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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ZNF649 Gene

protein-coding GIFtS: 48
GCID: GC19M052392

zinc finger protein 649

Search for ZNF649
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Zinc Finger Protein 649¹ ²
FLJ12644¹

External Ids:	HGNC: 25741¹	Entrez Gene: 65251²	Ensembl: ENSG00000198093⁷	OMIM: 611903⁵	UniProtKB: Q9BS31³

Export aliases for ZNF649 gene to outside databases

Previous GC identifers: GC19M057085 GC19M048724

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ZN649_HUMAN, Q9BS31

Function: Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1

transcription activities mediated by growth factor signaling pathways

Gene Wiki entry for ZNF649

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ZNF649 gene promoter:
c-Fos AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ZNF649 promoter sequence

Search SABiosciences Chromatin IP Primers for ZNF649

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ZNF649

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41 Ensembl cytogenetic band: 19q13.41 HGNC cytogenetic band: 19q13.41

ZNF649 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ZNF649 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M052392: view genomic region (about GC identifiers)

Start:	52,392,488 bp from pter	End:	52,408,305 bp from pter
Size:	15,818 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZN649_HUMAN, Q9BS31 (See protein sequence)

Recommended Name: Zinc finger protein 649

Size: 505 amino acids; 57683 Da

Subcellular location: Nucleus

Developmental stage: Expressed in fetal heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas

Secondary accessions: A8MYJ5 B2RDC4 Q9H9N2

Explore the universe of human proteins at neXtProt for ZNF649: NX_Q9BS31

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BS31

ZNF649 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_075562.2

ENSEMBL proteins:

ENSP00000347043

Reactome Protein details: Q9BS31
Human Recombinant Protein Products:

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	Uscn Proteins for ZNF649

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--

ZNF649 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ZNF649 for domains About GeneDecksing

4 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR001909 Krueppel-associated_box

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q9BS31

ProtoNet protein and cluster: Q9BS31

1 Blocks protein family: IPB001909 KRAB box

UniProtKB/Swiss-Prot: ZN649_HUMAN, Q9BS31

Domain: The KRAB domain is required for transcriptional repression

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 10 C2H2-type zinc fingers

Similarity: Contains 1 KRAB domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ZN649_HUMAN, Q9BS31

Function: Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1

transcription activities mediated by growth factor signaling pathways

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In Situ Assay
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

ZNF649 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Reactome Pathways for ZNF649

	Generic Transcription Pathway
	Gene Expression

ZNF649 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ZNF649

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

4 Interacting proteins for ZNF649 (Q9BS31³ ENSP00000347043⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADAM15	Q13444³	I2D: score=1
DVL3	Q92997³	I2D: score=1
CBX5	ENSP00000209875⁴	STRING: ENSP00000209875
SMARCAD1	ENSP00000351947⁴	STRING: ENSP00000351947

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

ZNF649 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for ZNF649
Search CenterWatch for drugs/clinical trials and news about ZNF649 / ZN649

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ZNF649 gene:

NM_023074.3

Unigene Cluster for ZNF649:

Zinc finger protein 649

Hs.148322 [show with all ESTs]

Unigene Representative Sequence: NM_023074

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000354957(uc002pxy.3)

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Additional cDNA sequence:

AF086241.1 AK000909.1 AK022706.1 AK225480.1 AK315487.1 AL713677.1 BC005368.1

5 DOTS entries:

DT.438066 DT.91942447 DT.100754781 DT.121426767 DT.121426760

24/64 AceView cDNA sequences (see all 64):

AI424306 BF725119 AK022706 H81971 BM678761 BM674864 AL713677 AU125298

BM678535 BM717588 CB145274 CR590368 AA862637 BM722022 BE504735 BX089598

AK000909 CD106294 NM_023074 AF086241 BM724141 AI588909 CF994209 BX954697

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ZNF649 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b
SP1:					-		-		-				-		-
SP2:					-		-		-				-		-				-
SP3:					-		-		-
SP4:							-		-				-		-
SP5:					-		-		-

ECgene alternative splicing isoforms for ZNF649

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ZNF649 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See ZNF649 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ZNF649

SOURCE GeneReport for Unigene cluster: Hs.148322

UniProtKB/Swiss-Prot: ZN649_HUMAN, Q9BS31

Tissue specificity: Highly expressed in heart, skeletal muscle, and brain. Lower expression in liver, lung, kidney,

pancreas and placenta

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ZNF649 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	-- -- (see all 8)	--	29(a) 25(a) (see all 8)	many ↔ many many ↔ many (see all 8)	Un(41687425-41690654) Un(54164034-54170097)

ENSEMBL Gene Tree for ZNF649 (if available)
TreeFam Gene Tree for ZNF649 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ZNF649 gene

ZNF175² ZNF674² LOC100287515² ZNF614² ZNF432² ZNF613² ZNF26² ZNF350²

ZNF81² ZNF605² ZNF577² ZNF84² ZNF630² ZFP37² ZNF484² ENSG00000229631²

ZNF182² ZNF41² ZNF268² LOC100996464² ZNF615² ZNF300²

18/441 SIMAP similar genes for ZNF649 using alignment to 6 protein entries: ZN649_HUMAN (see all proteins) (see all similar genes):

DKFZp313M0722 ZNF323 ZNF696 DKFZp666C237 ZNF232 ZNF397

ZNF267 ZNF835 zf30 DKFZp686G16228 GLI4 ZFS-1

ZNF316 ZNF432 ZNF501 ZNF502 ZNF544 ZNF623

ZNF649 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7256926^1,2	C,F,A,	--	52391988(+)	`ACTGAA/GACTCA`	4	--	us2k¹ int¹		11		NA WA CSA EA	509
rs17768248^1,2	C,F,	--	52392061(+)	`TCAGAG/AAACCT`	4	--	int¹ us2k¹		5		NA EA	376
rs4584941^1,2	C,F,H,	--	52392141(+)	`TTGTGC/TGTGCT`	4	--	us2k¹ int¹		20		NS EA NA WA CSA	2346
rs191418730^1,2		--	52392204(+)	`ACATTC/GTACTG`	4	--	int¹ us2k¹		0	--	--	--	--
rs140514893^1,2		--	52392247(+)	`GCTAAC/GTGTTG`	4	--	int¹ us2k¹		0	--	--	--	--
rs183560743^1,2		--	52392369(+)	`GAATGC/TTAGAA`	4	--	us2k¹ int¹		0	--	--	--	--
rs147062300^1,2		--	52392381(+)	`GAATTC/TATCAT`	4	--	int¹ us2k¹		0	--	--	--	--
rs189511386^1,2		--	52392402(+)	`GATTAC/TCCATA`	4	--	us2k¹ int¹		0	--	--	--	--
rs138332681^1,2		--	52392439(+)	`TAGAAC/GACAAT`	4	--	int¹ us2k¹		0	--	--	--	--
rs1125222^1,2	C,F,H,	--	52392636(-)	`GGAACG/ATGAGA`	4	--	us2k¹ ut3¹		13		MN NS EA NA WA	1106

HapMap Linkage Disequilibrium report for ZNF649 (52392488 - 52408305 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for ZNF649
5 CNVs: 8875 4086 3195 34482 53103

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ZNF649 for disorders About MalaCards

ZNF649 for disorders About GeneDecksing

OMIM gene information: 611903 OMIM disorders: --

Export disorders for ZNF649 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ZNF649 gene, integrated from 9 sources (see all 15) (see top 10):
(articles sorted by number of sources associating them with ZNF649)

Utopia: connect your pdf to the dynamic
world of online information

ZNF649, a novel Kruppel type zinc-finger protein, functions as a transcriptional suppressor. (PubMed id 15950191)^{1, 2, 3} Yang H.... Liu M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Maintenance of silent chromatin through replication r equires SWI/SNF-like chromatin remodeler SMARCAD1. (PubMed id 21549307)¹ Rowbotham S.P....Mermoud J.E. (2011)
Human POGZ modulates dissociation of HP1alpha from mi totic chromosome arms through Aurora B activation. (PubMed id 20562864)¹ Nozawa R.S....Obuse C. (2010)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)¹ Wiemann S.... Poustka A. (2001)
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)¹ Simpson J.C.... Wiemann S. (2000)
DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)¹ Hartley J.L....Brasch M.A. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 65251	HGNC: 25741	AceView: FLJ12644	Ensembl:ENSG00000198093	euGenes: HUgn65251
ECgene: ZNF649	H-InvDB: ZNF649

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ZNF649	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ZNF649 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ZNF649 gene:
Search GeneIP for patents involving ZNF649

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ZNF649 gene at Home site.

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ZNF649 Gene

zinc finger protein 649

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ZNF649 Gene

zinc finger protein 649

Aliasesfor ZNF649 gene

Summariesfor ZNF649 gene

Genomic Viewsfor ZNF649 gene

Proteinsfor ZNF649 gene

Protein Domains /Familiesfor ZNF649 gene

Functionfor ZNF649 gene

Pathways & Interactionsfor ZNF649 gene

Drugs & Compoundsfor ZNF649 gene

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Disorders / Diseasesfor ZNF649 gene

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for ZNF649 gene

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for ZNF649 gene

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for ZNF649 gene

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for ZNF649 gene

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for ZNF649 gene

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for ZNF649 gene

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for ZNF649 gene

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for ZNF649 gene

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for ZNF649 gene

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for ZNF649 gene

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for ZNF649 gene

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for ZNF649 gene

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for ZNF649 gene