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Aliases for ZNF649 Gene

Aliases for ZNF649 Gene

  • Zinc Finger Protein 649 2 3 5

External Ids for ZNF649 Gene

Previous GeneCards Identifiers for ZNF649 Gene

  • GC19M057085
  • GC19M052392
  • GC19M048724

Summaries for ZNF649 Gene

GeneCards Summary for ZNF649 Gene

ZNF649 (Zinc Finger Protein 649) is a Protein Coding gene. Among its related pathways are Gene Expression. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF613.

UniProtKB/Swiss-Prot for ZNF649 Gene

  • Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways.

Gene Wiki entry for ZNF649 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF649 Gene

Genomics for ZNF649 Gene

Regulatory Elements for ZNF649 Gene

Enhancers for ZNF649 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G051821 1.7 FANTOM5 Ensembl ENCODE dbSUPER 16.8 +82.1 82105 5.0 ZNF146 NFIB TAL1 CEBPG FOSL1 TCF12 NCOR1 CBX5 NFE2 TRIM24 ZNF649 SIGLEC14 FPR3 RPL7P51 SIGLEC5 ZNF577 ZNF841 ZNF350 FPR1 SIGLEC10
GH19G051687 1.8 FANTOM5 ENCODE dbSUPER 11 +214.6 214562 6.9 CREB3L1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZNF610 ZNF808 ZNF836 ZNF616 ZNF841 ZNF137P ENSG00000268970 ZNF766 ENSG00000269825 ZNF528 ZNF175
GH19G051393 1.5 FANTOM5 ENCODE 10.3 +510.0 510005 2.8 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ZFP64 ARID4B SIN3A YY1 ZNF143 ZNF766 ZNF577 SPACA6P-AS ZNF836 C19orf84 ZNF432 ZNF616 ZNF880 ENSG00000268015 ZNF175
GH19G051018 1.2 Ensembl ENCODE 12.2 +885.6 885620 2.4 TCF12 GLIS2 ZNF302 EGR1 ZNF366 ZNF416 ETV6 EGR2 SMARCA5 SP3 KLK10 ZNF577 ZNF175 ZNF649 KLK13 KLK6 ZNF350 KLK14 SNORD88C C19orf48
GH19G051016 1.2 Ensembl ENCODE 10.6 +887.7 887676 1.5 PKNOX1 ATF1 SIN3A GLI4 ZNF121 GLIS2 ZNF143 KLF7 SP3 REST ZNF175 ZNF615 KLK10 ZNF577 LRRC4B SPACA6 KLK13 KLK6 ZNF649 KLK14
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ZNF649 on UCSC Golden Path with GeneCards custom track

Promoters for ZNF649 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111273 739 2200 HDGF CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766
ENSR00000111273 751 2200 HDGF CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766

Genomic Location for ZNF649 Gene

Chromosome:
19
Start:
51,888,538 bp from pter
End:
51,905,052 bp from pter
Size:
16,515 bases
Orientation:
Minus strand

Genomic View for ZNF649 Gene

Genes around ZNF649 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF649 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF649 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF649 Gene

Proteins for ZNF649 Gene

  • Protein details for ZNF649 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BS31-ZN649_HUMAN
    Recommended name:
    Zinc finger protein 649
    Protein Accession:
    Q9BS31
    Secondary Accessions:
    • A8MYJ5
    • B2RDC4
    • Q9H9N2

    Protein attributes for ZNF649 Gene

    Size:
    505 amino acids
    Molecular mass:
    57683 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF649 Gene

Post-translational modifications for ZNF649 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF649 Gene

No data available for DME Specific Peptides for ZNF649 Gene

Domains & Families for ZNF649 Gene

Gene Families for ZNF649 Gene

Protein Domains for ZNF649 Gene

Suggested Antigen Peptide Sequences for ZNF649 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BS31

UniProtKB/Swiss-Prot:

ZN649_HUMAN :
  • The KRAB domain is required for transcriptional repression.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The KRAB domain is required for transcriptional repression.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF649: view

Function for ZNF649 Gene

Molecular function for ZNF649 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways.

Gene Ontology (GO) - Molecular Function for ZNF649 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0005515 protein binding IPI 23455924
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with ZNF649: view
genes like me logo Genes that share phenotypes with ZNF649: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF649 Gene

Localization for ZNF649 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF649 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF649 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF649 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with ZNF649: view

Pathways & Interactions for ZNF649 Gene

SuperPathways for ZNF649 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF649: view

Pathways by source for ZNF649 Gene

2 Reactome pathways for ZNF649 Gene

Gene Ontology (GO) - Biological Process for ZNF649 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ZNF649: view

No data available for SIGNOR curated interactions for ZNF649 Gene

Transcripts for ZNF649 Gene

Unigene Clusters for ZNF649 Gene

Zinc finger protein 649:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF649 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6:

Relevant External Links for ZNF649 Gene

GeneLoc Exon Structure for
ZNF649
ECgene alternative splicing isoforms for
ZNF649

Expression for ZNF649 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF649 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF649 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF649 Gene:

ZNF649

SOURCE GeneReport for Unigene cluster for ZNF649 Gene:

Hs.148322

mRNA Expression by UniProt/SwissProt for ZNF649 Gene:

Q9BS31-ZN649_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, and brain. Lower expression in liver, lung, kidney, pancreas and placenta.

Evidence on tissue expression from TISSUES for ZNF649 Gene

  • Nervous system(4.4)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF649: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF649 Gene

Orthologs for ZNF649 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF649 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF649 34 35
  • 99.6 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 37 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 31 (a)
OneToMany
Species where no ortholog for ZNF649 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF649 Gene

ENSEMBL:
Gene Tree for ZNF649 (if available)
TreeFam:
Gene Tree for ZNF649 (if available)

Paralogs for ZNF649 Gene

Paralogs for ZNF649 Gene

(529) SIMAP similar genes for ZNF649 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF649: view

Variants for ZNF649 Gene

Sequence variations from dbSNP and Humsavar for ZNF649 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000097541 -- 51,901,626(+) GGCAA(C/G)AGAGC intron-variant
rs1000178939 -- 51,898,973(+) AGGTC(A/G)GGGGT intron-variant
rs1000204402 -- 51,904,138(+) CTTTT(C/T)TGTCT intron-variant
rs1000646421 -- 51,890,642(+) GCAAA(C/T)TCACA intron-variant, reference, synonymous-codon
rs1000806392 -- 51,905,144(+) TTCTT(G/T)TGTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ZNF649 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3626n100 CNV gain 25217958
dgv425n27 CNV gain 19166990
dgv6523n54 CNV gain 21841781
esv2758767 CNV gain+loss 17122850
esv3644680 CNV gain 21293372
esv3644682 CNV gain 21293372
nsv1063362 CNV gain 25217958
nsv1140251 OTHER inversion 24896259
nsv580001 CNV gain 21841781
nsv580005 CNV loss 21841781
nsv978837 CNV duplication 23825009

Variation tolerance for ZNF649 Gene

Residual Variation Intolerance Score: 42.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 42.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF649 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF649

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF649 Gene

Disorders for ZNF649 Gene

Relevant External Links for ZNF649

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF649

No disorders were found for ZNF649 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF649 Gene

Publications for ZNF649 Gene

  1. ZNF649, a novel Kruppel type zinc-finger protein, functions as a transcriptional suppressor. (PMID: 15950191) Yang H. … Liu M. (Biochem. Biophys. Res. Commun. 2005) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 64
  5. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naA^ve to therapy. (PMID: 23580065) Pieragostino D. … Del Boccio P. (Mol Biosyst 2013) 3 64

Products for ZNF649 Gene

Sources for ZNF649 Gene

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