression patterns with ZNF652: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZNF652 Gene

Orthologs for ZNF652 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF652 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF652 34 35
  • 99.78 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF652 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF652 34 35
  • 94.44 (n)
dog
(Canis familiaris)
Mammalia ZNF652 34 35
  • 94.22 (n)
rat
(Rattus norvegicus)
Mammalia Zfp652 34
  • 89.04 (n)
mouse
(Mus musculus)
Mammalia Zfp652 34 16 35
  • 88.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF652 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF652 34 35
  • 85.75 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF652 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14592 34
zebrafish
(Danio rerio)
Actinopterygii znf652 34 35
  • 62.76 (n)
Species where no ortholog for ZNF652 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF652 Gene

ENSEMBL:
Gene Tree for ZNF652 (if available)
TreeFam:
Gene Tree for ZNF652 (if available)

Paralogs for ZNF652 Gene

Paralogs for ZNF652 Gene

Pseudogenes.org Pseudogenes for ZNF652 Gene

genes like me logo Genes that share paralogs with ZNF652: view

Variants for ZNF652 Gene

Sequence variations from dbSNP and Humsavar for ZNF652 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1047104 -- 49,289,538(-) CTTCC(A/C)TGAGT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs10542422 -- 49,315,574(+) AAGTT(-/A)AAAAA intron-variant
rs10551912 -- 49,319,095(+) TTTTT(-/AA)AAAGC intron-variant, upstream-variant-2KB
rs10601579 -- 49,304,879(+) ATGTG(-/TA)TATAT intron-variant
rs1060868 -- 49,352,497(-) CTGTT(A/T)ATATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF652 Gene

Variant ID Type Subtype PubMed ID
nsv526307 CNV gain 19592680
nsv2075 CNV deletion 18451855
nsv1138553 CNV deletion 24896259
nsv1118765 CNV deletion 24896259
nsv1112712 CNV deletion 24896259
esv3640739 CNV loss 21293372
esv3326018 CNV insertion 20981092
esv3307703 CNV mobile element insertion 20981092

Variation tolerance for ZNF652 Gene

Residual Variation Intolerance Score: 17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 49.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF652 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF652

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF652 Gene

Disorders for ZNF652 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF652 Gene - From: DISEASES

Disorder Aliases PubMed IDs
vulva cancer
  • ca vulva
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ZNF652

Genetic Association Database (GAD)
ZNF652
Human Genome Epidemiology (HuGE) Navigator
ZNF652
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF652
genes like me logo Genes that share disorders with ZNF652: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF652 Gene

Publications for ZNF652 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain L.V. … van Duijn C.M. (Nat. Genet. 2011) 3 46 64
  3. Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. (PMID: 21602798) Haiman C.A. … Henderson B.E. (Nat. Genet. 2011) 3 46 64
  4. Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population. (PMID: 20414254) Hong K.W. … Oh B. (J. Hum. Genet. 2010) 3 46 64
  5. Confirmation of top polymorphisms in hypertension genome wide association study among Han Chinese. (PMID: 20542020) Niu W. … Zhu D. (Clin. Chim. Acta 2010) 3 46 64

Products for ZNF652 Gene

Sources for ZNF652 Gene

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