ZNF652 Gene
protein-coding GIFtS: 47
GCID: GC17M047366
|
|
zinc finger protein 652
| |
Aliases
for ZNF652 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Zinc Finger Protein 6521 2 | | KIAA09241 3 |
Export aliases for ZNF652 gene to outside databasesPrevious GC identifers: GC17M044728 GC17M042731 |
Summaries
for ZNF652 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ZN652_HUMAN, Q9Y2D9Function: Functions as a transcriptional repressor
|
Genomic Views
for ZNF652 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ZNF652 gene promoter:
HOXA9 AhR GATA-6 E4BP4 Egr-4 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for ZNF652
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF652 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.32 Ensembl cytogenetic band: 17q21.33 HGNC cytogenetic band: 17q21.32ZNF652 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M047366: view genomic region
(about GC identifiers)
Start:
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47,366,568 bp from pter |
End:
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47,439,835 bp from pter |
Size:
|
73,268 bases |
Orientation:
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minus strand |
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Proteins
for ZNF652 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZN652_HUMAN, Q9Y2D9 (See
protein sequence)Recommended Name: Zinc finger protein 652 Size: 606 amino acids; 69744 Da
Subunit: Interacts with CBFA2T3
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAA76768.2; Type=Erroneous initiation;
Secondary accessions: A4QPD9 Q5H9Q0Explore the universe of human proteins at neXtProt for ZNF652: NX_Q9Y2D9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y2D9
ZNF652 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001138837.1 NP_055712.1
ENSEMBL proteins: ENSP00000424848 ENSP00000354686 ENSP00000416305
Human Recombinant Protein Products for ZNF652:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ZNF652 for ontologies About GeneDecksing
ZNF652 Antibody Products:
Assay Products for ZNF652: |
Protein
Domains /
Families
for ZNF652 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ZNF652 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y2D9ProtoNet protein and cluster: Q9Y2D9 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: ZN652_HUMAN, Q9Y2D9Similarity: Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity: Contains 9 C2H2-type zinc fingers |
Function
for ZNF652 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ZN652_HUMAN, Q9Y2D9Function: Functions as a transcriptional repressor Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ZNF652 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF652 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF652 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF652 (NM_014897) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF652 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF652 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF652 |
|
Pathways & Interactions
for ZNF652 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ZNF652
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5 Interacting proteins for ZNF652 (Q9Y2D91, 3 ENSP000003546864) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
ZNF652 for ontologies About GeneDecksing
|
Drugs & Compounds
for ZNF652 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ZNF652
Search CenterWatch for drugs/clinical trials and news about ZNF652 / ZN652
|
Transcripts
for ZNF652 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ZNF652 gene (2 alternative transcripts): NM_001145365.1 NM_014897.2 Unigene Cluster for ZNF652: Zinc finger protein 652 Hs.463375 [show with all ESTs]Unigene Representative Sequence: NM_0011453654 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000513488 ENST00000508237(uc002iou.4) ENST00000362063(uc002iov.4 uc002iow.3)
ENST00000430262
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF652 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ZNF652 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ZNF652 (NM_014897) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ZNF652 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ZNF652 |
Additional cDNA sequence: AB023141.1 AK093834.1 AK292667.1 BC028045.1 BC034987.1 BC139779.1 BC152440.1 BX641027.1 CR933680.1 13 DOTS entries: DT.92417618 DT.101983728 DT.403079 DT.99959428 DT.95159338 DT.120947208 DT.100700422 DT.100023698 DT.100767085 DT.91693476 DT.95184426 DT.95370005 DT.91652041 24/234 AceView cDNA sequences (see all 234): BM987984 AI336093 BU838341 BQ008150 AI208548 AI221814 BI018211 AW373278 BC034987 AI916447 BQ305749 AL036450 BM664153 BU607811 BX644173 AB023141 AA057773 AI273672 AA402937 BF057297 AA355371 AI669936 AI094559 CB322024
GeneLoc Exon Structure
|
Expression
for ZNF652 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ZNF652 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ZNF652 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF652
SOURCE GeneReport for Unigene cluster: Hs.463375
UniProtKB/Swiss-Prot: ZN652_HUMAN, Q9Y2D9Tissue specificity: Widely expressed with higher expression in breast, prostate, vulva and pancreas
SABiosciences Custom PCR Arrays for ZNF652
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ZNF652
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ZNF652 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF652 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF652 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ZNF652 |
Orthologs
for ZNF652 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ZNF652 gene from 5/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ZNF6521 |
zinc finger protein 652 |
85.75(n)
92.57(a) |
|
419987 XM_003642788.1 XP_003642836.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ZNF6526 |
-- |
88(a) |
1 ↔ 1 |
6(76257405-76270812) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.145922 |
Transcribed sequence with moderate similarity to protein more |
78.88(n) |
|
CF221869.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
znf6521 |
zinc finger protein 652 |
63.85(n)
64.64(a) |
|
557571 XM_680657.4 XP_685749.4 |
fruit fly
(Drosophila melanogaster) |
Insecta |
dwg6 |
deformed wings |
20(a) |
1 → many |
X(2621733-2624092) |
ENSEMBL Gene Tree for ZNF652 (if available)
TreeFam Gene Tree for ZNF652 (if available) |
Paralogs
for ZNF652 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ZNF652 gene
- ZBTB472
18/110 SIMAP similar genes for ZNF652 using alignment to 2 protein entries: ZN652_HUMAN (see all proteins)
(see all similar genes):ZNF148 DKFZp434J0650 ZBTB47 ZNF227 ZNF72 ZNF78L1
ZFS-2 ZNF235 ZFS-4 A-328A3.4 ZNF500 ZNF55
ZNF555 ZNF845 kr-znf3 ZNF ZNF234 ZNF664
ZNF652 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ZNF652
PGOHUM00000237627
|
Genomic Variants
for ZNF652 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ZNF652 (47366568 - 47439835 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ZNF652: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF652 |
|
Disorders
/ Diseases
for ZNF652 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ZNF652 for disorders About GeneDecksing
OMIM gene information: 613907
OMIM disorders: --
6  diseases for ZNF652: About MalaCardsvulva carcinoma essential hypertension hypertension prostate cancer
prostatitis carcinoma
Human Genome Epidemiology (HuGE) Navigator: ZNF652 (5 documents)
Export disorders for ZNF652 gene to outside databases
|
Publications
for ZNF652 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ZNF652 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with ZNF652) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
- ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription. (PubMed id 16966434)1, 2 Kumar R.... Callen D.F. (2006)
- A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid ho rmone regulation. (PubMed id 22829776)1 Coviello A.D....Perry J.R. (2012)
- Genome-wide mapping of ZNF652 promoter binding sites i n breast cancer cells. (PubMed id 21678463)1 Kumar R....Callen D.F. (2011)
- Discovery and replication of novel blood pressure gen etic loci in the Women's Genome Health Study. (PubMed id 21045733)1 Ho J.E....Chasman D.I. (2011)
- Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1 Wain L.V....van Duijn C.M. (2011)
- Genome-wide association study of prostate cancer in m en of African ancestry identifies a susceptibility locus at 17q21. (PubMed id 21602798)1 Haiman C.A....Henderson B.E. (2011)
- Common variants in or near FGF5, CYP17A1 and MTHFR ge nes are associated with blood pressure and hypertension in Chinese Hans. (PubMed id 20852445)1 Liu C....Lin X. (2011)
- Confirmation of top polymorphisms in hypertension gen ome wide association study among Han Chinese. (PubMed id 20542020)1 Niu W....Zhu D. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
|
External Searches for ZNF652 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ZNF652 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ZNF652 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ZNF652 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ZNF652 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ZNF652 gene:
Search GeneIP for patents involving ZNF652
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ZNF652 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for ZNF652 | | OriGene Custom Protein Services for ZNF652 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ZNF652 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ZNF652 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF652 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ZNF652 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ZNF652 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ZNF652 |
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